복강경을 이용한 대장 부분 절제 시행 1예

박재갑,서경석,정회원,김선회,오용석,송인성,박용현 대한대장항문학회 1993 Annals of Coloproctolgy Vol.9 No.1

방사선치료실 주변의 선량 측정

서경진,이정범,김재철 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 고에너지 선형가속기 및 고선량율 원격조정 애프터로딩 근접치료장치 사용 시 치료실주변의 누설선량에 대한 측정을 하여 원자력법에서 허용하는 기준선량 이하인지를 확인하기 위하여 본 실험을 시행하였다. 또한 Co-60 선원의 방사능을 교정하기 위하여 방사능을 계산하였다. 대상 및 방법 : 누설선량은 주당 12시간에 방사성 동위원소의 activity와 Γ-constant를 곱한 값 및 본 시설물의 두께와 십가층(TVL)을 이용하여 계산하였다. Co-60 선원의 측정은 선원과 전리함 사이의 거리를 10㎝으로 하여 온도와 압력, 교정계수 (58.5345R/nC) 을 보정한 평균 분당 선량을 X(0.475R/min) 에 10㎝의 측정거리를 1m로, 시간을 1시간으로 환산하여 이를 1 Ci의 Co-60에 대한 Γ-constant 로 나누어 실제 선원의 activity로 나타내었다. 결과 : 2개의 Cs-137과 1개의 Co-60를 이용한 치료 중에 측정한 값으로 점유도와 주당 사용시간을 고려한 일반구역에서의 주당누설선량은 원자력법에서 정한 허용선량보다 낮은 것으로 나타났다. 또한, 방사선 선원이 저장용기 내에 있을 때의 afterloading system의 누설선량 측정은 시스템에서 1m 떨어진 거리에서 측정하였는데 그 측정치는 0.05mR/h 이하로 나타났다. Co-60 선원의 측정값은 0.221 Ci였으며 이 값은 선원을 구입할 때 측정한 값 1.04 Ci의 시간에 따른 감소율을 고려한 값 0.249 Ci 보다 약 11% 더 작은 것으로 나타났다. 이는 측정 시에 선원을 스테인레스로 된 tandem 내에 놓고 측정하였기 때문에 그에 따른 흡수율을 고려하면 신뢰성 있는 측정값으로 생각되었다. In this experiment, we presented the calibration of a Buchler high dose rate remote afterloading system and the radiation survey around the radiotherapy treatment room to guarantee the health of personnel and patients. The radiation survey of the radiotherapy treatment room indicates that the leakage radiation is less than 0.1 mSv at every point and the use of present shielding will provide an adequate protection for personnel and patients. We also presented a unique procedure for performing the calibration of a radioactive isotope with an acryl device and it was strongly considered as a reliable one.

측두골 전산화단층촬영의 3차원 재구성의 의의 : Normal and Pathologic Temporal Bones

서정출,고의경,전경명,김재혁,이동건 釜算慶南耳鼻咽喉科學會 1994 임상이비인후과 Vol.5 No.1

고혈압치료제의 in vitro및 in vivo 이용률간의 상관성 연구(Ⅱ)

