경침뇌파진동수련 프로그램이 당뇨노인의 혈당, 우울, 수면의 질에 미치는 영향

남궁은하 ( Eun Ha Nam Gung ),최재호 ( Jae Ho Choi ),신혜숙 ( Hea Suck Sin ),최남율 ( Nam Yul Choi ),서호찬 ( Ho Chan Seo ) 국제뇌교육종합대학원 국학연구원 2015 선도문화 Vol.19 No.-

이 연구는 경침뇌파진동 수련이 당뇨노인의 혈당, 우울, 수면의 질에 대한 영향을 조사한 것으로 당뇨의 지표인 식후혈당, 당화혈색소, 우울에서는 비활력요인, 우울요인, 수면의 질에서는 수면양상, 수면평가, 수면저해원인의 정도를 파악하며 당뇨지표와 삶의 질의 상관관계를 살펴보는 것을 목적으로 하였다. 연구 대상자는 65세 이상의 노인으로 식후혈당 200 mmHg이상, 당화혈색소(HbA1C) 6.5이상의 당뇨질환이 있는 실험군 15명과 대조군 15명을 선발하여 경침뇌파진동 수련을 1주 1회, 8주간 실시하여 다음과 같은 결과를 나타냈다. 첫째, 경침 뇌파진동 수련을 적용한 후 식후혈당과 당화혈색소의 변화를 알아본 결과 사전보다 사후에서 감소되었으며 유의미한 결과를 보였다. 둘째, 경침 뇌파진동 수련을 적용한 후 우울의 변화를 알아본 결과, 급격한 감소효과를 보였으며 특히 하위영역에서 비활력요인과 우울요인에서 탁월한 효과를 보였다. 셋째, 경침뇌파진동 수련을 적용한 후, 수면의 질을 알아본 결과, 수면양상과 수면저해원인, 그리고 전체 수면에서 각각 집단효과가 나타났으며 특히 수면을 방해하는 원인을 제거하는 데 긍정적인 변화가 있었다. 이상의 결과로 경침뇌파진동수련은 우울, 수면의 질에 긍정적인 영향을 미쳤고 식후혈당과 당화혈색소의 감소에 효과가 있었으므로 몸 건강은 물론이고 정신건강까지 유지할 수 있으며 짧고 빠른 시간내에 효과적으로 치유할 수 있는 뇌건강법으로 제시되었으며 당뇨노인에게 현장에서 적극적으로 활용될 수 있는 가능성을 보였다. The study looked into the effects of Brain Wave Vibration Training with Wooden Pillow to the elderly with diabetes for the quality of Sleep, depression, glycated hemoglobin and blood sugar after meals. For the quality of sleep of the elderly with diabetes this looked into the sleep pattern, the sleep result, the degree of cause of sleep hindrance. For depression looked into the quality of life by finding the degree of the cause of losing vitality and depression factor. For Blood pressure looked into effects of contraction period responses and relaxation period responses, also for diabetes aimed to find the correlation of the quality of life and the index of diabetes by measuring the degree of Glycated hemoglobin and blood sugar after meals as an index of diabetes. The targets for the study was aged 65 or older group of 15 people with diabetes in blood sugar after meals more than 200 mmHg, HbA1C over 6.5 and the comparison group 15, conducted a brainwave vibration training with wooden pillow for eight weeks, eight hours once a week. The results of research are as follow : First, Brain Wave Vibration Training with Wooden Pillow is reduced in the post-test than the prior case of postprandial blood glucose and HbA1c showed a significant change was the result. Second, the change in depression showed a drastic reduction in the subregion was particularly excellent effects in non-energy factors and depressive factors. Third, after Brain Wave Vibration Training with Wooden Pillow, sleep patterns and sleep inhibition causes, and no significant effect was observed on the whole surface of the water was a particular show positive change to eliminate the causes that interfere with sleep. Since the results of Brain Wave Vibration Training with Wooden Pillow showed a positive influence on sleep quality, depression and the effect of reducing blood sugar after meals and Glycated hemoglobin it showed the possibility to utilize actively in the field to the elderly with diabetes.

