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Hoang Thai Hoa,Nguyen Thi Thu,Nguyen Thuong Dong,Tran Thi Oanh,Tran Thi Hien,Do Thi Ha 한국생약학회 2020 Natural Product Sciences Vol.26 No.3
The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. Compounds 1 – 4 (10 μM) upregulated p-ACC expression at different levels. Compound 4 induced the most significant changes in p-AMPK expression, followed by 1 and 2. Sterol regulatory element-binding proteins (SREBPs) play a functional role in the transcriptional regulation of the lipogenic pathway, including fatty acid synthase (FAS) and ACC. The effects of compounds 2 and 4 (10 μM) on FAS and SREBP-1c expression under high glucose conditions (30 mM) in HepG2 cells were evaluated further. Both dose-dependently inhibited FAS and SREBP-1c expression as well as lipid accumulation (1 – 10 μM) were compared to high-concentration glucose control, which upregulated FAS and SREBP-1c. These results suggest that compounds 2 and 4 upregulate AMPK, suppress FAS and SREBP-1c, and have potential effects on glucose and lipid metabolism.
Optimal Data Scheduling and Admission Control for Backscatter Sensor Networks
Hoang, Dinh Thai,Niyato, Dusit,Wang, Ping,Kim, Dong In,Bao Le, Long Institute of Electrical and Electronics Engineers 2017 IEEE Transactions on Communications Vol. No.
<P>This paper studies the data scheduling and admission control problem for a backscatter sensor network (BSN). In the network, instead of initiating their own transmissions, the sensors can send their data to the gateway just by switching their antenna impedance and reflecting the received RF signals. As such, we can reduce remarkably the complexity, the power consumption, and the implementation cost of sensor nodes. Different sensors may have different functions, and data collected from each sensor may also have a different status, e.g., urgent or normal, and thus we need to take these factors into account. Therefore, in this paper, we first introduce a system model together with a mechanism in order to address the data collection and scheduling problem in the BSN. We then propose an optimization solution using the Markov decision process framework and a reinforcement learning algorithm based on the linear function approximation method, with the aim of finding the optimal data collection policy for the gateway. Through simulation results, we not only show the efficiency of the proposed solution compared with other baseline policies, but also present the analysis for data admission control policy under different classes of sensors as well as different types of data.</P>
Thai Hoang,Nguyen Thuy Chinh,Nguyen Thi Thu Trang,To Thi Xuan Hang,Dinh Thi Mai Thanh,Dang Viet Hung,하창식,Maëlenn Aufray 한국고분자학회 2013 Macromolecular Research Vol.21 No.11
Ternary nanocomposites based on ethylene/vinyl acetate copolymer (EVA), maleic anhydride-grafted EVA (EVAgMA), and nanosilica were prepared in a Haake Rheomixer. The structure of the EVA/EVAgMA/silica nanocomposites was characterized by Fourier transform infrared spectroscopy and field emission scanning electron microscopy. The blending sequence was found to have a significant effect on the microstructure of EVA/EVAgMA/silica nanocomposites and the dispersion behavior of the nanosilica in the EVA matrix. The tensile properties (tensile strength and elongation at break), thermal behavior, crystalline structure and weatherability of the nanocomposites were also studied. The results showed that the above properties of the nanocomposites were enhanced remarkably using 1 wt% EVAgMA.
Hoang Thai Pham,이향숙 인하대학교 정석물류통상연구원 2019 JOURNAL OF INTERNATIONAL LOGISTICS AND TRADE Vol.17 No.2
A boom in e-commerce in Korea has sparked off high daily-volume demand for small-sized home delivery services, which poses a great challenge to distribution networks, especially in urban areas where traffic congestion, accessibility, and pollution are serious problems. In addition, security issues for people who live in small townhouses and detached houses without security systems and guards have received increasing attention from the government and society. Thus, the introduction of a new alternative for home delivery services, unmanned parcel lockers, is urgent for residents living in these areas. This paper examines and compares potential socio-economic impacts in terms of costs and benefits when such lockers are installed at selected locations in residential areas. The results show that this policy is worthy of adoption, with several undeniable benefits to local communities. In addition, sensitivity analyses estimate the economic performance of this project at different social discount rates, and they check the sensitivity of economic performance based on variations in the variables. The value of travel time savings was identified as a critical and dominating factor directly affecting economic performance.
