치아 교환기 어린이에서 근단변위부분층 판막술을 이용한 하악 거대 협소대의 위치

이성룡,오유향,이난영,이창섭,이상호 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

영구치의 맹출 지연이 발생하는 원인은 다양하다. 유치의 만기 잔존과 조기 상실, 과잉치나 치아종과 같은 이형물의 존재등과 같이 비정상적인 경조직 인자에 의해 발생할 수 있고, 치은 판개 조직(opercula)과 같은 상부 치은 조직의 섬유성 비후나 소대의 과증식과 같은 연조직성 인자에 의해 발생하기도 한다. 영구치의 맹출 지연시의 공간의 상실 및 영구치의 비정상적인 맹출, 그리고 그에 따른 치열궁의 비대칭과 같은 교정적 문제와 대합치의 정출 등에 의한 교합적인 문제등이 발생할 수 있어 조기에 진단하여 처치하는 것이 중요하다. 본 증례에서는 12세 남자 아이가 충치가 많고 치아가 나오지 않는다는 것을 주소로 내원하여 진단한 결과, 하악 좌측 소구치들이 맹출하지 못하고 매복되어 있는 것을 알 수 있었다. 원인은 맹출 공간이 부족하였고 동시에 거대 협소대가 치아의 맹출을 방해하는 것으로 파악되었다. 이에 대한 처치로 우선 공간을 획득하고 난 후, 부착치은의 회복과 맹출 촉진을 위해 근단변위부분층 판막술을 시행하였다. The mandibular buccal frenum becomes a problem when its attachment is too close to the marginal gingival. Heavy buccal frenum mucogingivally results in insufficient attached gingiva, inadequate vestibular depth and also difficulty in eruption of mandibular premolar. The aim of this study is to demonstrate the effectiveness of apically positioned partial-thickness flap as adequate mothod in order to remove heavy buccal frenum and expose impacted teeth. The author presents the case of a 12-year-old boy. He had problems that was prolonged eruption of #34, #35 due to high pull buccal frenum. After space regaining for normal eruption of #34, #35, we performed apically positioned partial-thickness flap on #34,35 area. As a results, we confirmed that eruption of #34, #35 has been processed normally. And vestibular depth, position of buccal frenum and width of attached gingival was within a normal range. Decrease in muscle pull, adequate width of attached gingiva and increased vestibular depth can be expected from this treatment.

위장관을 침범한 Henoch-Soho¨nlein purpura 1예

이승곤,김채규,서종옥,이호영,이호준,정회상,박유환,정춘해 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

위장관을 침범한 Henoch-Sch o¨nlein purpura 1예

이승곤,김채규,서종옥,이호영,이호준,정회상,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2

Henoch-Scho¨nlein purpura(H-S purpura) is a systemic necrotizing vasculitis of small vessels that is characterized by nonthrombocytopenic palpable purpura on the buttocks and extremities, arthritis of knees and ankles, glomerulonephritis, and colicky abdominal pain, histologically characterized by leukocytoclastic vasculitis. Gastrointestinal involvement with colicky abdominal pain and GI bleeding, most frequently in jejunum and ileum, occurs in above a half of all patients, but common in children. We performed GI endoscopy in a case of H-S Purpura. Gastroduodenoscopic findings showed erythemas and erosions in gastric antrum, and mucosal edema and petechiae in duodenal 2nd portion. Colonoscopic findings showed 5-10㎜ sized multiple shallow hemorrhagic ulcers in transverse and descending colons We report a case of H-S purpura involving colon with literatural review.

