맥파 전달 속도(PWV) 측정을 위한 특징점 검출 알고리즘 개발

최정현 ( Jung Hyeon Choi ),조욱현 ( Wook Hyun Cho ),박준호 ( Jun Ho Park ),김남훈 ( Nam Hoon Kim ),성향숙 ( Hyang Sook Seong ),조종만 ( Jong Man Cho ) 한국센서학회 2011 센서학회지 Vol.20 No.5

The compliance and stiffness of artery are closely related with disease of arteries. Pulse wave velocity(PWV) in the blood vessel is a basic and common parameter in the hemodynamics of blood pressure and blood flow wave traveling in arteries because the PWV is affected directly by the conditions of blood vessels. However, there is no standardized method to measure the PWV and it is difficult to measure. The conventional PWV measurement has being done by manual calculation of the pulse wave transmission time between coronary arterial proximal and distal points on a strip chart on which the pulse wave and ECG signal are recorded. In this study, a pressure sensor consisting of strain gauges is used to measure the blood pressure of arteries in invasive method and regular ECG electrodes are used to record the ECG signal. The R-peak point of ECG is extracted by using a reference level and time windowing technique and the ascending starting point of blood pressure is determined by using differentiation of the blood pressure signal and time windowing technique. The algorithm proposed in this study, which can measure PWV automatically, shows robust and good results in the extraction of feature points and calculation of PWV.

채식자와 비채식자에서 혈청 지질, 지단백 및 총 항산화능의 비교

김수길(Su Gil Kim),김현일(Hyun Il Kim),엄민섭(Min Sup Yum),조호(Ho Jo),오용열(Yong Yeol O),권한진(Han Jin Kwan),조욱현(Wook Hyun Cho),박정식(Jeong Sik Park) 대한내과학회 2000 대한내과학회지 Vol.58 No.2

N/A Background : Previous studies have demonstrated that modified or oxidized lipoproteins play a key role in the process of atherogenesis, particularly in hyperlipidemic individuals. Low density lipoprotein(LDL) is modified by oxygen free radical from damaged tissue or inflammatory cells. Further changes in the LDL molecule lead to an oxidized form (oxidized LDL), which is recognized by the macrophage scavenger receptor. Scavenger receptors on macrophages recognize and bind oxidized LDL. As uptake continues, the macrophages change to lipid-laden foam cells, the components of the fatty streak, which is the precursor atherosclerotic lesion. Antioxidants are known to prevent modification of LDL by free radicals and possibly also atheroma formation. This study was designed to compare the total antioxidant status and other lipid profiles in vegetarian and non-vegetarian groups in Korean adults to see the effect of diet modification on antioxidant status. Methods : 174 vegetarian and 150 non-vegetarian male adults were recruited for lipid test including total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, lipoprotein(a), and total antioxidant status during annual routine physical examination. Result : 1) Total antioxidant status was significantly high in vegetarian group(1.390±0.288 mmol/L) compared to non-vegetarian group(1.155±0.290 mmol/L)(p<0.001). 2) In non-vegetarian group, total antioxidant status was significantly low in smokers(1.041±0.288 mmol/L) compared to non-smokers(1.227±0.328 mmol/L)(p<0.001). 3) Correaltions between lipid profiles and total antioxidant status in vegetarian and combined groups were not significant. Conclusion : Total antioxidant status in vegetarian group was significantly higher compared to non-vegetarian group. Among non-vegetarian group, smoker group showed lower total antioxidant status compared to non-smoker group. And there was no significant correlations between lipid profiles and total antioxidant status.(Korean J Med 58:197-203, 2000)

울산지역 건강인에서의 C 형 간염 항체 양성율

정지인(Ji Inn Jung),손석호(Suk Ho Sohn),조욱현(Wook Hyun Cho),정정희(Jung Hee Jung),김용림(Yong Lim Kim),이진관(Jin Kwan Lee) 대한내과학회 1993 대한내과학회지 Vol.45 No.3

