Comparison of Virologic Response and Renal Safety of Long-Term Antiviral Therapy with Tenofovir and Entecavir in Naive Patient with Chronic Hepatitis B

( Hong Seon Son ),( Sung Hoon Choi ),( Na Eun Lee ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Tenofovir (TDF) entecavir (ETV) are considered as the preferred treatment options for treatment-naïve chronic hepatitis B (CHB) patients. We compared the virologic response and renal safety of long-term TDF versus ETV therapy in naïve CHB patients. Methods: This retrospective study included total 432 patients who were treated with TDF (n=205) or ETV (n=227) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients, sex, baseline serum levels of AST, ALT, creatinine, and HBV DNA were not significantly different between TDF and ETV groups. The cumulative rates of VR between TDF and ETV groups were 71.6% vs. 61.8% (p=0.477), 88.1% vs. 79.6% (p=0.058), and 84.8% vs. 83.7% (p=0.966) at 1, 2, and 3 years, respectively. The cumulative rates of genotypic resistance between TDF and ETV groups were 0% vs. 0%, 0% vs. 1.5% (p=0.404), and 0% vs. 2.2% (p=0.447) at 1, 2, and 3 years, respectively. Incidences of renal impairment and hypophosphatemia during treatment up to 3 years were not significantly different between two groups. Multivariate analysis showed that HBeAg-positivity (OR 0.27, 95% CI 0.12-0.58, p=0.0012) and serum HBV DNA at 1 year 2000 IU/mL (OR 0.09, 95% CI 0.03-0.25, p<0.0001) were significantly associated with VR. Conclusions: Long-term TDF and ETV treatments appear to have similar virologic response and renal safety in naïve CHB patient. However, long-term ETV therapy might to be associated with genotypic resistance in 2.2% up to 3 years, while none of patients on TDF therapy did.

Active Packaging Systems for Preventing Oxidation

Kwang Seon Choi,Seok In Hong,Seok Min Son 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

The rapid growth of the food packaging field is powered by the ever growing health conscious consumers and demand for fresher and higher quality foods. Active packaging technologies provide solutions for extending products shelf life with specially altered packaging systems. Among the several shelf life enhancer systems, active packaging system for preventing oxidation is discussed in this paper. Oxidation is generally regarded as the main factor in the development of rancidity of fats and oils. The oxidative processes result in the food becoming unacceptable for consumers. Such oxidation is inhibited by exclusion of oxygen and by the presence of antioxidants. First of all, oxygen scavengers made up of substances which chemically or enzymically react with oxygen were developed to remove oxygen. The commercial oxygen scavengers such as “ageless sachet”, “platinum catalyst”, and “glucose/oxidase enzyme” have been greatly discussed in their action mechanisms and applications. The use of antioxidants in packaging manufacture has so far been limited to stabilizing the polymer during the processing or retarding the change of polymer's physical properties during storage when UV irradiated. However, a further benefit derived from incorporation of an antioxidant into the polymer is more interesting for its ability to retard lipid oxidation of the packaged food via slow migration of an antioxidant from the polymer to food. In view of which, in this paper we will review some oxygen scavenger systems as well as antioxidant-impregnated or antioxidant-coated polymer packaging material.

Effect of Non-Tumor Cell Contamination on Detection of p53 Gene Mutations in Human Gastric Cancer Cells by Polymerase Chain Reaction Single-Strand Conformation Polymorphism Analysis

Weon Seon Hong,Seok Il Hong,Dong Soon Lee,Young Sook Son 대한내과학회 1994 The Korean Journal of Internal Medicine Vol.9 No.1

박리성 올가미를 이용하여 제거한 대장 과립세포종 1예: 단일 기관에서 경험한 과립세포종의 임상양상과 함께

손홍선 ( Hong Seon Son ),박관우 ( Kwan Woo Park ),장슬아 ( Seol A Jang ),장지원 ( Ji Won Jang ),임성균 ( Sung Kyun Yim ),이상연 ( Sang Youn Lee ),이수택 ( Soo Teik Lee ),김성훈 ( Seong Hun Kim ) 전북대학교 의과학연구소 2011 全北醫大論文集 Vol.35 No.1