운동부하시 흰쥐 호흡근의 당원 대사

남북현,이석강,김은정 영남대학교 의과대학 1997 Yeungnam University Journal of Medicine Vol.14 No.1

생리적 특성이 독특한 횡격막의 운동시 당원이용양상과 운동 후 경구 토여한 당이 당원으로 재축적되는 과정을 적색비복근과 비교하여 횡격막의 생리적 특성의 일단을 규명하고자 시도한 연구 결과를 요약하면 다음과 같다. 대조군에서 횡격막의 당원농도는 적색비복근보다 높은 경향을 보였으며, 운동군에서 운동부하 첫 1시간에 횡격막의 당원농도는 약 1/2로 감소하였고 그 후 지속되는 1시간동안에는 별 차이를 보이지 않았으며 적색비복근의 당원농도와는 유의한 차이를 발견할 수 없었다. 그러나 당원 감소속도를 분석한 결과 횡격막이 적색비복근보다 빠른 경향을 보였다. 횡격막의 당원 재축적량 및 재축적속도를 분석한 결과 운동부하군에서 최대축적량은 적색비복근보다 낮았으며 재축적속도는 대조군에서는 양근에서 비슷하였으나 운동부하군에서는 적색비복근이 빨랐다. 당투여에 의한 골격근의 당원축적은 주로 근원 섬유사이에 분포함을 전자현미경 관찰을 통해서 알 수 있었다. 이상의 결과로 미루어보아 횡격막은 운동부하시 당원의 소모는 비교적 빠른 경향이었으나 당투여에 의한 재축적은 느린 것을 알 수 있었다. Diaphragm is thought to play the most important role in breathing and has a substantially greater proportion of slow oxidative and fast glycolytic fibers, and low proportion of fast oxidative fibers. The respriratory muscle, diaphragm, has the functional characteristics of slow speed of contraction, high resistance to fatigue and the ability to respond to intermittent ventilatory loads, for example of exercise. In the present study, the characteristics of the metabolism (depletion and repletion) of glycogen and the structural changes of diaphragm during depletion and repletion of glycogen were observed in rats. For comparison, the red gastrocnemius muscle which has a greater proportion of fast oxidative glycolytic (FOG) and slow oxidative (SO) fibers, and low proportion of fast glycolytic (FG) fiber, was also studied. The glycogen concentration of diaphragm in overnight fasted rats was 2.30±0.14mg/gm wet weight. The values of glycogen concentration at 60, 90 and 120 minutes of treadmill exercise loaded rats was significantly decreased compared to that of the overnight fasted rats. There was no significant difference among the glycogen concentrations of diaphragm at 60, 90 and 120minutes of treadmill exercise loaded rats was significantly decreased compared to that of the overnight fasted rats. There was no significant difference among the glycogen concentrations of diaphragm at 60, 90 and 120minutes of exercises. The glycogen concentration of diaphragm was decreased to 1.12±0.17 from 2.30±0.14mg/gm wet weight by treadmill exercise. The glycogen depletion rate of diaphragm during exercise was faster than that of red gastrocnemius in both of the first 60minutes and 120minutes duration of exercise. The glycogen repletion of diaphragm after intragastric glucose administration by stomach tube was studied in control and exercise groups. The glycogen concentration was significantly increased after glucose administration in both of control and exercise groups. All of the concentration of exercise group at 60, 120 and 180minutes after glucose administration was significantly higher than those of control group. In conclusion, one of the characterics of diaphragm in glycogen metabolism is fast glycogen depletion during exercise, and slowness of glycogen repletion after glucose ingestion in rats.

