Successful Treatment of Chronic Eosinophilic Pneumonia with Anti-IgE Therapy

Shin, Yoo Seob,Jin, Hyun Jung,Yoo, Hye-Soo,Hwang, Eui-kyung,Nam, Young Hee,Ye, Young-Min,Park, Hae-Sim The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.10

<P>Anti-IgE therapy, using recombinant humanized anti-IgE antibodies, is clinically effective in patients with eosinophil-related disorders such as allergic asthma, allergic rhinitis, and chronic urticaria. Chronic eosinophilic pneumonia tends to respond promptly to systemic corticosteroid therapy, however; relapses are common following corticosteroid tapering. We treated two patients (17- and 19-yr-old males) of chronic eosinophilic pneumonia whose symptoms were cough and dyspnea on exertion. The symptoms were recurrent while tapering off corticosteroid. They were treated with anti-IgE antibody without recurrence for 2 yr and 15 months. Here, we first describe clinical experience of the 2 cases of chronic eosinophilic pneumonia.</P>

Spontaneous reporting of adverse drug events by Korean regional pharmacovigilance centers

Shin, Yoo Seob,Lee, Yong-Won,Choi, Young Hwa,Park, Byungjoo,Jee, Young Koo,Choi, Sung-Kyu,Kim, Eung-Gyu,Park, Jung-Won,Hong, Chein-Soo John Wiley Sons, Ltd. 2009 PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol.18 No.10

<B>Purpose</B><P>Patterns of prescriptions are markedly influenced by regional disease entities, medical education, culture, economic status, and available pharmaceutical companies. Features of adverse drug reactions (ADRs) may vary in different countries. In this study, we analyzed the causative drugs and clinical manifestations of spontaneously reported ADRs in Korea.</P><B>Methods</B><P>Six Korean Regional Pharmacovigilance Centers collected 1418 cases of spontaneously reported adverse drug events (ADEs) by doctors, pharmacists, and nurses, and the clinical features and causative drugs were evaluated. The data were collected from general hospitals (76.5%), primary clinics, and pharmacies (23.5%).</P><B>Results</B><P>Based upon the World Health Organization (WHO)-Uppsala Monitoring Center criteria (certain—13.7%, probable—46.1%, possible—32.1%), 91.9% of the collected events were suspected to be ADRs and 15.8% of patients experienced serious ADRs. The most prevalent causative drugs were antibiotics (31.6%), followed by contrast dyes (14.0%), non-steroidal anti-inflammatory drugs (NSAIDs) (11.1%), anti-psychotics (5.4%), anti-convulsants (5.2%), cardiovascular agents (4.8%), anti-neoplastics (4.6%), and opiates and non-opiate pain killers (3.5%). Among the antibiotics, cephalosporins (8.1%) were the most common, followed by anti-tuberculosis agents (5.7%), quinolones (4.0%), vancomycin (3.1%), and penicillin (2.8%). The most common side effect was skin manifestations, which were seen in 42% of the patients, followed by neurologic manifestations (14%), gastrointestinal involvements (12.9%), generalized reactions (9.4%), and respiratory involvements (4.5%).</P><B>Conclusion</B><P>Antibiotics, contrast dyes, and NSAIDs were the most common causative drugs for ADRs, which reflects the prescription pattern and the prevalence of diseases in Korea. These data may be useful in establishing a Korean pharmacovigilance system. Copyright © 2009 John Wiley & Sons, Ltd.</P>

Endotoxin Is Not Essential for the Development of Cockroach Induced Allergic Airway Inflammation

Shin, Yoo Seob,Sohn, Jung-Ho,Kim, Joo-Young,Lee, Jae Hyun,Cho, Sang-Heon,Hong, Soo-Jong,Lee, Joo-Shil,Hong, Chein-Soo,Park, Jung-Won Yonsei University College of Medicine 2012 Yonsei medical journal Vol.53 No.3

<P><B>Purpose</B></P><P>Cockroach (CR) is an important inhalant allergen and can induce allergic asthma. However, the mechanism by which CR induces airway allergic inflammation and the role of endotoxin in CR extract are not clearly understood in regards to the development of airway inflammation. In this study, we evaluated whether endotoxin is essential to the development of CR induced airway allergic inflammation in mice.</P><P><B>Materials and Methods</B></P><P>Airway allergic inflammation was induced by intranasal administration of either CR extract, CR with additional endotoxin, or endotoxin depleted CR extract, respectively, in BALB/c wild type mice. CR induced inflammation was also evaluated with toll like receptor-4 (TLR-4) mutant (C3H/HeJ) and wild type (C3H/HeN) mice.</P><P><B>Results</B></P><P>Intranasal administration of CR extracts significantly induced airway hyperresponsiveness (AHR), eosinophilic and neutrophilic airway inflammation, as well as goblet cell hyperplasia in a dose-dependent manner. The addition of endotoxin along with CR allergen attenuated eosinophilic inflammation, interleukin (IL)-13 level, and goblet cell hyperplasia of respiratory epithelium; however, it did not affect the development of AHR. Endotoxin depletion in CR extract did not attenuate eosinophilic inflammation and lymphocytosis in BAL fluid, AHR and IL-13 expression in the lungs compared to CR alone. The attenuation of AHR, eosinophilic inflammation, and goblet cell hyperplasia induced by CR extract alone was not different between TLR-4 mutant and the wild type mice. In addition, heat inactivated CR extract administration induced attenuated AHR and eosinophilic inflammation.</P><P><B>Conclusion</B></P><P>Endotoxin in CR extracts may not be essential to the development of airway inflammation.</P>

