자궁내막에 발생한 점막 연관 림프조직 (MALT) 림프종 1예

전균호,조현진,박성균,김천복,김대연,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

Non-Hodgkin's 림프종의 약 40%는 결절외(extranodal) 림프종으로 대개 위장관에서 발생하며 이들 중 점막 연관 림프조직(mucosa-associated lymphoid tissue: MALT)에서 기원한 림프종은 MALT 림프종으로 분류된다. 위 외의 부위에서 원발성으로 발생하는 MALT 림프종은 매우 드물지만 실제 거의 모든 신체 장기에 발생하는 것으로 알려져 있는데, 가장 흔한 부위인 위 외에도 폐, 갑상선, 침샘, 눈물샘에 발생하고, 드물게 안구, 유방, 방광, 신장, 흉선 등에도 보고된 바 있다. MALT 림프종은 오랜 기간동안 원격 전이하지 않고 국소 병변으로 남아 있는 특징이 있어 치료 방향 또한 국소 병변의 치료에 집중되며, 예후도 림프절 기원의 림프종에 비해 양호한 것으로 알려져 있다. 본 저자 등은 자궁 내막에 원발성으로 발생한 MALT 림프종 1예를 경험하였기에 문헌 고찰과 함께 이를 보고하고자 한다. Mucosa associated lymphoid tissue (MALT) lymphoma can rarely develop primarily in extranodal sites other than stomach which is the most common site for it. Other rare primary sites are small intestine, colorectum, esophagus, lung, thyroid, salivary gland, lacrymal gland, breast and skin. MALT lymphoma represents a distinct clinicopathologic features: it is usually localized to their original site for a long time and shows much more favorable prognosis than lymphoma at other site, but some MALT lymphoma can arise simultaneously or successively in different organ or give rise to another MALT lymphoma of other organ and can be multifocally disseminated or recurred. We report a very rare case of high grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) of the uterine endometrium, which was confirmed by immunohistochemical assay.

흰쥐에 Xylene 반복 투여가 Xylene의 대사에 미치는 영향

전태원,이혜자,윤종국,이상일,조현국 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1999 Journal of biomedical laboratory sciences Vol.5 No.1

실험동물에 xylene의 반복 투여가 이물질의 대사에 어떠한 영향을 미치는지를 알아보기 위하여 흰쥐에 m-xylene과 olive oil의 동량혼합액을 체중 100g당 0.25ml씩 2일 간격으로 1, 4, 8, 12 및 16회 복강으로 투여한 다음 마지막 투여 24시간 후에 처치하여 다음과 같은 결과를 얻었다. 요 중 m-methylhippuric acid 함량은 m-xylene 4회 투여군의 경우 1회 투여군에 비하여 약 56%의 유의한 증가를 보였으며 이후 12회 투여까지 유사한 결과를 나타내었으나 m-xylene 16회 투여시에는 xylene 1회 투여군 치와 유사한 치로 감소되었다. 그리고 간조직의 microsomal aniline hydroxylase와 alcohol dehydrogenase 활성은 m-xylene 12회 투여시 까지는 대체적으로 점진적인 증가를 보였으나 이후 16회 투여시에는 12회 투여군에 비하여 유의한 감소를 보였다. 또한 aldehyde dehydrogenase 활성은 m-xylene 투여 회수에 비례해서 전 실험기간 동안 감소되었으며 특히 16회 투여군에서 본 효소활성의 현저한 감소를 보였다. 한편 본 실험조건에서 투여기간에 따른 진자현미경적 미세구조의 변화는 초기에 활면소포체의 증식이 보이다가 16회 투여군에서는 활면소포체가 감소되고 조면소포체가 증가되었다. 이상 실험결과는 흰쥐에 있어서 xylene 투여 회수에 따라서 요 중 m-methylhippuric acid의 농도 변동이 초래되며 이는 효소단백 유도에 따른 xylene 대사효소 활성 변동에 기인된 결과로 생각된다. To evaluate the effect of repeated treatment of xylene on its metabolism, m-xylene (0.25ml of 50% in olive oil/100 g body weight) has been intraperitoneally given to the rats 1, 4, 8, 12 and 16 times every other day. m-Xylene was once more administered to the animals after 24 hrs since last injection of it. And then the animals were sacrificed after 24 hrs. Four times xylene treated rats showed the significantly elevated urinary m-methylhippuric acid, compared to those treated with the singe dose of m-xylene with the continued similiar high levels of urinary m-methylhippuric acid up to the animals pretreated 12 times and then those treated 16 times defined the significantly decreased urinary m-methylhippuric acid compared to those treated 12 times. On the other hand, hepatic aniline hydroxylase and alcohol dehydrogenase activities demonstrated a gradual increase from the first group to the 12 times xylene-treated animals, but those treated 16 times showed the significantly decreased value compared with the 12 times treated-group. And aldehyde dehydrogenase activities in rats treated with m-xylene 8, 12 or 16 times were significantly decreased compared to those pretreated one or four times. In the early stage of xylene administration, proliferation of SERs were seen whereas SERs were decreased and RERs were clearly increased in xylene-treated rats 16 times. These results indicate that the frequency of xylene injection may influence upon the changes in xylene metabolite, m-methylhippuric acid and it may be due to induction of xylene metabolizing enzymes.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

