포상기태 임신시 혈청내 Progesterone Estradiol-17B 및 Prolactin 값의 관찰

이명우(MW Lee),박혜동(HD Park),김창이(CY Kim),정구윤(KY Chung),송승규(SK Song),이헌영(HY Lee) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.2

포상기태 임신시의 병태생리중 호르몬분비의 변화를 이해하기 위하여 1978년 6월부터 1979 년 12월까지 가톨릭의대 부속성모병원 산부인과에 입원치료한 무월경 10-20주의 포상기태 환자 25예의 혈중 Progesterone, Estradiol-17B and Prolactin을 측정하여 정상임신군과 비교 분석하여 다음과 같은 결론을 얻었다. 1. 정상임부의 혈중 Progesterone, Estradiol-17B and Prolactin 농도는 임신주수에 따라 증가 하였으나, 포상기태군에서는 임신주수와 무관하게 불규칙하였다. 2. 태반조직의 완전 포상기태화 16예의 혈중 Progesterone, Estradiol-17B and Prolactin 은 정 상 임신군보다 높았고, 불완전 포상기태화 9예에서는 정상임신군보다 낮았다. 3. 포막황체낭종을 가진 예에서는 혈중 Progesterone, Estradiol-17B and Prolactin 의 농도는 낭종을 안가진군보다 모두 높았다 4. 요중 hCG가 높은 예들은 낮았던 예들보다 혈중 Progesterone, Estradiol-17B and Prolactin 의 농도가 높았다. 이상의 성적으로 보아 포상기태 환자의 혈정 Progesterone 및 Estrogen의 증가는 포상기태 화 하지 않은 일반 태반의 존재여부, 포막황제낭종의 동반 여부 및 요중 hCG값의 인자와 밀접한 인과관계가 있으며, prolactin은 이들 증가된 호르몬의 자극으로 분비 증가된 것으로 추측된다. Serum Progesterone, Estradiol-17B and Prolactin level in the patients of Hydatidiform Moles registered at Trophoblastic Disease Clinic in Catholic Medical Center from June, 1978 to December, 1979 were measured by radioimmunossay serum Progesterone, Estradiol-17B and Prolactin during the clinical course of treatment. The results were as follows. 1. Serum Progesterone, Estradiol-17B and Prolactin levels in normal pregnancies increased according to increasing to increasing gestational weeks. But those of hydatidiform moles revealed irregular levels during the experiment. 2. Serum Progesterone, Estradiol-17B and Prolactin levels were higher in the group of `complete` molar change of placenta and lower in the group of `incomplete` molar change of placenta than normal control. 3. Serum Progesterone, Estradiol-17B and Prolactin levels in the patients of hydatidiform moles with theca lutein cyst were higher than in those without theca luteiin cysts. 4. Serum Progesterone, Estradiol-17B and Prolactin levels of hydatidiform moles with high 24 hours-urinary hCG titer were higher than those with low 24 hours-urinary hCG titer. considering above findings it can be concluded that the serum Progesterone, Estradiol-17B in hydatidiform mole may be influenced by the degree of molar change of placenta, theca lutein cyst, and 24 hours-urinary hCG titer and the prolactin levels were supposed to be closely correlated with the change of those hormones.

외음암의 2예

이명우(MW Lee),오보훈(BH Oh),이종현(JH Lee),이진용(JY Lee) 대한산부인과학회 1974 Obstetrics & Gynecology Science Vol.17 No.4

저자는 1972년 2예의 외음암을 경험하였기에 증례보고와 간단한 문헌적 고찰을 하였다. Few cases of vulva cancer have been reported in Korea, although its known incidence accounts for 3-4% of all primary malignancies of the genital canal. Enaluations of the effect of radical operation on survival rate revealed that more aggressive surgical managemant had resulted in better cure rates than that of previously performed. Two cases of vulva cancer which were performed radical vulvectomy and groin dissections as one stage procedure were presented with brief review of literatures.

난소의 유피낭포에서 발생한 편평세포암의 1예

이명우(MW Lee),김종우(CW Kim),신순철(SC Shin),이의형(EH Lee) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.6

A case of squamous cell carcinoma arising from a dermoid cyst was reported and a brief review of the literature was herewith presented.

임신중에 발생한 급성임파성 백혈병 1예

이의순(WS Lee),이명우(MW Lee),이용희(YH Lee) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.12

Pregnancy associated with leukemia is rare. We are reporting a case of acute lymphocytic leukemia coexistant with pregnancy with literature reivew.