대장의 과립세포종은 일반적으로 양성이 며 증상이 없고 우연히 발견되는 매우 드문 종양이다. 최근 감별진단을 위해 내시경초음 파를 이용한 시도가 보고되었지만, 아직까진 절제를 통한 조직검사만이 확진 방법으로 알려져 있다. 저자 등은 증상이 없었던 47세 남자에서 우연히 발견된 대장 점막하 종양을 박리성 올가미를 사용하여 내시경적으로 절제하여 조직학적으로 확진 된 증례와 3차 단일기관에서 10년간 모든 장기에서 과립세 포종으로 진단된 21예의 임상양상을 비교하여 고찰과 함께 보고하고자 한다. Granular cell tumor (GCT) of the colon is rare, benign, asymptomatic and usually found incidentally. Although EUS has been tried for diagnosis, endoscopic resection and histological examination is mandatory to confirm. In this case report, submucosal mass of the colon in an asymptomatic 47-year-old male was removed by detachable snare and was confirmed GCT. Here we also reviewed clinical characteristics of 21 cases of GCT which developed at various organs for 10 years in a single tertiary medical institute.

원저 : 사람 폐암세포주에서 p53 종양억제유전자의 변이

홍원선 ( Weon Seon Hong ),홍석일 ( Seok Il Hong ),이동순 ( Dong Soon Lee ),손영숙 ( Young Sook Son ),이춘택 ( Choon Taek Lee ) 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.6

Effect of Dongchunghacho on Gene Expression in Aorta and Liver in ApoE -/- Mice Fed a High-fat/high-cholesterol Diet

Nam Sook Park,Han Seok Kang,Seon Ku Kim,Yong Gyun Kim,Byung Uuk Cho,Teak Soon Shin,Keun Ki Kim,Hyun Chul Park,Hong Joo Son,Hong Gu Lee,Sook Jae Sea,Hong Ja Kim,Eunju Park,Gyeong Im Jeon,Hyun Jung Lee, 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05

A full genomic DNA microarray technique was employed to investigate the effects of Dongchunghacho on aortal and hepatic gene expression in apolipoprotein E knockout mice fed a high-fat/high-cholesterol diet. Male 8- week - old ApoE-/- mice were randomly divided into two groups, control(high cholesterol group; HC) and supplementation of Dongchunghacho (SD). All of the mice were fed a high-fet/high cholesterol diet with or without Dongchunghacho supplemented by 1% for 6 weeks. At first, lipid profile of the Dongchunghacho was measured by biochemical analysis. No differences were observed in serum triglyceride and total cholesterol levels between the two groups. Antigenotoxic effect of the Dongchunghacho was measured by the single cell gel electrophoresis assay (Comet assay) and quantified as % fluorescence in tail. Dongchunghacho supplementation decreased significantly leukocytic DNA damage and also there was a tendency of reduction in hepatic DNA damage in Dongchunghacho group compared with the control group. In up regulated genes in liver and aorta of the mice, genes with 0 to 2- fold difference in expression level between the two group (HD and SD) was very much more in liver than in aorta, on the contrary, those with 2-fold to 16-flod difference increased greatly rather in aorta than in liver. Also, almost the same results were observed in down regulated genes in liver and aorta between the two groups. These results suggested that supplementation of Dongchunghacho might be helpful in preventing leukocytic DNA damage induced by high fat diet, and has a more crucial roles in aortal gene expression.