Long-Term Clinical Outcomes of Korean Patient With Crohn`s Disease Following Early Use of Infliximab

( Nam Hee Kim ),( Yoon Suk Jung ),( Chang Mo Moon ),( Shin Yeong Lee ),( Eun Ran Kim ),( Young Ho Kim ),( Chang Kyun Lee ),( Suck Ho Lee ),( Jae Hak Kim ),( Kyu Chan Huh ),( Soon Man Yoon ),( Hyun Joo 대한장연구학회 2014 Intestinal Research Vol.12 No.4

Background/Aims: Several recent studies have reported that the early use of infliximab (IFX) improves the prognosis of Crohn`s disease (CD). However, no data are available from Asian populations, as the forementioned studies have all been conducted in Western countries. The aim of the current study was to evaluate the impact of early use of IFX on the prognosis of Korean patients with CD. Methods: Patients with a diagnosis of CD established between July 1987 and January 2012 were investigated in 12 university hospitals in Korea. Because insurance coverage for IFX treatment began in August 2005, patients were assigned to either of 2 groups based on diagnosis date. The first group included patients diagnosed from July 1987 to December 2005, and the second from January 2006 to January 2012. We compared the cumulative probabilities of operation and reoperation between the two groups using the Kaplan-Meier method and a log-rank test. Results: Of the 721 patients investigated, 443 (61.4%) comprized the second group. Although the cumulative probabilities of immunosuppressant (P<0.001) and IFX use (P<0.001) after diagnosis were significantly higher in the second group, there were no significant differences in cumulative probabilities of operation (P=0.905) or reoperation (P=0.418) between two groups. Conclusions: The early use of IFX did not reduce CD-related surgery requirements in Korean patients with CD. These study results suggest that the early use of IFX may have little impact on the clinical outcome of CD in Korean patients in the setting of a conventional step-up algorithm. (Intest Res 2014;12:281-286)

The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis

( Ki-nam Shim ),( Jin Il Kim ),( Nayoung Kim ),( Sang Gyun Kim ),( Yun Ju Jo ),( Su Jin Hong ),( Jeong Eun Shin ),( Gwang Ha Kim ),( Kyung Sik Park ),( Suck Chei Choi ),( Joong Goo Kwon ),( Jie-hyun K 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.5

Background/Aims: Irsogladine maleate, an enhancer of gastric mucosal protective factors, has demonstrated its efficacy for various gastric mucosal injuries. The aim of this study was to evaluate the efficacy and safety of irsogladine for prevention of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin-induced peptic ulcer and gastritis. Methods: In this multicenter, randomized, double-blind, exploratory clinical trial, 100 patients over 50 years of age who needed continuous NSAIDs or aspirin for more than 8 weeks were randomly assigned to either test group (irsogladine maleate 2 mg, twice daily, 39 patients for full analysis) or placebo group (37 patients for full analysis). Primary outcomes were incidence of peptic ulcer and ratio of modified Lanza score (MLS) 2 to 4. Secondary outcome was the number of acute erosions confirmed by endoscopy at 8 weeks. Adverse effects were also compared. Results: There were no significant differences in gastric protective effects between test and placebo groups. However, two cases of peptic ulcer in the placebo group but none in the test group were observed. These two cases of peptic ulcer were Helicobacter pylori-negative. In addition, H. pylori-negative group showed significant changes in MLS score (p = 0.0247) and edema score (p = 0.0154) after the treatment compared to those before treatment in the test group. There was no significant difference in adverse events between the two groups. Conclusions: The efficacy of irsogladine maleate was found in H. pylori-negative group, suggesting its potential as a protective agent against NSAIDs or aspirin-induced peptic ulcer and gastritis.

