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EGFR 돌연변이와 ROS1 전위를 동시에 가진 폐선암 환자의 Erlotinib 치료 1예
김민환,박예현,박혜정,지아영,송창호,진무년,김영주,김선욱,이중희,김인수,김혜련,김주항,조병철 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1
The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.
김성민,이종호,김남열,안강민,최원재,최시호,차미주,이주영,황순정,장정원,명훈,최진영,서병무,정필훈,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4
Schwann cells(SCs), an important component of the peripheral nervous system, intract with nerous to mutually support growth and replication for the peripheral nerve regentation. Recently, ading SCs to the lumen of guidance channel is widely tried to improve regeneration or to make regeneration possible over otherwise irreparable gaps. however, it is not easy to isolate and multiplicate SCs as much as enough to help the axonal regeneration. For the allogeneic SCs source for tubular nerve guidance, we developed a little bit improved technique of harvesting and multiplicating SCs. by culturing dispersed dorsal root ganglia in specially designed medium with growth factors and serial processing, we repeatedlly generate relatively homogenous SC cultures. Our technique was compared with other methods of literature using immunostaining methods such as GFAP, S100, BDNF and the total SC count assessment at different time interval after primary culture.
김운중,문수회,김영균,민병무 朝鮮大學校 建設技術硏究所 2007 建設技術硏究 Vol.27 No.1
To estimate the change of riverbed geography by the operation of movable weir, two-dimensional RMA-2 and SED-2D were used in this study. Hydraulic elements like flowrate or depth were simulated by RMA-2 and the change of riverbed geography according to sediment transport was simulated by SED-2D. Suktop stream was chosen as a project river for the simulation. Under the condition of 50-year rainfall frequency, the estimated flood of Suktop was 123cms. At the points of movable weir the simulation results showed that the difference of high water level from the result of HEC-RAS was less than 0.64m. And the difference of water velocity was less than 0.21m/sec. Based on the sediment simulation by SED-2D, predicted riverbed elevation was 29.70-30.22m at the point of ST1 and 28.26~28.82m at the point of ST2. Measured riverbed elevation was 29.70-30.16m, 28.28-28.69m, respectively. So, the predicted elevations are closely similar to the measured elevation. At the point of ST1, sediment transport simulation results showed that erosion of riverbed was predicted by the operation of movable weir. This erosion was ranged up to 200m upstream and the riverbed would be eroded away as much as 0.07m for one year. At the point of ST2, upstream of movable weir would be eroded and the erosion depth was estimated 0.261m. The erosion was higher at the point of movable weir and the erosion depth was estimated 0.310m. But the sediment would be deposit downstream of the movable weir. SED-2D followed by RMA-2 is well applicable to the stream which has movable weirs and can estimate not only hydraulic parameters such as flowrate or depth but also riverbed elevation change caused by erosion or deposit of fluvial sediment.
Representation Theorem of The Operator Valued Measure
金炳茂 忠州大學校 1995 한국교통대학교 논문집 Vol.30 No.1
We prove the basic theorem on representation of bounded linear operators on Co(T,X) in the form of an integral with respect to a Baire operator valued measure.
김운중,민병무 朝鮮大學校 建設技術硏究所 2007 建設技術硏究 Vol.27 No.1
In this study the potential flood damagef (PFD) of Young-San river basin is analysed on 32 sub regions divided by the tributary characteristics of the whole basin. The analysis of PFD is based on the factors about the possibilities, the potentials of flood events and the weakness of protection facilities. PFD is proposed for the establishment of the degree of safety for flood protection and is applied for the investment schedule of flood protection facilities. The results of this study on PFD could be used for deciding the priorities of the each flood protection plans and for flood management of the river basin.
동종 골수이식을 시행받은 환자에서 폐색성 세기관지염에 의하여 발생한 자발성 기종격동과 피하 기종
이병환,이제중,이연경,안재숙,김여경,황호인,박무림,조상희,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2
저자들은 만성골수성백혈병으로 동종 골수이식과 이식편 부전으로 인하여 추가적인 말초혈액 조혈모세포이식을 시행 받은 환자에서 만성 이식편대숙주질환과 그 폐 합병증인 폐색성 세기관지염에 동반된 자발성 기종격동과 피하 기종이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Obstructive lung disorders following after allogeneic bone marrow transplantation (BMT) in association with graft- versus-host disease (GVHD) contribute significant morbidity and mortality. We report a case of a 28-year-old man who developed spontaneous pneumomediatinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic BMT. He received an allogeneic BMT for chronic phase of chronic myeloid leukemia. Five months after BMT, he was boostered by allogeneic peripheral blood stem cells from the same donor due to graft failure. One month after the boostering, chronic GVHD developed and were treated with cyclosporine and steroid. The patients developed spontaneous pneumomediatinum and subcutaneous emphysema secondary to severe bronchiolitis obliterans 4 months after boostering donor cells. The air-leak syndromes were recovered by conservative management, including high-flow oxygen.