Efficacy of Long-Term Tenofovir-Based Therapy in Chronic Hepatitis B Patients with Previous Nucleos(t)ide Analogues Treatment Experience

( Na Eun Lee ),( Hong Seon Son ),( Sung Hoon Choi ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Tenofovir disoproxil fumarate (TDF) is considered as the preferred treatment option for chronic hepatitis B (CHB) patients with treatment failure or resistance to prior nucleos(t)ide analogues (NAs) treatment. We investigated the efficacy of long-term TDF-based therapy in CHB patients with previous NAs-experience. Methods: This study included total 251 patients who had previous history of NAs therapy and were treated with TDF mono (n=173) or TDF combined with other NA (n=78) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients was 49.3 years, median duration of TDF therapy was 27.2 months, 75.7% were HBeAg-positive, and median HBV DNA was 3.7 log10IU/mL. The cumulative rates of VR were 188/244 (77.0%), 180/211 (85.3%), and 146/161 (90.7%) at 12, 24, and 36 months, respectively. Multivariate analysis showed that body mass index (OR 0.77, 95% CI 0.61-0.95, p=0.0189) and duration of TDF therapy (OR 1.09, 95% CI 1.02-1.18, p=0.0221) was significantly associated with VR. TDF monotherapy, HBeAg-positivity, platelet count, serum albumin was associated with VR in the univariate analysis, but not significant in the multivariate analysis. In relation to renal safety, patients showed renal impairment (7, 3.0%), mild hypophosphatemia (15, 7.2%), severe hypophosphatemia (1, 0.4%). Conclusions: Long-term TDF-based therapy demonstrated highly effective in viral suppression and relatively favorable renal safety in CHB patients with previous NA-experience. The body mass index and duration of TDF therapy was independent factors associated with VR.

Comparison of Virologic Response and Renal Safety of Long-Term Antiviral Therapy with Tenofovir and Entecavir in Naive Patient with Chronic Hepatitis B

( Hong Seon Son ),( Sung Hoon Choi ),( Na Eun Lee ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Tenofovir (TDF) entecavir (ETV) are considered as the preferred treatment options for treatment-naïve chronic hepatitis B (CHB) patients. We compared the virologic response and renal safety of long-term TDF versus ETV therapy in naïve CHB patients. Methods: This retrospective study included total 432 patients who were treated with TDF (n=205) or ETV (n=227) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients, sex, baseline serum levels of AST, ALT, creatinine, and HBV DNA were not significantly different between TDF and ETV groups. The cumulative rates of VR between TDF and ETV groups were 71.6% vs. 61.8% (p=0.477), 88.1% vs. 79.6% (p=0.058), and 84.8% vs. 83.7% (p=0.966) at 1, 2, and 3 years, respectively. The cumulative rates of genotypic resistance between TDF and ETV groups were 0% vs. 0%, 0% vs. 1.5% (p=0.404), and 0% vs. 2.2% (p=0.447) at 1, 2, and 3 years, respectively. Incidences of renal impairment and hypophosphatemia during treatment up to 3 years were not significantly different between two groups. Multivariate analysis showed that HBeAg-positivity (OR 0.27, 95% CI 0.12-0.58, p=0.0012) and serum HBV DNA at 1 year 2000 IU/mL (OR 0.09, 95% CI 0.03-0.25, p<0.0001) were significantly associated with VR. Conclusions: Long-term TDF and ETV treatments appear to have similar virologic response and renal safety in naïve CHB patient. However, long-term ETV therapy might to be associated with genotypic resistance in 2.2% up to 3 years, while none of patients on TDF therapy did.

유압관로에서 비정상 압력측압공의 동특성에 관한 연구

나기대,유영태,김지환 조선대학교 에너지.자원신기술연구소 2000 에너지·자원신기술연구소 논문지 Vol.22 No.2

In this study, the analysis of the dynamics characteristics and performance investigation of the pressure measurement in the hydraulic pipe. The exact solution of the frequency response is obtained by using the complicated transfer function. The discrepancy with the exact and the approximate is small, so the approximation solution is adopted to compare the experimental result with the theoretical analysis. The pressure measurement in the hydraulic pipe is caused by length of capillary and according to the end volume size. The experimental and calculate result show that characteristic of the pressure .measurement in the hydraulic pipe varies with the length of capillary and volume size. Therefore present theoretical formulation and experimental result can be used generally in designing and performance evaluation of all the hydraulic pressure measurement in the hydraulic pipe

