도장작업시 유해인자들의 노출수준과 작업환경관리실태

이세기,문덕환,이채관,황용식,선병관,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objectives: For the purpose of preparing the fundamental data and assessing the status of exposure level of chemical substances in painting process. Methods and Materials: The author determined the concentration of organic solvents, lead(Pb), Chromium(Cr), and Toluene-2, 4-diisocyanate(TDI) in air of painting process to 90 industries classified by 15 types of manufacturing industry during a period from Jan. 1st 2001 to Dec. 31st 2001. Results: The results were as follows: 1. The geometric mean level of each chemical substance was 0.1706 ppm for exposure index in organic solvents, 0.0019㎎/㎥ for Pb, 0.0024 ㎎/㎥ for Cr, and 0.0004ppm for TDI, respectively. 2. The exposure level of each chemical substances by type of painting was the highest in dipping and brush painting for organic solvent, in spray-painting for TDI, and in spray gun-painting for Pb and Cr, respectively. 3. The exposure level of each chemical substances by type of local ventilation equipment was higher in enclosed and booth type for organic solvents. Cr, and TDI, and in exterior type for Pb, respectively than those of other types. 4. The exposure level of each chemical substances by type of hazardous material arresting media was higher in using water for organic substances, in using bag filter for Pb, TDI, respectively than those of other types. Conclusion: According to above results, this study suggests that the exposure level by type of industry exceeded the exposure level in wooden furniture and metal furniture manufacturing industry for organic solvents and Pb, respectively.

월경전 불쾌기분장애가 식이패턴에 미치는 영향

이은정,홍인선,김선희,정은영,장은재 동덕여자대학교 생활과학연구소 2008 생활과학연구 Vol.13 No.-

The purpose of this study was to identify the change of the dietary pattern, food craving in accordance with menstrual cycle among women with the premenstrual dysphoric disorder(PMDD) and women with no premenstrual symptoms(Non-PMS). The 24 subjects were divided by two groups, PMDD group and Non-PMS group. And the change of dietary pattern and food craving were measured for 4 weeks according to the menstrual cycle. The frequency of meal, the amount of meal and the change of palatability of meat intake, fatty food, carbonate drinks, fruit, confectionery and caffeine containing beverage were more significantly increased in luteal and menstrual phase than follicular phase without regard to PMDD group and Non-PMS group, but there were no statistically difference between groups. The change of palatability of vegetable & alcohol were no difference among the phase without regard to PMDD group and Non-PMS group, and there were no statistically difference between groups. Above the findings showed that the change of women's dietary pattern has connection with the change of menstrual cycle. It is considered that unconsidered variables in this study could be applied for the therapy of premenstrual symptom or management method in connection with variable related to menstrual cycle the systematic study is requested.

cDNA array 방법을 이용한 망간에 노출된 흰쥐 뇌기저핵의 유전자발현 분석

이채관,노성민,문덕환,,김정호,손병철,김대환,이창희,김휘동,김정원,김종은,안진홍,이채언 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study investigated the gene expression profile in basal ganglia of manganese-exposed rats based on cDNA array analysis. Methods: For cDNA array, 25 male Sprague-Dawley rats (250±25 g) were intraperitoneally injected with 25 ㎎/㎏ B. W./day of MnCl2 (0.3 ㎖) for 10 days. For dose-related gene expression analysis, rats were intraperitoneally injected with 0.2, 1.0, and 5.0 ㎎/㎏ B. W/day of MnCl2 for 10 days. Control rats were injected with an equal volume of saline. RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α^(32)P]-dATP. Membrane sets of the Atlas Rat 1.2 array Ⅱ and Toxicology array 1.2 kit (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. Northern blot hybridization method was employed to assess the dose-related gene expression. Results: Fifty-two genes showed significant changes in expression of more than two-fold. Twenty-eight were up-regulated and 24 were down-regulated in the manganese-exposed group compared to the control. Among the 52 genes, 28 genes including nuclear factor I-X1 (NF1-X1), neuroligin 2 and 3, mitochondrial stress-70 protein (MTHSP70), neurodegeneration-associated protein 1 (Neurodap 1), multidrug resistance protein (MDR), and endoplasmic reticulum stress protein 72 (ERP72), were reported for the first time related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia. According to the dose-related gene expression analyses, MTHSP70, Neurodap 1 and ERP72 genes were up-regulated compared to the control even in the group exposed to low manganese dose ( 0.2 ㎎/㎏ B.W./day). Conclusions: Twenty-eight genes detected for the first time in this study were closely related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia and further study of these genes can give some more useful information about the manganese metabolism.