N/A Background: The prevalence of antibody to hepatitis C virus (anti-HCV) in healthy subjects from Korean has been investigated in various studies. But most of these studies were estimated from data in blood donors who were mostly young adults. So these studies could not represent the prevalence of anti-HCU in all age groups and its age distribution. Method: The prevalence of anti-HCV among healthy subjects in Ulsan area was evaluated using commercially available enzyme immunoassay. We studied a correlation between anti-HCV and alanine aminotransferase (ALT) level, and between anti-HCV and HBs Ag. Effects of increasing age and blood transfusion were also evaluated. Results: 1) The overall prevalence of anti-HCV was 1.079 among 3,000 healty subjects. 2) Male to female ratio was 2.5:1. The prevalence of anti-HCV among male subjects (1.21%) was higher than that among female subjects (0.7%). 3) Anti-HCV prevalence increased with increasing age through the fourth decade of life. 4) There was no significant difference both in the prevalence of anti-HCV in healthy subjects with or without HBs Ag and in the prevalence of anti-HCV in healthy subjects with or without the history of transfusion. 5) Anti-HCV prevalence increased linearly with the increase of alanine aminotransferase level. Conclusion: The prevalence of anti-HCV in healthy subjects in Ulsan area was 1.07%. There was a significant increase with increasing age above 30 years. There was a good correlation between the prevalence of anti- HCV and ALT level, but the prevalence of anti-HCV was not associated with blood transfusion.

종합검진상 발견된 C형 간염 항체 양성자의 추적과 HCV RNA 검출율

이진관(Jin Kwan Lee),김정철(Jung Chul Kim),정정희(Jung Hee Jung),이창구(Chang Goo lee),최형경(Hyeong Kyoeng Choi),손석호(Suk Ho Sohn),조욱현(Wook Hyun Cho),허충(Chung Hur) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6

N/A Follow up study and HCV RNA test by PCR was performed on the 26 asymptomatic subjects with anti-HCV found in routine health check. Among the 26 sugjects, 16 have persistently normal ALT level and 10 abnormal ALT level. In 6 subjects, anti-HCV turned to be negative on follow up test and among those, 5 have normal ALT level and one abnormal ALT level. 15 subjects with normal ALT level have HCV RNA and those subjects were assumed to be asymptomatic hepatitis C carrier. HCV RNA was positive in 8 out of 10 subjects with abnormal ALT level. In conclusion, 23 out of 26 asymptomatic subjects with anti-HCV have HCV-RNA and among them 15 with normal ALT level were assumed to be asymptomatic hepatitis C carrier.

급성 ST 분절 상승 심근경색증의 표준진료지침 설계

권선옥,김우식,오명기,나종천,이홍기,조욱현,최석구 인제대학교 2006 仁濟醫學 Vol.27 No.-

The use of critical pathways for a variety of clinical conditions has grown rapidly in recent years, particularly pathways for patients with acute myocardial infarction. We intend to determine the impact of a clinical pathway on ST-elevation myocardial infarction (STEMI) and to evaluate the efficacy and safety of facilitated percutaneous coronary intervention (PCI) compared with primary PCI. Low risk STEMI patients (ST elevation >0.1mV in more than 2 limb leads or ST elevation >0.2mV in contiguous precordial lead, chest pain lasting more than 30 min without response to nitroglycerin) will be included. All patients will be also treated medically according to critical pathway. STEMI is one of the common diseases in emergency medicine and so it is necessary to establish realistic treatment guidelines. The use of critical pathways will improve the quality of care.

Lutembacher 증후군 환자 증례 보고

김성범,서정주,곽철훈,김상민,이보라,민선경,황은구,김용인,조욱현,최석구 인제대학교 2008 仁濟醫學 Vol.29 No.-

Lutembacher's syndrome is rare combination of mitral stenosis (MS) and atrial septal defect (ASD). The hemodynamic interplay between the MS and ASD leads to wide variation of clinical presentation. Here we describe a 43-year-old female with Lutembacher's syndrome and tricuspid regurgitation with pulmonary hypertension, who underwent direct closure of ASD and tricuspid valvuloplasty successfully. We also reviewed other literatures in an effort to increase awareness of this condition.

