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Vo Minh Hoang Do,Long Giang Bach,Diem-Huong Nguyen Tran,Van Du Cao,Thi Nhu Quynh Nguyen,Duc Thuan Hoang,Van Cuong Ngo,Dai Hai Nguyen,Thai Thanh Hoang Thi 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2
Polyamidoamine (PAMAM) dendrimer is emerging as an effective nanocarrier for delivering anticancer drugs. Still, unmodified PAMAM dendrimer is hardly used in vivo because of unsatisfied drug release, high tendency of interfering with cellular membranes, and rapid clearance by reticuloendothelial system. In this study, low generation polyamidoamine (PAMAM) dendrimer G3.0 is developed and surface modified with methoxypolyethylene glycol (PAMAM G3.0-mPEG) to overcome its limitations. Specifically, PAMAM G3.0 conjugated with mPEG at different ratios are investigated to effectively eliminate its charge-associated toxicity, in which PAMAM G3.0-mPEG- 8 is chosen for oxaliplatin (OX) loading. Results reveal that OX-loaded PAMAM G3.0-mPEG-8 has desirable size, good entrapment efficiency, and sustained release with minimum drug leakage. In addition, Resazurin assay indicates that the toxicity of loaded OX is reduced as compared to free drug but still maintain substantially anticancer activity on HeLa cells, suggesting the potential application of PAMAM G3.0-mPEG-8 for OX delivery in cancer therapy.
Biomedical and Environmental Applications of Chitosan-based Nanomaterials
( Jae Kweon Park ),( Lam Dai Tran ),( Hoang Vinh Tran ),( Trang Thu Mai ),( Thu Phuong Ha ),( Binh Hai Nguyen ),( Hoang Thai ),( Hoang Dinh Vu ),( Dien Gia Pham ),( Phuc Xuan Nguyen ) 한국키틴키토산학회 2011 한국키틴키토산학회지 Vol.16 No.1
Being naturally abundant resources and having many interesting physicochemical and biological properties, chitin/chitosan have been found useful in many fields. This paper describes the strategy to design a multifunctional, chitosan based nanomaterials and their biomedical and environmental applications. Different physicochemical methods including FESEM/TEM, PPMS were used to characterize the obtained nanomaterials. For each application, a series of specific characterizing methods were used for evaluating the applicability/capacity of materials.
Ngoc Nhon Hoang,Tri Khoi Nguyen,Tuyet Hoa Vo,Ngoc Hoi Nguyen,Dai Hai Nguyen,Dieu Linh Tran 한국고분자학회 2022 Macromolecular Research Vol.30 No.2
Fucoidan, a natural sulfated polysaccharide extracted from seaweed, has been widely used in pharmaceutical field due to its excellent biological activities including antiviral, anticancer, antioxidant, anticoagulant, etc. Therefore, investigating the new natural sources of fucoidan has been received growing attention recently. This study reported for the first time the isolation, purification, characterization, and biological activities of fucoidan from Ceratophyllum submersum (FCS). The molecular weight of obtained FCS was 9.7 kDa, composed of fucose (42.11%) and sulfate (16.38%). The FCS contained (1→3)-α-L-Fucopyranose and β-D-galactose bond in the structure. In addition, FCS showed strong antioxidant properties against 2,2-diphenyl-1-picrylhydrazyl, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid), and reactive oxygen species radicals with inhibitory concentration 50 values were 765.48 ppm, 845.31 ppm, and 1760.00 ppm, respectively. The FCS also performed good antibacterial, antifungal, anticoagulant and anti-inflammatory activityies. Especially, it expressed a better inhibition activity on breast cancer cell line (MCF-7) than that on liver cancer cells (HepG2), lung cancer cells (NCI-H460), and cervical cancer cells (HeLa). FCS demonstrated potential utility in functional food, cosmeceutical, and pharmaceutical industries. In the trend of discovering new sources for fucoidan with outstanding bioactivities, this report would contribute a basic platform and valuable information for further studies on fucoidan from C. Submersum.
