S-528 : The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

경막외 마취하 제왕절개술시 술중 경막외 모르핀의 투여가 술후 정맥내 자가통증조절(IV-PCA)에 미치는 영향

최덕환,김지애,심우석 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.1

Background : Intravenous patient-controlled analgesia (IV-PCA) has been widely used for pain relief after cesarean delivery under epidural anesthesia. However, IV-PCA alone has a limited effect on early postoperative pain relief. Epidural morphine injected intraoperatively could alleviate the early post-cesarean pain. We evaluated the effects and side effects of intraoperative epidural mo17hine on post-operative IV-PCA. Methods : Forty patients scheduled for cesarean section under epidural anesthesia were randomly assigned to one of two groups. The patients in the intravenous group (IV group, n=20) received intra-venous morphine 3-5 mg after the operation in the recovery room when patients complain of pain, and the patients in the epidural group (EPI group, n = 20) received intraoperative epidural morphine 3 mg afrer fetus delivery. After that, both groups received morphine IV-PCA (no basal infusion, bolus 1.0 mg, lock-out time 6 min). Analgesic efficacy, degree of patient satisfaction, drug consumption and side effects were compared at 4 and 24 hours after surgery. Results : The EPI group had significantly lower VAS for pain at 4h after surgery on movement and resting than the IV group, whereas no significant difference was observed at 24h after surgery. The cumulative morphine consumptions at 4h and 24h after surgery were more in the IV group (each, p $lt; 0.001). Fewer patients in the EPI group had drowsiness at 24h after surgery, but there were no significant differences in other side effects and degree of satisfaction between the two groups. Conclusions : We conclude that intraoperative epidural morphine was effective with less side effects for postoperative IV-PCA in the cesarean patients under epidural anesthesia. (Korean J Anesthesiol 2000; 38: 112 ∼ 117)

An update on the pathogenesis of the upper airways in aspirin-exacerbated respiratory disease

Choi, Jeong-Hee,Kim, Mi-Ae,Park, Hae-Sim by Lippincott Williams Wilkins, Inc. 2014 Current opinion in allergy and clinical immunology Vol.14 No.1

PURPOSE OF REVIEW: The key features of aspirin-exacerbated respiratory diseases (AERDs) include chronic, severe asthma and a high prevalence (60–80%) of chronic rhinosinusitis with nasal polyps, all of which are exacerbated by exposure to aspirin and other NSAIDs. Although the pathogenic mechanisms of AERD are not completely understood, repeated instances have shown intense eosinophilic infiltrations of upper and lower airway mucosa, and dysregulation of arachidonate metabolisms. Here, recent updates on the pathogenic mechanisms of chronic rhinosinusitis with nasal polyps in aspirin-exacerbated respiratory diseases are summarized. RECENT FINDINGS: Intense eosinophilic infiltration is closely related to the elevated production of cytokines and chemokines such as IL-5 and eotaxin. The response of local immunoglobulin E to staphylococcal enterotoxins contributes to eosinophilic inflammation in nasal polyp tissue. Other characteristics include the overproduction of cysteinyl leukotrienes and increased expression of cysteinyl leukotriene receptor-1, reduced production of prostaglandin E2, and the down-regulation of cyclooxygenase-2 and E-prostanoid receptor subtype-2. A recent gene expression profiling study has also suggested that periostin is the most up-regulated gene in the nasal polyp tissue of AERD patients. SUMMARY: Chronic rhinosinusitis with nasal polyps is a major comorbid condition of AERD patients that is closely associated with severe asthmatic symptoms. Significant pathologic findings in nasal polyp tissues include intense eosinophilic inflammation, which is caused by elevated production of eosinophil-related cytokines and chemokines, specific immunoglobulin E responses to staphylococcal enterotoxins, and altered arachidonic acid metabolism. This could affect the current treatments and methodologies that are used to control asthma, leading to a more severe and intractable AERD phenotype.