LED 광중합기의 조사 mode가 복합레진의 미세경도 및 수축응력에 미치는 영향

박인호,오유향,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

이 연구의 목적은 LED 광중합기(Elipar Freelight 2?, 3M-ESPE, USA)의 조사 mode에 따른 복합레진(Supreme?, Filtek Flow?, 3M-ESPE USA)의 수축응력과 미세경도를 평가하는 것이다. 수축응력을 측정하기 위해 스트레인 게이지가 사용되었다. 표본은 조사 mode와 충전방법에 따라 6개의 군으로 나누어졌다. A군: Filtek Flow?이장, Supreme? 충전, 10초 광중합, B군: Filtek Flow?이장, Supreme? 충전, 15초 광중합, C군: Filtek Flow?이장, Supreme?충전, 15초 soft start 광중합, D군 Supreme? 충전, 10초 광중합, E군: Supreme?충전, 15초 광중합, F군: Supreme?충전, 15초 soft start광중합. 스트레인 게이지를 아크릴릭 링에 부착하고 strain meter에 연결한 후 광중합하고 10분 동안 1초 간격으로 측정하고 기록하였다. 24시간 후에 각각 표본의 미세경도를 측정하였다. 결과는 ANOVA와 Tukey test를 이용해 통계학적으로 분석하였다. 결과는 다음과 같았다. 1. Soft start curing 했을 때 수축응력 이 낮았다(p<0.05). Flow able resin을 이장한 군에서는 효과가 없었다. 2. 10초간 조사한 군은 15초간 조사한 군에 비해 수축응력이 적었다(p<0.05) 3. 미세경도 측정결과 상면과 하면에서 각 군 간에 차이는 없었다(p>0.05). 하지만, 하면의 미세경도가 상면에 비해 80%에 이르지 못했다. The purpose of this study was to evaluate the polymerization contraction and the micro hardness of composite resin(Supreme?, Filtek Flow?, 3M-ESPE, USA) according to irradiation modes of LED curing unit(Elipar Freelight?, 3M-ESPE, USA). The strain guage method was used for determination of polymerization contraction. Sample were divided by 6 groups according to curing modes and filling method. Group A: Supreme?, Filtek Flow? lining, 10seconds curing, Group B: Supreme?, Filtek Flow? lining, 15seconds curing, Group C: Supreme?, Filtek Flow? lining, 15seconds soft start curing, Group D: Supreme? only, 10seconds curing, Group E: Supreme? only, 15seconds curing, Group F: Supreme? only, 15seconds soft start curing Preparations of acrylic molds were followed by filling and curing. Strain guage attached to each sample were connected to a strain meter. Measurements were recorded at each second for the total of 10 minutes including the periods of light application. And micro hardness of each group after 24hours from light irradiation were measured. Obtained data were analyzed statistically using Repeated measures ANOVA and Tukey test. The results of the present study are as follows: 1. In flow able resin liner group, soft start curing group was not found decrease of polymerization contraction. But, In Supreme only filling group, the lowest polymerization contraction was found in soft start curing group. 2. 10 seconds curing group showed statistically significant reduction of polymerization contraction compared with 15 seconds curing group(p<0.05). 3. The micro hardness values of each group not revealed significant difference(p>0.05). But, lower surface micro hardness was not reached 80% of upper surface micro hardness.