Rifampin으로 유도된 혈소판 감소증 1례

손혜영,천선희,홍기숙 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.4

Rifampin-induced thrombocytopenia has been recognized as an immunological reaction associated with intermittent high dose therapy, or after administration of rifampin fo11owing aninterruption of therapy, and rarely seen with daily low dose therapy. The patient was a 64 year-old male who was given rifampin 600mg daily for treatment of recurrent pulmonary tuberculosis. He had been received antituberculous treatment includingriftmpin 4 years ago. Spontaneous gum bleeding, petechiae on whole body, hemoptysis wasnoted two weeks after initiating the treatment. His platelet count was 5000/mm^3. Antituberculous medication was discontinued, but the platelet count was not recovered. He diedof severe hypoxemia due to pulmonary hemorrhage. With the essential use of rifampin for the treatment of tuberculosis infections, clinicianshould recognize the possible complication of this drug causing such serious immunologic reactions as thrombocytopenia, hemolytic anemia, and acute renal failure with daily or intermittenttheupy.

Synthesis and properties of phenothiazylene vinylene-based polymers: New organic semiconductors for field-effect transistors and solar cells

Son, Seon-Kyoung,Choi, Yoon-Suk,Lee, Woo-Hyung,Hong, Yongtaek,Kim, Jae-Ryoung,Shin, Won-Suk,Moon, Sang-Jin,Hwang, Do-Hoon,Kang, In-Nam Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of polymer science Part A, Polymer chemist Vol.48 No.3

<P>A series of new phenothiazylene vinylene-based semiconducting polymers, poly[3,7-(4′-dodecyloxyphenyl)phenothiazylene vinylene] (P1), poly[3,7-(4′-dodecyloxyphenyl)phenothiazylene vinylene-alt-1,4-phenylene vinylene] (P2), and poly[3,7-(4′-dodecyloxyphenyl)phenothiazylene vinylene-alt-2,5-thienylene vinylene] (P3), have been synthesized via a Horner-Emmons reaction. FTIR and <SUP>1</SUP>H NMR spectroscopies confirmed that the configurations of the vinylene groups in the polymers were all-trans (E). The weight-averaged molecular weights (M<SUB>w</SUB>) of P1, P2, and P3 were found to be 27,000, 22,000, and 29,000, with polydispersity indices of 1.91, 2.05, and 2.25, respectively. The thermograms for P1, P2, and P3 each contained only a broad glass transition, at 129, 167, and 155 °C, respectively, without the observation of melting features. UV–visible absorption spectra of the polymers showed two strong absorption bands in the ranges 315–370 nm and 450–500 nm, which arose from absorptions of the phenothiazine segments and the conjugated main chains. Solution-processed field-effect transistors fabricated from these polymers showed p-type organic thin-film transistor characteristics. The field-effect mobilities of P1, P2, and P3 were measured to be 1.0 × 10<SUP>−4</SUP>, 3.6 × 10<SUP>−5</SUP>, and 1.0 × 10<SUP>−3</SUP> cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>, respectively, and the on/off ratios were in the order of 10<SUP>2</SUP> for P1 and P2, and 10<SUP>3</SUP> for P3. Atomic force microscopy and X-ray diffraction analysis of thin films of the polymers show that they have amorphous structures. A photovoltaic device in which a P3/PC<SUB>71</SUB>BM (1/5) blend film was used as the active layer exhibited an open-circuit voltage (V<SUB>OC</SUB>) of 0.42 V, a short circuit current (J<SUB>SC</SUB>) of 5.17 mA cm<SUP>−2</SUP>, a fill factor of 0.35, and a power conversion efficiency of 0.76% under AM 1.5 G (100 mW cm<SUP>−2</SUP>) illumination. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 635–646, 2010</P> <B>Graphic Abstract</B> <P>A series of new phenothiazylene vinylene-based semiconducting polymers (P1, P2, and P3) have been synthesized via a Horner-Emmons reaction with weight-averaged molecular weight (M<SUB>w</SUB>) around 22,000–29,000. Solution–processed field-effect transistors fabricated from these polymers showed p-type organic thin-film transistor characteristics. The field-effect mobilities of P1, P2, and P3 were measured to be 1.0 × 10<SUP>−4</SUP>, 3.6 × 10<SUP>−5</SUP>, and 1.0 × 10<SUP>−3</SUP> cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>, respectively, and the on/off ratios were on the order of 10<SUP>2</SUP> for P1 and P2, and 10<SUP>3</SUP> for P3. The atomic force microscopy images of the polymer thin films revealed that all polymers were characterized by an amorphous structure. A photovoltaic device in which a P3/PC<SUB>71</SUB>BM (1/5) blend film was used as the active layer exhibited an open-circuit voltage (V<SUB>OC</SUB>) of 0.42 V, a short circuit current (J<SUB>SC</SUB>) of 5.17 mA cm<SUP>−2</SUP>, a fill factor of 0.35, and a power conversion efficiency of 0.76% under AM 1.5 G (100 mW cm<SUP>−2</SUP>) illumination. <img src='wiley_img/0887624X-2010-48-3-POLA23814-gra001.gif' alt='wiley_img/0887624X-2010-48-3-POLA23814-gra001'> </P>

