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- 저자 : Binh D.T. Trinh (검색결과 1 건)
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Thai Thanh Hoang Thi,Binh D.T. Trinh,Phuong Le Thi,Dieu Linh Tran,박기동,Dai Hai Nguyen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-
Because of the toxic glutaraldehyde, the chitosan-glutaraldehyde hydrogels are seriously limited inbiomedical applications. In this study, exploiting bioactive compounds of Aloe barbadensis Miller, the chitosan/Aloe barbadensis Miller-glutaraldehyde (CS/AV-GDA) hydrogels were fabricated with 4-fold lowerglutaraldehyde concentration without compromising hydrogel characteristics. The gelation time wascontrolled from a few seconds to several hours. The elastic modulus was varied from 483 to 99940 Pa. The CS/AV-GDA hydrogels could release the natural nitrite amount from 24.0 to 89.6 lM within the firsthour for antibacterial activity, then continuously deliver a few lM every next hour for cell activities. Theantibacterial test against Escherichia coli and Staphylococcus aureus revealed that the CS/AV-GDA hydrogelscould kill the planktonic bacteria 5-fold more highly than control and prevent bacteria attachmenton hydrogel surface effectively. Although the CS/AV-GDA hydrogels consumed only 0.25% glutaraldehydeconcentration, their antibacterial capacities were comparable to chitosan-only hydrogels with 2% glutaraldehyde. For cytotoxicity tests, the CS/AV-GDA hydrogels using 0.25% glutaraldehyde concentrationinduce the human dermal fibroblasts proliferation significantly. All CS/AV-GDA hydrogels with glutaraldehydecrosslinker less than 1% showed non-cytotoxicity. As a result, the new CS/AV-GDA hydrogelsmight become an attractive candidate for medicine regeneration and tissue engineering.
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