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만성 알코올 급여 흰쥐에서 보리 추출물 섭취가 Cytochrome P450 효소 조절 및 항산화계에 미치는 영향
이유현(Yoo-Hyun Lee),이정민(Jeongmin Lee),임은정(Eun-Jeong Im),전우진(Woojin Jun),조홍연(Hong Yon Cho) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.10
본 연구에서는 보리 추출물을 이용하여 알코올 유도 P450 계열 효소 활성을 조절함으로써 라디칼 및 중간체의 발생감소와 항산화 효소의 활성증강에 의한 보호효과를 연구하였다. ICR mice를 대상으로 대조군(Control), 알코올군(EtOH), 알코올-보리 추출물 급여군(EtOH-B)으로 나누어 전체 열량의 35%에 해당하도록 조성된 알코올 액체 식이를 알코올군 및 알코올-보리 추출물 급여군에 28일 간 공급하였다. 알코올 투여군은 P450 함량에 있어서 대조군에 비하여 급격한 증가를 보였으며, 알코올-보리추출물 급여군은 대조군 수준으로 유의적인 감소를 하였다. 알코올 유도 CYP2E1, CYP1A2는 알코올군에서는 유의적인 증가를 보였으며, 알코올-보리 추출물 투여군에서 이들 효소의 활성을 유의적으로 억제시키는 결과를 확인할 수 있었다. 생체 내 방어시스템의 변화 면에서 알코올 급여군에서 급격하게 감소한 catalase 활성이 보리 추출물 급여군에서는 유의적으로 증가하여, CYP2E1의 활성억제에 의한 라디칼 발생 저하를 확인할 수 있었다. 이상의 실험 결과로서, 보리 추출물은 알코올 유도 CYP2E1, CYP1A2 효소 활성의 억제와 생체 내 방어 기작의 효과적인 활성화에 의하여 알코올성 간 손상의 개선 소재로 활용가능 할 것이라고 사료된다. The effects of methanol extract of barely (Hordeum vulgare) on alcohol-induced damages of liver were investigated in male ICR mice. Mice were divided into three groups, control, ethanol, and ethanol plus 0.15% of barley extract. After four weeks of ethanol feeding, ethanol group significantly increased the P450 content, CYP2E1 and CYP1A2 enzyme activities, whereas ethanol plus barely group markedly decreased to levels similar to control group. Catalase activity in ethanol group was significantly lower than that in control group; however, ethanol plus barely group stimulated catalase activity as well as SOD activity significantly. These results indicated that barely extract modulated P450 enzymes for ethanol-induced liver damage and might be useful in developing functional food for alcoholic liver damage.
이유재(Yoo Jai Lee),변준형(Joon Hyung Byun),조주연(Ju Yeon Cho),정수인(Su In Chung) 한국디자인문화학회 2014 한국디자인문화학회지 Vol.20 No.2
최근 대중의 여가시간 활용에 대한 관심이 증가하며, 리조트웨어 혹은 비치웨어라고도 불리는 스타일들은 단순한 수영복의 범위를 넘어 패셔너블하게 발전하고 있다. 현재 국내에는 전문적인 리조트웨어 패션 브랜드는 없으며, 기능성과 실용성을 겸비한 리조트웨어 패션제품과 멀티 코디네이션이 가능한 프리미엄 리조트웨어 제품의 연구 및 참신하고 개성 있는 우리 상품의 개발은 절실한 실정이다. 이 연구의 목적은 국내 브랜드의 리조트웨어 컬렉션 개발을 위한 기초 연구 자료를 제공하는데 목적이 있다. 연구 범위로는 국내 여성복 브랜드, 해외디자이너컬렉션, 수영복 전문 브랜드. 일반 스포츠 웨어 브랜드의 4분야로 구분하고, 연구방법으로는 리조트웨어 산업의 국·내외 현황을 문헌 및 조사 연구하고, 리조트웨어의 복종 및 아이템별로 브랜드 인터넷 사이트에 나타난 이미지를 활용하여 실루엣, 소재, 색상, 텍스타일 디자인 등의 조형적 특성을 분석하는 방법으로 진행하였다. 분석 결과 첫째, 국내 여성복 브랜드에서는 편안한 맞음새와 긴 길이의 썬 드레스가 주종을 이루었고 평상복으로도 가능한 스타일이었다. 하의의 경우 대담한 프린트가 다수 전개되었다. 둘째, 디자이너 컬렉션의 경우 가벼운 소재의 다양한 컬러의 썬 드레스가 주류를 이루었으며 여성스러운 디테일과 패턴이 있는 아우터도 다수 있었다. 셋째, 수영복 브랜드에서는 리조트웨어 아이템이 전체에서 차지하는 비중이 증가하는 추세이며 매쉬 소재의 탑과 모자가 있는 아우터가 주종이었다. 넷째, 전문 스포츠웨어 브랜드에서는 실내 수영복 위주로 아이템이 전개되고 있었다. 이상 연구의 결과는 국내 시장에서의 리조트웨어 디자인 개발에 기본 자료로서 활용 가능할 것이다. In recent years, as many people enjoy leisure time more and more, their interest toward resort wear style clothing have increased. Resort wear, or beach wear is clothing suitable for wearing on the beach, though not necessarily for swimming. Although there is not a professional resort wear brand so far, resort wear style is being designed by many fashion brands, such as women’s casual wear brands, designer’s collection brands, swim wear brands, and sports wear brands. Resort wear, sometimes known as cruise wear, is a specialized clothing style as well as a year-round fashion season. The purpose of this study is to provide the basic research data for developing the resort wear collection. In research methods, we examined the literature and web site data of fashion industry, first. We collected the picture images of resort wear items through internet web sites, and analyzed the formative design characteristics. They were silhouette, material, color, textile design. The range of this study is four categories such as women’s wear brands, designer’s collection, swim wear brands, and sports wear brands to figure out the resort wear design. The results of this study were as follows. First, in women’s casual wear brands, sun dresses are main items for resort wear. Easy fitted and maxi-length dress could go with both daily wear and resort wear. Skirts and pants are usually made with bold prints. Second, sun dresses with various colors in light material are popular resort wear items in designer’s collections. The outer garments with girlish details or textile patterns are popular for resort wear. Third, in swim wear brands, resort wear or beach wear items are being increased. Mesh materials are used for tops and hooded zip up outer garments. Fourth, professional sports wear brands focus on indoor swimsuits in swim wear. This study would be a basic research for the development of resort wear design.