Al-Cu-Mg合金의 時效析出에 미치는 豫備時效의 影響

趙顯麒,洪俊杓,全在英 경북대학교 공과대학 1983 工大硏究誌 Vol.12 No.-

The influences of preageing on age-precipitation in Al-2.02t% Cu-1.1wt% Mg alloy have been investigated by means of measurements of hardness, tensile strength and electrical resistivity and transmission electron microscopy. The results obtained are summarized as follows. The two-step aged alloy is more age-hardenable than the onestep aged alloy in early stage of ageing. It is because of the formation and growth of solute atom cluster and GPB zones. The maximum hardness and strength of the alloy aged 200℃ is obtained by preaged at 100℃. It is because of fine and dense distribution of S'metastable phase. The hardness and strength are remarkably decreased with sufficient ageing time after preageing at room temperature and 170℃. It is because of the formation and coarsening of S'metastable phase by the preageing.

갑상선기능저하증에 기인한 내인성 급사 1예 보고

이정규,전지현,김민정,이규재,김한겸,조현득,채양석 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2

Although it is known that hypothyroidism can cause cardiac dysfunction, it is very hard to find a case report on sudden death due to hypothyroidism. There are only two reported cases on mediline; one is about a 15-year-old girl who died suddenly of Hashimoto's thyroiditis and the other is about a 31-year-old man who also died suddenly of hypothyroidism associated with chronic lymphocytic thyroiditis. Recently we found a young woman who unexpectedly died while she was sleeping. She was diagnosed as hypothyroidism when she went to hospital about a month before she died. At autopsy there were roughly four abnormal findings; Hashimoto's thyroiditis, mild chronic active hepatitis, diverticulosis and accessory spleen. Trace of chlorpheniramine was detected in gastric remains and blood alcohol level was 0.37 percent. To our knowledge, this is the first case reporting sudden and unexpected natural death associated with hypothyroidism in Korea.

골반통증을 동반한 폐쇄신경 기원의 퇴행성 신경초종

이상욱,김두상,조현득,이창호,전윤수,이남규 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

..

A metal-ion-chelating organogel electrolyte for Le Chatelier depression of Mn³⁺ disproportionation of lithium manganese oxide spinel

Cho, Yoon-Gyo,Jung, Seo-Hyun,Joo, Se Hun,Jeon, Yuju,Kim, Minsoo,Lee, Kyung Min,Kim, Seungmin,Park, Jong Mok,Noh, Hyun Kuk,Kim, Young-Soo,Hong, Jung-Eui,Jeon, Sang-Ik,Kim, Taewon,Kwak, Sang Kyu,Kong, H The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.45

<P>We present a metal-ion-chelating organogel electrolyte, thermally gelated within cells, to solve the problems triggered by metal dissolution from cathodes of lithium ion batteries. The organogel significantly improved the capacity retention of lithium manganese oxide spinel during cycling. The organogel mitigated metal deposition on anodes by capturing metal ions (anode protection). Interestingly, the organogel inhibited metal dissolution by keeping dissolved metal ions highly concentrated around the cathode surface (cathode protection by Le Chatelier's principle).</P>

A report of 29 unrecorded bacterial species belonging to the phylum Bacteroidetes in Korea

Cho, Sang Hyun,Yoon, Jung-Hoon,Kim, Seung-Bum,Jahng, Kwang-Yeop,Cho, Jang-Cheon,Joh, Ki-seong,Cha, Chang-Jun,Seong, Chi-Nam,Bae, Jin-Woo,Im, Wan-Taek,Jeon, Che Ok The National Institute of Biological Resources 2017 Journal of species research Vol.6 No.2

