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중국 靑島의 한국 산업 이전 유치효과 향상방안 연구 : 靑島 진출 한국 기업의 투자동기 분석을 중심으로
徐永輝,全冬梅 신라대학교 경제경영연구소 2007 경제경영연구 Vol.8 No.-
This study analyzed the main motive of Korean firm's FDI into Qingdao of China in order to improve the effects of attracting Korean firm's FDI to Qingdao. This study first researched the literatures and studies on FDI motive systematically. Then classified it into two groups(low product's costs and Chinese domestic market) and measured Korean firm's features of real motive using survey data of (Korean) firm-level in Qingdao. Finally discussed and showed suggestions for Improving effects of attracting Korean firm's FDI to Qingdao.
마그네슘 풍부 해양미네랄 용액이 hairless 마우스의 아토피성 피부염에 미치는 영향
김동희,이규재,최주봉,이영미,윤양숙,김정례,장병수,양용석 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.3
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p<0.01), and a decrease in epidermal water loss (p<0.01). Serum IgE level was also significantly decreased (p<0.01). These results suggest that magnesiumrich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD. 아토피성 피부염은 주로 천식과 비염 등을 동반하는, 주위에서 흔히 볼 수 있는 만성 염증성 피부질환으로 유전학적, 환경적, 면역학적 요인이 복잡하게 연관되어 발병한다. 해수에 포함된 마그네슘염은 피부에 작용하여 피부장벽을 보호하는 것으로 알려지고 그에 대한 면역학적인 연구와 조직학적 연구는 아직 부족한 실정이다. 이번 연구에서는 피부염을 인위적으로 일으키는 hapten 형성물질인 DNCB를 hairless mice에 도포하여 아토피 피부염 동물 모델로 만든 후, 마그네슘이 다량 함유된 해양 미네랄수를 처리한 후 피부장벽에 미치는 영향을 관찰하였다. DNCB로 피부염을 유발한 hairless mice에 해양미네랄수를 국소적으로 도포하였을 때 유의한 피부수분함량이 증가와 경피수분손실의 감소를 확인하였다 (p<0.01). 피부측정에서 피부거칠기(skin roughness, p<0.05)와 스케일생성 (skin scaliness, p<0.01)은 실험군에서 유의한 개선효과를 나타내었으며 조직학적 검사에서도 피부손상지수의 유의한 감소 (p<0.01)와 비만세포와 (p<0.01) 호산구의 감소(p<0.05) 소견을 보였고 또한 혈청 IgE의 감소를 관찰할 수 있었다(p<0.01). 이상과 같이 마그네슘이 다량 함유된 해양 미네랄수 도포는 피부장벽의 손상을 줄이고 피부수분손실을 효과적으로 줄임으로 아토피성 피부염 증상 유발을 억제할수 있음을 확인하였다. 현재까지 아토피성 피부염의 관리를 위하여 세라마이드나 식물성 오일의 보습제가 주로 활용되고 있는 상황에서 부가적인 피부장벽의 보호를 위하여 탈염 해양 미네랄수의 활용이 가능할 것으로 판단되며 장기적으로 아토피 피부염치료의 대체, 혹은 보조적 물질로 활용될 수 있을 것으로 기대된다.
Hyperglycemia Influences Apoptosis and Autophagy in Porcine Parthenotes Developing In Vitro
Xu, Yong-Nan,Li, Ying-Hua,Lee, Sung Hyun,Kwon, Jung-Woo,Lee, Seul Ki,Heo, Young-Tae,Cui, Xiang-Shun,Kim, Nam-Hyung The Korean Society of Animal Reproduction 2013 Reproductive & developmental biology Vol.37 No.2
The objective of this study was to examine the effects of high concentrations of glucose on porcine parthenotes developing in vitro. Addition of 55 mM glucose to the culture medium of embryos at the four-cell-stage significantly inhibited blastocyst formation, resulting in fewer cells in blastocyst-stage embryos and increased levels of apoptosis and autophagy compared to control. Quantitative reverse transcriptase (RT) PCR analysis revealed that the expression of pro-apoptotic genes (Caspase 3, Bax and Bak) and autophagy genes (Atg6 and Atg8/Lc3) were increased significantly by the addition of 55 mM glucose to the culture medium compared to control. MitoTracker Green fluorescence revealed a decrease in the overall mitochondrial mass compared to control. However, the addition of 55 mM glucose had no effect on mRNA expression of the nuclear DNA-encoded mitochondrial-related genes, cytochrome oxidase (Cox) 5a, Cox5b and Cox6b1. These results suggest that hyperglycemia reduced the mitochondrial content of porcine embryos developing in vitro and that this may hinder embryonic development to the blastocyst stage and embryo quality by increasing apoptosis and autophagy in these embryos.
