발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

7차 교육과정에 의한 중학교 과학교과서간 비교 분석 : 1학년 생물단원을 중심으로 With Reference to Biology Part

채현정,조현욱,김종홍 順天大學校 師範大學 附屬 科學敎育硏究所 2002 科學과 敎育 Vol.10 No.-

The aim of this study was to compare and analyze seven textbooks of science scheduled to be used for the first graders of middle school according to the 7th curriculum. In the frequency of the organization of biological contents between 6th and 7th textbooks, average number of page was changed from 79 pages to 65 pages. In the analysis of the inquiry content, the total number of themes in seven kinds of textbook was 152 contents. The number of inquiry content in seven kinds of textbook was diverse. For the analysis of inquiry process dimension, observation (54%) and interpreting data (22%) were generally emphasized. Concerning the analysis of the inquiry activities, the percentage of inquiry activities presented experiment (55%). discussion (28%), and survey (0%), respectively. The experiment showed the largest percentage of inquiry activities.

Double scanning 방식을 적용한 X-ray video converter 개발

이채욱,문병현,오신범 大邱大學校 科學技術硏究所 1999 科學技術硏究 Vol.6 No.1

With the rapid development of medical technology, the digital radiological imaging techniques, such as CT, MRI, PET, CR and X-ray, have been widely used. The demand of medical image storage and noiseless signal requires good video converter system. In this paper we develop a new x-ray video converter using double sunning method. This converter can simplify the monitoring system and improve the image enhancement.

소각처리기반 N구의 폐기물처리기본정책 수립을 위한 처리현황의 조사·분석

배재근,김현갑,백광욱 서울産業大學校 1998 논문집 Vol.47 No.1

As of the waste investigation result for N district. the living waste generated(living waste+home industry waste) was 327 ton/day in 1995.315 ton/day in 1996. 270ton/day in 1997. and 250ton/day in early 1998. so the overall waste was 0.632kg/man?day. In terms of waste classification in N district. it shown 59% of food waste. 17.66% of paper, 8.55 of vinyl, 3.99% of plastic, 1.97% of textile, 1.67% of rubber-leather, 1.44% of metals, and so on. The food waste portion is getting increased after starting waste classifying collection recyable waste which can be valuable resources and the observed high hydrous rate as 53.15% due to the food waste comparing to the past days. The caloric value shown not higher than that of foreign countries but it was higher than that of other domestic area. But the another point of view. the high hydrous rate generates more precipitated waste water and low caloric efficiency. And also, around 18% of incinerated ashes was generated in year 1997 basis and the lime powder was observed as high rate. The waste collecting efficiency was reviewed based on number of waste collection trucks. collecting time at the recycling facility of N district. As of result it concludes that current waste collecting system should be reviewed for improving the system. The collection waste is very small by a contractor's 2 to 3 times manpower and trucks. it means financial self-supporting is very poor for waste tretment. and the self-supporting rate is 14.15% by N district, and the total rate is 30.66% including by a contractor. The financial self-supporting rate is 51.67% by only the living waste point of view.

적응 알고리즘을 이용한 DS/CDMA 간섭제거

문병현,손준일,이채욱 대구대학교 과학기술연구소 1998 科學技術硏究 Vol.5 No.2

A DS/CDMA receiver with adaptive filter has more benefit than conventional DS receiver, such as near-far problem, multiuser interference rejection and artificial jamming. Usually in the CDMA receiver, filter length is same as spreading sequence length. So the more PN sequence length, the more number of calculation is needed for convergence. Recently, partial update algorithm like SNLMS or SBNLMS is proposed to resolve this problem. But these algorithms have defect that convergence is slow because of partial updating. We propose the effective adaptive algorithm for DS/CDMA multiuser interference rejection and show the correlation between the number of block and convergence in selective coefficient update algorithm.