Effect of Nitrogen Application Rates on Nitrous Oxide Emission during Crop Cultivations in Upland Soil

( Jong Eun Lee ),( Yeo Uk Yun ),( Moon Tae Choi ),( Suck Kee Jung ),( Yun Gyu Nam ),( Prabhat Pramanik ),( Pil Joo Kim ) 한국환경농학회 2012 한국환경농학회지 Vol.31 No.3

BACKGROUND: Generally, nitrogen (N) fertilization higher than the recommended dose is applied during vegetable cultivation to increase productivity. But higher N fertilization also increases the concentrations of nitrate ions and nitrous oxide in soil. In this experiment, the impact of N fertilization was studied on nitrous oxide (N2O) emission to standardize the optimum fertilization level for minimizing N2O emission as well as increasing crop productivity. Herein, we developed N2O emission inventory for upland soil region during red pepper and Chinese milk vetch cultivation. METHODS AND RESULTS: Nitrogen fertilizers were applied at different rates to study their effect on N2O emission during red pepper and Chinese milk vetch cultivation. The gas samples were collected by static closed chamber method and N2O concentration was measured by gas chromatography. The total N2O flux was steadily increased due to increasing N fertilization level, though the overall pattern of N2O emission dynamics was same. Application of N fertilization higher than the recommended dose increased the values of both seasonal N2O flux (94.5% for Chinese cabbage and 30.7% for red pepper) and N2O emission per unit crop yield (77.9% for Chinese cabbage and 23.2% for red pepper). Nitrous oxide inventory revealed that the N2O emission due to unit amount of N application from short-duration vegetable field in fall (autumn) season (6.36 kg/ ha) was almost 70% higher than that during summer season. CONCLUSION: Application of excess N-fertilizers increased seasonal N2O flux especially the N2O flux per unit yield during both Chinese cabbage and red pepper cultivation. This suggested that the higher N fertilization than the recommended dose actually facilitates N2O emission than boosting plant productivity. The N2O inventory for upland farming in temperate region like Korea revealed that N2O flux due to unit amount of N-fertilizer application for Chinese cabbage in fall (autumn) season was comparatively higher than that of summer vegetables like red pepper. Therefore, the judicious N fertilization following recommended dose is required to suppress N2O emission with high vegetable productivity in upland soils.

급성 소장 폐쇄를 동반한 십이지장 주위 탈장 1예

조은영 ( Eun Young Cho ),최창수 ( Chang Soo Choi ),유남진 ( Nam Jin Yoo ),황의태 ( Eui Tae Hwang ),이준영 ( Jun Young Lee ),강동백 ( Dong Beak Kang ),최석채 ( Suck Chei Choi ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.6

Paraduodenal hernias are rare congenital malrotational anomalies of midgut that arise in the potential spaces and folds of the posterior parietal peritoneum adjacent to the ligament of Treitz and can lead to intestinal obstruction. Also, they have shown several presentation patterns, such as asymptomatic, chronic intermittent abdominal pain, and acute severe abdominal pain. If symptomatic hernias with strangulation are untreated, according to the previous reports, they lead to overall mortality exceeding 50%. We report a case of the left paraduodenal hernia combined with small bowel obstruction from the patient who had no history of surgery before and developed abdominal pain after drinking of alcohol heavily. Abdominal CT scan showed sac-like mass of clustered in the left upper quadrant. The patient underwent the surgery of the bowel reduction and adhesiolysis and got uneventful recovery. (Korean J Gastroenterol 2009;53:369-372)

주의력결핍/과잉운동 장애(ADHD) 남자 아동들에서 Methylphenidate 치료 전후에 Tc-99m ECD SPECT로 측정된 국소 뇌혈류 이상과 인지적 특성변화와의 연관관계 : Statistical Parametric Mapping(SPM)과 전산화된 한국판 주의력 장애 진단 시스템(ADHD Diagnostic System, ADS)을 이용한 정량적 분석 Quantitative Analysis by Using Statistical Parametric Mapping(SPM) and ADHD Diagnostic System(ADS)

