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Dong Dong Zhang,Yang Fang Wu,Wei Xia Chen,Yao Xu,Si Yan Liu,Huang Huang Luo,Guang Mei Jiang,Yue Wu,Peng Hu 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Renal osteodystrophy (ROD) occurs as early as chronic kidney disease (CKD) stage 2 and seems ubiquitous in almost all pediatric patients with CKD stage 5. Fibroblast growth factor (FGF)-23, a bone-derived endocrine regulator of phosphate homeostasis, is overexpressed in CKD and disturbs osteoblast differentiation and matrix mineralization. In contrast, C-type natriuretic peptide (CNP) acts as a potent positive regulator of bone growth. In the present study, we infused CNP into uremic rats and observed whether CNP could attenuate ROD through the inhibition of FGF-23 cascades. In uremic rats, CNP administration significantly alleviated renal dysfunction, calcium phosphate metabolic disorders, hypovitaminosis D, secondary hyperparathyroidism, the decrease in bone turnover markers and retarded bone pathological progression. More importantly, within FGF-23/mitogen-activated protein kinase (MAPK) signaling, the fibroblast growth factor receptor-1, Klotho and alternative (STAT-1/phospho-STAT-1) elements were upregulated by CNP, whereas FGF-23, RAF-1/phospho-RAF-1, and downstream (ERK/phospho-ERK and P38/phospho-P38) elements were paradoxically underexpressed in bone tissue. Therefore, CNP exerts a therapeutic effect on ROD through inhibition of FGF-23/MAPK signaling at the RAF-1 level.
Dong Xia,Ling Chen,Huizhong Chen,Xuyu Luo,Tao Deng 한국기상학회 2016 Asia-Pacific Journal of Atmospheric Sciences Vol.52 No.4
The atmospheric aerosols can absorb moisture from the environment due to their hydrophilicity and thus affect atmospheric radiation fluxes. In this article, the ultraviolet radiation and relative humidity (RH) data from ground observations and a radiative transfer model were used to examine the influence of RH on ultraviolet radiation flux and aerosol direct radiative forcing under the clear-sky conditions. The results show that RH has a significant influence on ultraviolet radiation because of aerosol hygroscopicity. The relationship between attenuation rate and RH can be fitted logarithmically and all of the R2 of the 4 sets of samples are high, i.e. 0.87, 0.96, 0.9, and 0.9, respectively. When the RH is 60%, 70%, 80% and 90%, the mean aerosol direct radiative forcing in ultraviolet is −4.22W m−2, −4.5W m−2, −4.82W m−2 and −5.4W m−2, respectively. For the selected polluted air samples the growth factor for computing aerosol direct radiative forcing in the ultraviolet for the RH of 80% varies from 1.19 to 1.53, with an average of 1.31.
Xia, Shuai,Wang, Xiu-Hua,Liu, Ji-Qiang,Liu, Chang,Chen, Jian-Bin,Zuo, Hua,Xie, Yong-Sheng,Dong, Wen-Liang,Shin, Dong-Soo Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
A facile and effective method has been developed for the synthesis of a novel series of benzofuran derivatives via N-acylation, O-alkylation and intramolecular condensation reactions, starting from readily available substituted o-hydroxy aryl ketone, and chloroacetyl arylamides. This metal-free transition process is characterized by mild reaction conditions, atom economy, short reaction time and a high yield with a decreased amount of by-products.
Dong-Xia Zhao,Jun-Min Wang,Ya-Ping Guo 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.1
This paper addresses the exponential stability for an interconnected system of an nth-order ODE systemwith the input governed by the Dirichlet boundary of a heat equation, and conversely, the output of the ODE isfluxed into the heat equation. The semigroup approach is adopted to show that the system operator is well-posed. We establish the exponential stability of the system by Riesz basis method. Furthermore, with MATLAB software,some numerical simulations are presented to show the effectiveness of the interconnection between the heat PDEand ODE systems.