일기엔트로피 및 정보비에 의한 장마기의 일기대표성 설정 : 서울, 대구, 광주, 충주, 부여를 중심으로 Focused on Seoul, Taegu, Gwangju, Chungju, Puyo

박현욱,문병채 한국환경과학회 2003 한국환경과학회지 Vol.12 No.4

The seasonal variation and frequency of rainfalls of Korea peninsula in Changma period show strong local weather phenomenon because of it's topographical and geographical factors in Northeast side of Asia. Based on weather entropy(statistical parameter)-the amount of average weather information-and information ratio, we cal define each area's weather representativeness, which can show us more constant form included topographical and geographical factors and seasonal variation. The data used for this study are the daily precipitation and cloudiness during the recent ten years(1990-1999) at the 73 stations in Korea. To synthesize weather Entropy, information ratio of decaying tendency and half-decay distance, Seoul's weather representativeness has the smallest in Summer Changma period. And Puyo has the largest value in September.

GIS를 이용한 문화정보시스템 구축방안에 관한 연구

문병채,박현욱,정태영 한국지리정보학회 2003 한국지리정보학회지 Vol.6 No.3

문화정보를 데이터베이스화하는데 있어서 여러 방안이 있을 수 있는데, 본 논문은 그 중에서도 지리정보시스템에 의한 구축방안에 대해서 연구한 것이다. 그것은 지역문화가 그 특성상 시·공간을 떠나서는 있을 수 없고 문화구성 요소들이 상호 기능적으로 복잡하게 얽혀있는 관계로 모든 내용이 시·공간과 결부되고 수많은 여러 데이터가 기능적으로 연계되어 있어 이들을 효과적으로 활용하기 위한 방안이 모색되어야 하기 때문이다. 또한 지금까지의 구축된 문화정보시스템들 대부분이 지역의 문화정체성 파악에 요구되는 지역문화의 영역설정이나 공동체적 생활권 설정에 한계를 보였을 뿐만 아니라 구축된 데이터베이스에 의해 문화현상을 분석하고 연구하는데도 한게가 있었던 데도 기인한다. 이러한 배경에서 본 논문에서는 단순한 유물·유적 지도가 아닌 즉, 객체적인 역사문화유적 지도를 뛰어 넘는 문화표현의 방식에 대한 연구방법과 그들을 효과적으로 데이터베이스화 하기 위해 XML을 이용한 데이터베이스 모델의 구축을 연구하였고, 더 나아가 다양한 문화 현상 분석한 함께 문화콘텐츠 제작에 보다 널리 활용할 수 있는 토대를 마련해보고자 하였다. The purpose of this study is to seek the methods of constructing a cultural information system based on GIS. It is impossible for regional culture to be formed apart from its surrounding space, so a study of culture should be based on realizing the features of its space. It is important to note that the elements composing a culture complicatedly interact with each other in their function and continuously change. Also they are interrelated in space and plentiful in their amount. Nevertheless, those studies practised so far in relation to culture and constructing cultural database are too limited in establishing cultural area or community life area required to recognize the regional identity. So it is now essential that we should study the methods of cultural expression surpassing objective historical and cultural site maps instead of simple maps depicting historical remains or sites. From this viewpoint, this study tries to find various cultural phenomena in relation to their space through seeking the methods of constructing the cultural database model using XML. In addition, this study tries to construct a base for increasing the utilization of information in making the cultural contents.

유도 전방회전낙법 동작의 키네메틱 분석

김의환,윤현,정재욱 龍仁大學校 武道硏究所 2003 武道硏究所誌 Vol.14 No.1

The purpose of this study was to analyze kinematic variable at the time of Judo obstacle forward rolling breakfall. To do so, three dimensional kinematic variable at the time of Judo forward rolling breakfall motions was calculated on five model males of Y university, and, time C. O. G. variable were established. That was standardized using cubic spline interpolation based on the maximum motions time by calculating average value and standard deviation per each factor. As a result of this analysis, I reached following conclusion. 1. Time variable At the time of Judo forward rolling breakfall motions, the total required time was 0.93 seconds, and to describe per phase: at the second phase, air phase, 0.50 seconds(54%): at the third phase, completion phase, 0.36 seconds(38%); and the first phase, take-off phase, 0.08(8%) seconds. 2. C. O. G. variable Left(0.01m)·front(0.26m)·up(0.13m) moved at take-off phase, and left(0.09m)·front(1.46m)·up(0.32m) moved at air phase, and left(0.15m)·front(3.79m)·down(0.71m) moved at breakfall phase. In conclusion, all the subjects conducted bending and stretching exercise and made the center move for jumping higher at take-off phase, assumed motions to keep balance at air phase, and assumed motions for widening base surface by lowering the center and extending the joint of the knee to reduce an impact and assume stable posture at breakfall phase.

