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식물에서 분리된 phenolic compound의 항암활성
이도익,조장현,이민원,홍순각 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-
3,4'-dihydroxypropiophenone, a phenylpropanoid, purified from Betula platyphylla var. latifolia was evaluated on the antitumor activity. In vitro, the cytoxicity was determined by 0.4% trypan blue dye exclusion method. And the most sensitivity cell line was L5178Y(ED_50=0.96ug/ml). The ED_50 of 3, 4'-dihydroxypropiophenone against sarcoma-180, L-1210 were 8.77 and 2.69ug/ml respectively. As a result, 3, 4'-dihydroxypropiophenone was considered to show the antitumor activity.
김석규,장원익,남정칠 東亞大學校建設技術硏究所 2004 硏究論文集 Vol.28 No.1
The the purpose of this study is to propose vegetation management device through analyzing vegetation structure and phytocociological Changes for ten years in Mt. Geumjeong. Eight belt transects of quadrat(20m×20m) were sampled to investigate and analyze the vegetation structure.
저질에 따른 바지락(Ruditapes philippinarum)의 염분내성
한경호,오성현,장선익,이우범,이원교 國立 麗水大學校 環境問題硏究所 2000 環境硏究論文集 Vol.3 No.-
Salinity tolerance of the manila clam, Ruditapes philippinarum in Gang-jin Bay on the from May to June was investigated in two different types of sedimentary composition. In the experimental groups of sandy-mud, the survival and infiltration rate were good at 20~40ppt, but all the manila clam, Ruditapes philippinarum died at more than 50ppt and less than 10ppt before the experiment finish. In the experimental groups of muddy, the survival and infiltration rate were the best at 25~35ppt and then 20ppt, 40ppt. All the manila clam, Ruditapes philippinarum died at more than 45ppt and less than 15ppt. The survival rate in the experimental groups of sandy-mud was higher than muddy ones, and the infiltration rate was the highest at 20~35ppt in the both of two experimental groups. In the sand-mud, the manila clam, Ruditapes philippinarum infiltrated half of their shells but in the muddy, they infiltrated more then half of their shells.
수평횡파형 유도초음파 산란에 대한 혼합형 경계요소 모델링
조윤호,이준현,Rose, J. L.,정상훈,장영익,이원근 한국비파괴검사학회 2004 학술대회 논문집 Vol.- No.-
Overlap에서의 유도 초음파 산란에 대한 정량적인 예측을 가능하게 하고 유도 초음파를 이용한 효율적인 NDE가 overlap 구조물들에서 수행되어지기 위해서 혼합형 경계요소법을 이용하였다. 다양한 joint를 가진 다층 구조물에서 적절한 모드를 선택하고 주파수를 조정함으로써 수행되어졌다. 두께의 차이에 의한 전달과 반사의 값들의 변화를 살펴보고 정해진 형상에서의 주파수 증가와 다수의 파동을 포함한 긴 overlap 길이를 가진 모델에 대한 산란 선도의 변동을 보여주게 된다.
간문부 담관암 환자에서 경피경관 양측성 금속 배액관의 효과
김금래,김주형,박원규,장재천,조재호,김태년,김준화,장병익 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Background: The purpose of this study was to determine the effectiveness of percutaneously place self-expanding metallic stent for the relief of biliary obstruction in patients with hilar cholangiocarcinoma. Materials and Methods: From November 2001 to December 2004, 48 patients with hilar cholangiocarcinoma were prospectively studied. After percutaneous placement of bilateral self-expanding, uncovered metallic stents, follow-up evaluation was carried out until July 2005. Results: There were 4 cased of Bismuth type Ⅱ,21 cases of Bismuth typeⅢa 8 cases of Bismuth type Ⅲb and 15 cases of Bismuth type Ⅳ. Stent placement was technically successful in all patients All patients had satisfactory biliary drainage, resulting in one week drainage rate of 72.8% and final drainage of 91.9% There were 12 cases (21.3%) of abdominal pain requiring analgesics and 1 case (7.1%) of cholangitis; both were successfully managed with conservative treatments. Late complications occurred in four patient (8.3%), including two patients with cholangitis, one patient with liver abscess, and one patient with biloma; all were appropriately managed by percutaneous drainage. The average length and median durations of stent patency and median survival time were 303 days (range, 60~815) and 338 days (range, 60 ~1175), respectively. Conclusion: Placement of a percutaneous metallic stent is an effective and safe method of palliation of patients with hilar cholangiocarcinoma.
한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률
조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4
Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.