척추-경막외 병용마취를 이용한 제왕절개술시 경막외 Top-up 의 효과

최덕환,김지애,심우석,박남기 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.1

Background : Epidural $quot;top-up$quot; has been blown to enhance spinal anesthesia in combined spinal-epidural anesthesia. Saline and local anesthetics were reported to have a volume effect when infused as epidural $quot;top-up$quot;. In cesarean deliveries where high sensory block has been achieved using a combined spinal-epidural technique, we evaluated the effects of epidural $quot;top-up$quot; on the underlying spinal block. Methods: Sixty-six parturients were allocated randomly into group C (control, n = 21), S (saline, N= 21), or B (bupivacaine. n = 24), Ten minutes after they received 8 mg of 0.5% hyperbaric bupivacaine intrathecally, nothing, 10 ml saline, or 10 ml of 0.25% bupivacaine were infused, respectively. The sensory level at 10 min, the maximal level and the time to reach it, and degrees of motor block and muscle relaxation were compared. We also investigated intraoperative side effects and postoperative findings in the PACU. Results : There were significant changes in sensory level after epidural top-ups in the group S and B, but no differences in maximal height of sensory block and degree of muscle relaxation among the groups. Intraoperative pain was complained in fewer patients in the group B. Times to sensory and motor recovery were longer in patients of the group B. Conclusions : Eight milligrams of hyperbaric bupivacaine using a combined spinal-epidural technique was not sufficient for cesarean section. Epidural saline top-up showed volume effect, which didn't improve the spinal block. Epidural $quot;top-up$quot; of 0.25% 10 ml bupivacaine enhanced the spinal block and sustained the black postoperatively (Korean J Anesthesiol 2000; 38: 69~75)

Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritisin rats

Sim, Boo Yong,Bak, Ji Won,Lee, Hae Jin,Jun, Ji Ae,Choi, Hak Joo,Kwon, Chang Ju,Kim, Hwa Young,Kevin J. Ruff,Karsten Brandt,Kim, Dong Hee 한국영양학회 2015 Journal of Nutrition and Health Vol.48 No.5

속담에 나타난 장애관련 내용 분석

최애경 ( Ae-kyung Choi ),강영심 ( Young-sim Kang ) 한국특수교육문제연구소 2008 특수교육저널 : 이론과 실천 Vol.9 No.2

본 연구는 장애관련 속담에 나타난 장애유형, 장애인관, 그리고 장애관련 내용을 분석함으로써 장애이해교육을 위한 바람직한 방향을 모색하고자 하였다. 분석결과는 다음과 같다. 첫째, 속담에 가장 많이 나타난 장애유형은 지체장애 영역이었다. 둘째, 속담에 나타난 장애인관을 알기 위해 장애인이 어떠한 모습으로 묘사되어 있는지를 분석한 결과 대부분의 속담에서는 교훈적이고 희망적인 내용을 담은 긍정적인 장애인관보다는 부정적인 장애관이 많이나타나고 있었다. 셋째, 속담에는 직접적 또는 간접적인 장애관련 내용이 포함되어 있었으며 능력, 도리, 가정생활 등의 주제로 분석되었다. This study tries to in analyze the attributes of disabilities in proverbs. Proverbs provide us with various suggestions regarding inclusive education because they contain understanding of the disabled experiences in real life and wisdoms of ancestors. In addition, they are interesting and simple to understand and thus easily applicable to real everyday life. This study focuses on the type of disabilitiy, views of disability, contents related to the disabilitiy. The results were as follows; First, person with physical disability appear predominantly in the proverbs. Second, negative perceptions larger than positive perceptions about disability. Third, the types of themes involved in proverbs represented ability, propriety and home life.

MIA 유도 골관절염 랫드에 Natural Eggshell Membrane (NEM)이 미치는 영향

심부용(Sim, Boo Yong),박지원(Bak, Ji Won),이해진(Lee, Hae Jin),전지애(Jun, Ji Ae),최학주(Choi, Hak Joo),권창주(Kwon, Chang Ju),김화영(Kim, Hwa Young),Kevin J. Ruff,Karsten Brandt,김동희(Kim, Dong Hee) 한국영양학회 2015 Journal of Nutrition and Health Vol.48 No.4

