진행성 위암과 동반된 후복막 섬유화증 7예의 임상적 고찰

장재영,천영국,최우봉,김진오,조주영,이준성,이문성,심찬섭 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background/Aims: Retroperitoneal fibrosis is a fibrosing disease process which frequently develops ureteral obstruction. Malignant retroperitoneal fibrosis has been reported that various types of cancer including cancer of the breast, stomach, prostate, lung, cervix, uteri, colon, pancreas, ovary, and even Hodgkin's disease. While the pathogenesis remains obscure, small foci of metastatic neoplasm in the retroperitoneal space can elicit a desmoplastic reaction in secondary form to malignancy. Methods: Recently we experienced 7 cases of retroperitoneal fibrosis with advanced gastric cancer. So, we report 7 cases of retroperitoneal fibrosis with clinical and radiologic characteristics. Results: The most common signs and symptoms were related irreversible renal dysfunction. The urologic finding noted medial deviation of the involved ureters and hydronephrosis Conclusions: Clinical manifestations are abdominal pain, back pain, hydronephrosis, and uremia. When sudden back pain and hydronephrosis develop in advanced malignancy, physicians should be considerd for retroperitoneal fibrosis.

항진균제 알릴아민류의 합성과 생물학적 평가

정병호,조원제,천승훈,박면지,유진철,천문우 朝鮮大學校 1998 藥學硏究誌 Vol.19 No.2

For the development of antifungal agents. modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole. piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds. (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyndylmethyl)amine(3D) showed relatively noticeable activity(MIC=50㎍/㎖). On the other hand. the other compounds had no activity.

Interference fit process development for the ITER Vacuum Vessel Gravity Support mock-up fabrication

Cheon, Jason,Park, Chulkyu,Moon, Hokyu,Chung, Woo-Ho,Kim, Hyun-Soo,Hong, Kwen-Hee,Kim, Gwang-Ho,Kim, Yu-Gyeong Elsevier 2019 Fusion engineering and design Vol.146 No.2

<P><B>Abstract</B></P> <P>The ITER Vacuum Vessel (VV) is supported by the nine VV gravity supports (VVGS) located on the cryostat toroidal pedestal. The VVGS is dual hinge type that fastened by dowel in the hinge-block hole. This paper presents the technical approach and result on the interference fitting process of the sleeve to the full-scaled VVGS mock-up. Since the sleeve and the hinge-block hole have under millimeter tolerance and around two-meter long length, the shrink fit method has been selected for the interference fitting of the sleeve into the hinge-block hole. The duration time for required shrinkage was expected by the simple analytical approach of natural convective heat transfer. The coolant charging method was suggested to secure a sufficient time for the process. The liquid nitrogen was charged to the handling fixture capped sleeve hole’s cavity. As a result, the necessary contraction time was secured as thousands of seconds. Consequently, the interference fitting was successfully done for VVGS mock-up fabrication, and the technical solutions will be applied to the VVGS manufacturing.</P>

외상성 비장 손상의 선택적 치료에 대한 임상적 고찰

문용식,김영배,목우균,장석균,김희천 대한외상학회 1993 大韓外傷學會誌 Vol.6 No.1

Recognition of a life-threatening risk of overwhelming infection after splenectomy has led to radical changes in the management of splenic trauma. Untill the 1970s, splenectomy was essentionally indicated to management of the splenic trauma. But recently, since many studies have demonstrated the importance of splenic function in the immune system and preventing infections, the splenic salvage procedures were studied by various methods, 1) applications of hemostatic agents, 2) splenorrhaphy, 3) partial splenic resection, 4) auto-transplantation. Splenic injuries were reported in the pediatric surgery and adults. But the many questions were in the salvage procedures of the all splenic injuries. Therefor strict criteria and exact decision for management were required. We have reviewed patients with splenic injury admitted to the Emergency Room of Capital Armed Forces General Hospital, Seoul, Korea. During the 4-years from January, 1988 through December, 1991, 34 cases (65.4%) of the 52 cases underwent immadiated splenectomy, 10 cases(19.2%) received splenic suture or partial splenectomy, 8 cases (15.4%) were selected for nonoperative managment. Immediated splectomy was indicated for extensive injuries of splenic parenchyme, including of splenic hilum, multiple organ injuries of hemodynamically unstable in the presence of life-threatening injuries. Splenic salvage procedures have been performed in the cases of hemodynamically stable who were alert, hemodynamically stable with CT evidence of isolated grade Ⅰ to Ⅲ splenic injuries. We have resulted that nonoperative treatment could be accomplished safely if strict criteria for selection were met in the splenic salvage mangements.

