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Han Zhang,Liangshan Hu,Wei Xiao,Yanqiong Su,Donglin Cao 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Melanoma is a highly aggressive form of skin cancer with increasing incidence and mortality rates. Chemotherapy, the primary treatment for melanoma, is limited by hypoxia-induced drug resistance and suppressed immune response at the tumor site. Modulating the tumor microenvironment (TME) to alleviate hypoxia and enhance immune response has shown promise in improving chemotherapy outcomes. Methods In this study, a novel injectable and in situ forming hydrogel named MD@SA was developed using manganese dioxide (MnO2) nanosheets pre-loaded with the chemotherapy drug doxorubicin (DOX) and mixed with sodium alginate (SA). The sustainable drug delivery, oxygen generation ability, and photothermal property of MD@SA hydrogel were characterized. The therapeutic efficacy of hydrogel was studied in B16F10 in vitro and B16F10 tumorbearing mice in vivo. The immune effects on macrophages were analyzed by flow cytometry, real-time quantitative reverse transcription PCR, and immunofluorescence analyses. Results The MD@SA hydrogel catalyzed the tumoral hydrogen peroxide (H2O2) into oxygen, reducing the hypoxic TME, down-regulating hypoxia-inducible factor-1 alpha (HIF-1α) and drug efflux pump P-glycoprotein (P-gp). The improved TME conditions enhanced the uptake of DOX by melanoma cells, enhancing its efficacy and facilitating the release of tumor antigens. Upon NIR irradiation, the photothermal effect of the hydrogel induced tumor apoptosis to expose more tumor antigens, thus re-educating the M2 type macrophage into the M1 phenotype. Consequently, the MD@SA hydrogel proposes an ability to constantly reverse the hypoxic and immune-inhibited TME, which eventually restrains cancer proliferation. Conclusion The injectable and in situ forming MD@SA hydrogel represents a promising strategy for reshaping the TME in melanoma treatment. By elevating oxygen levels and activating the immune response, this hydrogel offers a synergistic approach for TME regulation nanomedicine.
Zhaojie Jiao,Xianming Zhang,Haifeng Gong,Donglin He,Hong Yin,Yunqi Liu,Xu Gao 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
This study aimed to treat toxic and refractory organic wastewater, and to address the limitations ofFenton method in treating organic wastewater, that the active components are easy to lose and usuallyoperate at the pH value of 2 3. In the present study, CuCe oxide catalyst was produced through citricacid-assisted complexation. Besides, the structural stability and catalytic wet peroxide oxidation (CWPO)performance of the catalyst after 5 times of application were delved into by characterization. The effectsof catalyst dosage and pH on quinoline removal were ascertained, while the reusability of the catalystwas explored. Moreover, the variations of pH, hydroxyl radical concentration and UV–Vis spectra inthe reaction system were analyzed. The possible degradation pathway and the catalytic mechanism werealso discussed. As suggested from the results, the catalyst exhibited high catalytic activity, structural stabilityand pH adaptability; it also had high CWPO performance for quinoline at the pH from 3.8 to 10.5,and the pH value need not be regulated. Under optimal conditions, 98.1% of quinoline and 86.1% of totalorganic carbon (TOC) were removed. In the CWPO process of quinoline, the OH attacked the nitrogen ringand the benzene ring in sequence.
Simulated Long-Term Vegetation–Climate Feedbacks in the Tibetan Plateau
Wei Hua,Zouxin Lin,Donglin Guo,Guangzhou Fan,Yongli Zhang,Kaiqin Yang,Qin Hu,Lihua Zhu 한국기상학회 2019 Asia-Pacific Journal of Atmospheric Sciences Vol.55 No.1
The Tibetan Plateau (TP) is an important region of land–atmosphere interactions with high climate variability. In this study, an atmosphere–vegetation interaction model was applied to explore the possible responses of vegetation to climate warming, and to assess the impacts of land cover change on the land surface physical processes across the TP. Results showed that long-term warming over the TP could influence vegetation growth via different mechanisms. Most likely, increased temperature would enhance the physiological activity in most high cold areas on the TP, whereas high temperature would inhibit vegetation growth by increasing respiration in areas with favorable water and temperature conditions. In addition, for areas where the climate is warmer but not wetter, higher temperature could influence photosynthesis via the moisture condition of the vegetation rather than by modulating respiration. Numerical simulations demonstrated that vegetation could control the land surface–atmosphere energy balance effectively. The change of land cover from vegetated land to desert steppe decreased the net radiation absorbed by the surface, weakening the surface thermal effects, and reducing sensible and latent heat fluxes. Furthermore, sensitivity simulations also revealed that global warming would likely accelerate vegetation growth in most areas of the TP, resulting in increased surface heat flux.