본 연구는 난각막 추출물 (NEM)이 골관절염 동물 모델에서 골관절염 유발 인자에 대한 예방과 개선에 미치는 영향을 조사하고자 실시하였다. 실험동물인 6주령의 랫드에 NEM을 골관절염 유발 2주전부터 농도별 (52 mg/kg, 200 mg/kg, 400 mg/kg)로 경구 투여하였으며, 2주간의 경구 투여 실시 후 정상군 (normal)을 제외한 대조군과 NEM 경구투여군에게 3.0 mg/mL의 농도로 MIA를 주사하여 골관절염을 유발하였다. 골관절염 유발 후 4주간 경구 투여를 지속적으로 실시한 후 혈액 및 관절, 조직 등을 이용하여 골관절염 유발 인자들을 확인하였다. NO 생성량은 NEM200, 400 (mg/kg)에서 유의성 있는 감소를 나타내었으며, PGE2 생성량은 모든 농도에서 유의성 있는 감소를 나타내었다. 사이토카인 IL-1β와 IL-6 생성량은 IL-1β에서는 모든 농도에서 유의성 있는 감소를 보였으나, IL-6에서는 400 mg/kg 농도에서만이 유의성 있는 감소를 나타내었다. hs-CRP 생성량은 모든 농도에서 대조군에 비하여 유의성있는 감소를 나타내었으며, MMPs 생성량과 LTB4 생성량을 모든 농도에서 유의성 있는 감소를 나타내었다. 또한, COMP 및 CTX-II 검사를 통해 골관절염의 진행 억제에 유의성 있는 감소를 나타내었다. 마지막으로 관절과 연골을 micro-CT 및 조직 염색을 실시한 결과, NEM 경구 투여군은 연골량 및 관절 조직의 변형, 연골세포의 손상도가 대조군에 비하여 손상이 적었음을 확인할 수 있었다. 이상의 결과로 미루어 볼 때, NEM은 농도 의존적으로 골관절염유발 인자를 감소시켜 관절 및 연골에 효능이 있음을 제시하고 있다. 이와 같은 결과는 NEM이 골관절염에 대한 예방과 개선 효과를 나타낼 수 있는 건강기능식품의 원료로 활용될 수 있을 것이라 사료된다. Purpose: The aim of this study is to investigate anti-arthritis activity using natural eggshell membrane (NEM). Methods: NEM was administered at 52 mg/kg, 200 mg/kg, and 400 mg/kg to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines including IL-1β, and IL-6 were measured by Luminex and PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Results: Production of NO, IL-1β, IL-6, PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane, and transformation of fibrous tissue. Conclusion: The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease the symptoms mentioned above.

Axillary approach versus the infraclavicular approach in ultrasound-guided brachial plexus block: comparison of anesthetic time

In Ae Song,Nam-Su Gil,Eun-young Choi,Sung Eun Sim,Seong-Won Min,노영진,김종수 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.61 No.1

Background: With ultrasound guidance, the success rate of brachial plexus block (BPB) is 95-100% and the anesthetic time has become a more important factor than before. Many investigators have compared ultrasound guidance with the nerve stimulation technique, but there are few studies comparing different approaches via the same ultrasound guidance. We compared the axillary BPB with the infraclavicular BPB under ultrasound guidance. Methods: Twenty-two ASA physical status I-II patients presenting with elective forearm surgery were prospectively randomized to receive an axillary BPB (group AX) or an infraclavicular BPB (group IC) with ultrasound guidance. Both groups received a total of 20 ml of 1.5% lidocaine with 5 μg/ml epinephrine and 0.1 mEq/ml sodium bicarbonate. Patients were then evaluated for block onset and block performance time was also recorded. Results: Group IC demonstrated a reduction in performance time vs. group AX (622 ± 139 sec vs. 789 ± 131 sec, P <0.05). But, the onset time was longer in group IC than in group AX (7.7 ± 8.8 min vs. 1.4 ± 2.3 min, P < 0.05). All blocks were successful in both groups. Conclusions: Under ultrasound guidance, infraclavicular BPB was faster to perform than the axillary approach. But the block onset was slower with the infraclavicular approach.

교통주제도 검수지침에 관한 연구

최정민(Choi Jung Min),주용진(Joo Yong Jin),최애심(Choi Ae Sim) 대한토목학회 2004 대한토목학회 학술대회 Vol.2004 No.10