전신성 홍반성 루푸스 환아에서 병발한 혈구 탐식성 조직구 증식증 1례

황자영,노석만,이진,장필상,김영훈,김진택,이준성,Hwang, Ja Young,No, Suk Man,Lee, Jin,Jang, Pil Sang,Kim, Young Hoon,Kim, Jin Tack,Lee, Joon Sung 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.10

본 저자들은 전신성 홍반성 루푸스와 미만성 증식성 사구체신염으로 진단된 남아의 치료과정 중 발열과 혈구 감소증이 지속된 환아에서 이차성 혈구 탐식성 조직구 증식증을 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Hemophagocytic lymphohistiocytosis is a reactive disorder characterized by a generalized non-malignant histiocytic proliferation with prominent hemophagocytosis by stimulated histiocytes in the bone marrow and reticuloendothelial systems resulting in pancytopenia and liver dysfunction. Several diseases including infection, malignancy and autoimmune disease are known to be causative disorders. This case demonstrated histiocytic hemophagocytosis in the bone marrow, resulting in pancytopenia during treatment of systemic lupus erythematosus and did not show any underlying disease.

박정희 경제 체제의 형성과 지속

황석만(Suk-man Hwang) 서울대학교 아시아연구소 2012 아시아리뷰 Vol.2 No.1

발전국가이론은 국가가 경제에 적극적으로 개입하여 경제성장에 성공할 수 있음을 일본을 비롯한 동아시아 국가 사례를 들어 보여주었다. 한국의 경제 발전 경험도 발전국가이론의 유용성을 보여주고 있다. 하지만, 경제성장을 설명하기 위해 필요한 변수를 경제성장 초기 전후에만 한정 짓는 것은 발전국가론의 한계이다. 한국의 경우 경제성장이 시작되기 전 이미 수백 년 이상 정교한 중앙집권적 국가를 경영했던 경험이 있으며, 상당한 수준의 교육, 일본 식민지하에서의 산업화 경험 등 발전에 필요한 조건의 상당 부분을 갖고 있었다. 당시 국제 정치경제적 요건도 발전국가가 작동하기에 유리한 조건을 형성하고 있었다. 한국 발전국가는 이처럼 선행했던 역사적 조건을 활용할 수 있었기 때문에 작동 가능했던 것이다. 이글은 한국 경제 발전 관련 변수를 시기적으로 확장하고 경로의존이론을 활용하여 발전국가이론을 보완, 확장하였다. 이를 통해 한국의 경제성장은 다양한 역사적 배경 요인에 힘입었으며, 사회구성원들의 행동 결과가 한국 발전국가 작동에 중요한 영향을 미쳤다는 점을 보여주고자 하였다. While the developmental state theory is known to successfully explain the East-Asian economic development, it has often been criticized for lacking a historical perspective. This paper attempts to overcome this shortcoming by examining the historical factors that preceded the development, which have influenced the working of Korean developmental state. Incorporating these historical factors, this paper takes a path-dependent approach to broaden the scope of the developmental state theory, so as to deepen our understanding of it.

앵두 Ethanol 추출물의 항균력과 Flavonoid

황호선(Ho-Sun Hwang),김중만(Joong-Man Kim),전예정(Ye-Jung Jeon),송영애(Young-Ae Song),박효숙(Hyo-Suk Park) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.6