Efficacy of an adhesive nanopesticide on insect pests of rice in field trials
Gao Yunhao,Li Donglin,Li Dongyang,Xu Pengfei,Mao Kaikai,Zhang Yunhua,Qin Xueying,Tang Tao,Wan Hu,Li Jianhong,Guo Mingcheng,He Shun 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.4
Nanopesticides with antiwashing capacity on leaves are the most promising new approaches for sustainable pest management and have been fully evaluated in the laboratory. However, few studies have tested these nanopesticides on pests, and their efficacy under field conditions has not been investigated. In this study, an adhesive hollow mesoporous silica hybrid with well-defined spherical shape and good monodispersity was used as a nanocarrier of cyantraniliprole (CNAP) to fabricate an adhesive nanopesticide (CNAP-HMS-PDAAM). The control efficacy of CNAP-HMS-PDAAM was tested under field conditions. The results indicated that the efficacy of four doses of CNAP-HMS-PDAAM (30.0–69.0 g a.i./ha) against Cnaphalocrocis medinalis (Guénee) 3, 7, and 14 days after spraying did not significantly differ from that of Benevia (34.5 g a.i./ha). Twenty-eight days after spraying, the efficacy of all four doses of CNAP-HMS-PDAAM was significantly better than that of Benevia. Additionally, the efficacy of CNAP-HMS-PDAAM at doses of 34.5, 39.0 and 69.0 g a.i./ha against Chilo suppressalis (Walker) were significantly higher than that of Benevia (34.5 g a.i./ha). Thus, CNAP-HMS-PDAAM showed long-term control efficacies against C. medinalis (Guénee) and C. suppressalis (Walker), mainly due to its strong adhesive property on rice leaves and its sustained release properties. In addition, the nanocarriers showed good biocompatibility and had no obvious influence on the growth of rice.
Finite element simulation and experiments on a new induction heating bearing replacer
Li Guofa,Ren Xiaoli,Wang Longshan,Zhang Donglin 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.8
A new shaft-bearing replacer used for bearing inner race based on the induction-heating technique by finite element method (FEM)was designed in this paper. The regularities of the distribution of the electromagnetic and thermal-structural coupled field in the replacer,temperature changes with time course, and expansion size in shaft and the bearing inner ring were simulated during the course of induction heating. The FEM simulation results not only proved the existence of the eddy skin effect, but also achieved the design parameters of the replacer. Experiments verified that the replacer can realize a fast disassembling of the bearing inner race, which assembled on an axle with interference fits.
Youping Sun,Lois Berg Stack,Donglin Zhang,Zhanying Gu 한국원예학회 2011 Horticulture, Environment, and Biotechnology Vol.52 No.4
Ethephon was sprayed on Euphorbia pulcherrima Willd. ex Klotzsch (poinsettia) ‘Sonora Jingle’ and ‘Sonora White’ to control their height and produce more compact potted plants. The results showed that Ethephon could effectively control the growth of ‘Sonora Jingle’ and ‘Sonora White’ poinsettia. Height was reduced by was 33.4 ± 0.8% for ‘Sonora Jingle’ and 30.8 ± 1.3% for ‘Sonora White’ poinsettia, when 700 mg・L^(-1) Ethephon was sprayed three times on 29 August, 20September, and 13 October 2005, respectively. Similar to other plant growth retardants, side effects including phytotoxicity and delays to first bract color were also observed on Ethephon treated poinsettia. However, all plants produced were still of a marketable quality.