New Insight for Fluoroquinophenoxazine Derivatives as Possibly New Potent Topoisomerase Ⅰ Inhibitor

Kang, Da-Hye,Kim, Jung-Sook,Jung, Mi-Ja,Lee, Eung-Seok,Jahng, Yurngdong,Kwon, Youngjoo,Na, Younghwa 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.18

Fluoroquinolones, represented by ciproxacin and norfloxacin, are well known clinical antimicrobial agents, and their phenyl ring expanded quinophenoxazines are reported as possible antitumor active compounds. These quinophenoxazines are known to inhibit DNA topoisomerase II essential for cell replication cycle. But there were no reports for topoisomerase I inhibition study for these compounds. In this report, we have prepared a few quinophenoxazine analogues and tested their topoisomerases I and II inhibitory activities and cytotoxicity. From the result, we found that qumophenoxazine analogues possessed strong topoisomerase I inhibitory capacity as well as topoisomerase II inhibition. Among the compounds prepared, A-62176 analogues showed strong topoisomerases I and II inhibitory activities. Interestingly, compound 8 missing the 3-aminopyrrolidine moiety at C2 position has similar potent inhibitory capacity against topoisomerases I & II at higher concentrations (20 and 10 uM, respectively). But compound 8 inhibited topoisomerase I function more selectively at lower concentration, 2 uM. Our observation mi&ht strongly implicate that fluoroquinophenoxazines can be developed as efficient topoisomerase I inhibitor with the elaborate modification.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

소형주택 모델하우스에 나타난 주거용 빌트인 가구의 계획특성

김다영, 차승언, 김미경 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.2

The purpose of this study was to analyze the planning characteristics of built-in furniture in small-sized urban type housing. A case study was used to analyze and classify the functional and formal characteristics of built-in furniture applied in urban type housing of Seoul in the first half of 2012. Findings of the study were as follows: (1) The most important characteristic of built-in furniture was multi-functional aspect which was focused on the combination of furnitures. The second characteristic was formal aspect which was focused on the rapidity of installation and dismantling, and ease of movement. (2) Most of built-in furnitures had multi-functionality as functional aspect by combination of some furnitures including beds, chairs, tables and clothes dryers, electronic devices such as refrigerators and washing machines, and the other residential space elements such as stairs and partitions. (3) The flexibility as formal aspect of built-in furnitures was divided into folding/unfolding, opening/closing, and moving/separating. This study shows that the combination of multi-functionality and flexibility of the housing built-in furniture will be more ideal in small-sized housing planning rather than relying on just one type.

브랜딩·스타일링·마케팅을 결합한 스페이스 디자인 프로세스 연구 - 작품‘Fill the Red, Feel the Red'를 중심으로 -

은다솜,장효실,최해원,홍지현,이진민,장미정,이성애 숙명여자대학교 디자인연구소 2018 숙명디자인학 연구 Vol.25 No.-

본 연구는 디자인 분야와 마케팅 분야의 전략을 종합하여 전략적 연결점을 찾아내 요소들 간 융합을 이루는 사례를 제시하여 브랜드·스페이스·마케팅에서 새로운 방향성과 아이디어를 제시하는데 목적을 둔다. 이에 본 연구는 2017년 9월~12월까지 ㈜애경과 산업 연계하여 진행된 숙명여대 환경디자인학과 ‘브 랜딩·스타일링·마케팅’ 교과목에서 도출된 ‘fill the red, feel the red’ 프로젝트를 마케팅 및 디자인 프로세스, 결과물을 도출하여 그 과정들을 밝힌다. 아울러 본 연구는 브랜드 스페이스 마케팅에 대한 이론적 고찰을 통해, 브랜드 스페이스(팝업스토어)를 개발 및 스타일링하며 ㈜애경의 화장품 브랜드 ‘LUNA’를 브 랜딩, 스타일, 마케팅적 측면에서 종합적으로 연계하여 도출되는 과정들을 제안함으로서 향후 브랜드 스페이스 디자인과 마케팅 분야에 체계적이고 창의적인 방법들로 결과물을 도출하는데 기초자료로 활용하는데 의의가 있다.

