The Korean Association of lnternal Medicine : Poster Session ; PS 1357 : Nephrology ; Age is the Strongest Effector for the Relationship between Estimated Glomerular filtration Rate and Coronary Artery Calcifi cation in Apparently Healthy Korean Adults

( Hyun Beom Chae ),( Eun Jung Rhee ),( Hae Jung Park ),( Min Kyung Lee ),( Won Seon Jeon ),( Se Eun Park ),( Cheol Young Park ),( Won Young Lee ),( Ki Won Oh ),( Sung Woo Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Cardiovascular disease (CVD) is a major clinical problem and the most common cause of morbidity and mortality in patients with chronic kidney disease (CKD). Coronary artery calcifi cation (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects. Methods: In 23,617 participants in the health screening program in Kangbuk Samsung Hospital health screening program from January 2010 to December 2011, estimated glomerular fi ltration rate (eGFR) was assessed by Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured by multi-detector computed tomography (MDCT). Subjects were divided into 3 groups according to the CKD Staging system with eGFR grade; stage 1: eGFR = 90 mL/min/1.73 m2, stage 2: eGFR 60-89 mL/ min/1.73 m2, stage 3: eGFR 30-59 mL/min/1.73 m2. Results: Mean age of the participants was 41.4 years, and mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed weakly negative but signifi cant association with CACS in bivariate correlation analysis (r=-0.076, p<0.01). Mean CACS signifi cantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC signifi cantly increased from CKD stage 1 to 3. Although odds ratio for CAC signifi cantly increased from stage 1 to 3 after adjustment for confounding factors, this signifi cance was inversed when age was included in the model. Age was the strongest factor that affects CAC. Conclusions: This study performed in young Korean subjects with relatively normal renal function, age was the mostly strongest effector on the association between eGFR and the degree of CAC.

Kano 모형과 잠재적 고객만족 개선지수를 이용한 공연장 서비스품질에 대한 연구

박성민(Park, Sung-Min),김채복(Kim, Chae-Bogk) 한국서비스경영학회 2016 서비스경영학회지 Vol.17 No.2

The interests of high value of living have been increased after applying 5 working days per week. People who visit art centers and enjoy cultural activities grow larger every year. It is important to provide better service to customers at art centers by analyzing customers" needs. This paper employs Kano model and potential customer satisfaction improvement(PCSI) index to investigate customers" satisfaction or dissatisfaction levels after finding factors which affect service quality at art center. Then, the priority of factors for service quality improvement is assessed. Based on the analysis results, factors of "sound and stage setting", "seat comfort", "gladness by performance", "variety of performances" are selected as attractive quality factors. Also, factors of "stage visibility of seat", "convenience of parking", "convenience of public transportation", "seat comfort", "appropriate staff allocation" are chosen by PCSI index.

Geometric effect of the hydrogel grid structure on in vitro formation of homogeneous MIN6 cell clusters.

Bae, Chae Yun,Min, Mun-kyeong,Kim, Hail,Park, Je-Kyun Royal Society of Chemistry 2014 Lab on a chip Vol.14 No.13

<P>A microstructure-based hydrogel was employed to study the relationship between spatial specificity and cellular behavior, including cell fate, proliferation, morphology, and insulin secretion in pancreatic β-cells. To effectively form homogeneous cell clusters in vitro, we made cell-containing hydrogel membrane constructs with an adapted grid structure based on a hexagonal micropattern. Homogeneous cell clusters (average diameter: 83.6 14.2 μm) of pancreatic insulinoma (MIN6) cells were spontaneously generated in the floating hydrogel membrane constructs, including a hexagonal grid structure (size of cavity: 100 μm, interval between cavities: 30 μm). Interestingly, 3D clustering of MIN6 cells mimicking the structure of pancreatic islets was coalesced into a merged aggregate attaching to each hexagonal cavity of the hydrogel grid structure. The fate and insulin secretion of homogeneous cell clusters in the hydrogel grid structure were also assessed. The results of these designable hydrogel-cell membrane constructs suggest that facultative in vitro β-cell proliferation and maintenance can be applied to biofunctional assessments.</P>

비팽윤성 운모의 표면코팅 및 특성평가

박라영,석정원,박선민,김판채,Park, Ra-Young,Seok, Jeong-Won,Park, Sun-Min,Kim, Pan-Chae 한국결정성장학회 2008 韓國結晶成長學會誌 Vol.18 No.3