위암세포주에서 Recombinant Human Interferon-r와 Adriamycin의 투여순서가 항암효과에 미치는 영향

홍원선,손영숙,김창민,강윤구,이춘택,김유철,임영혁,남현석,이진오,강태웅 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

Numerous previous studies, both in vitro and in vivo, have demonstrated that the cytotoxicity can be enhanced by the combination of chemotherapeutic agent and interferons(IFNs) in various types of cancer cells. We have previously reported that combined treatment of MKN-45, human gastric adenocarcinoma cells, with adriamycin(ADM) and recombinant human interferon-r(rh-IFN-r) increased in the cytotoxicity. In this study, the effects of combination timing of rh-IFN-r and ADM on the cytotoxicity against MKN-45 were investigated using MTT assay. MKN-45 was treated with rh-IFN-r and ADM in vitro on three schedules : Treat A ; rh-IFN-r and ADM were treated simultaneously, Treat B ; rh-IFN-r was treated 24 hours after the treatment with ADM, Treat C ; rh-IFN-r was treated for 72 hours and followed by the treatment with ADM. The survival of MKN -45 was inhibited by ADM dose-dependently. 102 and 103U/ml of rh-IFN-r significantly inhibited the survival of MKN-45(% survival : 35.1 ±-1.2% and 34.4 ±1.1% in Treat A and 42.5 ± 2.1% and 45.9-±2.5% in Treat C, respectively). However no difference in the survival was observed between 102 and 103U/ml of rh-IFN-r. Combined treatment with rh-IFN-r and ADM significantly augmented the cytotoxicity at low concentrations of ADM. Combined effects of rh-IFN-r and ADM were evaluated using IC30(,ag/ml) to ADM. IC30s of MKN-45 in Treat A, B and C at 102 U/ml of rh -IFN-r _ were 0.019 -?- 0.003, 0.045 :I:0.001 and 0.054 ± 0.012, respectively, while IC30 of MKN-45 treated with ADM alone was 0.052±0.004. IC30s of MKN-45 in ADM alone group, Treat A, Treat B and Treat C at 103U/ml of rh-IFN-r were 0.047 ±0.003, 0.004 -±0.001, 0.031 ±0.004 and 0.056 0.008, respectively. These results indicate IC30s of Treat A and B were significantly lower than those of ADM alone(p<0.05) and IC30s of Treat A was significantly lower than those of Treat B(p <0.01). IC30s of Treat C, however, were not different from those of ADM alone. From these results demonstrating that cytotoxic effects were increased by the combination of rh-IFN-r and ADM in the order, Treat A > Treat B> Treat C, it can be concluded that the simultaneous administration of rh-IFN-r and ADM may be the most effective method to combine these two therapeutic modalties.

Electronic topological transition in sliding bilayer graphene

Son, Young-Woo,Choi, Seon-Myeong,Hong, Yoon Pyo,Woo, Sungjong,Jhi, Seung-Hoon American Physical Society 2011 Physical review. B, Condensed matter and materials Vol.84 No.15