실험적으로 유도된 이독성 난청에서의 Ginkgo Extract의 효과

이상흔,조영채,도현우,강현욱,조태환 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

이독성 난청에서의 Ginkgo extract의 효과를 보고자 기닉픽 22마리를 대상으로 이음향방사를 측정하여 난청군과 치료군을 비교 검토한 바 성적을 요약하면 다음과 같다. 난청군에서의 DP-OAE는 대군조에 비해 전 주파수에서 감소 내지 소실을 보였으며4KHz 에서만 선택적으로 큰 감소를 나타낸것도 있었다. Ginkgo estract로 예방 치료한 군에서는 난청군에 비해 DP-OAE가 현저하게 출현 하였으며 정상 DP-OAE소견을 나타낸 것도 있었다. 난청치료군에서도 난청군에 비해 전체적으로 DP-OAE 가높게 출현되고 있었다. 이상의 소견으로 보아 Ginkgo estract가 이독성 난청과 감각신경성 난청에서의 예방 및 치료 효과의 가능성을 제시해 준다고 생각되는 바이다. This study was designed to investigate the effect of Ginkgo biloba extract on the kanamycin induced ototxicity in inner ears 22 guinea pigs. The animals were divied into 4 groups. In ototoxic group, kanamycin was injected 400mg/kg per day for 7 to 10 days. In preventive treated group, kanamycin with same dose and Ginkgo biloba extract(50mg/kg)were simultaneously injected daily for same duration. In post treated toup, Ginkgo extract was treated for 15 days in kanamycin injected group. The Preyer's reflex and DP-OAE (distortion product otoacoustic emissions) were used for the monitoring of hearing changes. In the ototoxic group, the amplitude of DP-OAE was marked decreased or disappeared in all test frequencies or 4KHz only. The Preyer's reflex was disappeared in all ototoxic group. In the preventive treated group with Ginkgo extract, normal DP-OAE or slightly decreased DP-OAE in 4 KHz was noticed. This finding was seemed to be similar to the post-treated group. From the above results, Ginkgo extract is suggested to have beneficial effects for the management of ototoxicity and sensorineural hearing loss.

한국인에서 CC-SIT와 비교한 KVSS Test의 임상적 유용성 평가 : 예비연구 Pilot study

김진국,장현종,임채형,남태욱,심대보 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Background and Objectives: Sniffin' Sticks test is the test of nasal chemosensory performance based on pen-like odor dispensing devices. KVSS(Korean Version of Sniffin' Sticks) Test was developed as the "Korean olfactory test" using the odorants which are familiar to Korean. Authors evaluated the clinical validity of KVSS Test compared with CC-SIT (Cross-Cultural Smell Identification Test) in Korean. Materials and Methods: The subjects of this study were 25 normosmic volunteers who were divided into five groups according to age. Each group was 5 normosmic volunteers. And they consisted of 12 men and 13 women. KVSS Test and CC-SIT were used for the evaluation of olfactory function. Results: Our study showed the negative correlation between age and olfactory function test (CC-SIT score, KVSS Test I score and KVSS Test II score). Normosmia rate of KVSS Test was more higher than that of CC-SIT. Also KVSS Test had more familiar items for Koreans compared with that of CC-SIT. CC-SIT score and KVSS Test score showed showed the positive corrclation. And each test revealed high reliability in test-retest evaluation. Conclusion: The KVSS Test can be used as an olfactory function test for Koreans.