본 연구에서는 합성운모에 대한 코팅기술을 확립한 뒤, 비수성을 나타내는 합성운모를 제조하였다. 합성운모의 표면코팅은 고속교반기를 사용하여 행하였으며, 스테아린산으로 코팅된 합성운모의 특성은 침적실험, XRD 및 SEM을 이용하여 분석하였다. 본 연구 결과, 교반기의 내부온도는 $70^{\circ}C$를 유지하고, 10분 동안 1600 rpm/min을 행함으로써 운모 표면에 스테아린산의 코팅이 가능하였다. 또한 SEM 관찰결과로부터, 스테아린산과 운모의 혼합비율, 교반기 내부온도, 회전속도에 의해 특성이 변화하는 반면 코팅처리시간과는 무관함을 알 수 있었다. This study is to establish the coating technique for synthetic mica and to prepare synthetic mica with the non-aqueous property. The surface coating of synthetic mica is prepared with stearic acid using the high speed stirrer. The characterizations for mica powders coated the stearic acid are carried out by the deposition test, XRD and SEM. The results of research could be coated the stearic acid on the mica by 1600 rpm/min at $70^{\circ}C$ for 10 min. From the observation of SEM was found that the non-aqueous property mica could obtained by mixture ratios for stearic acid and mica, the inner temperature and rotation speed of the stirrer but treated time be unrelated.

조직 배양된 실험쥐 해마부위 신경원의 전기적 발작 손상에 대한 발열의 영향

채수안(Soo Ahn Chae),박용민(Yong Min Park),유병훈(Byoung Hoon Yoo),김동욱(Dong Wook Kim) 대한소아신경학회 2002 대한소아신경학회지 Vol.10 No.2

목 적 : 간질환자들은 고열 발생시 발작의 발현이 증가하는 경향이 있다. 이것은 간질상태의 뇌에서 고체온이 신경원의 과흥분성 및 손상과 관련이 있음을 시사하는 것이다. 따라서 본 저자들은 실험쥐 해마부위 조직배양을 이용하여 신경원의 발작 손상에 대한 발열의 영향을 알아보고자 하였다. 방 법 : 실험쥐 해마부위 조직배양을 aCSF의 온도를 39℃까지 단순히 상승시킨 단순 발열군과 aCSF 온도의 상승 없이 36℃에서 조직을 유지시킨 단순 비발열군으로 분류하여 발열이 정상 신경원에 손상을 유발시키는지의 여부와 처음에 36℃에서 stimulus train을 가한 후 aCSF의 온도를 39℃까지 상승시킨 후 2번째 stimulus train을 가한 발열 발작군과 2번째 stimulus train을 가할 시에도 온도를 36℃로 유지시킨 비발열 발작군에서 발열중의 발작과 비발열중의 발작시 신경원 손상의 차이가 있는지를 알아보았다. 결 과 : 발열이 정상 신경원에 손상을 유발시키는지의 여부를 알아보기 위한 단순 발열군과 단순 비발열군 간의 신경원 손상정도 비교에서 해마의 CA1과 CA3 부위 모두에서 실험 24, 48, 72시간 경과 후 두 군간의 통계적으로 의미 있는 신경원 손상의 차이를 발견할 수 없었다. 발열증의 발작과 비발열증의 발작시 신경원 손상의 차이가 있는지를 알아보기 위한 발열 발작군과 비발열 발작군의 신경원 손상정도의 비교에서 해마의 CA1 부위이 션경원 손상정도는 AD 유발 후 24, 48, 72시간 경과 후 모두에서 발열 발작군이 비발열 발작군에 비하여 신경원 손상이 통계적으로 의미 있게 많았고, CA3 부위의 신경원 손상 정도는 AD 유발 후 24시간과 48시간 경과 후에서는 두 군간에 통계적으로 의미 있는 신경원 손상의 차이가 없었지만 72시간 경과 후에서는 발열 발작군이 비발열 발작군에 비하여 통계적으로 의미 있게 신경원 손상의 정도가 심하였다. 결 론 : 정상 뇌에서 단순 고체온은 신경원 손상을 유발시키지 않으나 간질상태의 뇌에서 고체온시의 발작은 정상체온에서의 발작시보다 신경원 손상을 심화시킬 수 있음을 시사하는 것이다. 이것은 간질 상태의 뇌에서는 발열이 발작으로 인한 뇌손상에 상승 효과를 유발시킬 수 있으므로 간질 환자에서 발열 발생 시 신속하고도 적절한 처치가 발열로 인한 발작으로 초래될 수 있는 뇌 손상을 예방하는데 중요할 것으로 생각된다. Purpose : Epileptic patients have a increasing tendency to develop seizure attack in high temperature. This finding suggests that high temperature may have an effect on neuronal hyperexcitability and injury of epileptic brain. Therefore, the influence of high temperature on normal and epileptic brain was studied in organotypic explant cultures of rat. Methods : Fourteen days-in-vitro cultures from 8 day-olf rat pups were perfused with standard aCSF bubbled with 95%/5% O/CO in a microchamber. Stimulus train(0.3 sec, 60 Hz) was applied to Schaffer collaterals in CA3 and extracellular field potential was recorded in the CA1 pyramidal layer. At 36℃ initially, AD was evoked. In high temperature(HT) group, the cultures were subjected to 39℃ for a period of 8 min before the second stimulus train was applied. They were then restored to 36℃ for 10 min. In normal temperature group, temperature was maintained at 36℃ for the second stimulus train. The cultures were returned to the incubator and observed serially for neuronal damage. Intensity of propidium iodide fluorescence indicative of neuronal injury was quantitated by digital image analysis. The cultures on the same insert that were not stimulated served as the unstimulated groups. Results : There was not a statistically significant difference in neuronal damage between the unstimulated high-temperature(HT) and normal-temperature(NT) group. In CA1 sector, % damage(mean±SEM) was 0.42±0.20 vs 0.27±0.05 at 24 hrs(HT vs NT)group, n=16 each, P>0.05, Student t-test); 1.81±0.79 vs 1.43±0.27 at 48 hrs(P>0.05); 3.50±1.32 vs 3.35±0.56 at 72 hrs(P<0.05). In CA3 sector, % damage was 0.34±0.10 vs 0.20±0.03 at 24 hra(P>0.05); 0.99±0.20 vs 0.83±0.23 at 48 hrs(P>0.05); 2.00±0.38% vs 2.26±0.35% at 72 hrs(P>0.05). Neuronal damage on AD induced cultures during febrile setting(n=16) was significantly higher than in nonfebrile setting(n=16). In CA1 sector, % damage was 6.63±2.56 vs 0.92±0.45 at 24 hrs(febrile setting vs nonfebrile setting, P=0.036); 26.37±7.44 vs 4.99±2.23 at 48 hrs(P=0.010); 38.59±9.63 vs 6.48±2.30 at 72 hrs (P=0.003). In CA3 sector, % damage was 1.23±0.48 vs 3.91±2.37 at 24 hrs(P=0.277); 13.09±5.75 vs 5.93±3.27 at 48 hrs(P=0.288); 27.86±8.68 vs 7.54±3.74 at 72 hrs(P=0.04). Conclusion : At high temperature, seizures in epileptic brain may be more injurious than seizures in normal temperature.