경계조건변화에 따른 동력전달관로의 동특성

나기대,유영태,김지환 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.6

Design for a quiet operation of fluid power system requires the understanding of noise and vibration characteristics of the system. It's not easy to analyze noise problem in hydraulic cylinder used in typical actuator Because they've got complex fluid dynamics. One of the fundamental problems associated with the hydraulic system is the pulsating flow in pipe lines, which can e tackled by the analysis under simplifying assumptions. The present study focuses on theoretic analysis and experimental study on the dynamics of laminar pulsating flow in a circular pipe. We analyze the propagation characteristics of the pressure pulse within a hydraulic pipe line taking into account the pulsating flow frequency variation. We also measure instantaneous pressure pulses within pipe line to identify the transfer functions. We conduct series of experiments to investigate the propagation characteristics of pressure pulse for various pressure of pulsating flow. The working fluid of the present study is ISO VG46 and the temperature ranges from 20 to 60℃ with normal pressure at 4000kPa. The flow rate is measured by using an ultrasonic flow meter. Pressures at fixed upstream and downstream positions are measured concurrently. The electric signals of the pressure sensor are stored and analyzed using a system analyzer(PKE 983 series). The frequency is varied in the range of 10~500Hz. The Reynolds number is kept below 2,000. In the present study, boundary condition was varied by installing a surge tank and an orifice at the end of pipe. Experimental and theoretical results were compared each other under various boundary conditions.

유전체 연구를 위한 Well-plate 자동 교환 시스템의 개발

나건영,김기대,이현동,이영규,김찬수 충남대학교 농업과학연구소 2004 농업과학연구 Vol.31 No.1

In this study, the automatic system exchanging well-plates was developed as a basic stage of the genome project. The developed system consisted of the plate fixing well-plates, the well-plate cassette, the head to move a well-plate from the well-plate cassette to the plate fixing well-plates before genome work or from the plate to the cassette after the work, the manipulator to move the head on the X, Y and Z axes and the control system. The performance test to exchange well-plates with the robotic system developed was carried out. The time to set an well-plate from the weD-plate cassette onto the board fixing well-plates was 55 seconds and the time for 9 ones was 8 minutes and 15 seconds. It took 57 seconds to move a well-plate from the board to the cassette and 8 minutes and 33 seconds for 9 ones.

紡績業體 情報管理시스템 개발에 관한 연구

나현식,김영대 호남대학교산업기술연구소 1997 산업기술연구논문집 Vol.4 No.-

기업내의 각 업무의 전산화와 정보의 통합화를 구축한다면 보다 효율성이 높은 관리시스템이 창출되어 수주에서 출하까지 모든과정이 일관되고 투명한 관리가 가능할 것이다. 본 연구에서는 방적생산 공정에 가장 적합한 관리 모델을 설정하고 중소기업 수준의 방적업체에 적합한 관리정보시스템을 구축하는 것을 제안하였다. 방적업체가 효율적인 관리정보시스템을 구축, 운영함으로써 무엇보다 전체적인 관리업무의 정보파악이 용이함은 물론, 재품생산에 따른 원가절감 및 생산성 증대를 기대할 수 있어 타업체와의 차별성에 의한 대외 경쟁력도 향상될 것으로 기대한다. It is possible to manage transparently and consistently from order to shipping, if each firm develops computing and integration of the information. The purpose of this study is to propose a development of the information management system of the spinning company. If the spinning company develops and operates the efficient management information system, it is expected that the business is easy to work, to reduce costs and to increase productivity. Also, it is expected to improve competitive advantages.

횡문근융해증과 급성 신부전 및 범발성 혈관내 응고장애를 동반한 열사병 1예

최대은,박수진,권오경,이한규,이영모,이상주,나기량,이강욱,신영태 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Heat stroke is a life-threatening illness characterized by an elevated core body temperature that rises above 40% and central nervous system dysfunctions that results in delirium, convulsions, or coma. Heat stroke is subdivided into two forms, classic and exertional. Since strenuous exercise is one of the major exacerbating and precipitating factors, the incidence of exertional heat stroke is high among young adult, especially military personnel undergoing military training. Exertional heat stroke commonly causes rhabdomyolysis, lactic acidosis, acute renal failure, shock and pulmonary edema. We report a case of heat stroke with rhabdomyolysis, acute renal failure, disseminated intravascular coagulopathy(DIC) after strenuous exercise. A 18 year old man was admitted to the hospital because of loss of consciousness. He was a wrestler and he had tried to lose 6kg in weight by jogging and strenuous exercise on that summer day with hot temperature. The development of this illness was favoured by much clothes inappropriate for that environmental condition with a purpose to enhance sweating, and by restricted intake of water and food. On admission, the blood pressure was 80/50mmHg, and body temperature was 39.4℃ with stuporous mentality. Laboratory finding were as follows : in complete blood cell count, hemoglobin was 16.7g/dL and platelet count was 158,000/ mm³. In blood chemistry, AST 1061U/L, ALT 201U/L, BUN 30mg/dL, Cr 2.2mg/dL, LDH 941IU/L, CK 696IU/L were resulted. In arterial blood gas analysis, pH 7.39, pCO₂ 30mmHg pO₂ 86mmHg, HCO₃ 18.4mEq/L, O₂ saturation 96.7% were resulted. In urinalysis, specific gravity 1.025, protein 3+, erythrocyte 2+ were resulted. In brain imaging study, brain CT finding was normal. After appropriate treatments with rapid cooling, hydration and supportive care, he improved with alert mental status. On 2nd hospital day, in laboratory result, thrombocytopenia and coagulopathy were appeared and renal insufficiency was aggravated. So he was treated with platelet concentrate and fresh frosen plasma for DIC, and enough hydration for appropriate urine volume preservation. After all, On 22nd hospital day, he fully recovered and discharged. Nowadays, with followed for some duration, he is wellbeing with no complications.

