Expanding the Diversity of Allosteric Bcr-Abl Inhibitors

Deng, Xianming,Okram, Barun,Ding, Qiang,Zhang, Jianming,Choi, Yongmun,Adriá,n, Francisco J.,Wojciechowski, Amy,Zhang, Guobao,Che, Jianwei,Bursulaya, Badry,Cowan-Jacob, Sandra W.,Rummel, Gabriele American Chemical Society 2010 Journal of medicinal chemistry Vol.53 No.19

<P/><P>Inhibition of Bcr-Abl kinase activity by imatinib for the treatment of chronic myeloid leukemia (CML) currently serves as the paradigm for targeting dominant oncogenes with small molecules. We recently reported the discovery of GNF-2 (<B>1</B>) and GNF-5 (<B>2</B>) as selective non-ATP competitive inhibitors of cellular Bcr-Abl kinase activity that target the myristate binding site. Here, we used cell-based structure−activity relationships to guide the optimization and diversification of ligands that are capable of binding to the myristate binding site and rationalize the findings based upon an Abl−compound <B>1</B> cocrystal. We elucidate the structure−activity relationships required to obtain potent antiproliferative activity against Bcr-Abl transformed cells and report the discovery of new compounds (<B>5g</B>,<B> 5h</B>,<B> 6a</B>,<B> 14d</B>, and <B>21j-I)</B> that display improved potency or pharmacological properties. This work demonstrates that a variety of structures can effectively target the Bcr-Abl myristate binding site and provides new leads for developing drugs that can target this binding site.</P>

Sensitivity analysis of rolling bearing fatigue life under cyclic loading

Xianming Wang,Qingling Meng,Tianxiao Zhang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.11

Rolling bearings are regularly subjected to cyclic loading, and the load changing sequence has a significant influence on bearing fatigue life. The study offers a cumulative fatigue damage theory based on the improved Lundberg-Palmgren method that takes into account the effect of load changing sequence on bearing fatigue life and then proposes a modified Miner bearing fatigue life model. Additionally, the state function for the bearing fatigue life analysis is developed based on the basic dynamic load rating and stress-strength interference model of the bearing. A moment-based sensitivity analysis method for bearing fatigue life is proposed for studying the influence of different variables on bearing fatigue life. Finally, a sensitivity analysis of the fatigue life of 6209 deep groove ball bearings was performed as an example. The calculation results demonstrate that the modified Miner life model is comprehensive and that the moment-based sensitivity analysis method is simple and accurate.

Research on The Network Cloud Teaching Mode of PBL Project Teaching Method

Lei Zhang,Zheng Ren,Xianming Shi,Qingqi Zeng 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.10

This paper designed the learning resource storage model mainly based on Hadoop platform, and the system structure was optimized on the basis of the original system against the problems of inefficient storage of massive small files, high memory overhead on the Hadoop platform. The PBL teaching resources are classified to improve the utilization ratio of resources and access efficiency of resources according to the file size and file correlation. When processing the small files, small files are merged according to the knowledge point, and then storage processing is conducted with the method of handling large files, giving full play to the advantages of processing files in the Hadoop. Simulation experiment is conducted in the laboratory environment, to compare the integrated storage space with the time required for resources storage. The result is that the model can reduce the storage space of the file, and improve the integrated storage efficiency on the basis of not affecting file storage.

The Pilot Study for Waste Oil Removal from Oilfields by Acinetobacter johnsonii Using a Specialized Batch Bioreactor

Yan Jiang,Xianming Zhang,Guoxu Chen,Yu Shen,Liang Zhou 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6

The batch bioreactor with a maximum capacity of 0.28 m3 was designed and manufactured according to oilfield conditions Acinetobacter johnsonii ioslated from waste oil in an aerobic environment was employed to cleanse waste oil and wash-down water using the bioreactor in a pilot scale. The aerating process was optimized from 2 to 4 m3/h corresponding to the different cell growth phases, ensuring sufficient dissolved oxygen and avoiding cell damage from the shearing forces due to strong aeration. The bio-treatment of waste oil underwent two stages:one was the wettability reversal of inorganic admixtures from oil phase into waster phase through enlarged wetting angles, and the other was the bio-flocculation in waster phase by intermediate metabolites excreted by cells. Finally,inorganic admixtures were effectively removed from waste oil and wash-down water at the optimal conditions, with the content less than 0.5% in oil phase and turbidity and sulfide less than 100 NTU and 1 mg/L in the water phase,respectively. Such bio-treatment made the oil-water interface clear against oil and water emulsification and in favor of smooth reclamations for waste oil and wash-down water.

