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Evaluation of Plasma NT-proBNP oncentration in Dogs with Chronic Mitral Valve insufficiency
이승곤,현창백 한국임상수의학회 2013 한국임상수의학회지 Vol.30 No.3
This study aimed to evaluate the plasma concentration of NT-proBNP in dogs with different stages of heart failure by chronic mitral valve insufficiency (CMVI). Fifty small-breed dogs with CMVI and 7 healthy control dogs without cardiac disease and critical systemic diseases were included in the study population. As a preliminary study,we compared the plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the echocardiographic parameters between dogs of the International Small Animal Cardiac Health Council (ISACHC) classes. Then,we evaluated the associations between NT-proBNP and echocardiographic parameters. Plasma NT-proBNP levels showed a significant difference among the ISACHC groups. In the comparison between echocardiographic parameters and NT-proBNP, NT-proBNP were found to be associated with left atrium/aorta (LA/AO), early diastolic transmitral flow (E) velocity, late diastolic transmitral flow (A) velocity, end diastolic volume index (EDVI). Our study found plasma NT-proBNP might be useful to predict the disease progression in dogs with CMVI.
이승곤,박성한,이정원,임혜민,정선영,박인철,박수철 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6
A putative cold shock protein gene, designated asArCspA, was isolated from Arthrobacter sp. A2-5 extracted fromsoil at the South Pole. The ArCspA gene is 873 nucleotide bp longand includes a 207-bp short open reading frame (ORF) with 49.3–92% amino acid identity to peptide sequences of other bacterialcold shock proteins. Northern blot analysis revealed that ArCspAwas highly expressed at low temperatures. Bio-functional analysisusing ArCspA-overexpressed transgenic Saccharomyces cerevisiaeshowed that ArCspA conferred cold tolerance on yeast at lowtemperatures (15oC). We then developed an ArCspA-overexpressedtransgenic tobacco line to determine whether ArCspA is alsofunctional in plants. After cold treatment at −25oC for 90 minfollowed by recovery for 4 weeks at 25oC, 17 transgenic linessurvived at a high rate (60.0%), whereas under the same treatmentconditions, wild-type plants did not survive. We also found thatprogeny of transgenic tobacco plants subjected to freezing stressat −20oC had significantly higher seed germination ability thanwild-type plants. These results clearly indicate that the ArCspAprotein plays an important role in cold tolerance in both yeast andplants.
Partial Atrioventricular Canal Defect in a Maltese Dog
이승곤,남소정,문형선,현창백 한국임상수의학회 2008 한국임상수의학회지 Vol.25 No.3
A 2-year-old female Maltese dog was referred with primary complaints of exercise intolerance and abnormalheart sound. Clinical and diagnostic investigation revealed split S2 and S4 gallop in the cardiac auscultation, tall Postium primum atrial septal defect and cleft of the anterior leaflet of the mitral valve on the echocardiography. Basedon those findings, the dog was diagnosed as the partial atrioventricular canal defect. Since the dog showed mild exerciseintolerance, enalapril and furosemide were prescribed.
The Relationship between Homocysteine, Obesity, Glucose and Lipid Profiles in Small-Breed Dogs
이승곤,남효승,현창백 한국임상수의학회 2012 한국임상수의학회지 Vol.29 No.4
This study was conducted to evaluate whether plasma homocysteine levels were related to obesity or its contributing factors (e.g., lipids, insulin, glucose, glucagon, and fructosamine) in dogs without systemic diseases such as diabetes or renal failure. For achieving our study goal, 100 client-owned dogs without systemic diseases were enrolled in this study. Fasting glucose concentration; lipid profile (i.e., total triglycerides [TG], total cholesterol [TC], highdensity lipoprotein cholesterol [HDL-C], and low-density lipoprotein cholesterol [LDL-C]); and fructosamine, insulin,and glucagon levels were determined. The dogs were subdivided by the body condition score (BCS). The median levels of homocysteine were considerably higher in obese dogs than in lean and normal dogs. Interestingly, not only was homocysteine positively associated with the level of HDL-C, but also found to have a significant positive association with TG, TC, plasma glucagon levels, and fructosamine. In contrast, LDL-C, fasting glucose and insulin did not show any association with homocysteine. The findings presented, suggest that elevated levels of homocysteine may play a biological role in obesity in dogs.