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Determination Method for Topology Configuration of Hybrid Cascaded H-Bridge Rectifiers
Yuan Zhuang,Cong Wang,Chang Wang,Hong Cheng,Yingcai Gong,Hao Wang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5
To reduce system complexity and implementation costs, fully-controlled H-bridge (FHB) modules and diode H-bridge PFC (DHB) modules are cascaded to form a hybrid cascaded H-bridge rectifier (HCHR). In this paper, the advantages of such a HCHR over other cascaded rectifiers are analyzed depending on the numbers of FHB modules and DHB modules. Therefore, to assign proper numbers to these two kinds of modules for the HCHR, a configuration determination method is investigated under balanced and imbalanced loads. Three principles are also presented to guide the configuration determination for the HCHR. In addition, the constraints for selecting the step-up ratio and filter inductance are derived based on a phasor diagram analysis. The proposed configuration determination method is validated by simulations under three different conditions in the PSIM environment. Finally, experiments are carried out on a scaled-down prototype where the configuration can be easily adjusted. The feasibility of the proposed theory is then verified by experimental results.
Yuan, Chun-Hui,Yang, Xue-Qin,Zhu, Cheng-Liang,Liu, Shao-Ping,Wang, Bi-Cheng,Wang, Fu-Bing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Interleukin-7 (IL-7) is a potent anti-apoptotic cytokine that enhances immune effector cell functions and is essential for lymphocyte survival. While it known to induce differentiation and proliferation in some haematological malignancies, including certain types of leukaemias and lymphomas, little is known about its role in solid tumours, including breast cancer. In the current study, we investigated whether IL-7 could enhance the in vivo antitumor activity of tumor-reactive $CD8^+$ T cells with induction of IFN-${\gamma}$ in a murine breast cancer model. Human IL-7 cDNA was constructed into the eukaryotic expression plasmid pcDNA3.1, and then the recombinational pcDNA3.1-IL-7 was intratumorally injected in the TM40D BALB/C mouse graft model. Serum and intracellular IFN-${\gamma}$ levels were measured by ELISA and flow cytometry, respectively. $CD8^+$ T cell-mediated cytotoxicity was analyzed using the MTT method. Our results showed that IL-7 administration significantly inhibited tumor growth from day 15 after direct intratumoral injection of pcDNA3.1-IL-7. The anti-tumor effect correlated with a marked increase in the level of IFN-${\gamma}$ and breast cancer cells-specific CTL cytotoxicity. In vitro cytotoxicity assays showed that IL-7-treatment could augment cytolytic activity of $CD8^+$ T cells from tumor bearing mice, while anti-IFN-${\gamma}$ blocked the function of $CD8^+$ T cells, suggesting that IFN-${\gamma}$ mediated the cytolytic activity of $CD8^+$ T cells. Furthermore, in vivo neutralization of $CD8^+$ T lymphocytes by CD8 antibodies reversed the antitumor benefit of IL-7. Thus, we demonstrated that IL-7 exerts anti-tumor activity mainly through activating $CD8^+$ T cells and stimulating them to secrete IFN-${\gamma}$ in a murine breast tumor model. Based on these results, our study points to a potential novel way to treat breast cancer and may have important implications for clinical immunotherapy.
Determination Method for Topology Configuration of Hybrid Cascaded H-Bridge Rectifiers
Zhuang, Yuan,Wang, Cong,Wang, Chang,Cheng, Hong,Gong, Yingcai,Wang, Hao The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5
To reduce system complexity and implementation costs, fully-controlled H-bridge (FHB) modules and diode H-bridge PFC (DHB) modules are cascaded to form a hybrid cascaded H-bridge rectifier (HCHR). In this paper, the advantages of such a HCHR over other cascaded rectifiers are analyzed depending on the numbers of FHB modules and DHB modules. Therefore, to assign proper numbers to these two kinds of modules for the HCHR, a configuration determination method is investigated under balanced and imbalanced loads. Three principles are also presented to guide the configuration determination for the HCHR. In addition, the constraints for selecting the step-up ratio and filter inductance are derived based on a phasor diagram analysis. The proposed configuration determination method is validated by simulations under three different conditions in the PSIM environment. Finally, experiments are carried out on a scaled-down prototype where the configuration can be easily adjusted. The feasibility of the proposed theory is then verified by experimental results.