일부 고지혈증 폐경 여성의 Isoflavone 공급에 따른 혈중지질 변화에 관한 연구

이다홍,승정자,이행신,김미현,서유리 대한지역사회영양학회 2001 대한지역사회영양학회지 Vol.6 No.1

Intake of soy protein may decrease the risk factors associated with cardiovascular disease in postmenopausal women. This study was designed to investigate the effects of isoflavone supplementation on serum lipids in 16 hyperlipidemic postmenopausal women. For this purpose, an intervention study was conducted for 12 weeks. Subjects were healthy, free-living women consuming habitual diets with 0.3 g/d of isoflavone. Food and nutrient intake was obtained by 24-hr recall method and anthropometric measurements were made. Systolic and diastolic blood pressure, total serum cholesterol, HDL-cholesterol and LDL-cholesterol were determined before and after the isoflavone supplementation. The results were summarized as follows. The average age, height, weight and BMI of the subjects were 65.3 years, 151.4 cm, 62.2 kg and 27.1, respectively. The systolic blood pressure and diastolic blood pressure were not reduced significantly with isoflavone supplementation. Total cholesterol (p < 0.001), HDL-C (p < 0.05), and LDL-C (p < 0.01) were significantly increased after isoflavone concentration. In conclusion, isoflavone supplementation was not effective to modify risk factors for cardiovascular disease.

社會經濟水準에 따른 都市 未就學兒童의 營養 및 健康狀態에 관한 調査硏究

崔美茶,李中姬 카톨릭대학교 생활과학연구소 1985 생활과학연구논집 Vol.5 No.1

The purpose of this study was to investigate the difference of nutritional and growth status for two preschool children with different socio-economic status. This study was conducted from June 10, 1984 to July 12, 1984. The information about general socio-economic status was obtained by survey questionnarre. Three day food recording method was utilized to assess food consumption and measured to estimate the difference of growth rate between the two groups. Hemoglobin and Hematocrit levels were also measured to assess the prevalence of anemia. According to these results. 1. Higher Educatonal status of mother and monthly income of each household were observed in Y, but higher Engel's coefficient was obtained in M. 2. Eventhough average nutrient intake was adequate compared to RDA for most of the preschool children in Y, inadquate intake of Ca, Fe, and Vit B2 were observed for 11.9%, 1.7%, and 2% of the preschool children, respectively. All the nutrients in take were observed below RDA in M expect Vit A, Vit B1 and Niacin. 42%, 18.7% and 10.4% of preschool children exhibited inadquate intake of Ca, Fe and Vit B2, respectively. 3. The proportion of preschool children with weight, height and skinfold thickness below standard in Y was significantly lower than those of preschool children in M(P<0.01). 4. Hemoglobin and hematocrit levels were positively correlated to the Calorie, protein, Fe and Vit. C intake in both area. It is suggestion nutritional education program in two areas.

교내 실내 공기에서 부유 미생물의 분포

박창은,임미소,이다은,김설아,강재원 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.2

The pathogenic and non-pathogenic microorganism have been isolated from the indoor airborne, the closest environment of human beings. Our purpose were to investigate the distribution of fungi and bacteria in indoor airborne sampled from 7 locations in Namseoul University for 2 months from September to October, 2010. The isolated bacteria were identified by Gram stain and biochemical test using VITEKTM system, also The fungus were identified by LPCB. The experiment on microorganism concentration of indoor air carried out and the average of total microorganism was measured. When airborne bacteria were isolated and identified. The isolation rates of Gram positive cocci, Gram positive bacilli, Gram negative bacilli, and Gram negative cocci were 38.3%, 22.4%, 2.7%, 0%, respectively. In Gram positive cocci, the most strains were identified as Micrococcus spp. In Gram positive bacilli, the most strains were identified as Bacillus spp. The frequently isolated fungi were Aspergillus sp, Penicillium sp, Alternaria sp, Rhizopus sp, Mucor sp. respectively. Further systematic studies are necessary with an emphasis on species identification. Key Words : Microorganism, Fungus, Indoor Airborne, Micrococcus, Aspergillus

당뇨병에 관한 한방적 연구 : 淸心蓮子飮, 加味調胃承氣湯, 杞菊地黃湯에 대하여 On the Cheungsimyeonjaeum, Kamijowiseunki-tang, Kikukjihwang-tang

