담낭종양에서 CD24의 역할

임성철,이용,김동출,강길,변익건,박정희,최석민 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

CD24 is a small heavily glycosylated glycosylphosphatidylinosito-linked cell surface protein, which is expressed in hematologic malignancies as well as in a large variety of solid tumors, It appears to function as a ligand of PUselectin, an adhesion molecule that is present in activated platelets and endothelial cells. The authors aimed to evaluate CD24 protein expression in adenoma and adenocarcinoma of gallbladder to correlate to clinicopathologic data. The staining- was evaluated as stainability (negative, weak-, moderate-, strong-positive) and staining' patterns (membranous vs. intracytoplasmic) for statistical analysis. A highly significant association of cytoplasmic CD24 expression with adenocarcinoma compared to the adenoma of gallbladder was demonstrated. The present study demonstrates that CD24 was abundantly expressed on adenocarcinoma rather than on adenoma, but it was not statistically significant, Interrelation between the stainability or intracytoplasmic staining of CD24 and lymph node metastasis was not statistically significant. The authors conclude that CD24 is involved in tumorigenesis of gallbladder mucosa and intracytoplasmic expression of CD24 is an important molecular marker for malignant transformation.

기관지내 섬유종

임성철,이용,김동출 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

A 61-year-old man with dyspnea and wheezing depending on recumbent posture was admitted to the hospital because of a tracheal mass, which was found on a routine check done by health care unit of the another hospital. Computed tomography of the chest revealed a polypoid endobronchial mass in the left bronchus. Bronchoscopy revealed a 2cm-sized polypoid mass at 7cm below the carina. The tumor was successfully removed without dropping any tumor fragments to obstruct the distal bronchus. A biopsy taken from the tumor was fibroma histologically. Endobronchial fibroma is a rare benign lung tumor. The patient had an uneventful postoperative recovery course. No adjuvant therapy was deemed necessary or given. Follow-up bronchoscopies done 1 day and 4 months after the polypectomy did not demonstrate any sign of recurrence or residue of the tumor, respectively.

신경베체트병에 의한 신경인성방광 : 증례보고

이길용,임건한,소영석,노준,김철성,장대수 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

The co-existence of mouth and genital ulceration with iritis was first defined as a syndrome by Behcet. It is now known to be a chronic and relapsing systemic disease, which involves many other systems. Neurogenic bladder dysfunction due to Behcet's disease, however, is extremely rare, and only a limited number of cases have been reported in the international literature. Voiding disfunction in Behcet's disease can be due to neurological or direct bladder involvement and can be related to bladder and sphmctehc components in both phases of micturition. We report on a 35-year old patient with a neuropathic bladder secondary to Behcet's disease.

백서 간재생중 H2B Histone 유전자 발현에 대한 Octamer Binding Transcription Factor의 역할

임규,방재웅,최두식,손미영,이영철,박청,김태동,김영래,박종일,윤완희,박승길,황병두 한국노화학회 2001 한국노화학회지 Vol.11 No.1

하지 절단자 보행의 운동역학적 분석

임규찬,박윤서,배성제,정철수,신인식,김복영 師範大學 體育硏究所 1994 서울大學校 體育硏究所論集 Vol.15 No.2

This study was conducted to investigate the biomechanical characteristics of the gait pattern in an amputee for the purpose of improving the proper gait posture and designing the prosthetic. The subjects were six males amputees and one normal person. The ground reaction force was measured using AMTI force platform. The conclusions were as follows; 1. In case of amputee group, the ground reaction force was revealed in specific figure according to position in which they used the prosthetic, whereas in case of normal person the ground reaction force was revealed in the figure of two humps in regard of vertical axis. 2. In case of amputee group, the ground reaction force in time between fight foot contact and left foot contact was deviated from a figure of rectangle, whereas in case of normal person the ground reaction force was revealed in the figure of rectangle. 3. In case of amputee group, the ground reaction force referred to both feet angle point of view was revealed in irregular figure, whereas in case of normal person the ground reaction force was revealed about 47。

위암의 진행에 따른 Fas관련 아포프토시스 유도의 상관성

임성철,황철기,오서진 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : The purpose of this study is to determine whether human gastric adenocarcinomas express Fas-L, sFas-L or Fas , whether serum sFas-L leyel is changed in gastric cancer patients after gastrectomy, whether Fas-L expression is associated with increased apoptotic induction, especially, tumor-infiltrating Iymphocytes(TIL) and whether apoptotic induction is associated with the tumor stage and histologic type. Materials and Methods : The author analysed 38 cases of early gastric carcinoma(EGC) and 61 cases of advanced gastric carcinoma (AGC) which received gastric resection from 1997 to 1998. Of them, the number of diffuse type is 38 cases and the number of intestinal type is 61 cases. The author used immunohistochemical staining for Fas, Fas L and CD45, TACS^TM in situ apoptosis detection kit, and sFas ligand ELISA kit. Results : Fas-L was localized to neoplastic cells in 23 cases (23/38; 61%) of EGC group and 40cases (40/61; 66%) of AGC group. The extent of Fas-L expression was variable, with both Fas-L was localized to neoplastic cells in 23 cases (23/38; 61%) of EGC group and 40 cases(40/61; 66%) of group. The extent of Fas-L expression was variable, with both FasL-positive and negative neoplastic region cccuring within. TIL were detected by co-expression of CD4S and TACS on serial histologic sections. TIL adjacent to Fas-L erxressing tumor regions were decreased in number and TIL adjacent to FasL-negative tumor regions were increased in number; apoptotic induction of TIL showed the opposite pattern (p<05). Fas expression was found essentially homogeneously throughout the tumor mass independent of tumor stage. Fas expression showed 39 cases (39/61; 64%) of intestinal type and 26 cases (26/38; 68%) of diffuse type. Labeling indces for tumoral apoptosis in EGC and AGC were 6.72% and 7.13%, respectively and this difference was statistically insignificant. Co-expression of Fas-L and Fas, which occurred over large areas of the tumors, did not result in an enhanced rate of tumor cell apoptosis. The mean serum sFas-L level was significantly higher in patients before treatment compared with controls, whereas in post-gastrectomy patients, it was significantly lower, In addition, tumor stage and other prognostic factors were not associated with Fas and Fas-L expression, serum sFas-L level, number of TIL and apoptotic induction. Conclusion: 'The author demonstrates a statistically significant reduction of TIL concomitant with significantly increased TIL apoptosis adjacent to FasL-expressing regions of gastric adenocarcinomas. Also an elevated level of ·serum sFas-L in the gastric adenocarcinoma group was noted. These findings suggest Fas-mediated apoptotic depletion of TIL in response to Fas-L expression by stomach cancers, and provide the evidence to support the Fas counter-attack as a mechanism of immune escape in gastric cancer. And These findings indicate that the serum sFas-L level is a useful indicator in evaluating postoperative follow-up. In addition, gastric carcinoma cells of the intestinal and diffuse type did not differ in their expression of the Fas-apoptotic system.