김계형,김낙현,김문석,김충종,전재현,박완범,장원종,박상원,김익상,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6
Infectious diseases imported from other countries have increased as more and more Koreans are going abroad for various purposes. Tsutsugamushi disease from other endemic area such as Southeast Asia is important, because it can occur in any season and eschar may be absent. We report a case of imported tsutsugamushi disease acquired in the Philippines. A patient presented with fever, headache, and maculopapular skin rash. However, eschar was absent. Polymerase chain reaction (PCR) for 56-kDa gene of Orientia tsutsugamushi using buffy coat was positive. Serum indirect immunofluorescent antibody assay was initially negative but became positive with a titer of 1:320 at follow-up, Sequencing analysis revealed the strain to be 100% identical to the TW73R strain identified in Taiwan. After the patient received doxycycline, body temperature normalized in 12 hours. Tsutsugamushi disease is one of the differential diagnoses that should be included for patients with fever who have recently returned from Southeast Asian countries. PCR for O. tsutsugamushi using patient's buffy coat was useful for early diagnosis.
( Won Ik Jang ),신영태 ( Young Tai Shin ),함영록 ( Young Rok Ham ),정지윤 ( Ji Yoon Jung ),장동석 ( Dong Suk Chang ),정사라 ( Sa Rah Chung ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6
Purpose: Intracranial manifestations associated with autosomal dominant polycystic kidney disease (ADPKD) include arachnoid cysts, dolichoectasias, and subdural hematoma (SDH), although there are only a few reports of SDH in patients with ADPKD. We report a case of spontaneous SDH in a patient with ADPKD. A 33-year-old woman complained of severe nausea and vomiting for 10 days. She had suffered from a headache for several months. She was diagnosed with ADPKD and hypertension 6 years earlier, and the hypertension was well controlled. Her mental state was drowsy in the emergency room. Her blood pressure was 180/105 mmHg. There was no evidence of head trauma. Results of a peripheral blood CBC and blood chemistry analysis were within normal limits, as were the results of a blood coagulation test and urinalysis. She was pregnant and in the eighth week of gestation. Brain magnetic resonance imaging revealed SDH in the left lateral convexity and focally in the right lateral convexity, and brain herniation. Surgical drainage was performed through a burr hole, under general anesthesia. Intra-operatively, 62 mL of liquefied subdural hematoma were removed. She recovered completely without sequelae.
( Won Ik Jang ),( Hyun Jun Ju ),( Dae Eun Choi ),( Ki Ryang Na ),( Kang Wook Lee ),( Young Tai Shin ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Introduction: Percutaneous biopsy of the kidney is a standard procedure to evaluate renal parenchymal disease in native kidneys and in renal transplants. The percutaneous approach using real-time ultrasound guidance and automated biopsy device is the standard method of obtaining tissue in patients without complications. This procedure remains safe with a few risks to the patients and provides adequate tissue for diagnosis in at least 95% of cases. However, serious complications, although rare, may occur in 2.7% of the patients and the majority of these are related to bleeding. We report a case of huge perirenal hematoma with renal dysfunction after percutaneous needle renal biopsy in transplanted kidney. Case: A 63-year old man presented with fever, chill, rhinorrhea from 3 days ago. He underwent a kidney transplant operation donated from his wife last year. He had been on regular hemodialysis for 3 years due to hypertensive ESRD.He was diagnosed upper respiratory tract infection and had been taken conservative management. Ultrasound sonograghy revealed no structural abnormality in transplanted kidney. The CBC showed WBC 13,270 /uL,Hb13.5 g/dl, platelet 135,000 cells/uL. The coagulation profile was normal. The blood chemistry revealed a serum creatinine level of 3.0 mg/dL from 1.1 mg/dL last 1 month. His urine output was good. He was performed a percutaneous ultrasound-guided allograft renal biopsy on the 3rd day in hospital. We had used 16G automated gun needle and gotten 5 pieces of tissue. The histologic diagnosis was acute rejection type IA. On 4 days after biopsy, his serum creatinine elevated up to 8.2 mg/dL and his urine output decreased to 300 ml/day. Abdominal computed tomography angiography showed a 8.5 X 2.8 cm hematoma at lateral aspect of transplanted kidney. Tc-99m DTPA Renal Perfusion &Renogram showed marked decreased perfusion and excretion in transplanted kidney. We intended radiologic intervention of drainage catheter insertion to perirenal hematoma, but the procedure failed. He performed acute hemodialysis two days. His serum creatinine decreased to 1.7 mg/dL and urine output increased to 2,700 ml/day after 5 days from acute hemodialysis. On the 22nd day in hospital, He was discharged.