Hoang Thi, Thai Thanh,Lee, Yunki,Le Thi, Phuong,Park, Ki Dong Elsevier 2019 Journal of industrial and engineering chemistry Vol.78 No.-
<P><B>Abstract</B></P> <P>Adhesive hydrogels offer considerable potential in biomedical applications because of the excellent integration between materials and tissues. Horseradish peroxidase (HRP)-catalyzed hydrogelation, with advantages that include ease of handling, simplicity in material design, high biocompatibility, and processability, is becoming a promising candidate to be engineered as an adhesive hydrogel. This review summarizes recent development of HRP-mediated hydrogelation towards the bioadhesive field, and other applications requiring the tissue adhesion of hydrogels. From the viewpoint of adhesive hydrogel designation, the basic chemistry of the adhesive mechanism, combinations of interactions, and currently commercial bioglues are summarized. The review recapitulated the adhesive hydrogel applications, the clinical translation ability, the controlling hydrogelation kinetics, the related physicochemical characteristics, cytotoxicity, and animal studies. Looking to the future, to make more substantial contributions to the bioadhesive field, or to various biomedical applications, higher adhesion should be continuously improved, and greater emphasis should be placed on clinical trials.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Thai Thanh Hoang Thi,Binh D.T. Trinh,Phuong Le Thi,Dieu Linh Tran,박기동,Dai Hai Nguyen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-
Because of the toxic glutaraldehyde, the chitosan-glutaraldehyde hydrogels are seriously limited inbiomedical applications. In this study, exploiting bioactive compounds of Aloe barbadensis Miller, the chitosan/Aloe barbadensis Miller-glutaraldehyde (CS/AV-GDA) hydrogels were fabricated with 4-fold lowerglutaraldehyde concentration without compromising hydrogel characteristics. The gelation time wascontrolled from a few seconds to several hours. The elastic modulus was varied from 483 to 99940 Pa. The CS/AV-GDA hydrogels could release the natural nitrite amount from 24.0 to 89.6 lM within the firsthour for antibacterial activity, then continuously deliver a few lM every next hour for cell activities. Theantibacterial test against Escherichia coli and Staphylococcus aureus revealed that the CS/AV-GDA hydrogelscould kill the planktonic bacteria 5-fold more highly than control and prevent bacteria attachmenton hydrogel surface effectively. Although the CS/AV-GDA hydrogels consumed only 0.25% glutaraldehydeconcentration, their antibacterial capacities were comparable to chitosan-only hydrogels with 2% glutaraldehyde. For cytotoxicity tests, the CS/AV-GDA hydrogels using 0.25% glutaraldehyde concentrationinduce the human dermal fibroblasts proliferation significantly. All CS/AV-GDA hydrogels with glutaraldehydecrosslinker less than 1% showed non-cytotoxicity. As a result, the new CS/AV-GDA hydrogelsmight become an attractive candidate for medicine regeneration and tissue engineering.
Thai-Hoang Le,이주원,Jeung Kun Kim,구윤모 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.5
In reversed-phase liquid chromatography (RP-LC), the separation of ionized compounds at neutral pH of the mobile phase is ineffective because these compounds easily become ionized and too hydrophilic to adsorb on the hydrophobic C18 stationary phase. The common method to separate ionized compounds in RP-LC is the usage of the ion pairing agent and the control of pH in the mobile phase. In this work, [hmim][BF4] ionic liquid was adopted as a mobile phase additive in reversed-phase simulated moving bed chromatography (RP-SMB) to overcome the problem mentioned above. The results showed that when 1.5 ml/l [hmim][BF4] was added to mobile phase, 3-hydroxy benzoic acid (3-HBA) and 4-hydroxy benzoic acid (4-HBA) were separated at neutral pH in the RP-SMB. In particular, purities of 3-HBA and 4-HBA products were 97.62% and 100%, respectively, and had a good agreement with simulation results.