Dark current suppression of amorphous selenium based photosensors by the ZnO hole blocking layer
Tung-Yuan Yu,Fu-Ming Pan,Cheng-Yi Chang,Tien Hu,Jenn-Fang Chen,Jia-Feng Wang,Jia-Feng Wang,Cheng-Lu Lin,Te-Ming Chen 한국물리학회 2014 Current Applied Physics Vol.14 No.5
To study the influence of defects in the hole blocking layer (HBL) on the dark current of amorphous selenium (a-Se) based photosensors, we prepared ZnO thin films by reactive sputter deposition (RSD) for the use as the HBL of the photosensors. The ZnO HBL layers prepared with different oxygen flow rates were characterized by X-ray photoelectron spectroscopy, Raman scattering analysis and photoluminescence, indicating that the density of oxygen vacancies in the ZnO thin films is significantly affected by the oxygen flow rate. The deep level transient spectroscopy measurement reveals two hole trap levels present in the RSD deposited ZnO thin films; one is at 0.94 eV and the other at 0.24 eV above the valence band edge. The electrical performance of the a-Se photosensor is largely influenced by the amount of oxygen vacancies in the ZnO thin film. The a-Se photosensor with the ZnO HBL of the most oxygen vacancies has the lowest dark current and demonstrates the highest breakdown field.
Precisely controlled preparation of uniform nanocrystalline cellulose via microfluidic technology
Shuxiu Wang,Jinsong Zeng,Zheng Cheng,Zhe Yuan,Xiaojun Wang,Bin Wang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.106 No.-
As a new type of biomass-based molecular material, nanocrystalline cellulose (NCC) has become aresearch hotspot in many fields. In present work, a novel microfluidic technology was employed to produceNCC from microcrystalline cellulose (MCC) via sulfuric acid hydrolysis. The microfluidic chip wasdesigned and made with complete load-bearing reaction according to flow characteristics. A closed reactionenvironment and fully automated operations can ensure the safety of experimenters. NCC (MN-60)with high yield and uniformity was obtained via acid hydrolysis in microfluidic system by 60 % sulfuricacid solution at 35 C for 40 min. The characteristics of MN-60 and conventional method NCC (N-60)under the same reaction conditions were compared. It was found that the yield of MN-60 reached48.13%, while it was only 17.30 % in the absence of microfluidic chip. Although the results showed thatMN-60 and N-60 exhibited similar rod-like structures, the size distribution of MN-60 was narrower thanthat of N-60. Furthermore, the width, length, and height of MN-60 were 15 ± 5 nm, 150 ± 75 nm, and5 ± 2 nm, respectively. The main functional groups and crystal forms of MN-60 were similar to MCC,but the crystallization index of MN-60 was higher than MCC. In conclusion, microfluidic technology couldrealize the preparation of high-yield and uniform NCC.
Yu-Shuai Wang,Yin-Ping Jin,Wei Gao,Sheng-Yuan Xiao,Yu-Wei Zhang,Pei-He Zheng,Jia Wang,Jun-Xia Liu,Cheng-He Sun,Ying-Ping Wang 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.3
Background: Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. Methods: Medium-pressure liquid chromatography and semipreparative high-performance liquid chromatography were used to isolate purified compounds and their structures determined by extensive one-dimensional- and two-dimensional nuclear magnetic resonance (NMR) experiments. Results: A new saponin, namely malonyl-ginsenoside Re, was isolated from the fresh flower buds of Panax ginseng, along with malonyl-ginsenosides Rb1, Rb2, Rc, Rd. Some assignments for previously published ¹H- and <SUP>13</SUP>C-NMR spectra were found to be inaccurate. Conclusion: This study reports the complete NMR assignment of malonyl-ginsenoside Re, Rb₁, Rb₂, Rc, and Rd for the first time.