Xia, Dong,Yao, Hui,Liu, Qing,Xu, Liang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Objective: The study aim was to prepare poly-DL-lactide-poly (PELA) microspheres encapsulating recombinant tissue inhibitors of metalloproteinase-1 (TIMP-1) in an adenovirus to investigate its inhibition on the proliferation of hepatocellular carcinoma cells HepG2. Methods: Microspheres were prepared by encapsulating the recombinant TIMP-1 adenovirus into biodegradable PELA. The particle size, viral load, encapsulation efficiency and in-vitro release were measured. Microspheres were used to infect HepG2 cells, then infection efficiency was examined under a fluorescent microscope and ultrastructural changes assessed by TEM. Expression of TIMP-1 mRNA in HepG2 cells was examined by semi-quantitative RT-PCR and proliferation by MTT and cell growth curve assays. Results: We successfully prepared microspheres encapsulating recombinant TIMP-1 adenovirus with a diameter of $1.965{\mu}m$, an encapsulation efficiency of 60.0%, a viral load of $10.5{\times}10^8/mg$ and approximate 60% of virus release within 120 h, the total releasing time of which was longer than 240 h. The microspheres were confirmed to be non-toxic with blank microspheres. Infected HepG2 cells could stably maintain in-vitro expression of TIMP-1, with significantly effects on biological behaviour Conclusion: PELA microspheres encapsulating a recombinant TIMP-1 adenovirus can markedly inhibit the proliferation of HepG2 cells, which provides an experimental basis for polymer/chemistry-based gene therapy of hepatocellular carcinomas.
Dong-xia Zhao,Dong-xia Fan,Ya-ping Guo 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
In this paper, the well-posedness and stability of a 1-d 2×2 hyperbolic system under proportional feedback control is addressed. The semigroup approach and norm equivalence theorem is adopted to obtain the explicit dissipative condition for control parameters. The asymptotic spectral analysis of the system is presented. It is shown that the real part of the eigenvalues goes to some negative constant as the modulus of eigenvalues goes to +∞. Moreover, we find that there is a group of generalized eigenfunctions which forms a Riesz basis of the Hilbert state space. Hence, the spectrum determined growth condition holds, and then the exponential stability is established.
Shuai Xia,Xiu-Hua Wang,Ji-Qiang Liu,Chang Liu,Jian-Bin Chen,Hua Zuo,Yong-Sheng Xie,Wen-Liang Dong,Dong Soo Shin 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
A facile and effective method has been developed for the synthesis of a novel series of benzofuran derivatives via N-acylation, O-alkylation and intramolecular condensation reactions, starting from readily available substituted o-hydroxy aryl ketone, and chloroacetyl arylamides. This metal-free transition process is characterized by mild reaction conditions, atom economy, short reaction time and a high yield with a decreased amount of by-products.
Antitumor Activity of Histone Deacetylase Inhibitor Trichostatin A in Osteosarcoma Cells
Cheng, Dong-Dong,Yang, Qing-Cheng,Zhang, Zhi-Chang,Yang, Cui-Xia,Liu, Yi-Wen Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Background: Histone deacetylase (HDAC) inhibitors have been reported to induce cell growth arrest, apoptosis and differentiation of tumor cells. The present study aimed to examine the effects of trichostatin A (TSA), one such inhibitor, on the cell cycle, apoptosis and invasiveness of osteosarcoma cells. Methods: MG-63 cells were treated with TSA at various concentrations. Then, cell growth and apoptosis were determined by 3-(4, 5-dimethyl-2-thiazolyl)-2H-tetrazolium bromide (MTT) and TUNEL assays, respectively; cell cycling was assessed by flow cytometry; invasion assays were performed with the transwell Boyden Chamber system. Results: MTT assays revealed that TSA significantly inhibited the growth of MG-63 cells in a concentration and time dependent manner. TSA treated cells demonstrated morphological changes indicative of apoptosis and TUNEL assays revealed increased apoptosis of MG-63 cells after TSA treatment. Flow cytometry showed that TSA arrested the cell cycle in G1/G2 phase and annexin V positive apoptotic cells increased markedly. In addition, the invasiveness of MG-63 cells was inhibited by TSA in a concentration dependent manner. Conclusion: Our findings demonstrate that TSA inhibits the proliferation, induces apoptosis and inhibits invasiveness of osteosarcoma cells in vitro. HDAC inhibitors may thus have promise to become new therapeutic agents against osteosarcoma.