Transplantation of Autologous Chondrocytes Seeded on a Fibrin/Hyaluronic Acid Composite Gel into Vocal Fold in Rabbits: Preliminary Results

( Yoo Seob Shin ),( Jin Seok Lee ),( Jae Won Choi ),( Byoung Hyun Min ),( Jae Won Chang ),( Jae Yol Lim ),( Chul Ho Kim ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.4

Injection laryngoplasty is an option for treatment of glottic insufficiency following vocal fold paralysis, vocal fold atrophy or scarring. We intended to evaluate the plausibility of autologous chondrocytes cultured with fibrin/hyaluronic acid (HA) for permanent vocal fold augmentation. Chondrocytes from rabbit auricular cartilage were expanded and cultured with fibrin/HA composite gel. 0.1 mL dosages of fibrin/HA gel with autologous chondrocytes were injected into the left vocal folds of six rabbits. Four months postoperatively, the site was evaluated endoscopically, histologically, and radiologically. None of the six rabbits showed signs of respiratory distress. Computed tomography images and endoscopic evaluation revealed sufficient augmentation volume of the injected vocal fold. Histologic data showed that the injected material did not migrate from their original insertion site. Even though the number of chondrocyte that settled down and survived in the injected site was varying in rabbits, chondrocytes successfully formed neo-cartilage at four months postoperatively in all cases. Histologically, the grafts showed no signs of inflammatory reaction and were covered with ciliated epithelium. The chondrocytes cultured with fibrin/HA could be a plausible injection material for vocal fold augmentation.

Cells and mediators in diisocyanate-induced occupational asthma

Shin, Yoo Seob,Kim, Mi Ae,Pham, Le-Duy,Park, Hae-Sim Lippincott Williams Wilkins, Inc. 2013 Current opinion in allergy and clinical immunology Vol.13 No.2

PURPOSE OF REVIEW: Diisocyanates are the most common cause of occupational asthma in many industrialized countries, and various pathogenic mechanisms have been suggested to be involved. Occupational asthma causes airway remodeling unless diagnosed and treated within a proper time frame. However, treatment modalities are limited because of an insufficient understanding regarding underlying pathogenic mechanisms. RECENT FINDINGS: Several immunological and nonimmunological mechanisms have been suggested, indicating that the pathogenesis of occupational asthma may be more complex than other types of asthma. Airway epithelial cells are the first to encounter diisocyanates and orchestrate various responses, such as cytokine release, oxidative stress generation, and autoantibody formation. Some evidence supports the involvement of adaptive immune responses. Additional evidence suggests that other mechanisms are involved in diisocyanate-induced occupational asthma. One such candidate mechanism is oxidative stress. Oxidative stress has been shown to trigger and aid in the development of diisocyanate-induced occupational asthma in human samples and genetic studies, and some therapeutic trials were performed based on this finding. SUMMARY: Diisocyanate-induced occupational asthma may be caused by a complex interaction of innate and adaptive immune responses. The knowledge presented in this review may help lead to the development of new treatment modalities through an increased understanding of occupational asthma pathogenesis.

구강암편평세포암에서 c-Met 발현여부에 따른 (-)-Epigallocatechin-3-Gallate의 세포사멸 및 종양침습억제효과의 변화분석

신유섭(Yoo Seob Shin),고윤우(Yoon Woo Koh),최은창(, Eun Chang Choi),강성운(Sung Un Kang),황혜숙(Hye Sook Hwang),추옥성(Oak-Sung Choo),이한빈(Han Bin Lee),김철호(Chul-Ho Kim) 대한두경부종양학회 2011 대한두경부 종양학회지 Vol.27 No.1

Hepatocyte growth factor(HGF) and c-Met play an important role in the control of tumor growth and inva-sion, and they are known to be good prognostic indicators of patient outcome. Epigallocatechin-3-gallate (EGCG) has been shown to have chemopreventive and therapeutic properties by modulating multiple signal pathways regarding the control of proliferation and invasion of cells. In this study, we evaluated the role of c-Met in EGCG-induced inhibition of invasion and apoptosis in an oral cancer cell line. In KB cells where c-Met was knocked down with siRNA, we performed invasion assay and FACS with Annexin V-FITC/PT staining. In addition, we checked the change of mitochondrial membrane potential(MMP) and the generation of reactive ox-ygen species(ROS). EGCG-induced inhibition of invasiveness was significantly decreased after the knock-down of c-Met. EGCG-induced apoptosis, MMP change and ROS generation was also reduced in c-Met knock-ed-down KB cells. These results suggest that c-Met is involved in EGCG-induced apoptosis and inhibition of invasiveness of oral cancer cell line.