Youmei Xiao,Zhanxue Xu,Yuan Cheng,Rufan Huang,Yuan Xie,Hsiang‑i Tsai,Hualian Zha,Lifang Xi,Kai Wang,Xiaoli Cheng,Yanfeng Gao,Changhua Zhang,Fang Cheng,Hongbo Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Ferroptosis, iron-dependent cell death, is an established mechanism for cancer suppression, particularly in hepatocellular carcinoma (HCC). Sorafenib (SOR), a frontline drug for the treatment of HCC, induces ferroptosis by inhibiting the Solute Carrier family 7 member 11 (SLC7A11), with inadequate ferroptosis notably contributing to SOR resistance in tumor cells. Methods To further verify the biological targets associated with ferroptosis in HCC, an analysis of the Cancer Genome Atlas (TCGA) database was performed to find a significant co-upregulation of SLC7A11 and transferrin receptor (TFRC), Herein, cell membrane-derived transferrin nanovesicles (TF NVs) coupled with Fe3+ and encapsulated SOR (SOR@TF-Fe3+ NVs) were established to synergistically promote ferroptosis, which promoted the iron transport metabolism by TFRC/TF-Fe3+ and enhanced SOR efficacy by inhibiting the SLC7A11. Results In vivo and in vitro experiments revealed that SOR@TF-Fe3+ NVs predominantly accumulate in the liver, and specifically targeted HCC cells overexpressing TFRC. Various tests demonstrated SOR@TF-Fe3+ NVs accelerated Fe3+ absorption and transformation in HCC cells. Importantly, SOR@TF-Fe3+ NVs were more effective in promoting the accumulation of lipid peroxides (LPO), inhibiting tumor proliferation, and prolonging survival rates in HCC mouse model than SOR and TF- Fe3+ NVs alone. Conclusions The present work provides a promising therapeutic strategy for the targeted treatment of HCC.
Chih-Jen Yang,Yu-Jung Huang,Cheng-Yuan Wang,Chuan-Sheng Wang,Pei-Hui Wang,Jen-Yu Hung,Tung-Heng Wang,Hseng-Kuang Hsu,Hurng-Wern Huang,S.P. Anand Kumar,Ming-Shyan Huang,Ching-Feng Weng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Toona sinensis is a traditional Chinese herb, and the extracts of T. sinensis leaf possess a variety of biological functions. This study attempted to test the antiproliferative effect of TSL-1 (a bioactive fraction of T. sinensis) in H441 cells (lung adenocarcinoma). The data showed that the antiproliferative effect of TSL-1 on H441 cells is prominent using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. TSL-1-induced apoptosis was confirmed by cell morphology, sub-G1 peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining. Furthermore, decreased Bcl-2 accompanied by increased Bax (in western blotting) was found with TSL-1 treatment of H441 cells. TSL-1 treatment-induced G1 arrest was concurrent with the down-regulation of protein levels of cyclin D1 and cyclin-dependent kinase 4 in H441 cells. Peroral and intraperitoneal administrations of TSL-1 were performed to evaluate the therapeutic efficacy, and peroral administration of TSL-1 was also used to elucidate the therapeutic efficacy in the H441 cell xenograft model in vivo. The data revealed that TSL-1 treatment inhibited H441 tumor growth in both therapeutic and preventive experiments. Taken together, these results demonstrate that TSL-1 possesses the capability of preventing and alleviating lung cancer proliferation in vitro and in vivo with proven nephrological and hepatic safety and has the potential to be developed as an anti–lung cancer drug.