THE EFFECTS OF AMINOGUANIDINE, MK-801, AND NIMODIPINE ON CEREBRAL ISCHEMIA - INDUCED RATS

CY Shin,CH Jun,TS Lee,HO La,Nl Lee,IH Huh,UD Sohn 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

The mechanism of ceramide-induced circular smooth muscle cells contraction in feline esophagus

Shin CY,Lee YP,Yim SH,Lee TS,Lee Nl,Huh IH,Sohn UD 대한약학회 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

신장이식술을 시행받은 여성에서의 임신

신희철,윤보현,전종관,허창영,권재희 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11

Background:Renal transplantation remains the best form of treatment for women with end-stage renal failure who wish to have children. Successful pregnancies have been reported after transplantation, but they are often associated with increased fetal and maternal risks. Therefore data about the outcome of pregnancy in renal transplant recipients should be available to facilitate the decision making process. Objective:To study the outcome of pregnancy in renal transplant recipients. Study Design:A retrospective review. Subjects:Pregnant women beyond the period of third trimester who had renal transplantation between 1969 and 1996. Results:There was a total of 10 patients and 12 pregnancies and 13 offsprings. One patient had a twin pregnancy and two patients had 2 pregnancies after renal transplantation. All patients continued their immunosuppressive regimens during the entire pregnancy. The mean interval from the time of transplantation to conception was 46.6 months(range, 11 to 97 months). There were complications of 3 cases of hypertension and 2 cases of acute rejection before conception. All had normal prior values of serum creatinine before conception(range, 0.8 to 1.2 mg/dl) except three patients whose serum creatinine values before conception were not available. The mean gestational age at delivery was 37+5 weeks(range, 32+6 to 41+1 weeks) with an incidence of prematurity(gestation <37 weeks) of 50%, and their offspring weighed from 1.46 kg to 3.13 kg(mean, 2.46 kg), presenting a high incidence of low birthweight(46.2%). There was one stillborn who had congenital anomaly of anencephaly. The obstetric complications were distributed as follows:premature rupture of membranes in 2 cases(16.7%), preterm labor in 2 cases(16.7%), pregnancy induced hypertension in 2 cases(16.7%), pregnancy aggravated hypertension in 1 case(8.3%), and intrauterine growth restriction detected before delivery in 1 case (8.3%). Cesarean section was necessary in 1 of 12 cases(8.3%). Neonatal complication was found in one case, pnuemonia. No patient had any rejection episode or graft loss during pregnancy, but 5 cases had experienced chronic renal rejection after delivery(range, 3 to 18 months). Conclusion:Women with a renal transplant can have a successful pregnancy, but there are definite risks for both mother and fetus. Pregnancy should be discussed with the woman wish ing to have pregnancy and encouraged only if there is good renal graft function.

HIV-1 Integrase Inhibitory Compounds from Korean Medicinal Plants

CY Kim,HJ Yoon,MJ Ahn,KD Yoon,DJ Kim,CG Shin,H.Huh 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

임신성 고혈압과 신생아 호흡곤란증후군

김창이,김수평,이종건,나종구,홍승덕,신종철,김찬주,송경근,조태준 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.8

