응급실을 내원한 구강악안면외과 안면골 골절 환자의 변화에 대한 비교 연구

신상훈,성화식,강영훈,황대석,김용덕,김욱규,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Although there have been many clinical studies about the facial trauma in the recent as well as in the past, severity and frequency of facial trauma are reported multifarious. It seemed to be because of variety of social, cultural, and environmental factors, and the view point of investigators. In this study, we investigated about the patients visiting emergency room during recent 4 years(2004-2007), and compared with retrospective study during former 10 years(1992-1996, 1999-2003) in Dept. OMS Pusan National University Hospital. We assessed the cause, type, demographic, etc, and analyzed alterations of facial bone fractures during past 3 periods. The results were as follows. The total number of patients was increased. 429 patients treated for maxillofacial fractures between January 1992 and December 1996, 466 patients treated between January 1992 and December 1996 and 764 patients treated between January 2004 and December 2007. The male-to-female ratio were 4.6:1, 3.9:1, and 4.16:1, respectively. Patient in the age groups of 10-19 years and 20-29 years increased in the latter two periods. Assaults and falls are decreased gradually, but slip down s are increased. Traffic accidents are still major cause of facial trauma. The mandibular fractures showed the highest incidence thorought three periods. Symphysis fractures of mandible was increased and condyle fractures of mandible was drecreased in the third period.

Prevalence of Chronic Obstructive Pulmonary Disease in Korea: The Result of Forth Korean National Health and Nutrition Examination Survey

Hwang, Yong-Il,Yoo, Kwang-Ha,Sheen, Seung-Soo,Park, Joo-Hun,Kim, Sang-Ha,Yoon, Ho-Il,Lim, Sung-Chul,Lee, Shin-Yup,Park, Jae-Yong,Park, Seoung-Ju,Seo, Ki-Hyun,Kim, Ki-Uk,Lee, Sang-Yeub,Park, In-Won,Lee The Korean Academy of Tuberculosis and Respiratory 2011 Tuberculosis and Respiratory Diseases Vol.71 No.5

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world and is the only major disease that is continuing to increase in both prevalence and mortality. The second Korean National Health and Nutrition Survey revealed that the prevalence of COPD in Korean subjects aged ${\geq}45$ years was 17.2% in 2001. Further surveys on the prevalence of COPD were not available until 2007. Here, we report the prevalence of spirometrically detected COPD in Korea, using data from the fourth Korean National Health and Nutrition Survey (KNHANES IV) which was conducted in 2007~2009. Methods: Based on the Korean Statistical Office census that used nationwide stratified random sampling, 10,523 subjects aged ${\geq}40$ years underwent spirometry. Place of residence, levels of education, income, and smoking status, as well as other results from a COPD survey questionnaire were also assessed. Results: The prevalence of COPD (defined as forced expiratory volume in 1 sec/forced vital capacity <0.7 in subjects aged ${\geq}40$ years) was 12.9% (men, 18.7%; women, 7.5%). In total, 96.5% of patients with COPD had mild-to-moderate disease; only 2.5% had been diagnosed by physicians, and only 1.7% had been treated. The independent risk factors for COPD were smoking, advanced age, and male gender. Conclusion: The prevalence of COPD was 12.9% in the KNHANES IV data. Most patients with COPD were undiagnosed and untreated. Based on these results, a strategy for early COPD intervention is warranted in high risk subjects.

DNA Chip Technologies

Hwang, Seoung-Yong,Lim, Geun-Bae The Korean Society for Biotechnology and Bioengine 2000 Biotechnology and Bioprocess Engineering Vol.5 No.3

The genome sequencing project has generated and will contitute to generate enormous amounts of sequence data. Since the first complete genome sequence of bacterium Haemophilus in fluenzae was published in 1995, the complete genome sequences of 2 eukaryotic and about 22 prokaryotic organisms have detemined. Given this everincreasing amounts of sequence information, new strategies are necessary to efficiently pursue the phase of the geome project- the elucidation of gene expression patterns and gene product function on a whole genome scale. In order to assign functional information to the genome sequence, DNA chip technology was developed to efficienfly identify the differential expression pattern of indepondent biogical samples. DNA chip provides a new tool for genome expreesion analysis that may revolutionize revolutionize many aspects of human kife including mew surg discovery and human disease diagnostics.

