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서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
Yoon, Hang Seob,Park, Yoo Jung,Lee, Moses,Choi, Woo Jin,Lee, Jin Woo SAGE Publications 2014 AMERICAN JOURNAL OF SPORTS MEDICINE - Vol.42 No.8
<P><B>Background:</B></P><P>Several studies have reported on the outcome of arthroscopic treatment or osteochondral autologous transplantation (OAT) for osteochondral lesions of the talus (OLT), with mixed results. None of these studies has compared the results of repeat arthroscopy and OAT after failed primary arthroscopic treatment.</P><P><B>Purpose:</B></P><P>To compare the outcomes of OAT and repeat arthroscopy for the treatment of OLT after primary arthroscopy</P><P><B>Study Design:</B></P><P>Cohort study; Level of evidence, 3.</P><P><B>Methods:</B></P><P>This study included 22 patients who underwent OAT (group A) and 22 patients who underwent repeat arthroscopy (group B) after failed treatment of OLT among 399 patients who received primary arthroscopic marrow stimulation at single institution between 2001 and 2009. All patients were evaluated clinically using the visual analog scale (VAS) for pain and American Orthopaedic Foot and Ankle Society (AOFAS) Ankle Hindfoot Scale. The cumulative success rates were compared by use of Kaplan-Meier life table analysis.</P><P><B>Results:</B></P><P>The patients’ demographic and clinical characteristics and indications for surgery were comparable between the groups. Both groups showed significantly improved (<I>P</I> < .001) VAS and AOFAS scores 6 months after surgery. However, group B showed significant deterioration over a mean follow-up period of 50 months. Overall, 18 of 22 (81.8%) patients in group A and 7 of 22 (31.8%) patients in group B achieved an excellent or good (≥80) AOFAS score (<I>P</I> < .001). No patient in group A and 14 of 22 (63.6%) in group B required further revisions.</P><P><B>Conclusion:</B></P><P>Osteochondral autologous transplantation was significantly superior to repeat arthroscopic treatment of OLT after a mean follow-up period of 48 months. Therefore, repeat arthroscopy should be used judiciously for the treatment of OLT after failed arthroscopic treatment.</P>
Hang Seob Yoon,최우진,성일훈,Ho Seong Lee,정형진,이진우 대한정형외과학회 2013 Clinics in Orthopedic Surgery Vol.5 No.2
Background: This study evaluated the effects of Beraprost sodium (Berasil) on subjective leg symptoms in patients with peripheral arterial disease caused by diabetes mellitus. Methods: Ninety-four diabetic patients with peripheral arterial disease were treated with Beraprost in a fixed-dose, prospective, multicenter, cohort study. Beraprost (40 μg) was administered orally 3 times daily (120 μg/day) for 12 weeks. We developed a new disease-specific symptom questionnaire, which evaluated the effect of peripheral arterial disease on leg discomfort in daily life and assessed therapeutic responses to treatment. Patients were asked for their subjective assessment of symptoms on a written questionnaire before treatment and after 12 weeks of therapy. Results: There was significant improvement in all estimated subjective symptoms (burning, coldness, edema, exertional pain, stabbing, and paresthesias) in the lower extremities at 12 weeks (p < 0.001). There were 18 patients with neuropathy in whom significant improvement was noted for 6 subjective symptoms at 12 weeks (p < 0.05). Adverse events considered to be drug-related were observed in 4 patients (4.3%), all of which were mild and resolved with discontinuation of the medication. Conclusions: Beraprost is effective as a treatment for improving various subjective symptoms in the lower extremities, such as burning, coldness, edema, exertional pain, stabbing, and paresthesias, in diabetic patients with peripheral arterial disease.
실험적 뇌경색에 미치는 Insulin, 2-Deoxyglucose 및 Dichloroacetate의 효과에 대한 연구
정흥섭,박윤관,이훈갑,이기찬,주정화 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.5
Hyperglycemia has been reported to worsen the tolerance of the brain to ischemia, and it has therefore been recommended that patient undergoing neurosurgical procedures not receive glucose-containing solutions. Since ischemic events lead to increased lactate production and accumulation and hence neruonal damage, the present study was designed to test the effect of insulin-induced hypoglycemia and decreased lactate accumulation by 2-Deoxyglucose and Dichloroacetate on focal cerebral ischemia in rats. Although the pre and post-ischemic blood glucose level of 2-Deoxyglucose group showed a significant increase (p=0.001), and insulim group a significant decrease(p=0.004). The reducing effects on the infarct zone in these three treated groups were found with statistical significance. As compared with control group, the tissue lactate levels of treated groups were decreased in both infarct zone and border zone but these data did not show statistical significance. From these observations, it is suggested that reduction of lactate production and accumulation could be beneficial by affording neuronal protection in ischemic tissues.