가톨릭의과대학 부속 성모병원에서 1990년 1월 1일부터 1992년 12월 31일 사이에 조기분만한 362명의 신생아(쌍태아 17명)와 345명의 산모의 의무기록을 조사하여 각 임신주수와 혈압, 임신중독증 여부, 24시간 이상된 조기 양막파수, 분만전 출혈여부, 분만전 진통유무, 분만방법, 신생아의 성별, 자궁내 태아의 발육지연 등의 유무에 따른 신생아 호흡곤란 증후군의 발생정도를 Multiple logistic technique을 이용하여 분석 비교한 후에 다음과 같은 결과를 얻었다. 1. 24시간이상 조기양막파수, 그리고 24시간 이상된 질출혈을 조정하였을 때 확장기 혈압이 110이상인 임신성 고혈압군은 정상 혈압군보다 유의하게 높은 신생아 호흡곤란 증후군의 위험도를 나타내었다. 2. 혈압, 24시간이상 조기 양막파수, 24시간 이상 질출혈, 산전분만통의 유무, 신생아의 성별, 자궁내 태아발육지연 등을 조정하였을 때, 임신주수와 분만방법이 신생아 호흡곤란증후군에 영향을 주는 유의한 위험인자로 입증되었다. Hypertension during pregnancy continues to be a major cause of preterm delivery and neonatal morbidity due to RDS. The effect of hypertension in pregnancy on the incidence of neonatal RDS remains controversial. It is due to the fact that the incidence of neonatal RDS was associated with confounding variable such as membrane rupture$gt;24 hours, vaginal bleeding, undergoing labor, having a cesarean section, growth retardation and neonatal sex. In order to investigate the assocation between maternal hypertension and the incidence of neonatal RDS, we used the multiple logistic regression to control for the above mentioned variabled and the 362 preterm birth were retrospectively analyzed. The results were as follows: 1. After adjustment for membrane rupture$gt;24 hours and vaginal bleeding, the risk of developing respiratory distress syndrome was significantly greater(adjusted odds ratio; 2,990, P value=0.002) in babies of hypertensive mothers(diastolic B.P.$gt;110 mmHg). 2. After adjustment for blood pressure, membrane rupture$gt;24 hours, vaginal bleeding, labor, neonatal sex and growth retardation, the risk of developing respiratory distress syndrome was significantly greater (adjusted odds ratio; 1.833, P value=0.04) in babies delivered by cesarean section without labor. These results suggests that the incidence of RDS in babies of hypertensive mothers might be more escalated due to the absence of labor before delivery because of the greater likehood of cesarean section.

Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis : Pharmacokinetics of oltipraz in LCD rats

Ahn, CY,Bae, SK,Bae, SH,Kim, T,Jung, YS,Kim, YC,Lee, MG,Shin, WG Wiley (Blackwell Publishing) 2009 British journal of pharmacology Vol.156 No.6

<P>BACKGROUND AND PURPOSE: The incidence of diabetes mellitus is increased in patients with liver cirrhosis. Oltipraz is currently in trials to treat patients with liver fibrosis and cirrhosis induced by chronic hepatitis types B and C and is primarily metabolized via hepatic cytochrome P450 isozymes CYP1A1/2, 2B1/2, 2C11, 2D1 and 3A1/2 in rats. We have studied the influence of diabetes mellitus on pharmacokinetics of oltipraz and on expression of hepatic, CYP1A, 2B1/2, 2C11, 2D and 3A in rats with experimental liver cirrhosis. EXPERIMENTAL APPROACH: Oltipraz was given intravenously (10 mg x kg(-1)) or orally (30 mg x kg(-1)) to rats with liver cirrhosis induced by N-dimethylnitrosamine (LC rats) or with diabetes, induced by streptozotocin (DM rats) or to rats with both liver cirrhosis and diabetes (LCD rats) and to control rats, and pharmacokinetic variables measured. Protein expression of hepatic CYP1A, 2B1/2, 2C11, 2D and 3A was measured using Western blot analysis. KEY RESULTS: After i.v. or p.o. administration of oltipraz to LC and DM rats, the AUC was significantly greater and smaller, respectively, than that in control rats. In LCD rats, the AUC was that of LC and DM rats (partially restored towards control rats). Compared with control rats, the protein expression of hepatic CYP1A increased, that of CYP2C11 and 3A decreased, but that of CYP2B1/2 and 2D was not altered in LCD rats. CONCLUSIONS AND IMPLICATIONS: In rats with diabetes and liver cirrhosis, the AUC of oltipraz was partially restored towards that of control rats.</P>

자궁파열 33예

최종열(CY Choi),신재진(JJ Shin),이명우(MW Lee),오원섭(WS O) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.6