CuO-doped Ce for catalytic wet peroxide oxidation degradation of quinoline wastewater under wide pH conditions

Zhaojie Jiao,Xianming Zhang,Haifeng Gong,Donglin He,Hong Yin,Yunqi Liu,Xu Gao 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

This study aimed to treat toxic and refractory organic wastewater, and to address the limitations ofFenton method in treating organic wastewater, that the active components are easy to lose and usuallyoperate at the pH value of 2 3. In the present study, CuCe oxide catalyst was produced through citricacid-assisted complexation. Besides, the structural stability and catalytic wet peroxide oxidation (CWPO)performance of the catalyst after 5 times of application were delved into by characterization. The effectsof catalyst dosage and pH on quinoline removal were ascertained, while the reusability of the catalystwas explored. Moreover, the variations of pH, hydroxyl radical concentration and UV–Vis spectra inthe reaction system were analyzed. The possible degradation pathway and the catalytic mechanism werealso discussed. As suggested from the results, the catalyst exhibited high catalytic activity, structural stabilityand pH adaptability; it also had high CWPO performance for quinoline at the pH from 3.8 to 10.5,and the pH value need not be regulated. Under optimal conditions, 98.1% of quinoline and 86.1% of totalorganic carbon (TOC) were removed. In the CWPO process of quinoline, the OH attacked the nitrogen ringand the benzene ring in sequence.

Field measurement-based wind-induced response analysis of multi-tower building with tuned mass damper

Xin Chen,Zhiqiang Zhang,Aiqun Li,Hu, Liang,Liu, Xianming,Fan, Zhong,Sun, Peng 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.2

The 246.8-m-tall Beijing Olympic Tower (BOT) is a new landmark in Beijing City, China. Its unique architectural style with five sub-towers and a large tower crown gives rise to complex dynamic characteristics. Thus, it is wind-sensitive, and a double-stage pendulum tuned mass damper (DPTMD) has been installed for vibration mitigation. In this study, a finite-element analysis of the wind-induced responses of the tower based on full-scale measurement results was performed. First, the structure of the BOT and the full-scale measurement are introduced. According to the measured dynamic characteristics of the BOT, such as the natural frequencies, modal shapes, and damping ratios, an accurate finite-element model (FEM) was established and updated. On the basis of wind measurements, as well as wind-tunnel test results, the wind load on the model was calculated. Then, the wind-induced responses of the BOT with the DPTMD were obtained and compared with the measured responses to assess the numerical wind-induced response analysis method. Finally, the wind-induced serviceability of the BOT was evaluated according to the field measurement results for the wind-induced response and was found to be satisfactory for human comfort.

Simplified PWM Strategy for Neutral-Point-Clamped (NPC) Three-Level Converter

Ye, Zongbin,Xu, Yiming,Li, Fei,Deng, Xianming,Zhang, Yuanzheng The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.3

A novel simplified pulse width modulation(PWM) strategy for neutral point clamped (NPC) three-level converter is proposed in this paper.The direct output voltage modulation is applied to reduce the calculation time. Based on this strategy, several optimized control methods are proposed. The neutral point potential balancing algorithm is discussed and a fine neutral point potential balancing scheme is introduced. Moreover, the minimum pulse width compensation and switching losses reduction can be easily achieved using this modulation strategy. This strategy also gains good results even with the unequal DC link capacitor. The modulation principle is studied in detail and the validity of this simplified PWM strategy is experimentally verified in this paper. The experiment results indicated that the proposed PWM strategy has excellent performance, and the neutral point potential can be balanced well with unequal DC link captaincies.