Original Article : Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data

( Moon Young Kim ),( Soon Ho Um ),( Soon Koo Baik ),( Yeon Seok Seo ),( Soo Young Park ),( Jung Il Lee ),( Jin Woo Lee ),( Gab Jin Cheon ),( Joo Hyun Sohn ),( Tae Yeob Kim ),( Young Suk Lim ),( Tae Hy 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.1

Background/Aims: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. Methods: The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. Results: The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). Conclusions: The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis. (Clin Mol Hepatol 2013;19:36-44)

Thermal stability of 2DEG at amorphous LaAlO3/crystalline SrTiO3 heterointerfaces

Moon Seon Young,Moon Cheon Woo,Chang Hye Jung,Kim Taemin,강종윤,Choi Heon-Jin,Kim Jin-Sang,백승협,장호원 나노기술연구협의회 2016 Nano Convergence Vol.3 No.7

At present, the generation of heterostructures with two dimensional electron gas (2DEG) in amorphous LaAlO3 (a-LAO)/SrTiO3 (STO) has been achieved. Herein, we analysed thermal stability of 2DEG at a-LAO/STO interfaces in comparison with 2DEG at crystalline LaAlO3 (c-LAO)/STO interfaces. To create 2DEG at LAO/STO interface, regardless of growing temperature from 25 to 700 °C, we found that environment with oxygen deficient during the deposition of LAO overlayer is essentially required. That indicates that the oxygen-poor condition in the system is more essential than the crystalline nature of LAO layer. 2DEG at a-LAO/STO interface is depleted upon ex situ annealing at 300 °C under 300 Torr of oxygen pressure, while that in c-LAO/STO interface is still maintained. Our result suggests that the LAO overlayer crystallinity critically affects the thermal-annealing-induced depletion of 2DEG at a-LAO/STO interface rather than the generation of 2DEG. We clearly provide that amorphous TiOx can efficiently prevent the thermal degradation of 2DEG at the a-LAO/STO interface, which gives a cornerstone for achieving thermal-stable 2DEG at a-LAO/STO interface.

Increments of α-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer

Moon, Yong Wha,Rha, Sun Young,Zhang, Xianglan,Jeung, Hei-Cheul,Yang, Woo Ick,Kwon, Obin,Jeong, Jae Heon,Cheon, Sung Hah,Yoo, Nae Choon,Chung, Hyun Cheol Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of surgical oncology Vol.100 No.6

<B>Background</B><P>Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between α-DG expression and prognosis in gastric carcinoma with liver metastasis.</P><B>Methods</B><P>For 40 patients with gastric adenocarcinoma and liver-only metastasis, α-DG expression was determined by immunohistochemistry in paraffin-embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between α-DG expression and prognosis were retrospectively analyzed.</P><B>Results</B><P>α-DG expression was higher in primary gastric cancer (P = 0.006) and lower in liver metastasis (P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower α-DG expression in tumors than in normal counterparts showed poor overall survival (OS) (P = 0.028). In contrast, in the liver, patients who had higher α-DG expression in tumors than in normal counterparts showed poor OS (P = 0.022). Also, higher α-DG expression in liver metastasis than in stomach tumors led to poor recurrence-free survival (P = 0.023) and OS (P = 0.056).</P><B>Conclusions</B><P>This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of α-DG dysregulation in liver metastasis. J. Surg. Oncol. 2009;100:459–465. © 2009 Wiley-Liss, Inc.</P>