저자들은 1975년 1월부터 1980년 8월까지 5년 8개월 동안 본 한강성심병원 산부인과에서 치험한 자궁파열 33예에 대하여 임상적으로 분석을 하여 다음과 같은 결과를 얻었다. 1. 총분만수 10509예중 자궁파열이 33예로서 발생빈도는 1:318이었다. 2. 연령분포는 30-34세군에서 42.4%로 분만회수는 1-2회에서 82%로 가장 많았다. 3. 자궁파열의 종류별 빈도는 기왕제왕절개반흔파열이 21예로 64% 자연자궁파열이 7예로 21% 가해자궁파열이 5예로 15%이었다. 4. 파열장소는 원의가 31에로 94% 원내가 2예로 6%였다. 5. 임신주수별 자궁파열은 대부분이 만삭임신이었다. 6. 가해자궁파열의 원인적 요소는 자궁수축제의 남용이 가장 많았다. 7. 자궁파열의 부위는 자궁체부가 49% 자궁하절부가 21% 자궁측벽이 30%였으며 자궁체부파열은 대부분이 반흔파열이었고 자연자궁파열과 가해자궁파열은 대부분이 측벽파열이었다. 8. 치료는 원칙적으로 전자궁적출술(67%)을 했으며 그의 환자의 상태 파열부위 및 정도에 따라 단순봉합 자궁경상부적출술을 하였다. 수혈량은 평균 6.2pints이었다. 9. 모체사망율은 9% 태아사망율은 52%이었다. This report concerns 33 cases of uterine rupture diagnosed among 10509 obstetric deliveries at Han Gang Heart Hospital in Seoul from Jan. 1975 through Aug. 1980. The results are summerized as follows. 1. There were 33 cases of uterine rupture among 10509 deliveries, an incidence of 1 in 318 deliveries. 2. The age distribution was from 29 to 39 years of age and about 82% of cases were in 25 to 34 years of age. According to parity, 82% of cases were in para 1 and 2.3. The incidence depending on the classification of rupture, 21 cases (64%) were ruptured previous Cesarean section scars, 7 cases (21%) were spotaneous rupture, 5 cases(15%) were traumatic rupture. 4. The place of rupture were 31 cases of extramural (94%) and 2 cases of intramural (6%). 5. According to gestational age, about 27 cases (82%) were over 38 weeks. 6. The major etiologic factor associated with traumatic rupture of the uterus noted to be the abuse of oxytocic drug. 7. The sites of rupure were composed of 7 cases (21%) in loxer uterine segment, 10(30%) in the lateral wall of uterus, and 16(49%) in the other sites of corpus. Corpus ruptures were largely due to ruptured scars, but lateral wall ruptures were almostly spotaneous and traumatic rupture. 8. About surgical management of uterine rupure, we have performed totoal hysterectomy(67%), simple repaire of defect(27%), subtotal hysterectomy(6%), according to suptured site, extensiion, patient`s general condition. During clinical management, the average blood transfusion was 6.2 pints. 9. Maternal mortality was 9% and the fetal mortality 52%.

The Role of Brain SPECT for Evaluation in the Patients with Severe Head Injury

권창영,신문수,이광수,정남,허승곤,최진옥 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.10

Brain SPECT studies with 99mTc-HMPAO(Hexa Methyl-Propylen-Amin-Oxim) were perf'ormed in seven patients with head trauma who showed no mass lesion on brain CT(or MRI) scan and whose mean GCS were below 7 to verifj, the relationship between regional cerebral blood flow(rCBF), level of consciousness and clinical outcome. Initial and follow up SPECT. were performed, and obtained the r-ray counts on the portion which showed many changes in brain SPECT and its percentage were compared to the control group. Comparison of the initial and follow up studies revealed that r-ray counts and its percentage declined to very low level in one patient who died, but 5 patients whose GCS improved to 14 showed increased r-ray counts and its percentages which meant incresed regional cerebral blood flow. However, how long the increased state of ICBF, which thought to be luxury perfusionwould last needs to be determined. It seems to be clear that the change of regional cerebral blood flow could be determined by comparing the rates of changed r-ray counts with 99 mTc-HMPAO SPECT.

쌍태아간 수혈증후군 1 례

박신근,신경재,안철영,김태국,전영식,박경원,강영제 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.6

본 병원 산부인과에서는 반복 양수천자로 임신을 지속시킨 쌍태아간 수혈증후군 1례를 경험 하였기에 문헌고찰과 함께 보고하는 바이다. TWIN-TWIN Transfusion Syndrome(TTTS) is a serious complication of monochorionic gestaions and is associated with high rates of perinatal morbidity and mortality resulting from shunting of blood from one twin(donor) to the other(recipient) through placental vascular anastomoses. We experienced a case of TTTS at 27 wks in which amniocentesis was attempted serially for therapeutic purpose. Therefore, we present this case with a brief review of the literatures.

Evaluation of PPARa Agonism of DY-105359 in Vitro and in Vivo

AHN BN,SHIN CY,KIM MK,SON MH,KIM JK,MOON HS,LIM JI,KIM SH,BAE MH,LEE CH,PARK CS 大韓藥學會 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.2