방사선에 노출된 환자에 발생한 갑상선결절의 세침흡인세포학적 소견

임성철,구자봉 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

배경 : 두경부의 각종 질환치료에 사응되는 방사선 조사는 갑상선암종의 발생위험을 높이고, 여러 가지 세포학적 변화를 초래한다고 잘 알려져 있다. 그러나, 대부분의 보고는 임상적, 방사선학적 및 병리학적 소견에 집중되고 세침흡인 세포학적 소견의 보고는 없는 실정이다. 이에 저자들은 세포학적소견을 절제생검된 조직과 연계하여 문헌고찰과함께 보고한다. 방법 : 세침흡인 세포검사는 초음파 유도하에 이루어졌고, 이어 시행된 절제 생검조직을 세침흡인 세포학적 소견에 바탕하여 고찰하였다. 결과 : 환자는 55세 여자로 21개월전에 진단된 혀의 편평세포암종으로 화학요법과 방사선요법을 받았으며, 내원 14개월전에 치료를 마쳤다. 또한 환자는 영아기에 흉선비데가 있어 방사선치료를 받은 과거력이 있다. 환자는 화학요법후 최근에 발생된 갑상선 기능저하증을 제외하고는 특별한 이상소견 없이 잘 지내왔다. 최근 갑상선 좌엽의 결절이 발견되어 세침흡인검사를 시행하였으며, 도말상 군집을 이루거나, 산재된 갑상선 여포세포들이 심한 세포학적 이형성을 보이며 관찰되었으나, 유사분열이나, 괴사의 소견은 없었다. 결론 : 세포학적 소견이 방사선조사에 의한 것에 부합되지만 여포병변의 가능성을 배제할 수 없어서 갑상선 전절제술을 시행하였는데, 피막에 잘 싸여진 여포선종이 관찰되었다. 그리고, 갑상선 전체에서 관찰되는 상피세포의 이형성은 악성변화와는 무관하며 방사선조사효과에 부합된다고 판단하였다. BACKGROUND. It is well known that any kind of radiation used to treat benign or malignant conditions in the head and neck area results in an increased risk of thyroid cancer and a cytomorphologic changes. Most of the reports have been described the clinical, radiological, and pathological features, but cytology of FNA has not. In the current study the authors report the cytologic findings in FNA specimens with literature review and attempt to correlate the cytologic features with the excisional biopsy findings. METHODS. FNA was performed with ultrasound guidance. Corresponding subsequent excisional biopsy tissue was reviewed in conjunction with the cytologic findings. RESULTS. A case of FNA cytologic atypia of the thyroid gland in radiation exposed patient. She is 55-year-old with history of a squamous cell carcinoma of the tongue, diagnosed in 21 months ago, and underwent chemotherapy, followed by radiation therapy, which was completed in 14 months ago. She also has a history of thymus enlargement in infancy, which was treated with radiation therapy. She has done well since chemotherapy except most recently developed hypothyroidism. She was found to have a left lobe thyroid nodule for which she has undergone fine needle aspiration. Smears showed clusters as well as scattered thyroid follicular cells with marked cytologic atypia. Areas with microfollicular arrangement and colloid were present. There was no evidence of mitosis or necrosis. CONCLUSION. Although the findings were compatible with radiation changes, the possibility of an underlying follicular lesion could not be excluded. She underwent total thyroidectomy and showed well-encapsulated follicular adenoma. The entire thyroid contained epithelial atypia consistent with radiation therapy effect.

조선대학교 의과대학 의학과 학사편입학제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

공업화부재의 생산/운반/양중관리를 위한 정보가시화 시스템 개발에 관한 연구

임형철,송영석,김창덕,송성진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Recently, The construction field in the urban area is short of working space and securing processing place because it is surrounded by adjacent buildings and nearby roads and have difficulties in rising labor costs. The insufficient space causes problems of interference and conflicts in transporting materials and working at the site. Therefore, Construction Manager find many alternative method and select industrialized method. The objective of this paper is to develop and give a method of information visualization system for manufacturing, delivering and lifting these materials in construction project stakeholders, using tools visualizing informations. The tools supports to stakeholders so many informations in material manufacturing, delivering, lifting in construction site. That is, order information, manufacture information in factory, sending information, carrying information, unloading and lifting in Site, and so on. Case studies are performed to evaluate the feasibility and applicability of the proposed method.

기관내삽관에 의한 후두손상

임상철,이준규,이동훈,윤태미 全南大醫大 2004 전남의대학술지 Vol.40 No.1