Hybrid DC-DC Converter Using Center-Tapped Clamp Circuit in Wide Range of High Output Voltage

Cheon-yong Lim,Ki-Mok Kim,Dongmin Kim,Tae-Woo Kim,Gun-Woo Moon 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

In this paper, a hybrid converter with a new clamp circuit is presented. This hybrid converter has the structure of combining a phase-shifted full-bridge (PSFB) converter with a half-bridge (HB) LLC converter. On the primary side, the lagging-leg of PSFB converter is shared by HB LLC converter. On the secondary side, the full-bridge rectifiers of two converters are connected in series. Due to the series-connected structure on the secondary side, this hybrid converter is suitable for high output voltage applications. In addition, by using a new center-tapped clamp circuit, which consists of two diodes and two capacitors with connected to the center of the transformer, the proposed converter can solve many drawbacks of PSFB converters in wide range of output voltage. Finally, the performance in efficiency, power density, and cost can be improved. In order to validate the feasibility of the proposed converter, a 3.3-kW prototype was tested.

Deposition of Fine Linewidth Silver Layer using a Modified Laser-induced Forward Transfer Technique

Cheon, Jonggyu,Nguyen, Manh-Cuong,Nguyen, An Hoang-Thuy,Choi, Sujin,Ji, Hyung-Min,Kim, Sang-Woo,Yu, Kyoung-Moon,Kim, Jin-Hyun,Cho, Seong-Yong,Choi, Rino 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.9

Development and Validation of Novel Diagnostic Criteria for Intestinal Behçet's Disease in Korean Patients With Ileocolonic Ulcers

Cheon, Jae Hee,Kim, Eun Soo,Shin, Sung Jae,Kim, Tae Il,Lee, Kang Moon,Kim, Sang Woo,Kim, Joo Sung,Kim, You Sun,Choi, Chang Hwan,Ye, Byong Duk,Yang, Suk-Kyun,Choi, Eun Hee,Kim, Won Ho American College of Gastroenterology 2009 The American journal of gastroenterology Vol.104 No.10

<P>OBJECTIVES: It is difficult to diagnose intestinal Behçet's disease (BD) due to various extraintestinal manifestations emerging at different time points in the disease course and a lack of reliable diagnostic criteria. We conducted this study to develop and validate novel diagnostic criteria for intestinal BD. METHODS: Experts from three universities generated the preliminary diagnostic criteria for intestinal BD, and a consensus was reached using a modified Delphi method with 13 gastroenterologists participating. To validate the criteria, we recruited 12,850 consecutive patients who underwent colonoscopic examinations between January 2000 and December 2006 at Severance Hospital, Yonsei University, Seoul, Korea. RESULTS: The novel diagnostic criteria were developed on the basis of two aspects: colonoscopic findings and extraintestinal manifestations. Of the 12,850 patients, 280 with ileocolonic ulcers were enrolled for validation. At the time of initial colonoscopic examinations, patients were categorized for BD status into 4 groups: definite (84 patients), probable (67), suspected (15), and nondiagnostic (114). At the end of the follow-up period (mean, 50.9+/-25.7 months), intestinal BD was confirmed in 145 patients (51.8%)-84 (100%) from the definite group, 49 (73.1%) from the probable group, 10 (66.7%) from the suspected group, and 2 (1.8%) from the nondiagnostic group. The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the diagnosis probability of these criteria were 98.6, 83.0, 86.1, 98.2, and 91.1%, respectively. CONCLUSIONS: These newly proposed, simple criteria might be useful in diagnosing intestinal BD, especially in patients with ileocolonic ulcers who do not fully satisfy the diagnostic criteria of systemic BD.</P>