완속기시(Soft-start)광조사 방식이 복합레진의 중합 및 수축응력에 미치는 효과

위유민,오유향,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

본 연구에서는 기존의 할로겐 광중합기를 이용하여 40초간 조사하여 복합레진을 중합한 경우와 플라즈마 광중합기를 이용한 고강도의 중합 및 완속기시 중합 방식, 그리고 LED 광중합기를 이용한 통법의 중합과 완속기시 중합 방식으로 복합레진을 중합하여 발생되는 수축응력을 비교하고 미세경도를 측정하여 중합도를 평가하였다. 내경 7mm, 외경 10mm의 아크릴릭 주형을 제작하고 외면에 스트레인게이지를 부착 시킨 뒤 각각의 광원에 따른 중합모드로 광중합 하였다. 광조사 시점부터 1초 간격으로 600초간 수축응력을 측정하였으며, 중합 24시간 후 각 군의 미세경도를 측정하여 통계 분석하였다. 수축응력 측정 후 시편을 종단하여 주사전자현미경으로 레진수복물과 아크릴릭 주형 계면을 관찰하였다. 이상의 실험을 통해 얻은 결과는 다음과 같다. 1. 플라즈마 광과 LED 광원의 완속기시 중합방식은 각각의 기본 중합방식에 비해 중함 10분 후에 수축응력 감소를 보였다(P<0.05). 2. 완속기시 중합방식의 플라즈마 광이 가장 낮은 수축응력을 보였으나 미세경도 또한 가장 낮았다(P<0.05). 3. 완속기시 중합방식의 LED 광중합은 기존의 할로겐 광과 LED 광중합 방법에 비하여 낮은 수축응력을 보였다(P<0.05). 4. 완속기시 중하장식의 LED 광으로 조사한 시편의 미세경도는 단일광도로 조사한 할로겐 광과 LED 광중합과 비교하여 유의할만한 차이가 나타나지 않았다(P>0.05). 5. 기존의 할로겐 장과 완속기시 중합방식의 LED로 중합한 시편이 플라즈마 광과 단일강도의 LED로 조사한 군보다 더 나은 번연봉쇄를 보였다. The purpose of this study was to evaluate the influence of soft-start light curing on contraction stress and hardness of composite resin. Composite resin mold was cured using the one-step continuous curing method with three difference light sources; conventional halogen light curing for 40 seconds at 400 mw/㎠, plasma arc light curing for 6 seconds at 1300 mW/㎠ and LED light curing for 10 seconds at 700 mW/㎠. For the soft-start curing method 2 seconds light exposure at 650 mW/㎠ followed by 3 seconds at 1300 mW/㎠ and exponential increase with 5 seconds followed by 10 seconds at 700 mW/㎠ were used. Contraction stress was measured using strain gauge method and Vickers hardness was measured 24 hours after polymerization at the top and bottom of specimens. Resin-acrylic interfaces were observed using a scanning electron micro scope(SEM). The results of present study can be summarized as follows: 1. Contraction stresses at 10 min after polymerization were significantly reduced with the soft-start curing both in plasma and LED light sources(P<0.05). 2. Plasma light curing with soft-start resulted in not only the lowest contraction stress, but also the lowest hardness (P<0.05). 3. LED light curing with soft-start showed lower contraction stress than the one-step continuous halogen and LED light curing(P<0.05). 4. Micro hardness of specimens cured by LED light with soft-start was equivalent to that of cured by the one-step continuous halogen and LED light(P>0.05). 5. Curing by LED light with soft-start and conventional halogen light resulted in better marginal sealing than plasma light and one-step LED light curing.

Antioxidant and hepatoprotective effects of Korean ginseng extract GS-KG9 in a D-galactosamine-induced liver damage animal model

Yun Ho Jo,Hwan Lee,Myeong Hwan Oh,Gyeong Hee Lee,You Jin Lee,Ji Sun Lee,Min Jung Kim,Won Yong Kim,Jin Seong Kim,Dae Seok Yoo,Sang Won Cho,Seon Woo Cha,Mi Kyung Pyo 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.4

BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6 groups. Rats were orally administrated with GS-KG9 (300, 500, or 700 mg/kg) or silymarin (25 mg/kg) for 2 weeks. The rats of the GS-KG9- and silymarin-treated groups and a control group were then intraperitoneally injected Ga1N at a concentration of 650 mg/kg for 4 days. To investigate the protective effect of GS-KG9 against GalN-induced liver injury, blood liver function indicators, anti-oxidative stress indicators, and histopathological features were analyzed. RESULTS: Serum biochemical analysis indicated that GS-KG9 ameliorated the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in GalN-treated rats. The hepatoprotective effects of GS-KG9 involved enhancing components of the hepatic antioxidant defense system, including glutathione, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT). In addition, GS-KG9 treatment inhibited reactive oxygen species (ROS) production induced by GalN treatment in hepatocytes and significantly increased the expression levels of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins, which are antioxidant proteins. In particular, by histological analyses bases on hematoxylin and eosin, Masson"s trichrome, α-smooth muscle actin, and transforming growth factor-β1 staining, we determined that the administration of 500 mg/kg GS-KG9 inhibited hepatic inflammation and fibrosis due to the excessive accumulation of collagen. CONCLUSIONS: These findings demonstrate that GS-KG9 improves GalN-induced liver inflammation, necrosis, and fibrosis by attenuating oxidative stress. Therefore, GS-KG9 may be considered a useful candidate in the development of a natural preventive agent against liver injury.

