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Chen Liang,Liu Yuting,Wang Zheyu,Zhang Leiyang,Xu Yi,Li Yinan,Zhang Lan,Wang Guiming,Yang Shuofei,Xue Guanhua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Neutrophil extracellular traps (NETs) play an important role in abdominal aortic aneurysm (AAA) formation; however, the underlying molecular mechanisms remain unclear. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) may exert therapeutic effects on AAA through their immunomodulatory and regenerative abilities. This study aimed to examine the role and mechanism of MSC-EVs in regulating the development of NET-mediated AAA. Excessive release of NETs was observed in patients with AAA, and the levels of NET components were associated with the clinical outcomes of the patients. Datasets from the Gene Expression Omnibus database were analyzed and revealed that the PI3K/AKT pathway and ferroptosis were strongly associated with NETosis during AAA formation. Further experiments verified that NETs promoted AAA formation by inducing ferroptosis in smooth muscle cells (SMCs) by inhibiting the PI3K/AKT pathway. The PI3K agonist 740 Y-P, the ferroptosis inhibitor ferrostatin-1, and Padi4 deficiency significantly prevented AAA formation. MSC-EVs attenuated AAA formation by reducing NET release in an angiotensin II-induced AAA mouse model. In vitro experiments revealed that MSC-EVs reduced the release of NETs by shifting NETosis to apoptosis. Our study indicates an important role for NET-induced SMC ferroptosis in AAA formation and provides several potential targets for AAA treatment
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Implementation of One-Cycle Control for Switched Capacitor Converters
Lei Yang,Xiaobin Zhang,Guann-pyng Li 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.6
An extension of the one-cycle control (OCC) method for switched-capacitor (SC) converters is proposed in this paper, featuring a fast dynamic response, wide line and load operation ranges, and simplicity in implementation. To illustrate the operation principle of this nonlinear control method and to demonstrate its simplicity in design, a dual-phase unity gain SC converter is examined. A new control loop based on the charge balance in a flying capacitor is formulated for the OCC technique and implemented with a 15W dual-phase unity gain SC converter on a circuit board for control verification. The obtained experimental results show that external disturbances can be rejected in one switching cycle by the OCC controlled SC converter with good line and load regulations. When compared to other control methods, the proposed nonlinear control loop exhibits superior dynamic performance in suppressing input and load disturbances.
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