病院 外來 患者에 있어서의 Toxoplasma 抗體價 分布에 關한 調査 硏究

辛大煥,徐志澤,李英河,羅榮彦 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

The results of Sabin & Feldman dye test for the detection of Toxoplasma antibody titer among 454 hospital outpatients were summarized as follows: 1. Among 454 test sera, 101 cases were positive, the positive rate was 22.2%. 2. According to age group, dye test positive rates were 33.3% (0-9 age group in years), 32.8% (40-49 age group in years), 31.6%(over 60 age group in years), 28.6%(10-19 age group in years), 20.1%(20-29 age group in years), 20.0%(30-39 age group in years), and 18.3%(50-59 age group in years). 3. According medical field, dye test postive rates were high in neurology(40%), pedatrics(37.5%), dermatology (36.4%), and surgery(30.6%) 4. Among 194 obstric and gynecological patients, abortion, anomaly, and retroversioflexion had high Toxoplasma antibody titers, but inflammatory disease, cancer, pregnancy and infertility revealed as relatively same antibody titers.

錦江流域 淡水魚의 Sparganum에 關한 調査硏究

辛大煥,羅榮彦,權斗星 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

Prevalence of the plerocercoid larva in the fresh-water fishes in Keum-river basin was surveyed from April to September, 1986. To observe whether this plerocercoid larva is really sparganum or not, and can be transfered to the paratenic host or not, a study was performed with the adequate experimental animal (domestic fowl and cat). It was collected the 1096 fresh-water fishes that was ranged 8.0^-16.0cm in length. The results obtained were as follows; 1. A number of ova of Diphyllobothrium spp, was confirmed under the microscopic study, 5 days after experimental infection through the mouth, and them sacrificed to the experimental animal (final host, cat). The adult worm of Diphylobothrium spp., 9.5cm in length, was obtained and that worm was located in the upper position of rectum, Therefore, this plerocercoid larva was confirmed as Sparganum. 2. Transference to the paratenic host (dowestic fowl) was not resulted. 3. Among the total number of 1096 fresh-water fishes, only the Z. platypus was infected with 107 worms corresonding to 9.8%. 4. Infection rate according to the length of Z. platypus was 66. 4% at 12-13. 9cm in length, and this percentage was the highest prevalent rate.

專攻-適性 不一致 大學生의 專攻學科 適應指導方案에 關한 硏究

張大雲,朴鎭玹,羅東晋,李永植 全北大學校 學生生活硏究所 1986 學生生活硏究 Vol.14 No.-

A large portion of college students show dissatisfaction with their majors. This study presumed that this satisfaction might be caused by discrepancy between major and aptitude and that the problems of this students might be serious. In these regards, this study was attempted to search for the causes of the problems and to develop a small group counseling program for solving them. This study is composed of two substudies. The first part of this study was to examine systematically the variables related to their dissatisfaction with their majors, on the bases of the expectancy motivation theory of organizational behavior. Subjects were 500 juniors, selected from 10 departments of Chon-buk National University. The dependent variables were measured by three. subscales taken from the Program Evaluation Survey. They included the satisfaction with intellectual level of major curriculum, the satisfaction with student-faculty relationships, and the general interests of major academics. Four independent measures were also collected, including major-related expectancy, central life interests, academic achievement, and aptitude. The results of this study were summarized as follows: 1) Consistent with the expectancy motivation model, the central life interests, major-related expectancy, and academic achievement were all a significant predictors of the subscales of satisfaction with majors, in group as well as individually, and these predictor variables also revealed differentiated effects on each of three dependent variables. 2) Contrast with the selected model, academic achievement revealed no significant relationship to the expectancy variables, except for the central life interests. The second part of this study was to develop a small group counseling program, through which students might perform successfully their own major tasks, overcoming their dissatisfaction caused by the major-aptitude discrepancy, and to examine its effectiveness in practice. Based on the conceptual nature of group counseling, group counseling theories and group career development programs, and group-establishing processes, this study developed a group counseling program for major-aptitude development. Subjects were 10 freshmen and 10 juniors, who had thought their majors were inconsistent to their central life interests. They worked through the program two hours a week six weekly long. This study has shown the following facts : 1) The program increased significantly their satisfaction with majors. This result was true equally for each subscore as well as the total score of the satisfaction scale. 2) Also, the effect of program differed significantly by sex and grade, but was not differentiated by grade alone. On the bases of these findings, finally, this study suggested some of research problems, which need to be investigated in future studies on major-adjustment programs for college students with major-aptitude discrepancy.