서수경,강현구,조재민,박인숙,안미령,이선우,최흥석,유태무,손수정,이용복,양지선 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약풍이 생체내로 흡수되는_파정에서 생리학적 인자 및 제제학적 인자들에 의해 생체이용률이 달라져 약물의 흡수과정을 연구함으로써 약물의 생체이용률을 예측하는 것이 가능하다. 그러나 제제학적 측면에서 용출시험과 흡수과정인. 장관막 투과도 나아가서 생체이용률간의 띤구가 미흡한 상태이다. 따라서 약물의 흡수과정을 연구하벼 생체이용률을 예측하기 위하여 장관막 투과도 및 혈중농도사이의 상관관계를 예견할 수 있는 모델을 개발하고자 1999년도 연구사업으로 고혈압치료제중 베타-차단약 (아테놀올, 메토프롤올, 프라프라놀꼴)을 선택하여 웅출시험과 장관막 투과도계수를 측정하여 사람의 흡수을을 예측할 수 있는 장관막 투파도 모델을 확림하였고, 2000년도에는 계속사업으로서 각 약물에 대한 횐쥐에서의 생체이용를 파라메타를 측정하고 1999년도 연구사업결과에서 얻은 장관막 투과도 시험결과를 가지고 생체이용률과의 상관섞을 구하고자 하였다. 각 베타-차단약을 경구 및 정맥투여하고 시간별로 채혈한 후 분리한 혈장으로부터 각 약물에 대한 EfLC를 이용한 분석준건을 확지하여 혈중농도를 측정하고 생체이용률 파라메타(AUC, Cma, Tme, 등)를 구하였다. 횐쥐의 소장을 이용하여 diffusion chamber 법으로 측정한 장관막 투과도계수와 각 생체이용률 파라미터 사이의 상관성을 구찬 결과 양호한 상관관계를 보였다. 이와 같은 연구결과를 통하여 약물의 특성에 따라 동물의 장관막 투도. 모델을 이용하여 사람의 생체이용률도 예측할 수 있을 것으로 사료된다. A biopharmaceutics drug classification system for correlation f'H uf'fro dissolution and rH ui'ㄴo bio3vailabi3ity is proposed based on recognizing that drug dissolution andgastrointestinal permeability are the fundamental parameters controlling rate and extent of drugabsorption. The objective of this stud)· was to assess whether partition coefficient and intestinalPermeabilit)'can be rorrelateo with l'H vluo bioalFaifability. Beta-blockers were administeredorall? and intrauenousl)· to rats and pkarrnacokinetlc parameters were calculated. The goodcorre)ations between fermeability and log P (n~octanol/buffer) was demonstrated in previous ratexpenments performed in our laboratory. In this study, good correlations were obseFYedbetuTeen panitlon coefficient and permeabilit)·· or I'n ui'vo bioayilability These resuats indiEatethat rat intestinal perme3bilit3T model couBd be used to predict intestinal absorption ofbeta-blockeTs f'H uiuo.

성인간호학회지 논문(1989-2000)의 내용과 경향 분석

서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4

"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.

보신 관광에서 감염된 수입성 Sparganosis 1예 : Intake of Thailand Snake during Trip

서환조,박명재,고경식,백영한,조유정,양현종,류경남,정형근,전정열 대한감염학회 1992 감염 Vol.24 No.1

Human sparganosois was reported more than 100 cases in Korean population. However no case reported yet in Korea as a patient was infected by sparganum from other geographical area, such as Thailand. The case we are reported here is a 38 year-old Korean male who had been suffered from mass being a small, round and soft consistance in upper portion of his right thigh. The patients stated that he had an opportunity to eat living snake in Bangkok, Thailand during trip. As therapy praziquantel (75㎎/㎏/day) was given p.o. for 14 days, but in vain to cure. Following medical treatment, surgical exicision was performed to remove a alive, soft, whitish-milky, mobile and elongated sparganum. Serlogical test by micro-ELISA for sparganum-specific antibody revealed a high serum antibody level of absorbance 0.67 (positive criterion: absorbance 0.22).