AN EXECUTABLE SPECIFICATION LANGUAGE-ChiSL
Xu, Chuang,Xu, Yong Sen 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
ChiSL, originally named NUSL, is an applicative executable specification language, centred around the concept of data abstraction, with module costruct in it. Both the algebraic and the model-oriented specification techniques of abstract data types are embedded in the language. ChiSL is an applicative language which is readable and mathematical. With the module construct, it is convenient to use ChiSL to write large specifications. Because the language is executable, a specification in ChiSL may be viewed as a prototype of the specified system and be executed on the supporting system. In this paper, we also show an application in developing a management system of library using ChiSL and its supporting system.
Xu, Yong-Kui,Hwang, Sekyu,Kim, Sungjee,Chen, Ji-Yao American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.8
<P>The metal-enhanced fluorescence (MEF) by metal nanoparticles is a useful technique for fluorescence detections in biological systems. The MEF effects with gold nanorods (AuNRs) and nanocubes (AuNCs) for fluorescence enhancements of sulfonated aluminum phthalocyanine (AlPcS), a commonly used and clinical approved photosensitizer for photodynamic therapy of cancers, were studied in this work. For the AuNRs which have the low aspect ratios with the corresponding longitudinal surface plasma resonance (LSPR) band in the region of 600–750 nm, the fluorescence quenching of conjugated AlPcS was found. Whereas for the AuNRs that have the LSPR bands of 800–900 nm, the MEF of AlPcS was obtained with the enhancing factor of 2–6 times, respectively. Using AuNCs, a great enhancement of AlPcS fluorescence was achieved with an enhancing factor of 150 times. Using two cancer cell lines as in vitro models, an outstanding fluorescence enhancement of AlPcS-AuNCs conjugates in cells, relative to AlPcS alone, was obtained under one-photon excitation (OPE) of 405 nm. Moreover, the bright fluorescence image of AlPcS-AuNCs in cells was also achieved under the two-photon excitation (TPE) of an 800 nm femtosecond laser. The high-quality cell imaging with either OPE or TPE demonstrated the potential of AlPcS-AuNCs in cancer cell detections.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-8/am500106c/production/images/medium/am-2014-00106c_0012.gif'></P>
Amperometric Determination of Nitrite at Poly(Methylene Blue)-Modified Glassy Carbon Electrode
Xu, Guang-Ri,Xu, Guifang,Xu, Ming-Lu,Zhang, Zhengqing,Tian, Yuan,Choi, Han-Nim,Lee, Won-Yong Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.2
Electrochemical characteristics of nitrite ion were investigated at a poly(methylene blue)-modified glassy carbon electrode by cyclic voltammetry and differential pulse voltammetry. The poly(methylene blue)-modified glassy carbon electrode exhibited enhanced anodic signals for nitrite. The effects of key parameters on the detection of nitrite were evaluated at the modified electrode, such as pH, accumulation time, and scan rate. Under optimum condition, the chemically modified electrode can detect nitrite in the concentration range $2.0{\times}10^{-6}$ to $5.0{\times}10^{-4}$ M with the detection limit of $2.0{\times}10^{-6}$ M and a correlation coefficient of 0.999. The detection of nitrite using the chemically modified electrode was not affected by common ions such as $Na^+$, $K^+$, $Ca^{2+}$, $Cl^-$, $HPO_4^{2-}$ and $H_2PO_4^- $. The modified electrode showed good stability and reproducibility. The practical application of the present method was successfully applied to the determination of nitrite ion in cabbage samples.