Simplified PWM Strategy for Neutral-Point-Clamped (NPC) Three-Level Converter

Zongbin Ye,Yiming Xu,Fei Li,Xianming Deng,Yuanzheng Zhang 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.3

A novel simplified pulse width modulation(PWM) strategy for neutral point clamped (NPC) three-level converter is proposed in this paper.The direct output voltage modulation is applied to reduce the calculation time. Based on this strategy, several optimized control methods are proposed. The neutral point potential balancing algorithm is discussed and a fine neutral point potential balancing scheme is introduced. Moreover, the minimum pulse width compensation and switching losses reduction can be easily achieved using this modulation strategy. This strategy also gains good results even with the unequal DC link capacitor. The modulation principle is studied in detail and the validity of this simplified PWM strategy is experimentally verified in this paper. The experiment results indicated that the proposed PWM strategy has excellent performance, and the neutral point potential can be balanced well with unequal DC link captaincies.

Application of copper sulfate based fenton-like catalyst in degradation of quinoline

Zhaojie Jiao,Haifeng Gong,Ye Peng,Guilin Zhou,Xianming Zhang,Xu Gao,Yunqi Liu 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.5

In the practical application of water treatment, the Fenton reaction usually works at a lower pH. To overcome the above shortcomings, a Fenton-like reaction system with copper sulfate as a catalyst was proposed. In this paper, quinoline was used as the target pollutant and the effects of catalyst dosage, H₂O₂ dosage, reaction temperature, and initial concentration of quinoline and pH on the removal effect were investigated, and the evolution in pH and hydroxyl radical concentration during reaction, as well as the possible catalytic mechanism and degradation pathway were clarified. The results show that under a catalyst dosage of 0.4 g・L<SUP>-1</SUP>, a H₂O₂ dosage of 196 mmol・L<SUP>-1</SUP>, a quinoline concentration of 100 mg・L<SUP>-1</SUP> and a temperature of 75°C, the removal of quinoline and total organic carbon (TOC) reaches 99.5% and 87.2% in 65 min, respectively. Furthermore, the copper sulfate-driven homogeneous Fenton system exhibits a superior adaptability to pH in the range of 3.8 to 8.8. In the degradation of quinoline, ·OH radicals may attack the nitrogen ring and the benzene ring in sequence. The work provides a technical support for the treatment of organic wastewater, and shows promising in practical applications.

Synthesis of Needle-Like Aragonite Crystals in the Presence of Magnesium Chloride and Their Application in Papermaking

Hu, Zeshan,Shao, Minghao,Li, Huayang,Cai, Qiang,Zhong, Chenghua,Xianming, Zhang,Deng, Yulin The Korean Society for Composite Materials 2009 Advanced composite materials Vol.18 No.4

PCC (precipitated calcium carbonate) and ground calcium carbonate have been widely used in alkaline papermaking. Unfortunately, although increasing filler level in papers can improve the paper properties such as brightness, opacity, stiffness gloss, smoothness, porosity, and printability, as well as decrease cost, some strength of the paper is negatively affected. In this research, needle-like aragonite was synthesized using $Ca(OH)_2$ and $CO_2$ as reactants in the presence of $MgCl_2$ and characterized with scanning electronic microscopy (SEM) and X-ray diffraction (XRD). The physical and optical properties of the paper handsheets containing these needle-like aragonite fillers were evaluated. Results indicated that tensile strength, Z-direction tensile strength and folding endurance of the paper were improved by the needle-like aragonite crystals compared to the paper using commercial PCC (precipitated calcium carbonate) as filler. The stiffness of the paper handsheet on the machine direction was increased, but no evident difference in the cross direction was found. The improvement of paper strength mainly resulted from the twining effect between the aragonite whiskers and paper fibers. The optical properties of the paper were slightly decreased with the use of the needle-like aragonites compared to commercial PCC. These results suggest that paper cost can be decreased by increasing the content of needle-like aragonite filler while paper strength will not be decreased compared to PCC filler.