HS 1-Associated Protein X-1 Is Cleaved by Caspase-3 During Apoptosis
Ah Young Lee,이유라,Yun Kyung Park,배광희,조사연,이도희,박병철,강성현,박성구 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.1
Caspase-3 (CASP3) plays a key role in apoptosis. In this study, HAX-1 was identified as a new substrate of CASP3 during apoptosis. HAX-1 was cleaved by CASP3 during etoposide-(ETO) induced apoptosis, and this event was inhibited by a CASP3-specific inhibitor. The cleavage site of HAX-1, at Asp127, was located using N-terminal amino acid sequencing of in vitro cleavage products of recombinant HAX-1. Overexpression of HAX-1 inhibited ETO-induced apoptotic cell death. It also inhibited CASP3 activity. Together, these results suggest that HAX-1, a substrate of CASP3, inhibits the apoptotic process by inhibiting CASP3 activity.
지진 재난대응을 위한 의사결정 가시화기술 설계 및 개발
이응준 ( Eungjoon Lee ),이유연 ( Yuyeon Lee ),최영철 ( Yeongcheol Choi ),최수영 ( Sooyoung Choi ),김경준 ( Kyungjun Kim ) 대한설비관리학회 2020 대한설비관리학회지 Vol.25 No.4
Social concerns by earthquakes in Korea are increasing. Currently, risk assessment for decision-making in emergency is not well established and delayed. Risk assessment in emergency is not conducted properly due to the inability, such as lack of manpower, manual evaluation, and lack of systematic disaster management, to predict damages. In this paper, we developed a visualization technology that combines ICT (Information and Communication Technology) to solve difficulties of decision-making caused by the lack of disaster information. To this end, we collected the ground and analysis information on facility in the areas of Buk-gu (Heunghae-eup) and Nam-gu. In order to provide a web-based geographic application API using open source, codes that can be linked to the web was developed and applied. This visualization technology can use to improve inefficient measures based on existing manuals, such as providing intuitive monitoring information, risk assessment and precision improvement and to support fast a disaster decision-making. The performance of the development system was evaluated and the result is improved.
수동조절형 제트환기장치(Manujet)의 개발 및 임상적용 : 전향적 연구
권기남,김규훈,문일하,이유재,유혜진,태기연,이승원,Kwon, Ki-Nam,Kim, Kyu-Hun,Moon, Il-Ha,Lee, Yu-Jea,Yu, Hye-Jin,Tae, Ki-Yeon,Lee, Seung-Woon 대한후두음성언어의학회 2011 대한후두음성언어의학회지 Vol.22 No.2
Background and Objectives : Previous jet ventilation is not becoming more common because of high price, making loud noise, and causing a movement of the vocal cords due to the jet stream. So we designed a new type of manually controlled jet ventilation using previous laryngoscope and introduced it's clinical application. Materials and Method : A prospective study involved 20 patients all having undergone surgical intervention under new type of manually controlled jet ventilation from June 2009 to January 2011. The prospective study was to assess the vital sign and operative and postoperative complications. Results : The Manually Controlled Jet Ventilation were performed in 20 patients. 50% of the patients have Post-located laryngeal lesion, 20% with tracheal stenosis, 20% with glottic cancer biopsy and laser cordectomy, 10% with postglottic stenosis. Conclusion : Manually Controlled Jet Ventilation (Manujet) can be used for airway surgery.
표준화된 간호진단 및 문제와 NANDA-I 교차분석: 4개 상급종합병원 사례를 중심으로
송미라 ( Song Mi Ra ),심소연 ( Shim So Yun ),김대성 ( Kim Dae Sung ),이경순 ( Lee Kyung Soon ),이유나 ( Lee Yu Na ),원미숙 ( Won Mi Suk ) 병원간호사회 2020 임상간호연구 Vol.26 No.3
Purpose: To explore the scope and method of applying standardized nursing terminologies to nursing diagnosis and problems used in nursing practice. Methods: A descriptive study was done with a retrospective analysis of the nursing records of 141,420 patients that were hospitalized in 4 tertiary hospitals. The nursing diagnosis and problems collected from the records were standardized, and the standardized nursing diagnosis and problems cross mapped with NANDA-I, confirmed in a nursing focus group. Results: 65 (67.7%) of the 96 standardized nursing diagnosis and problems were equal with NANDA-I and included in the 10 domains of NANDA-I. Among 86 nursing diagnosis and problems excluded from the cross mapping with NANDA-I, the 63 terms (73.3%) related to surgery/procedure were the most common. Conclusion: It is meaningful that multi-tertiary hospital nursing diagnosis and problems were standardized and cross mapping with standard nursing terminologies was performed. As for the method of applying standardized nursing terminologies in nursing practice, it is appropriate to use several standardized nursing terminologies complementarily.