大邱地域住民의 生活體育 實態分析 : 早起運動參與度를 中心으로 Focusing on participation degree of populations exercising in the morning

蔡鴻遠,金柄斗,李敏炯,金基學,朴宇奎 慶北大學校 體育科學硏究所 1991 체육과학연구지 Vol.7 No.-

The purpose of this study is to get the source materials to activate mass sports of regional populations. At first, it was by sex, age, and occupations examined and analysed populations that would participate in physical activities from 5 to 8 Am at 28 pate-up mountains and 477 workplaces, schools, public facilities, and commercial facilities sontrolled by 7 district offices in Daegu. The mothod of investigation made a preliminary inquiry in advance and set in place 70 investigators in entrance of path-up mountains and sports facilities. Especially, the occupational classification was adopted from socilolgical job calssification model and every result value of analysis was dealed and compared with percentage by means of Daewoo Corona 286 PC. Accordiangly, the concrete conclusions are summarized as follows : 1) The total number of persons participating in mass sports in the morning is 18,045(men 10,850 : 59%, women 7,465 : 41%), and it is about 1% level by the rate of population and low participation rate in comparison with advanced nations. ① It is showed that the participation value in proportion to sex is 17.4% more in men's case taking 10,587 persons(58.7%) than 7,458 persons(41.3%) in women's case. ② Taking the dimensions of participation degree in proportion to age, it is taken the most value in fifties age with 5,092 persons (28%), showing in sixties, forties, thirties, twenties age in sequence. ③ Taking the dimensions of participation degree in proportion to occupation, it is taken the most value in housewife with 5,569 persons (31%), showing the unemployed, independent enterprise, technical expert, clerical work, deministrative position, student, technical work, manual labor, agriculture and forestry, and fishery in sequence. 2) Judging from the participation degree in proportion to district office, it is taken the most value in Mam-gu with 3,821 persons(21.2%) and Dalseo-gu with 3,776 persons(20.9%) and the least in Joong-gu with 1,612 persons(8.9) and Seo-gu with 1,589 persons(8.8%). It is assumed that low participation value in Joong-gu and Seo-gu should result from deficient facilities and close space of urban.

工業專門大學 食品工業科 敎育課程 開發에 關한 硏究

朴正吉,柳寅德,李雄洙,趙載敏 忠州大學校 1982 한국교통대학교 논문집 Vol.15 No.2

This is a study on the improvement of the curriculum of food technology department in technical junior college in parallel with the development of scientific technique. The results obtained is as follows; 1. It is emphasised with training the middle-level technician in both quality control and food processing course in curriculum. 2. It is established with new subject; Instrumental Analysis, EDPS, Introduction to Electric Technology, Industrial Management, Quality control. 3. With elimination of overlapping subjects it is assembled with 18, 19 subjects in each course. 4. It is suggested with the topic of experiments and practices extracted from the result of job analysis.

