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      • 그레이브스병에서 치료에 따른 폐동맥압의 변화

        남택만,조한수,이진서,송영림,김두만,두영철,박철영,정인경,홍은경,이성진,오기원,김현규,유재명,최문기,유형준,박성우 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

        연구배경: 갑상선기능항진증에 의한 갑상선중독증 환자들은 호흡곤란을 호소하며, 그 원인으로 호흡근의 근력 약화, 좌심실부전으로 인한 폐모세혈관의 울혈, 기도저항의 증가, 갑상선종으로 인한 기관의 압박, 호흡기능 이상 등이 거론되고 있다. 폐동맥고혈압이 동반된 그레이브스병 환자가 여러 증례가 보고되었으며, 폐동맥고혈압 환자에게서 갑상선 자가항체와 갑상선기능저하증의 빈도가 높음이 알려지면서 갑상선중독증이 동반된 그레이브스병 환자에게서 관찰되는 호흡곤란의 한 원인으로 폐동맥압 증가가 작용할 가능성이 제시되고 있다. 이에 저자 등은 그레이브스병 환자를 대상으로 폐동맥압을 측정하고 치료 전후의 폐동맥압의 변화를 전향적으로 연구하였다. 방법: 갑상선중독증이 동반된 그레이브스병 환자와 정상 갑상선기능을 나타낸 대조군을 대상으로 갑상선기능검사 및 갑상선 자가항체를 측정하고, 심초음파를 이용하여 치료 전후로 폐동맥압을 측정하여 폐동맥압과 갑상선기능 및 갑상선 자가항체와의 관계, 폐동맥압의 변화 등을 관찰하였다. 결과: 1. 연구대상은 대조군 10명 (남녀비 1:9, 관해 상태의 그레이브스병 3명, 갑상선종 3명, 정상인 4명), 그레이브스병 환자 26명 (남녀비 7:19)이었다. 2. 대조군과 치료 전 그레이브스병 환자의 폐동맥압은 각각 23.5±2.32 mmHg, 29.6±10.3 mmHg이었고, 치료 전의 폐동맥압과 혈청 갑상선자극호르몬 결합억제 면역글로불린 (TBII) 농도는 유의한 양의 상관관계를 보였다. 3. 26명의 그레이브스병 환자 중에서 10명 (38.5%)이 폐동맥고혈압 (기준: 폐동맥압 > 30 mmHg)으로 진단되었다. 4. 치료 전후로 폐동맥압을 측정한 13명은 폐동맥압이 치료 전 29.6±10.3 mmHg에서 치료 후 폐동맥압 22.2±6.48 mmHg로 의미있게 감소하였다. 결론: 갑상선중독증을 보이는 그레이브스병 환자의 약 40% 정도에서 폐동맥고혈압이 발견되어 폐동맥고 혈압은 그레이브스병에 흔하게 동반하는 질환으로 생각된다. 향후 그레이브스병 환자에서 관찰되는 폐동맥압의 증가와 관련한 병인, 발생기전 및 임상적 의의 등에 대한 연구가 필요할 것으로 생각된다. Background: Exertional symptoms, dyspnea and impaired effort tolerance are common in patients with Graves' disease. Proposed explanations include: high-output left heart failure, ineffective oxygen utilization and respiratory muscle weakness. In addition, pulmonary hypertension has also been reported in patients with Graves' disease. A high prevalence of hypothyroidism and positive thyroid autoantibody were also observed in patients with pulmonary arterial hypertension. Therefore, the pulmonary artery pressure in patients with Graves' disease was evaluated. Methods: Two-dimensional and Doppler echocardiographic examinations (Hewlett Packard Sonos 2500) were performed to determine the pulmonary artery (PA) pressure in 26 Graves' disease patients, both before and after treatment (23 patients with propylthiouracil and 3 with RAI), and in 10 euthyroid controls. The changes in the PA pressure after treatment were evaluated in 13 patients with Graves' disease, who became euthyroid after treatment. Results: The pulmonary artery pressure was increased in the untreated Graves' disease patients compared to the normal controls (23.5±2.32 vs. 29.6±10.3 mmHg). 38.5% of the Graves' disease patients (10/26) showed pulmonary arterial hypertension (PA>30 mmHg) and the serum TBII level was higher in the Graves' disease patients with pulmonary arterial hypertension than in those with normal PA pressure (P<0.05). In the Graves' patients who became euthyroid after treatment, the PA pressure was significantly decreased. Conclusion: 38.5% of the untreated Graves' disease patients showed pulmonary arterial hypertension, and the pulmonary artery pressure was significantly decreased in those who became euthyroid after treatment. The pathogenesis and clinical importance of pulmonary arterial hypertension in Graves' disease requires further studies (J Kor Soc Endocrinol 18:465∼472, 2003).