Monocyte Chemoattractant Protein-1[MCP1] -2518 유전자 다형성과 주요 우울장애

배치운,이지현,신윤경,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Object : This study was designed to examine the association between monocyte chemoattractant protein-l (MCPl) -2518poly morphism and major depressive disorder (MDD). Methods : Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results : Genotype and allele distributions in patients with MDD were significantly different from those of the controls, In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion : The present study suggests that the MCPl -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

공극 매질체에서 이온강도의 변화에 따른 박테리아의 부ㆍ탈착

이창구 ( Lee Chang-gu ),박성직 ( Park Seong-jik ),김현정 ( Kim Hyon-chong ),한용운 ( Han Yong-un ),김성배 ( Kim Song-bae ) 한국농공학회 2008 한국농공학회 학술대회초록집 Vol.2008 No.-

Column experiments were performed to investigate the influence of ionic strength on the attachment and detachment of Staphylococcus aureus to quartz sand and iron-coated sand. Experimental results showed that the mass recovery in quartz sand decreased with increasing ionic strength and bacteria detachment was occurred when ionic strength was changed. In the coated sand, however, the mass recovery remained constant even though ionic strength was changed. Also, no detachment occurred with ionic strength change.

주요 우울장애가 동반된 혈액 종양 환자에서 Paroxetine의 효과 및 안정성

배치운,이혁재,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.4

Objectives : The efficacy and safety of paroxetine in the treatment of depressive disorders are well known, however its efficacy and safety for the treatment of depression in patients with cancer has been poorly studied. This study therefore aimed to evaluate the efficacy and safety of paroxetine in treatment of depressed patients with hematological malignancy (HM). Methods : Fifty-two patients with major depressive disorder (MDD) based on DSM-IV criteria along with comorbid HM were allotted to 8 weeks trial with a flexible-dose regime of paroxetine in combination with their chemotherapy or supportive pharmacotherapy. Treatment response was assessed at baseline, week 2, week 4, and week 8 with 17-item Hamilton Rating Scale for Depression (HAM-D17), Montgomery A sberg Depression Rating Scale (MADRS), and Clinical Global Impression-severity (CGI-S). Side effects were collected with the reported adverse events and laboratory test throughout the study period. Results : 44.2% of 52 patients completed the eight weeks trial. Scores on the HAM-D17, MADRS, and CGI-s (last Observation carried forward, LOCF) at baseline were significantly reduced with mean reduction of 30.5%, 32.8%, and 39.1%, respectively, after 8 weeks treatment with paroxetine. Forty-six patients (88.5%) reported at least one adverse event. The most common adverse event observed in this study was nausea and no serious adverse event was found. Conclusion : In this preliminary study, overall results showed paroxetine could be used for the treatment of depressed patients with HM, but more controlled study is needed to confirm the efficacy and safety of paroxetine in this area.