白鼠에 있어서 加齡에 따른 顎關節 圓板의 形態 및 微細構造的 變化

徐惠敬,성재현 慶北大學校 齒科大學 1991 慶北齒大論文集 Vol.8 No.2

The purpose of this study was to investigate change in the shape, elastic fiber and ultrastructure of the articular disc of the rat mandibular joint with aging. Mechanical stress applied to the articular disc changes during neonatal, suckling, juvenile, adult and senile stages. Mandibular joints of 6 groups of rates (1-, 7-, 17-, 27-, 55-day over-1-year groups) were removed en bloc and processed for light and electron microscopic study. The changes in the shape of articular disc were examined by light microscope in each group. Concentration, diameter and arrangement of elastic fiber of articular disc were examined by light microscope. Structural and ultrastructual changes in the articular disc were examined by light and electron microscope in each group. The results were as follows: In the 1-day and 7-day groups, the articular disc was long and slender in shape and the articular disc was not fitted with the shape of the mandibular fossa and condyle. However, after that time, the anterior and posterior portions of the articular disc were more bulged and the middle portion was shorter and biconcave. Thus the articular disc was well fitted with the shape of the mandibular fossa and condyle. The elastic fibers increased in concentration and diameter from the 1-day to the 55-day groups and was maintained after that time. The elastic fibers were irregularly arranged in 1-day and 7-day groups, but regularly arranged after that time. The elastic fibers were arranged anteroposteriorly, transversely and vertically in anterior and posterior portions, but in the middle portion arranged mainly anterposteriorly; a few fibers were arranged transversely. The cell density decreased with aging. In the 1-day and 7-day groups, the Golgi apparatus, rough endoplasmic reticulum and free ribosome, which are involved in the synthesis of intracellular and extracelluar matrix, were developed. In the 17-day, 27-day and 55-day groups, not only the cell organelles involved in the synthesis of the intracelluar and extracellular matrix but also the cell organelles involed in the remodeling of the extracellular matrix (i.e., finger-like cell porcess, lysosome and mitochondria) were well developed. With advancing age, intracytoplasmic microfilaments were more accumulated and chondroid cell increased. In the over-1-year group, the majority of cells of the articular disc were chondroid cells. The majority of cytoplasmic compartment were filled with intracytoplasmic microfilaments and cell organelles were not developed. Therefore, metabolic activities of the cell was markedly reduced and cells contained structures enduring mechanical stress, and cells which were in the process of degeneration were observed occasionally.

韓國人 混合齒列期 兒童 및 成人에 관한 頭部放射線學的 計測

徐惠敬,成在鉉,權五源 慶北大學校 齒科大學 1986 慶北齒大論文集 Vol.3 No.1

正常咬合을 가진 混合齒列期 兒童(男子 55名, 女子 46名) 및 成人(男子 41名, 女子 36名)을 對象으로 側貌 頭部放射線規格寫眞上에서 坂本分析法에 의해 頭蓋顔面骨의 成長 變化를 觀察하여 다음과 같은 結論을 얻었다. 9才, 11才, 成人에서 男女別 各 計測項目의 平均値, 標準偏差 및 profilogram을 얻었다. 頭蓋顔面骨의 크기는 深度에서는 9, 11 才에서 男女間 有意差는 거의 나타나지 않았으나, 高徑은 9才에서 男子가 上顔面部 및 下顎部에서 더 크게 나타났으며 11才에서는 N, PTM, PNS를 제외한 全 項目에서 男子가 더 크게 나타났다. 成人에서는 深度에서 GO, 高涇에서 N을 제외한 金 項目에서 男子가 더 크게 나타났다. 9才에서 11才까지의 平均成長量은 上顎 中切齒 및 上下顎 第一大臼齒, 신부에서는 큰 것으로 나타났고 上顔面部, 上顎部에서는 비교적 작은 것으로 나타났으며, 頭蓋顔面骨의 전반적 成長은 S를 中心으로 하였을 때 下方性 長傾向이 優勢한 前下方成長을 하였다. The purpose of this study was to investigate the growth change of craniofacial complex in korean children & adults. The subjects included 55 males and 46 females in children, 41 males and 36 females in adults. A series of 2 lateral cephalometric radiographs obtained from each child at age 9 and 11 and 1 lateral cephalometric radiograph obtained from each adult were analyzed by Sakamoto's coordinate system. The conclusions were as follows : Means, standard deviations and profilograms from measurements were obtained at age 9, 11 and adult. Sexual difference in depth of craniofacial complex was hardly found at age 9 and 11, but in height male was larger than female in upper facial and mandibular portion at age 9 and in all of the items except N, PTM, PNS at age 11. At Adult male was larger than female in all of the items except Go in depth and N in height. Growth increments of upper and lower incisors, upper and lower first molars and chin portion from age 9 to 11 were large, whereas those of upper facial and maxillary portions were relatively small, and the craniofacial complex grew forward and downward, but more downward.