      • Aluminium板의 環境破壞에 關한 基礎的 硏究

        崔壯宇,金榮萬,李龍福 弘益大學校 1982 弘大論叢 Vol.14 No.2

        It is known that the most of Enviroment Assisted Fracture affected remarkably by the various environmental effect are brittle fracture, and that the above field is very wide. In this paper, Environment Assisted Fracture is discussed from the view point of fracture mechanics. Aluminium and SUS304 Stainless Steel in solutions of several percentage of MgCl₂(10%, 15%, 20%) at the temperature(60℃±3℃)is investigated according to the crack growth, and the value of K is compared with the K obtained by the changes of deflection according to the crack growth. THe results of the experiment is summarized as following 1)The tendency of crack growth as time goes by is shown as 4 region in both materials. 2)The experimental value of K of SUS304 Stainless Steel is same as the calculated value from the variation of the compliance according to crack growth, but not in Aluminium.

      • 鐵筋 콘크리트 有孔보의 거동에 관한 실험적 연구(Ⅱ)

        최종만,이화직,하영철,곽윤근 國立金烏工科大學校附設生産技術硏究所 1994 産業技術開發硏究 Vol.10 No.-

        Openings through beams are required for the passage of utility ducts and pipes, and they are freqently encountered in the design of modern buildings. They are particularly important in multistory buildings where the use of openings in beams can mean lower story heights, leading in turn to a multiplicity of savings. Therefore, the designers are often faced with the necessity of providing adequate openings in the buildings. However, provision of openings may cause problems of excessive cracking and deflection, and may severly affect the strength of a beam. An experimental investigation is carried out on twelve reinforced concrete beams with square openings. The size of opening, and it's location are considered as major variables. The specimens were tested under two point loading. Loads were usually applied in steps of 0.5 ton up to failure to observe the crack initiation and propagation, initial diagonal cracking, midspan deflection, concrete strain and reinforcement strain.

      • 케이블 TV 광고의 활성화 방안에 관한 연구

        崔永萬 東新大學校 1995 論文集 Vol.7 No.-

        In the information age cable television broadcasting is the basis of information superhighway industries. This paper begins with the premise that cable television (CATV) advertising should be activated in order to keep the stable development of CATV. This paper consists of five chapters. Chaper 1 is the introduction, dealing with The objectives and methods of the study. Chapter 2 examines the concept,characteristics,and structure of CATV chapter 3 investigates the present situation and advertising enviroment of CATV in Korea. Chapter 4 comes up with the activating strategies of CATV advertising: the strategies of government and those of advertising industries. Finally, chapter 5 forms the conclusion. I suggest in this paper that the government and the advertising industries should work out these strategies: the government should amend the CATV laws and institutions to activate CATV, lower the deliberation standards of CATV advertising, and support CATV advertising by giving the advertising industries all kind of the possible benefit in tax, finance. The advertising industries should urge program providers to arrange the system interconnects to increase the number of audience, make the use of rational media mix as an advertisement-marketing strategy, and arrange the system-operator interconnects of broadcasting companies to raise the number of subscribers. In conclusion, if the above strategies are effectively put into practice, cable television will certainly attain its stable development through CATV advertising.