후복막강에 발생한 활막육종

채승완,심정원,안혜경,이민철,박영의 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.4

韓國 低所得層 老人生活에 관한 社會ㆍ經濟 및 空間問題 硏究

李效再,池淳,朴敏子 이화여자대학교 한국문화연구원 1979 韓國文化硏究院 論叢 Vol.34 No.-

The problems of the aged are emerging as a social problem in Korea. These problems are resulting from various factors : urban- industrialization, the change of family structure and occupational structure, the change of values and increased life-span owing o the advancement of medical science. Compared with Western developed countries where old-age welfare policies have been institutionalized, our social programs for the aged are in the beginning stage og development. In order to solve the problems of the aged, and to design old-age welfare policies, it is important that we have a clear understanding of the nature of these problems. This study was designed to find out the problems of the aged in urban low-income neighborhoods, and analyze the problems in connection with their life in family and community. Finally, the study attempted to examine the correlation between some variables and life satisfaction for the old people. The analysis was based n the data obtained from the questionnaire method of sample survey and case studies conducted through interviews. The sample was randomly selected, with the interviewees consisting of 149 residents in apartment areas and 151 in traditional housing areas. 100 three-generation households were selected in both areas purposely. The case study was used for grasping the situation of the community facilities for the elderly. 4 cases in Seoul and 1 in a rural area were selected purposely. Major findings are as follows: 1. The problems of the aged in the family directly result from their economic status. Difficulties stem from the fact that their major income source is their children's help and that even the children belong to the low-income group. This economic problem causes a lack of living space as well as health problems. They cannot afford to have proper medical care such as regular check ups or medical care during disease. The Economic problems limit their social activity and hinder their relations with their children, relatives, and friends. Nevertheless they are not interested in having jobs or work to do. They prefer, rather, to go on trips or just to rest at home in their old days. This way of thinking differs from that of their children, who believe it would be good for the old people to have work or jobs appropriate to their health condition and ability. This difference of attitude or values could be a source of strain in family relations. Related to those problems in the family is the steady corrosion of the traditional belief that old people's problems should be solved by their own family. To cope with this change, community acre programs are urgently needed. 2. The only public facility existing for the elderly on a community level, is an organization known the OLD PEOPLES HALL. The economic problems of low-income people also have an effect on the operation of the organization. That is, the lack of finances brings about a series of problems such as inadequate space, insufficient facilities and unsatisfactory programs. Institutionalized support from the government or private organization is greatly needed to have more old people participate voluntarily in this organization. 3. By the Chi-square (χ2) test it was found that some variables have a significant effect on the degree of life satisfaction of the aged. The variables are marital status, educational attainment, religious affiliation, job (whether he/she has a job or not), how (leisure) time is spent, social participation, and the frequency of visits from their childrens. It has been shown that sex, age, type pf living arrangement, frequency of going out and kinds of hobby have no strong relation to the degree of the elderlys life satisfaction. The suggestions on the basis of the above problems are as follows : 1. Since the traditional family-centered way of caring for aged has and continues to wane, various solutions are required to provide alternatives for their own selection, i.e., for the aged who want to be separated from their children public and private pay nursing homes equipped with good facilities could be established. 2. It is desirable to give priority in housing loans to low-income families who rake care of their parents in the same household, in order to reduce the dwelling space problem. 3. Institutionalized medical aid program and discount on public fares for the low-income aged are urgently needed. In addition, the arrangement of proper jobs for the aged who wish to work is recommended. 4. For the low-income aged who have nothing to do and no space for spending leisure time, increasing the number of old peoples' centers as well as developing program for recreation and education are required. 5. Counselling centers are needed for both the old people and their children who need advice for their family-related problems. Also to be recommended is the development of research institutions for providing systematic information and data to design old-age welfare policy for the future.

董氏鍼의 頸項痛 治療에 관한 臨床的 考察

이채우,조태성,박인범,김상우,안창범,송춘호,윤현민,장경전 대한침구학회 2003 대한침구의학회지 Vol.20 No.2

Objective : The purpose of this study was to evidence the effect of Dong-Shi Acupuncture by improving degree of forty four patients who have received a Dong-Shi Acupuncture therapy at Dong Eui oriental hospital OPD and chiefly complained for neck pain and related symptoms. Materials and Methods: Forty four patients were diagnosed with physical inspection and readiography, and investigated into the effect of treatment sharing before treatment and after 2 weeks and 4 weeks treatment by Dr. Kim's method. Results and Conclusions: The conclusion of this study was that improving degree of forty four patients who have received a Dong-Shi acupuncture therapy for all items and excellence of the Dong-Shi Acupuncture was evidenced.