블랙초크베리(Aronia melanocarpa)의 유용 성분 함량 및 항산화 활성 능력

신유섭(Yoo-Seob Shin),김원우(Won-Woo Kim),김성무(Cheng-Wu Jin ),조동하(Dong-Ha Cho) 한국약용작물학회 2012 한국약용작물학회 학술대회논문집 Vol.2012 No.1

설문조사 분석을 활용한 제조업 작업자의 위험행동 요인 분석

신지섭(Ji-Seob Shin),이훈기(Hunggi Lee),유상우(Sangwoo Yoo),신동일(Dongil Shin) 한국가스학회 2021 한국가스학회지 Vol.25 No.2

제조업 작업자들에 대한 위험행동 요인의 분석은 효과적인 휴먼에러 예방과 효율적인 안전관리제도의 시스템화를 가능하게 한다. 본 연구는 작업자들의 작업심리, 작업환경, 작업일탈 요인이 위험행동의도에 미치는 영향과 이러한 위험행동의도가 위험행동에 미치는 영향의 관계를, 중소 제조업 중 제조가공업 작업자 80명을 대상으로, 설문조사를 중심으로 분석하였다. 결과를 살펴보면, 작업심리와 작업일탈은 위험행동의도에 영향을 미치는 것으로 나타났으나, 직무만족과 작업부하에 해당하는 작업환경요인은 위험행동의도에 영향을 미치지 않는 것으로 나타났다. 동료들과의 관계, 업무의 만족 내지는 불만족 정도, 작업자가 느끼는 직무의 중요성 정도와 많은 작업량을 소화하기 위한 시간의 촉박함 등이 의도적인 위험 작업 유발에는 영향을 미치지 않지만, 위험행동에는 영향을 미치는 것으로 나타나, 의도성이 결여된 상태에서 작업환경요인은 위험행동을 수반하는 것으로 나타났다. Analysis of risky behavior factors for workers in the manufacturing industry enables effective human error prevention and systemization of an efficient safety management system. This study examines the relationship between the effects of workers work psychology, work environment, and work deviation factors on risky behavior intentions and the effects of such risky behavior intentions on risky behaviors. Among the small and medium-sized manufacturing industries, the analysis was focused on a survey of 80 workers in the manufacturing and processing industry. Looking at the results, it was found that work psychology and work deviation had an effect on the intention of risky behavior, but the work environment factors corresponding to job satisfaction and workload did not affect the intention of risky behavior. The relationship with colleagues, the degree of satisfaction or dissatisfaction with the job, the degree of importance of the job that the worker feels, and the tightness of time to digest a large amount of work do not affect intentionally inducing dangerous work, but they do affect risky behavior. In the absence of intention, the work environment factor was found to accompany dangerous behavior.

Simultaneous determination and anti-inflammatory effects of four phenolic compounds in Dendrobii Herba

Yoo, Sae-Rom,Jeong, Soo-Jin,Lee, Na-Ri,Shin, Hyeun-Kyoo,Seo, Chang-Seob Taylor & Francis Health Sciences 2017 NATURAL PRODUCT RESEARCH Vol.31 No.24

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일부 병원에서의 입원비 본인부담양상

신영전,유원섭,하헌영,정설희 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

The purpose of this study was to estimate the proportion of user charges out of total treatment costs and to investigate the occuring status of the charge of non-benefit service. The data were collected from 6 hospitals in 3 cities (Seoul 2, Incheon 3, Shihung 1), which containing 1,752 discharge-bills of discharged patients insured by health insurance. The data were analyzed after standardization of the items of non-benefit services. The result are as follows; 1. the average percent of the cost-sharing of discharged patients was 38.1%(benefit : 15.5%, non-benefit : 22.6%) and the proportion of the cost-sharing due to non-benefit services was greater than that due to benefit services. 2. The occurrence rate and the occurred number of non-benefit services were different among hospitals and showed characteristic occurrence rate in individual hospitals. 3. In acute appendicitis, the characteristics of the occurrence rate and the occurred number of non-benefit services by individual hospitals was similar to those of hospitals. It suggest that the hospitals intentionally applied non-benefit item to patients in order to increase their profit. These findings suggest that the burden of cost-sharing is still high especially due to non-benefit services, so it is necessary to extend the coverage of insurance benefits and to develop management system for the appliance of non-benefit services. Regarding the discharge-bill, all service charges should be included in the bill.