실험적 뇌경색에 미치는 Insulin, 2-Deoxyglucose 및 Dichloroacetate의 효과에 대한 연구
정흥섭,박윤관,이훈갑,이기찬,주정화 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.1
Hyperglycemia has been reported to worsen the tolerance of the brain to ischemia, and it has therefore been recommended that patient undergoing neurosurgical procedures not receive glucose-containing solutions. Since ischeruc events lead to increased lactate production and accumulation and hence neuronal damage, the present study was designed to test the effect of insulin-induced hypoglycemia and decreased lactate accumulation by 2-Deoxyglucose and Dichloroacetate on focal cerebral ischemia in rats. Although the pre and post-ischemic blood glucose levels of control group and Dichloroacetate group showed no change, the blood glucose level of 2-Deoxyglucose group showed a significant increase(p=0.001), and insulin group a significant decrease(p=0.004). The reducing effects on the infarct zone in these three treated groups were found with statistical significance. As compared with control group, the tissue lactate levels of treated groups were decreased in both infarct zone and border zone but these data did not show statistical significance. From these observations, it is suggested that reduction of lactate production and accumulation could be beneficial by affording neuronal protection in ischemic tissues.
Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury
Lee, Kee-Hang,Pyeon, Hee-Jang,Nam, Hyun,Won, Jeong-Seob,Hwang, Ji-Yoon,Lee, Kyung-A,Yeon, Je Young,Hong, Seung-Chyul,Nam, Do-Hyun,Lee, Kyunghoon,Lee, Sun-Ho,Joo, Kyeung-Min Elsevier 2018 Stem cell research Vol.31 No.-
<P><B>Abstract</B></P> <P>Neural stem cells are emerging as a regenerative therapy for spinal cord injury (SCI), since they differentiate into functional neural cells and secrete beneficial paracrine factors into the damaged microenvironment. Previously, we successfully isolated and cultured adult human multipotent neural cells (ahMNCs) from the temporal lobes of epileptic patients. In this study, we investigated the therapeutic efficacy and treatment mechanism of ahMNCs for SCI using rodent models. When 1 × 10<SUP>6</SUP> ahMNCs were transplanted into injured spinal cords at 7 days after contusion, the injection group showed significantly better functional recovery than the control group (media injection after contusion), which was determined by the Basso, Beattie and Bresnahan (BBB) score. Although transplanted ahMNCs disappeared continuously, remained cells expressed differentiated neural cell markers (Tuj1) or astrocyte marker (GFAP) in the injured spinal cords. Moreover, the number of CD31-positive microvessels significantly increased in the injection group than that of the control group. The paracrine pro-angiogenic activities of ahMNCs were confirmed by <I>in vitro</I> tube formation assay and <I>in vivo</I> Matrigel plug assay. Together, these results indicate that ahMNCs have significant therapeutic efficacy in SCI <I>via</I> replacement of damaged neural cells and pro-angiogenic effects on the microenvironment of SCI.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ahMNCs are neural stem cell-like cells derived from adult human temporal lobes. </LI> <LI> ahMNCs have significant preclinical therapeutic effects on spinal cord injury. </LI> <LI> ahMNCs differentiate into astrocytes, neurons, and oligodendrocytes in damaged spinal cords. </LI> <LI> ahMNCs increase microvessel density significantly in damaged spinal cords. </LI> </UL> </P>
Lee, Kee-Hang,Nam, Hyun,Won, Jeong-Seob,Hwang, Ji-Yoon,Jang, Hye Won,Lee, Sun-Ho,Joo, Kyeung Min The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.4
Objective : The purpose of this study was to find an optimal delivery route for clinical trials of intrathecal cell therapy for spinal cord injury in preclinical stage. Methods : We compared in vivo distribution of Cy5.5 fluorescent dye in the spinal cord region at various time points utilizing in vivo optical imaging techniques, which was injected into the lateral ventricle (LV) or cisterna magna (CM) of rats. Results : Although CM locates nearer to the spinal cord than the LV, significantly higher signal of Cy5.5 was detected in the thoracic and lumbar spinal cord region at all time points tested when Cy5.5 was injected into the LV. In the LV injection Cy5.5 signal in the thoracic and lumbar spinal cord was observed within 12 hours after injection, which was maintained until 72 hours after injection. In contrast, Cy5.5 signal was concentrated at the injection site in the CM injection at all time points. Conclusion : These data suggested that the LV might be suitable for preclinical injection route of therapeutics targeting the spinal cord to test their treatment efficacy and biosafety for spinal cord diseases in small animal models.
흉추부 경막외에 발생한 골수의 형질세포종 : 증례 보고 Case Report
문수현,박정율,박윤관,정흥섭,서중근,이훈갑 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.10
Spinal cord compression associated with plasma cell neoplasm is observed always in the patients suffering from the multiple myeloma or solitary plasmacytoma that occur in the marrow of the spine. Authers report a rare case of extramedullary plasmacytoma forming a mass in the epidural space of the thoracic spine. In 70 year old woman with paraplegia, MRI of the thoracic spine indicated a presence of epidural mass at the 2nd to 8th thoracic vertebrae. There was no abnormal bony changes in the spine on plain X-ray and MFU. Total removal of the epidural mass was performed by posterior approach. Histopathologic examination including immunohistochemical stain showed the plasma cell neoplasm producing IgM and kappa light chain. Cancer workup after operation including bone marrow study and whole body simple radiologic studies supported the diagnosis of extramedullary plasmacytoma.