      • Videodensitometer를 이용한 치은연하소파술후 치간골 골밀도의 변화

        최진근,이만섭,권영혁 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.1

        The purpose of this study was to evaluate the changes of interproximal bone density by means of videodensitometer and to examine the clinical applicability of videodentitometer to assess the periodontal disease activity: Twelve interproximal sites, with periodontal pockets deeper than 5mm and vertical Loss of bone on standard dental radiograph, were treated by subgingival curettage. The papilla bleeding index, the plaque index, the degree of mobility, the depth of pockets, and the level of attachment were measured. Standardized reproducible radiographs were taken by using the occlusal stent with parallelling film holder. The density of the interdental bone was measured on the radiographs by a videodensitometer at three levels : the most 'superficial' level; the 'deep' level, arbitrarily 1.5mm below; and the `apical' level, where no bony changes were to be expected. The clinical parameter and the radiographical change were measured at initial, and 1 month, 3 months, and 6 months after treatment. The results were as follows 1. The papilla bleeding index and the degree of mobility decreased significantly until 3 months after subgingival curettage and showed the same level in the remaining experimental periods. 2. The pocket depth mainly decreased due to the gingival recession until 1 month after treatment, but to the attachment gain after 1 month. 3. The density of the interdental bone did not show a significance increase until 1 month after treatment, but showed a steady increase throughout the 6 months of observation. 4. The close relationships were shown between the decrease in pocket depth and the gain of attachment and the improvement of bone density at 6 months after treatment.

      • 小兒 腸重疊症의 臨床的 考察

        崔龍萬 梨花女子大學校 韓國生活科學硏究院 1979 韓國生活科學硏究院 論叢 Vol.23 No.-

        1973년 8월1일부터 1978년 8월 말까지 만 5년간 이화여자대학교 부속병원 외과에서 치료한 장중첩증환자 62에를 가지고 임상적 및 통계적 분석을 하였다. 장중첩증은 소아의 급성복증 중 가장 흔한 질환이며, 조기에 진단하여 적절한 치료를 함으로써 100%의 완치가 되는 질환이다. 62예를 가지고 연령 및 성별분포, 발병후 내원까지의 기간, 계절별 빈도, 발병원인, 임상증상 및 증후, 검사소견, 방사선소견, 유형별 분포, 치료 및 합병증에 대한 것을 비교 검토하였다. 고찰의 결과 장중첩증은 남아에서 1세 미만에 주로 발병하여 발병되고나서 대부분 24시간 이내에 병원에 오는 것이며, 호흡기 질환이 많은 겨울철에 장중첩증이 많이 발생한다는 연관성을 알게 되었고, 병의 원인은 특발성이며, 이 병의 삼대증상 및 증후군을 대부분 나타내고 있으며,ㅣ ileocecal type이 가장 흔한 형이며, 대부분 수술요법으로 완치가 되었다. Intussusception is the most important and frequent surgical disease in infancy and childhood. This clinical studt was performed on 62 cases with intussusception who were admitted to the Department of surgery, Ewha Womans University Hospital for the past 5 years from August 1973 to August 1978. The following results were otained: 1) In age distribution, the peak incidence was bwtween 6 months and 9 months of age. 51 cases(82.3%) were under one year of age, and the malw tp female ratio was about 3.81:1;males were more affected than females. 2) 40cases(64.5) visited our hospital within the first 24 hours following the onset of symptoms 3) The seasonal distribution showed peaks in summer(25.8%), and the least in autumn(12.9%). 4) The etiology was idiopathic in all cases. 5) The cardina; symptoms and signs were vomiting (90.3%), current jelly stool(85.5%), irritabillty(67.7%) and palpable mass(64.5%). 6) Nimber of W.B.C was most frequent within 10,000~15,00/Cu.mm(46.8%). 7) In the X-ray study, intestinal obstruction signs were manifested in 83.7% with olain abdominal conditions, and intussusception signs were manifested in 89.5% with barium enema. 8) The most common type of itussusception was ileocecal type(48.4%) 9) In the treatment, surgical procedure was performed on 80.6%, of which manual reduction was the most frequent with 86%. Barium reduction was successful in 63.2% of the cases. 10) Among cases admitted to our hospital within 24 hours after the onset of symptoms, postoperative complications occurred in 24% of the cases, with an overall moratlity rate of 3.2%.

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