Thai Thanh Hoang Thi,Binh D.T. Trinh,Phuong Le Thi,Dieu Linh Tran,박기동,Dai Hai Nguyen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-
Because of the toxic glutaraldehyde, the chitosan-glutaraldehyde hydrogels are seriously limited inbiomedical applications. In this study, exploiting bioactive compounds of Aloe barbadensis Miller, the chitosan/Aloe barbadensis Miller-glutaraldehyde (CS/AV-GDA) hydrogels were fabricated with 4-fold lowerglutaraldehyde concentration without compromising hydrogel characteristics. The gelation time wascontrolled from a few seconds to several hours. The elastic modulus was varied from 483 to 99940 Pa. The CS/AV-GDA hydrogels could release the natural nitrite amount from 24.0 to 89.6 lM within the firsthour for antibacterial activity, then continuously deliver a few lM every next hour for cell activities. Theantibacterial test against Escherichia coli and Staphylococcus aureus revealed that the CS/AV-GDA hydrogelscould kill the planktonic bacteria 5-fold more highly than control and prevent bacteria attachmenton hydrogel surface effectively. Although the CS/AV-GDA hydrogels consumed only 0.25% glutaraldehydeconcentration, their antibacterial capacities were comparable to chitosan-only hydrogels with 2% glutaraldehyde. For cytotoxicity tests, the CS/AV-GDA hydrogels using 0.25% glutaraldehyde concentrationinduce the human dermal fibroblasts proliferation significantly. All CS/AV-GDA hydrogels with glutaraldehydecrosslinker less than 1% showed non-cytotoxicity. As a result, the new CS/AV-GDA hydrogelsmight become an attractive candidate for medicine regeneration and tissue engineering.
Trieu Ngan Hoang Kim,Phan Xuan Thi,Tran Linh Thanh,Pham Huy Minh,Huynh Dai Quang,Nguyen Tuan Manh,Mai Anh Tuan,Du Quan Quoc Minh,Nguyen Bach Xuan,Pham Thao Thi Ngoc 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.3
Background: Hemostatic dysfunction during extracorporeal membrane oxygenation (ECMO) due to blood-circuit interaction and the consequences of shear stress imposed by flow rates lead to rapid coagulation cascade and thrombus formation in the ECMO system and blood vessels. We aimed to identify the incidence and risk factors for cannula-associated arterial thrombosis (CaAT) post-decannulation. Methods: A retrospective study of patients undergoing arterial cannula removal following ECMO was performed. We evaluated the incidence of CaAT and compared the characteristics, ECMO machine parameters, cannula sizes, number of blood products transfused during ECMO, and daily hemostasis parameters in patients with and without CaAT. Multivariate analysis identified the risk factors for CaAT. Results: Forty-seven patients requiring venoarterial ECMO (VA-ECMO) or hybrid methods were recruited for thrombosis screening. The median Sequential Organ Failure Assessment score was 11 (interquartile range, 8–13). CaAT occurred in 29 patients (61.7%), with thrombosis in the superficial femoral artery accounting for 51.7% of cases. The rate of limb ischemia complications in the CaAT group was 17.2%. Multivariate analysis determined that the ECMO flow rate–body surface area (BSA) ratio (100 ml/min/m2) was an independent factor for CaAT, with an odds ratio of 0.79 (95% confidence interval, 0.66–0.95, P=0.014). Conclusions: We found that the incidence of CaAT was 61.7% following successful decannulation from VA-ECMO or hybrid modes, and the ECMO flow rate–BSA ratio was an independent risk factor for CaAT. We suggest screening for arterial thrombosis following VA-ECMO, and further research is needed to determine the risks and benefits of such screening.
Ngoc Thuy Nguyen,Nhat Thong Tran,Tan Phat Phan,Anh Thu Nguyen,My Xuyen T. Nguyen,Nguyen Ngan Nguyen,Young Ho Ko,Dai Hai Nguyen,Tran T.T. Van,DongQuy Hoang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
While the efficient usage of biomass waste can significantly help in addressing environmental issues,there are only a few reports that discuss about processing such waste effectively at a low-cost. Such challengearises from the strong association between the components biomass. In this study, an abundantagricultural byproduct, rice husk (RH), was used as the starting resource. A simple biorefining processof alkaline peroxide treatment followed by acid precipitation and ethanol extraction was performed onRH to obtain cellulose, hemicellulose, lignin, and silica. The chemical structures, morphologies, andphysic-chemical properties of the separated components were identified through a wide range of characterizationapproaches. The final products obtained from of this process were (i) bundles of fiber-likecellulose with a fiber width of 6 mm and (ii) small particles of hemicellulose and lignin with nonuniformshapes. The lignocelluloses products had over 90 wt% carbon with 52.28% crystalline ratio. Meanwhile, the other products comprising hemicelluloses, lignin, and silica were amorphous. The outcomeof this study contributes to expanding and developing the simple and efficient conversion processof biomass waste into sustainable value-added materials. It is crucial to reduce the environmental impactby using renewable materials as the new building block resources for synthetic chemicals.