Prevalence of Chronic Obstructive Pulmonary Disease in Korea: The Result of Forth Korean National Health and Nutrition Examination Survey

( Yong Il Hwang ),( Kwang Ha Yoo ),( Seung Soo Sheen ),( Joo Hun Park ),( Sang-Ha Kim ),( Ho Il Yoon ),( Sung Chul Lim ),( Shin Yup Lee ),( Jae Yong Park ),( Seoung Ju Park ),( Ki Hyun Seo ),( Ki Uk K 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.5

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world and is the only major disease that is continuing to increase in both prevalence and mortality. The second Korean National Health and Nutrition Survey revealed that the prevalence of COPD in Korean subjects aged ≥45 years was 17.2% in 2001. Further surveys on the prevalence of COPD were not available until 2007. Here, we report the prevalence of spirometrically detected COPD in Korea, using data from the fourth Korean National Health and Nutrition Survey (KNHANES IV) which was conducted in 2007∼2009. Methods: Based on the Korean Statistical Office census that used nationwide stratified random sampling, 10,523 subjects aged ≥40 years underwent spirometry. Place of residence, levels of education, income, and smoking status, as well as other results from a COPD survey questionnaire were also assessed. Results: The prevalence of COPD (defined as forced expiratory volume in 1 sec/forced vital capacity <0.7 in subjects aged ≥40 years) was 12.9% (men, 18.7%; women, 7.5%). In total, 96.5% of patients with COPD had mild-to-moderate disease; only 2.5% had been diagnosed by physicians, and only 1.7% had been treated. The independent risk factors for COPD were smoking, advanced age, and male gender. Conclusion: The prevalence of COPD was 12.9% in the KNHANES IV data. Most patients with COPD were undiagnosed and untreated. Based on these results, a strategy for early COPD intervention is warranted in high risk subjects.

근육질환 진단의 최근 진전

黃龍昇 대한의학협회 1995 대한의학협회지 Vol.38 No.6

신생아 경련

黃龍昇 대한의학협회 1993 대한의학협회지 Vol.36 No.6

결핵균 및 기타 3종 Mycobacteria 의 파쇄추출항원과 교차반응하는 폐결핵환자의 항체분석

황응수,조명제,심영수,김익상,차창용,국윤호,이승훈,한용철,배길한,김상재 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1

It is important to discriminate between tuberculosis and tuberculosis-like disease by Mycobacteria other than tuberculosis in the serodiagnosis of tuberculosis. But because common antigens share among Mycobacteria, their antigenicities to human are similar. Therefore degree of cross-reactivity of anti-body in the sera of patients with tuberculosis between M. tuberculosis and Mycobacteria other than tu- berculosis should be checked to increase the specificity in the serodiagnosis of tuberculosis. The activity levels of IgG antibody in the sera of 106 patients confirmed as active pulmonary tuber-culosis and 30 normal healthy control person to the pressate extract antigen (TE, BE, AE, and FE antigen) from M. tuberculosis, M. bovis, M. avium, and M. fortuitum were measured by enzyme-linked immunosorbe:nt assay and the crossreactivity of IgG antibody with mycobacterial species was analysed. The results were as follows; 1. The activity level (O.D. at 492nm) of 1gG to TE antigen in sera of patients with pulmonary tuber- culosis was 0.228±0.167 in minimal tuberculosis; moderately advanced, 0.556±0.616; far advanced, 1.116±0.651 and 0.315±0.245 in miliary tuberculosis. 2. The actiivity level (O.D. at 492nm) of IgG to BE antigen in sera of patients with pulmonary tu-berculosis was 0.190+0.162 in minima1 tuberculosis; moderately advanced, 0.337+0.361; far advanced, 0.713+0.460 and 0.204±0.162 in miliary tuberculosis. 3. The activity level (O.D. at 492nm) of IgG to AE antigen in sera of patients with pulmonary tu-berculosis was 0.165±0.114 in minimal tuberculosis; moderately advanced, 0.392±0.494; far adven- ced, 0.751±0.512 and 0.2330.191 in miliary tuberculosis. 4. The activity level (O.D. at 492nm) of IgG to FE antigen in sera of patients with pulmonary tub- erculosis was 0.280±0.227 in minimal tuberculosis; moderately advanced, 0.460±0.564; far advan- ced, 0.845±0.573 and 0.257±0.103 in miliary tuberculosis. 5. The activity level (O.D. at 492nm) of IgG in sera of healthy control person was 0.126±0.084 to TE antigen, 0.105±0.041to BE antigen, 0.103±0.052 to AE antigen, and 0.095±0.061 to FE antigen. 6. Degree of correlation(r) in activity level of IgG between TE antigen and BE antigen was 0.905; between TE antigen and AE antigen, 0.760; between TE antigen and FE antigen, 0.790, and be- tween AE antigen and FE antigen,0.945. 7. As O.D. above 0.200 was determined positive for the serodiagnosis of pulmonary tuberculosis, the sensitivity and specificity in ELISA using TE antigen were 80% and 87% respectively, whereas in the case of using BE antigen, 66% and 100%; in the case of using AE antigen, 62% and 100 %, and in the case of using FE antigen, 72% and 93%, respecitively.