유해화학물질의 계통분석

박성우,박유신,이진훈,김남이,김유나,임미애,이상기,유재훈,진광호,신호상,노동석 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

TNF-α로 유도된 혈관내피세포의 혈관염증에 미치는 오적산(五積散)의 억제 효과

한병혁 ( Byung Hyuk Han ),윤정주 ( Jung Joo Yoon ),김혜윰 ( Hye Yoom Kim ),안유미 ( You Mee Ahn ),홍미현 ( Mi Hyeon Hong ),손찬옥 ( Chan Ok Son ),나세원 ( Se Won Na ),이윤정 ( Yun Jung Lee ),강대길 ( Ho Sub Lee ),이호섭 대한본초학회 2018 大韓本草學會誌 Vol.33 No.4

Objectives : Ojeoksan, originally recorded in an ancient Korean medicinal book named “Donguibogam” and has been used for the treatment of circulation disorder of blood which was called blood accumulation (血積) in Korean medicine. Therefore, this study was carried out to investigate the beneficial effect of OJS on vascular inflammation in HUVECs. Methods : We evaluated the effect of OJS on the expression of cell adhesion molecules and protective role in HUVEC stimulated by TNF-α by using Western blot. Results : Pretreatment with OJS decreased the adhesion of HL-60 cells to TNF-α-induced HUVEC. OJS suppressed TNF-α-induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and endothelial cell selectin (E-selectin). Moreover, OJS significantly decreased TNF-α-induced production of intracellular reactive oxygen species (ROS); and inhibited the phosphorylation of IκB-α in the cytoplasm compared to the experimental group. Pretreatment with OJS inhibited the trans-location of NF-κB p65 to the nucleus. OJS also inhibited phosphorylation of MAPKs compared to the experimental group. OJS significantly increased the protein expression of Nrf2 and HO-1. Conclusions : Ojeoksan has a protective effect on vascular inflammation, and might be a potential therapeutic agent for early atherosclerosis.

만성 신부전증 환자의 중중 고혈당에 따른 의식 변화 결정에 대한 연구

위형중,이창범,박성광,강성귀,임천규,박은주,윤경택,한상웅,안유헌,김호중· 대한신장학회 2000 대한신장학회잡지 Vol.19 No.6

전자선치료시 유효 선원 피부간 거리 결정에 관한 연구

이병구,이상록,정덕양,권영호,김유현 高麗大學校 倂設 保健大學 保健科學硏究所 2002 保健科學論集 Vol.28 No.2

Under the various clinical circumstances, there is a condition to change source to skin distance(SSD). It is possible to correct photon beam by well-known inverse square law. On the other hand, the electron beam is not exact location of source, that's why it is difficult to apply as it is. In case of electron beam, we should correct the difference of SSD by measure effective SSD . There are many ways to measure effective SSD. In this study, Faiz Khan's method was used. The measurement energy is 6,9,12,16,20 MeV and field size is set standard applicator 6×6, 10×10, 15×15, 20×20, 25x25㎠. From the bottom of the standard applicator to skin distance is set to 5㎝. So we measured dose at the gap to 0∼20㎝. According to a production company of linear accelerator, or even though same production company, the qualities of electron beam can be different. So, effective SSD can be different every several accelerator. Therefore, it is desirable to use the effective SSD measured at every electron beam energy and field size actually.