하루 콩단백질 25g 섭취를 위한 메뉴작성 및 영양성분 분석

한재숙,김정애,서봉순,이연정,서향순,조연숙,한경필,이신정,오옥희,우경자,조은자,구성자,김수진,李承彦,南出隆久 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.2

The purpose of this study was to develop menus for daily intake of 25g soybean protein and to analyse nutrients of these foods. Analytical values were compared to the theoretical one using the food composition table and recommended dietary allowances for Koreans (7th revision). The results are as follows. 1. Soybean curd residue stew, Soybean curd, Kimchi saute, and hard boiled soybean and lotus root were selected for the menu for January, of which the content of soy bean protein(SBP) was 33.1g, soybean stew, soybean curd and soybean sprout saute, and Italian deep fried soybean curd were for February, of which the content of SBP was 35.0g. The content of SBP in soybean paste soup with soybean curd, fried soybean curd and fried soybean curd roll, the menu for March, was 24.9g. That of April were soybean curd gratin with soymilk, soybean curd and ham with garlic dressing and the content of SBP was 26.3g. That of May were soybean porridge, soybean flour cake with honey (Dasik), soybean sprout soup and the content of SBP was 26.7g. That of June were soymilk, pan-fried soybean curd, steamed soybean curd with chicken and the content of SBP was 28.4g. That of July were noodle with soymilk, mapatofu, soybean curd salad and the content of SBP was 24.7g. That of August were soybean sprout with mustard dressing, Tossed green pepper with raw soybean flour, Tofu and Kimchi stew, soybean curd steak and the content of SBP was 26.2g. That of September were Chinese cabbage soup with raw soybean flour, sweet and sour tofu and the content of SBP was 23.2g. That of Oct. were Fermented soybean stew, soybean pan cake and the content of SBP was 24.3g. That of November were not-pressed soybean curd casserole, pan-fried mashed soybean curd with egg, stir frying deep-fried soybean curd with vegetables and the content of SBP was 22.4g. That of December were soybean curd and mushroom casserole, fried soybean curd and vegetables, hard boiled soybean curd and the content of SBP was 28.9g. 2. The ratio of the analytical value over theoretical value (A/B%) of one serving in kcal, carbohydrate, protein, fat, ash and dietary fiber were 57.7~107.7%, 42.9~131.9%, 79.2~118.3%, 54.5~100%, 40.7~80.8% and 42.1~113.2%, respectively. 3. The ratio of A/B% of one serving in Ca, K, Na, P and Fe were 44.1~93.6%, 59.0~153.1%, 53.1~117.7% 64.6%~138.8 and 33.8~77.3%, respectively. That in Fe was the lowest among minerals. 4. The ratio of analytical value over Korean R.D.A(A/C%) in Ca was relatively higher (22.0~85.9%) than that in kcal(18~63%). 5. The ratio of A/C% in Fe was 25.1~64.3% and lower than that in Ca and protein in general.

기종성 신우신염 1례

이재욱,구정태,서정일,양창헌,이정호,이동철,이영현,이활,이경섭 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

기종성 신우신염은 주로 당뇨병환자나 폐쇄성 요로질환을 가진 환자에 발생하며 특징적으로 신실질 및 그 주위조직에 가스를 형성하면서 심한 조직괴사를 일으키는 매우 드문 급성 화농성 신감염으로 사망률이 높은 질환이다. 이 질환은 1989년 Kelly와 MacCallum에 의해 처음 보고된 이래 외국문헌에 약 90례 정도가 보고되어 있으며 국내에는 28례가 보고되어 있다. 수액 및 전해질 보충, 인슐린 투여를 통한 적절한 혈당조절 및 항생제 투여등의 내과적 치료와 절개배농 및 신적출술등의 수술적 치료 방법이 있다. 내과적 치료로 가스의 감소가 없는 경우에는 즉각적인 수술적 치료를 시행하여야하므로 이 가스변화에 대한 추적관찰이 중요하다 하겠다. 본 저자들은 당뇨병환자에서 발생한 기종성 신우신염 1례를 내과적 요법을 치험하였기에 문헌고찰과 함께 보고하고자 한다. Emphysematous pyelonephritis is rare, life-threatening infection of the renal parenchyma and perirenal tisseue. This disease is characterized by the production of intrarenal and perirenal gas and is frequently encountered in patients with diabetes mellitus or urinary obstruction. We experienced a case of emphysematouse pyelonephritis in a 62 years old women with poorly controlled diabetes mellitus who had been managed with medical theraphy. So we report this case with a review of the referenced literatures.