경상좌수영성 의례의 지속과 변화

이창언(Lee, Chang-Un) 실천민속학회 2014 실천민속학연구 Vol.23 No.-

이 연구는 조선시대 해안의 주요 전초기지의 하나로서 해안 관방의 중요한 기능을 담당했던 경상좌수영성의 군사적 의례의 전승에서 나타나는 변화를 살펴보고, 의례 전승에 나타나는 지역적 가치에 대한 인식과 실천의 변화와 관련된 논의를 전개하고 있다. 관방성의 의례는 군사적 요충지로서의 장소적 특성을 반영하는 동시에 생활공간으로서 읍치사회를 구성하는 제 세력들의 이해가 드러나고 조정되는 정치사회적 공간으로 작용하였다. 이러한 의례의 지속과 변화를 다루는 것은 지역사회의 제 이해관계가 거시적인 사회적 변화에 조율하는 과정에서 드러내는 행위자들의 취사선택의 의지를 인식하는 작업이 될 수 있다. 경상좌수영성에서 행했던 둑제의 민간신앙화, 민간신앙의 대상이었던 인물신의 국가제사인 둑제의 신격과의 중첩 개연성, 지역의 주요 집단에 의한 향사의 주관, 최근 관의 지원으로 전승되는 향사를 통해 의례의 지속과 관련된 여러 집단의 의지와 이들이 의례에 부여하는 의미의 지속과 변화를 살필 수 있다. This study focuses on the continuation and change of the national rituals in Gyeongsangjoasuyoung fortress which was one of naval headquarters in the Joseon dynasty. Dukje was one of the national rituals carried out periodically for memorizing the military diety at military bases in the Joseon dynasty. After the reformation of the end of 19th century, most old institutions including most national rituals like Dukje had been abrogated. Transmission basis of Dukje at Gyeongsangjoasuyoung fortress has been weakened after the reformation. Ritual performers has been changed from officials to civilians, as a result the ritual has been transmitted as a form of folk religion. However another national rituals carried out periodically at Gyeongsangjoasuyoung fortress for memorizing 25 martyrs who resisted and died against Japanese army in the late 16th century has been lasted until a few decades ago by the descendant of old ritual performers. Difference in transmission of the two national rituals reflects agents’ choice whenever they should adjust to the macroscopic social change. Because the rituals at military base have not only had their own religious significance but also served as a sociopolitical space which interests of groups concerned had been revealed and adjusted.

Development of vitrification protocol in Rubia akane (nakai) hairy roots using a systematic approach.

Park, Sang-Un,Kong, Hyunjung,Shin, Dong-Jin,Bae, Chang-Hwan,Lee, Sheong-Chun,Bae, Chang-Hyu,Rha, Eui-Shik,Kim, Haeng-Hoon Royal Veterinary College 2014 Cryo letters Vol.35 No.2

<P>A solution-based vitrification protocol is a process of sequentially changing-solutions from which both influx of cryoprotectants (loading) and efflux of water (dehydration) were accomplished before cryo-exposure. Hence, we need to properly control the concentration /composition of the cryoprotectant solutions.</P>

척수손상후 운동 유발전위와 지각 유발전위의 비교

지철,이재수,하영수,최창락,송진언 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.4

Electrical monitoring of the nervous system offers the potential for the detection of injury, intraoperatively. The relationship of MEP(Motor Evoked Potential) and SEP(Sensory Evoked Potential) taken in 30 rats before and after spinal cord injury is reported. MEP was obtained from distal portion to the site of spinal cord injury by electrical stimulation of the cerebral motor cortex after insertion of a ball electrode in the cerebral motor cortex. SEP was collected at the cerebral somatosensory cortex during the sciatic nerve stimulation. Experimental animals were divided into a 20g㎝ spinal cord-trauma group and 50g㎝ spinal cord-trauma group. Changes of cardiopulmonary function after cerebral motor cortex stimulation and pre-and post-injury MEP and SEP were obtained at constant time interval. The results were follows : 1) Significant changes in blood pressure, pulse rate, and respiratory rate were noted to be elevated after stimulation of cerebral motor cortex and these were returned to normal in 10 minutes after stimulation. 2) MEP in control group showed that the latency was 8.6±1.54msec and the amplitude was 20.60±3.2㎶. In MEP of 20g㎝ spinal cord trauma group, the latency was increased to 30% (11.26±1.76msec) compared to control group at 10 minutes after the injury and the amplitude was decreased to 29% (14.60±2.99㎶). The latency was slowly decreased with the passage of time, to 21% increase. (10.42±1.84msec) at 1 hour after injury but the amplitude was not changed. In 50 g㎝ spinal cord-trauma group the latency was decreased to 75%(4.9±1.52㎶) compared to control group. With the passage of time, no change was revealed in latency but amplitude was decreased. The amplitude was decreased to 80%(4.00±1.49㎶) compared to control group. Change of MEP was marked in 50g㎝ spinal cord-trauma group. With the passage of time MEP was slightly improved in 20g㎝ spinal cord-trauma group but deteriorated in 50g㎝ spinal cord-trauma group. 3) The latency of SEP in control group was 12.22±0.7msec and the amplitude of those was 20.00±2.21㎶. No significant statistical change was recorded in the SEP of each spinal cord-trauma group compared to control group. MEP might be more important indicator than SEP in estimation and evaluation of the functional change of spinal cord injury.

리스페리돈과 올란자핀이 투여된 정신과 환자들에서 간 효소 변화에 대한 후?적 연구

임현국,배치운,박석준,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3