Osborne J 파를 보인 저체온증 2예

박정식,김현일,조욱현,오용열,권한진,조호,엄민섭 대한내과학회 2000 대한내과학회지 Vol.59 No.5

$quot;Authors report two cases of hypothermic patients with Osborne's J wave on electrocardiogram. A 46-year-old male with liver cirrhosis was brought to the emergency room by ambulance due to comatous mental status. On exammination, the body temperature was below 35 ℃. By rewarming using warm normal saline intravenous infusion and hot pack application on the chest, his body temperature rose up to 36 ℃ and regained consciousness. Later, he expired with afterdrop phenomenon. Another 41-year-old stuporous quadriplegic male with post-traumatic cerebral palsy was brought to the emergency room by his family complaining weakness and vomiting. On exammination, the body temperature was below 35℃. He was rewarmed using warm normal saline intravenous infusion and hot pack application on the chest. However, he could not regain his normal body temperature and expired due to irreversible shock.(Korean J Med 59:561-564, 2000)$quot;

급성 심근 허혈과 악성 심실빈맥으로 인한 심인성 쇽으로부터 응급수술에 의하여 회복된 급성 A 형 대동맥 박리증

이상훈,김덕경,강수정,조욱현,이원로,박표원,이방훈 대한내과학회 1998 대한내과학회지 Vol.55 No.3

Acute myocardial infarction is a common initial incorrect diagnosis in patients with acute aortic dissection. Distinction between these two conditions could be especially difficult in a patient who has severe chest pain and abnormal ECG findings. The consequence of such a misdiagnosis in the era of thrombolytic therapy could be catastrophic. We report a case of acute type A aortic dissection who was recovered from acute myocardial ischemia and malignant ventricular tachycardia by emergency surgical treatment. A 54-year-old male patient with no previous cardiac history visited ER because of syncope and severe chest pain of acute onset. Physical examination was normal except for a low blood pressure (90/40 mmHg) and heart rate of 55 beats/min. The ECG showed ST depression and negative T waves in leads II, III, aVF and V4 to 6. A chest X-ray was normal Acute myocardial infarction complicated by cardiogenic shock was diagnosed. Emergency cardiac catherization was performed. An aortogram demonstrate4 type A aortic dissection. The patient had a circulatory arrest with ventricular tachycardia and cardiogenic shack Cardiopulmonary resuscitation was performed for 50 minutes. He underwent emergency surgical correction. The ST segment returned to normal and there was no evidence of myocardial ischemia after these procedures. The postoperative course was unevenful.

지주막하출혈에 의해 발생한 Takotsubo 심근병증의 1예

김선영,김우식,박종혁,오명기,권선옥,나종천,조욱현,최석구 인제대학교 2007 仁濟醫學 Vol.28 No.-

A 64-years-old man was admitted to emergency department with symptom of chest pain. The characteristic of symptom was squeezing pain at substernal area. The patient had a history of hypertension and diabetes mellitus. His electrocardiogram(ECG) showed ST elevation in lead Ⅰ, Ⅱ, V3-6 and his laboratory results revealed mild increase in cardiac enzymes. And his echocardiogram showed apical hypokinesis. Based on the suspicious symptoms and results for acute anterior myocardial infarction, we decided to take a coronary angiogram for further evaluation. However, coronary angiogram revealed normal epicardial coronary arteries. He was admitted at Intensive Care Unit for monitoring and treatment of heart failure. After 3 days of hospitalization, his mental status was changed. His brain computed tomography revealed subarachnoid hemorrhage. After 5 days, hypokinesis of apex was improved to nearly normal on echocardiogram. This is a case of transient left ventricular apical ballooning or takotsubo cardiomyopathy associated with subarachnoid hemorrhage.

성인에서 발견된 Prune-belly Syndrome 1 예

김종수,이병화,김용림,이진관,손석호,조욱현 대한내과학회 1995 대한내과학회지 Vol.48 No.1

A 28-year-old man was diagnosed as having prune-belly syndrome, a congenital disease characterized by abdominal wall defects, undescended testes, a generalized dilatation of the urinary tract, and chronic renal failure. The patient also demonstrated metatarsus varus and pectus excavatum. The patient was asymptomatic until the diagnosis was made at the age of 28 years. This is the first case report of prune-belly syndrome in adulthood in Korea.