The Effect of Ankle Balance Dual Task Including Motor Training on Static Balance and Dynamic Balance in the Elderly

( Seoung-uk Park ),( Yong-ho Cho ),( Yoon-tae Hwang ) 대한물리의학회 2017 대한물리의학회지 Vol.12 No.3

PURPOSE: The purpose of this study was to investigate the effect of ankle dual task including motor training on the static balance, dynamic balance in the elderly. METHODS: 30 elderly people were randomly divided into 3 groups: 10 people in the single motor task group, 10 people in the double motor dual task group and 10 people in the motor-cognitive dual task group. In the double motor dual tasks group was performed ankle balance motor task additional motor task. Motor-cognitive dual task group was performed ankle balance motor task additional cognitive task. Single motor task group was performed ankle balance motor task. It was performed three times intervention a week for six weeks. Statistical analysis method was performed using one way ANOVA for comparison between groups, and the paired t-test was used for comparison pre and post intervention. RESULTS: Static and dynamic balance were significant differences between pre and post intervention by three groups (p<.05). In static balance, there was a significant difference among groups (p< .05), but there was not a significant difference between groups in dynamic balance (p >.05). CONCLUSION: The results of the research, the ankle balance dual task including motor or cognitive task was more effective than single motor task on static balance in the elderly.

급성 췌장염의 진단에 있어서 Urinary Trypsinogen-2 Dipstick 검사의 유용성

황성준 ( Seoung Joon Hwang ),정준표 ( Jun Pyo Chung ),김영균 ( Young Gyun Kim ),송대훈 ( Dae Hoon Song ),이재성 ( Jae Sung Lee ),백승석 ( Seung Seok Baek ),김도연 ( Do Yun Kim ),이덕용 ( Dok Yong Lee ),정연수 ( Yon Soo Jeong ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.6

Background/Aims: The clinical usefulness of urinary trypsinogen-2 dipstick test is still in controversy. We evaluated the usefulness of urinary trypsinogen-2 dipstick test in patients with acute pancreatitis. Methods: Urinary trypsinogen-2 dipstick test was prospectively performed in 50 patients with acute pancreatitis, 50 patients with non-pancreatic abdominal pain, and 50 healthy controls. Results: On admission, urinary trypsinogen-2 dipstick test was positive in 36 of 50 patients with acute pancreatitis (sensitivity, 72%) and in 4 of 50 patients with non-pancreatic abdominal pain (specificity, 92%). On the other hand, it was all negative in controls. The sensitivity and specificity of serum lipase were 78% and 94%, respectively. At 24 hours after admission, the positive rate of urinary trypsinogen-2 dipstick test rose from 72% to 94% (p=0.02). The results of urinary trypsinogen-2 dipstick test was positive in 14 of 15 patients with severe pancreatitis and 22 of 35 patients with mild pancreatitis according to the criteria by Atlanta International Symposium, 1992. Conclusions: Urinary trypsinogen-2 dipstick test is comparable to serum lipase in diagnosing acute pancreatitis. Delayed measurement and severe pancreatitis are more likely to yield positive results with urinary trypsinogen-2 dipstick test. Thus, we suggest that the cut-off value of urinary trypsinogen-2 dipstick test should be lowered to increase its sensitivity. (Korean J Gastro-enterol 2004;43:364-369)

Effects of Chlorella Dietary Supplementation on Bone Biochemical Markers of Turnover in Postmenopausal Women

Kim, Yong-Ho,Hwang, Yoo-Kyeong,Hwang, Jung-Min,Seoung, Hee-Kyung,Kim, Dong-Uk 대한의생명과학회 2003 Biomedical Science Letters Vol.9 No.1

Currently bone biochemical markers are considered to be the best indicators of present and the future state of bone turnover. A recent study has reported that chlorella increases the bone mineral density (BMD) on postmenopausal women, but presently there are no studies on bone biochemical markers treated with chlorella dietary supplementation. The purpose of the present study was to assess the bone biochemical markers for the short term and long term treatment groups, and non-treatment group as a control. Twenty two postmenopausal woman were treated for four months and eighteen for one year with 4 gm of chlorella dietary supplementation per day, and then assessed bone biochemical markers from serum and urine samples. Bone turnover rates calculated with Osteocalcin (OC), bone specific alkaline phosphatase (BAP) as a bone formation markers and deoxypyridinoline (DP), cross-linked N-telopeptides of type I ollagen (NTx) as a bone resorption markers, showed 113±87% for control group, 61±11% for short term treated group and 190±101% forlong term treated group. We conclude that chlorella dietary supplementation enhances the bone formation, and NTx as a single markers, OC/Dp as a single markers of bone turnover rate were very useful tools for determine the effectiveness of chlorella dietary supplementation for the postmenopausal women.