Within a comprehensive, widescale investigation of indigenous prokaryotic species in Korea, 29 bacterial strains in the phylum Bacteroidetes were isolated from diverse environmental habitats that included soil, plant roots, natural caves, tidal flats, freshwater from lakes, and seawater. Based on their high 16S rRNA gene sequence similarities (>99.1%) and the formation of robust phylogenetic clades with the closest type species, each strain likely belonged to an independent and predefined bacterial species. There are no publications or official reports of the isolation of these 29 species in Korea. Our study provides strong evidence that seven species in three genera in the order Cytophagales, 15 species in 13 genera in the order Flavobacteriales and seven species in five genera in the order Sphingobacteriales, all within the phylum Bacteriodetes, are new reports of bacterial species in Korea. Gram reaction, colony and cell morphology, basic biochemical characteristics, isolation source, and strain IDs are described in the species description section.

Synthesis and characterization of Pt-, Pd-, and Ru-promoted Ni–Ce_0.6Zr_0.4O₂ catalysts for efficient biodiesel production by deoxygenation of oleic acid

Jeon, Kyung-Won,Shim, Jae-Oh,Cho, Jae-Wan,Jang, Won-Jun,Na, Hyun-Suk,Kim, Hak-Min,Lee, Yeol-Lim,Jeon, Byong-Hun,Bae, Jong Wook,Roh, Hyun-Seog Elsevier 2019 Fuel Vol.236 No.-

<P><B>Abstract</B></P> <P>Herein, we prepared Pt-, Pd-, and Ru-promoted Ni–Ce<SUB>0.6</SUB>Zr<SUB>0.4</SUB>O<SUB>2</SUB> catalysts with improved oleic acid deoxygenation performance and investigated their physicochemical properties by N<SUB>2</SUB> adsorption-desorption, X-ray diffraction (XRD), NH<SUB>3</SUB> temperature-programmed desorption (NH<SUB>3</SUB>-TPD), and X-ray photoelectron spectroscopy (XPS). Among the above catalysts, the highest oleic acid conversion, C<SUB>9</SUB>–C<SUB>17</SUB> selectivity, and oxygen removal efficiency were observed for Pt/Ni–Ce<SUB>0.6</SUB>Zr<SUB>0.4</SUB>O<SUB>2</SUB>, which was mainly ascribed to its highest surface defect oxygen fraction and acidity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pt-, Pd-, and Ru-promoted Ni–Ce<SUB>0.6</SUB>Zr<SUB>0.4</SUB>O<SUB>2</SUB> catalysts (Me/Ni–CZO) were prepared. </LI> <LI> The above catalysts were used for oleic acid deoxygenation to produce biodiesel. </LI> <LI> Pt/Ni–CZO showed the best deoxygenation performance. </LI> <LI> Pt/Ni–CZO exhibited the highest surface defect oxygen fraction and acidity. </LI> </UL> </P>

Comparison of the Effectiveness of Interventional Endoscopy in Bleeding Peptic Ulcer Disease according to the Timing of Endoscopy

( Hyun Seok Cho ),( Dong Soo Han ),( Sang Bong Ahn ),( Tae Jun Byun ),( Tae Yeob Kim ),( Chang Soo Eun ),( Yong Cheol Jeon ),( Joo Hyun Sohn ) 대한소화기기능성질환·운동학회 2009 Gut and Liver Vol.3 No.4

Background/Aims: The optimal timing for interventional endoscopy in bleeding peptic ulcer disease is controversial. This study compared the outcomes between early endoscopy and delayed endoscopy in patients with bleeding peptic ulcer disease. Methods: We conducted a prospective analysis of data from 90 patients with bleeding peptic ulcer disease who visited the emergency room between May 2006 and September 2007. Patients were categorized into two groups: the early-endoscopy group (admitted during the daytime or at night with prompt endoscopic management) and the delayed-endoscopy group (admitted at night or during weekends, with endoscopic management delayed until the next day). We compared the clinical outcomes of endoscopy between the two groups. Results: There were 49 patients in the early-endoscopy group and 41 patients in the delayed-endoscopy group. Patient demographics, clinical characteristics, bleeding control modality, and Rockall score did not differ between the two groups. There were also no significant differences between the early- and delayed-endoscopy groups in the re-bleeding rate (3/49 vs 5/41, p=0.313), the duration of hospital stay (10.7 vs 9.3 days, p=0.437), and the total amount of blood transfused (3.4 vs 2.7 units, p=0.240). Conclusions: The effectiveness of interventional endoscopy for patients with bleeding peptic ulcer disease is not significantly affected by the timing of endoscopy. (Gut and Liver 2009;3:266-270)