오은영,황이삭,문재석,조선미,윤석남,이명훈 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2

Objective The purpose of this study was to examine the regional cerebral blood-flow (CBF) difference between boys with pure ACHD and normal controls before and after methylphenidate treatment, and also we examined the association between rCBF changes and cognitive characteristics of boys with pure ADHD before and after methylphenidate treatment. Methods The rCBF of 5 boys with pure AOHD and 5 control boys were examined by Tc-99m ECD brain SFECT and cognitive characteristics by ADS and every 5 ADHD boys took MPH for 12 to 16 weeks After that all ADHD boys took Tc-99m ECD brain SPECT and checked ADS again rCBF difference and changes before and after MPH treatment were quantified and analyzed by using SPM And associations between types of cognitive changes measured by ADS and rCBF changes were examined and quantitative associations between them were also analyzed by using Pearson's coefficient correlation. Results 1) Before MPH treatment, rCBF of ADHD boys were significantly decreased in left orbitofrontal area and left caudate nucleus compared to normal controls 2) After MPH treatment. rCBF of the same regions were significantly increased. 3) There was positive correlation between the degree of commission error(impulsivity disinhibition) among the ADS variables and the degree of blood-flow decrease in above two areas before MPH treatment but after MPH treatment, only with the degree of rC3F increase in Lt orbitofrontal area. Conclusion : These results suggest that the pathophysiology of impulsivity of disinhibition of the characteristic symploms of AOHD boys IS associated with hypoactivties of left orbibfrontal area and left caudate nucleus, and MPH pharmacodynamics in ADHD boys is associated to their actions on these two areas.

Expression and Localization of Neuregulins and their receptors, ErbB family during sciatic nerve regeneration

(Ju Suck Nam),(Eun Mi Hwang),(Yun Hee Kim) 경희대학교 동서약학연구소 1997 연구업적집 Vol.12 No.-

초음파 수술흡인기(CUSA)를 이용한 척수 경막내 종양 수술에 대한 임상적 연구

김은영,정환영,김남규,김광명,오석전 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6

The cavitron ultrasonic surgical aspirator(CUSA) has been used for the surgical removal of 26 cases of spinal intradural tumors. In 26 patients, total removal was possible in 77% and there was no neurological deterioration due to surgical removal using CUSA. 21 of 26 patients(84%) showed neurological improvement at long term follow-up examination. The cavitron ultrasonic surgical aspirator had advantages in the surgical removal of spinal intradural tumors, as follows : 1) precise removal of tumor without excessive mechanical manipulation of normal tissue ; 2) rapidity of action relative to the consistency of the tissue ; 3) direct visualization of the tissue being removed and good proprioceptive feedback for the surgeon ; 4) preservation of large vessel and very little bleeding ; 5) lack of thermal injury. The limitation of CUSA was obscuring of operation field by large and straight hand piece.

급성 뇌경막외 혈종의 비수술적 치료 결과 : Analysis of 43 Cases

김은영,정환영,김남규,김광명,오석전 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.5

The authors present 43 cases of intracranial acute epidural hematomas(EDH's) managed by close observation. In each of 43 cases, the following criteria were met : 1) the patient was conscious soon after head injury ; 2) the volume of hematoma was under 30㎖(10㎖ in case of posterior fossa EDH's) ; 3) there was no severe effacement of basal cistern of 4th ventricle ; 4) there was no associated intradural lesion ; 5) the patient showed neither cerebral herniation nor cardiorespiratory abnormalies. Of the 43 patients, 31 (72%) showed no hematoma enlargement, and showed resolution of hematoma on computerized tomography(CT) scans over a period of 4 to 11 weeks. Repeat CT scans within 24 hours of initial CT revealed enlargment of EDH in 12 of 43 patients(28%), of these 12 EDH's, 5 were reabsorbed spontaneously from 6 to 10 weeks, and 7 were evacuated surgically. All patients recovered without morbidity except one who had craniotomy during observation. There was no specific location of EDH which was indicated or contraindicated for conservative treatment. Factors that influence outcome include the age of patient, initial CT finding, cerebrospinal fluid(CSF) leakage, the use of mannitol, and recovery from shock. Hematoma enlargement did not always accompany deterioration of consciousness, therefore repeat CT scans within 24 hours is strongly recommended.