이인자,이다미 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1

In order to study the effect of oriental medicine on experimental diabetes mellitus and cataract, Cheungsimyeonjaeum, Kamijowiseungkitang and Kikukjihwang-tang were administered to streptozotocin indeced diabetic rats and glactose-induced cataractic rats. The results are summarized as follows; 1. Variation of body weight were significantly increased in 7th day by administration of Cheungsimyeonjaeum and Kamijowiseungkatang. 2. Weight of liver were significantly recovered by administration of Cheungsimyeonjaeum and Kikukjihwang-tang. Weight of kidney were significantly recovered by administration of Kikukjihwang-tang. 3. The consumption of water significantly decreased by administration of Cheungsimyeonjaeum, Kamijowiseungki-tang and Kikukjihwasng-tang. 4. The consumption of food were significantly decreased by administration of Chungsimyeonjaeum, Kamijowiseungki-tang and Kikukjihwang-tang. 5. Onset of cataract in experimental group was not significantly different from control group. These results suggest that Cheungsimyeonjaeum, Kamijowiseungkitang and Kikukjihwang-tang may play protective and therapaeutic roles in diabetes mellitus.

교내 수도꼭지형 냉온수기의 생수 배출 부위와 생수에 존재하는 미생물의 분포

박창은,김설아,임미소,이다은,박유진 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.1-1

The distributed species and number of viable microorganisms in drinking water were monitored according to water dispenser maintenance. our purpose was to investigate the distribution of bacteria in drinking water dispenser. To analyze possible dispenser contaminations sampling were performed from 14 locations in Namseoul University for 3 months from March to May, 2010. The isolated bacteria were identified by Gram stain and biochemical test using VITEKⅡ systems. The microorganism concentrations around the water discharge areas were measured and the average of total microorganisms was determined. The number of bacteria were measured by McFarland turbidity. The water and water discharge areas were separated and identified. The isolation rates of Gram positive cocci and Gram negative bacilli were 56.5%, 17.4% respectively. The frequently isolated bacteria were Staphylococcus epidermidis, Enterobacter aerogenes, Enterbacter sakazakii, Alcaligenes faecalis, Acinetobacter baumannii, Staphylococcus hominis, respectively. Further systematic studies are necessary with an emphasis on species identification. Key Words : Microorganisms, Water Discharge Areas, Drinking Water, McFarland

초등학교 3학년 학생의 수학에 대한 인식 태도 연구

박순길,강지우,고대용,김다희,임언미 大邱大學校 師範大學 附設 敎育硏究所 2009 學校敎育硏究 Vol.5 No.1

The purpose of this study was to investigate a study on awareness attitudes of mathematics education in elementary school. This study was conducted with 152 W elementary school of Gwang Ju, 105 H elementary school of Gyeong Ju making up 257 in total. Mean, standard deviation, t-test were done to draw out the conclusions according to different study purposes. The findings of this study were as follows; First, the awareness attitudes of mathematics education was non-significant compared to those in the male-female group. Second, it can be said that the awareness attitude of Gwang Ju toward the elementary students was more positive compared to the Gyeong Ju elementary students. Third, it can be said that the awareness attitude of mathematics attend a lecture group toward the elementary students was more positive compared to the non-mathematics attend a lecture group. 본 연구는 초등학교 3학년 학생들의 수학에 대한 인식태도를 알아보고자 하였다. 본 연구의 대상은 광주광역시 W초등학교 3학년 152명과 경주시 H초등학교 3학년 105명이며, 연구결과를 알아보기 위하여 기술통계와 t검정을 하였으며 연구결론은 다음과 같다. 첫째, 초등학교 3학년 학생들의 수학에 대한 인식태도에서 남녀 간의 차이가 나타나지 않았다. 그러므로 수학에 대한 자신감이나 흥미에서 남녀 간에 차이를 보이지 않았다. 둘째, 지역별로 대도시에 사는 초등학교 3학생들이 중소도시에 사는 초등학교 3학년 학생들보다 인지적 영역에서 차이가 있었으며, 더 긍정적인 인식을 가지고 있었다. 셋째, 수학학원에 다니고 있거나 다닌 경험이 있는 초등학교 3학년 학생들이 학원에 다니지 않은 초등학교 3학년 학생들보다 수학에 대한 인지적 영역, 정의적 영역, 전체인식태도에서 더 긍정적인 인식을 가지고 있었다.