3-Hydroxykynurenine (3HK)에 의한 SKN-SH 세포사멸 과정에서 heat shock protein 90에 의한 활성기 산소의 억제 효과

김대성(Kim DS),이명우(Lee MW),노유헌(Noh YH),이도연(Lee DY),이현정(Lee HJ),박재형(Bach JH),한정우(Han JW),이광길(Lee KG),여주흥(Yeo JH),이원복(Lee WB),김성수(Kim SS) 대한체질인류학회 2020 해부·생물인류학 (Anat Biol Anthropol) Vol.33 No.3

임신성 고혈압성 질환에 있어서 신사구체여과 값의 측정

박혜동(HD Park),이명우(MW Lee),최인호(IH Choi),김윤호(YH Kim),김수평(SP Kim) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.1

저자들은 정상임신, 전자간증 및 자간증에서 신사구체여과치의 변화를 알아보기 위하여 1979년 3월1일부터 1980년 2월 28일까지 가톨릭의대부속 성모병원에 입원하여 치료받은 임 신성 고혈압성질환 환자중, 그 기록과 이화학적 검사기록이 확실한 경증 전자간증 20예, 중 증전자간증 26예, 자간증 20예와 산모 및 태아가 모두 건강하였던 초임부 20예 및 경산부 20예를 대조군으로 삼아 혈청 creatinine값은 spectrophotometry로 측정하였다. 24시간뇨중 creatinine값은 folin-Wumethod에 의하여 측정하여 신사구체여과치를 산출 비교관찰한 바 다 음과 같은 결과를 얻었다. 1. 혈청 creatinine의 평균값은 대조군에서는 0.93±0.18mg/dl, 경증 전자간증에서는 0.95±0.16mg/dl, 중증 전자간증에서는 1.07±0.21mg/dl이었고, 자간증에서는 1.19±0.20mg/dl 이엇다. 2. 24시간뇨중의 Creatinine의 평균값은 대조군에서는 76.75±9.33mg/dl이었고, 경증 전자간증 에서는 68.90±7.91mg/dl, 중증 전자간증에서는 65.85±8.91mg/dl이었고, 자간증에서는 59.45±5.65mg/dl이었다. 3. 24시간뇨량의 평균값은 대조군에서는 2207.5±313.4ml, 경증 전자간증에서는 1978.5±336.3ml 중증 전자간증에서는 1838.4±369.1ml이었고, 자간증에서는 1645.0±238.9ml 이었다. 4. 신사구체여과치의 평균값은 대조군에서는 128.72±19.83ml/min, 경증 전자간증에서는 99.62±13.01ml/min, 중증 전자간증에서는 78.69±9.53ml/min이었고, 자간증에서는 57.51±6.09ml/min이었다. 이상의 결과로 보아 중증 전자간증 및 자간증에서는 신사구체여과치의 감소가 현저한 것을 알 수 있었다. Renal funciton is reflected by many features such as glomerular filtration rate, excretion of water, electrolytes and metabolites. Renel function in normal pregnancy is altered as well as in pregnancy-induced hypertension. Glomerular filtration rate is the basis of most critical tests for renal function, which is probably a simple reflection of renal plasma flow. Although various reports have been made on decreased of GFR in hypertensive disorders in pregnancy compared to normal pregnancy, their decreasing values were contradictory . In this study , the rate of decrease of GFR in relation to classification of toxemia was evaluated . The results were as follows; 1. The mean serum creatinine value was 0.93±0.18mg/dl in control group, 0.95±0.16mg/dl in mild preeclampsia , 1.07±0.21mg/dl in severe preeclampsia and 1.19±0.20mg/dl in eclampsia. 2. The mean creatinine value of 24 hours urine was 76.75±9.33mg/dl in control group, 68.90±7.91mg/dl in mild preeclampsia , 65.85±8.91mg/dl in severe preeclampsia and 59.45±5.65 mg/dl in eclampsia 3. The mean total volume of 24 hours urine were 2207.5±313.4ml in control group, 1987.5±336.3 ml in mild preeclampsia , 1838.4+-369.1 ml in severe preeclampsia and 1645.0±238.9 ml in eclampsia. 4. The mean GFR were 128.72±19.83ml/min in control group, 99.62±13.01ml/min in mild preeclampsia , 78.69±9.53 ml/min in severe preecampsia and 57.51±6.09ml/min in eclampsia. GFR of severe preeclampsia and eclampsia showed significant difference from that of control group.

난소의 유피낭포에 발생한 평편세포암의 1예

박경자(KJ Park),이명우(MW Lee),김기종(KC Kim),이진용(JY Lee) 대한산부인과학회 1974 Obstetrics & Gynecology Science Vol.17 No.1

희유한 유피낭포에서 발생한 악성변화된 1예를 보고하고 아울러 간단한 문헌적 고찰을 하였다. Squamous cell carcinoma arising in dermoid cyst(cystic teratoma) is so infrequently encountered and a case presented with a brief review of literatures.

자궁근지방종 1예

오규철(KC Oh),이명우(MW Lee),강길전(KC kang),신순철(SC Shin),신희철(HC Shin) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.2

자궁근지방종 1예를 보고하는 바이다. Lipoma of the uterus rarely occur either in pure form, consisting of adipose tissue with minimal supporting stroma, or as mixed form containing muscle, fibrous tissue, or cartilage. A case of myolipoma of the uterus was presented with brief review of the literature.

Aminofusin L300의 비경구적 추여에 대한 임상적 고찰

나건영(KY Na),이명우(MW Lee) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.6

Aminofusin L300 (25% solution of essential amoni acids and non-essetial amino acids, carbohydrates, electrolytes and vitamins) has been tested in hyperemesis gravidarum patients at Seoul National Unviersity Hospital during the period from January 1974 to July 1975. The results obtained are as follows; 1. The body weight was initially decreased for 3 days but thereafter gardually increased and returned to normal weight. 2. The level of blood sugar BUN protein, and electrolytes were not changed sighnificantly and kept within normal ranges. 3. With infusion of aminofusin L300, positive nitrogen balance was obtaiend from the 4th day. 4. No unpleasant side effects were observed.

자궁파열 33예

최종열(CY Choi),신재진(JJ Shin),이명우(MW Lee),오원섭(WS O) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.6

저자들은 1975년 1월부터 1980년 8월까지 5년 8개월 동안 본 한강성심병원 산부인과에서 치험한 자궁파열 33예에 대하여 임상적으로 분석을 하여 다음과 같은 결과를 얻었다. 1. 총분만수 10509예중 자궁파열이 33예로서 발생빈도는 1:318이었다. 2. 연령분포는 30-34세군에서 42.4%로 분만회수는 1-2회에서 82%로 가장 많았다. 3. 자궁파열의 종류별 빈도는 기왕제왕절개반흔파열이 21예로 64% 자연자궁파열이 7예로 21% 가해자궁파열이 5예로 15%이었다. 4. 파열장소는 원의가 31에로 94% 원내가 2예로 6%였다. 5. 임신주수별 자궁파열은 대부분이 만삭임신이었다. 6. 가해자궁파열의 원인적 요소는 자궁수축제의 남용이 가장 많았다. 7. 자궁파열의 부위는 자궁체부가 49% 자궁하절부가 21% 자궁측벽이 30%였으며 자궁체부파열은 대부분이 반흔파열이었고 자연자궁파열과 가해자궁파열은 대부분이 측벽파열이었다. 8. 치료는 원칙적으로 전자궁적출술(67%)을 했으며 그의 환자의 상태 파열부위 및 정도에 따라 단순봉합 자궁경상부적출술을 하였다. 수혈량은 평균 6.2pints이었다. 9. 모체사망율은 9% 태아사망율은 52%이었다. This report concerns 33 cases of uterine rupture diagnosed among 10509 obstetric deliveries at Han Gang Heart Hospital in Seoul from Jan. 1975 through Aug. 1980. The results are summerized as follows. 1. There were 33 cases of uterine rupture among 10509 deliveries, an incidence of 1 in 318 deliveries. 2. The age distribution was from 29 to 39 years of age and about 82% of cases were in 25 to 34 years of age. According to parity, 82% of cases were in para 1 and 2.3. The incidence depending on the classification of rupture, 21 cases (64%) were ruptured previous Cesarean section scars, 7 cases (21%) were spotaneous rupture, 5 cases(15%) were traumatic rupture. 4. The place of rupture were 31 cases of extramural (94%) and 2 cases of intramural (6%). 5. According to gestational age, about 27 cases (82%) were over 38 weeks. 6. The major etiologic factor associated with traumatic rupture of the uterus noted to be the abuse of oxytocic drug. 7. The sites of rupure were composed of 7 cases (21%) in loxer uterine segment, 10(30%) in the lateral wall of uterus, and 16(49%) in the other sites of corpus. Corpus ruptures were largely due to ruptured scars, but lateral wall ruptures were almostly spotaneous and traumatic rupture. 8. About surgical management of uterine rupure, we have performed totoal hysterectomy(67%), simple repaire of defect(27%), subtotal hysterectomy(6%), according to suptured site, extensiion, patient`s general condition. During clinical management, the average blood transfusion was 6.2 pints. 9. Maternal mortality was 9% and the fetal mortality 52%.