앵두의 기능성 물질을 검색하기 위하여 50%, 70% 및 95% (v/v)의 ethanol 추출물에 대한 flavonoid류를 정량하고 MIC와 disk test를 이용한 항균력 및 자외선 차단효과를 조사하였다. 앵두의 70%(v/v) ethanol 추출액에서 가장 높은 flavonoid함량을 나타냈고 quercitrin의 함량은 ethyl acetate 분획에서 12.70 ㎎%, buthanol분획에서 2.11 ㎎%로 대부분 ethyl acetate 분획에서 분리되었다. 또한 앵두 70%(v/v) ethanol추출물의 flavonoid류는 quercitrin 14.9 ㎎%, tannin 6.0 ㎎% 및 catechin 5.2 ㎎%로 정량되어 quercitrin이 앵두의 주요 flavonoid임을 확인하였다. 앵두의 ethanol 추출물에 대한 Staphylococcus aureus(ATCC 6538)와 Staphylococcus epidermidis(ATCC 12228)의 항균력은 flavonoid함량이 높은 ethyl acetate 분획에서 가장 높은 항균력을 나타내어 앵두의 flavonoid에 의한 결과로 확인되었다. 앵두의 ethanol 추출물의 자외선 차단효과는 인체의 피부에 손상을 주는 UVB 파장인 290~320 ㎚를 포함하는 210~380 ㎚로 넓게 자외선 흡수대를 형성하고 catechin과 quercitrin의 흡수대와 동일한 패턴을 나타내어 그의 기능성이 예상되었다. 따라서 앵두의 기능성을 나타내는 주요 성분은 quercitrin으로 피부에 관련된 항균효과와 자외선 차단효과를 예상할 수 있었다. Quantitaties of flavonoids were determined by HPLC in three different ethanol extract (50, 70 and 95%, v/v) from Korean cherry. Antimicrobial activity of the ethanol extract and its solvent fraction (ethyl acetate and n-butanol fractions) against Staphylococcus aureus (ATCC 6538) and Staphylococcus epidermidis (ATCC 12228) was evaluated using MIC and disk test. Additionally, UV protective effect was also determined. The highest flavonoid quantity was found in 70% ethanol extract of Korean cherry. The quantities of quercitrin were 12.7 ㎎% and 2.1 ㎎% in ethyl acetate fraction and in buthanol fraction, respectively. In addition, the flavonoid in 70% (v/v) ethanol extract of Korean cherry included 14.9 ㎎% of quercitrin, 6.0 ㎎% of tannic acid and 5.2 ㎎% of catechin. Therefore, it was confirmed that main flavonoid of Korean cherry was quercitrin. For antimicrobial activity of ethanol extract of Korean cherry against Staphylococcus aureus (ATCC 6538) and Staphylococcus epidermidis (ATCC 12228), MIC and disk test using ethyl acetate fraction and butanol fraction were carried out. As a result, ethyl acetate fraction with higher quantity of flavonoid showed higher antimicrobial activity. Therefore, it was confirmed that the higher antimicrobial activity was brought about by flavonoid in Korean cherry. For UV protective effect of Korean cherry, ethanol extract showed the absorption zone of ultraviolet rays in 210~380 ㎚ including 290~320 ㎚ that is the wave length of UV-B harmful to the skin of human body. The pattern is the same as the absorption zone of 220~300 ㎚ in catechin and 210~400 ㎚ in quercitrin. Then, the functionalities of catechin and quercitrin were anticipated. It is expected that quercitrin in Korean cherry has the antimicrobial effect and UV protective effect related to the skin.

소아 야제에 대한 추나요법 효과 체계적 문헌고찰

황만석 ( Man Suk Hwang ),신병철 ( Byung Cheul Shin ),허광호 ( Kwang Ho Heo ),허인 ( In Heo ),김병준 ( Byung Jun Kim ),김기봉 ( Ki Bong Kim ),천진홍 ( Jin Hong Cheon ),박재홍 ( Jae Hong Park ),황의형 ( Eui Hyoung Hwang ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.3

Objectives To evaluate the evidence supporting the effectiveness of Chuna manual therapy for nocturnal crying. Methods We conducted search across the 3 electronic databases (Pubmed, CAJ and Oasis) to find all of randomized controlled clinical trials(RCTs) that used Chuna manual therapy as a treatment for nocturnal crying. The methodological quality of each RCTs was assessed using the Cochrane Risk of Bias tool and nRCTs was assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study tool. Results Two RCTs and three nRCTs met our inclusion criteria. The meta-analysis showed positive results for the use of Chuna manual therapy in terms of the efficacy rate when compared to medication treatments alone. Positive results were also obtained, in terms of the efficacy rate, when comparing Chuna manual therapy combined with acupoint application therapy to Chuna manual therapy alone, but was not statistically significant. Conclusions Our systematic review found encouraging but limited evidence of Chuna manual therapy for nocturnal crying. We recommend clinical trials which compare the effectiveness of Chuna manual therapy with usual care to obtain stronger evidence without the demerits of trial design. (J Korean Med Rehab 2015;25(3):51-57)

RESTRUCTURING REVISITED

HWANG SUK-MAN(황석만),LIM HYUN-CHIN(임현진) 서울대학교 사회발전연구소 2003 Journal of Asian Sociology Vol.32 No.2

UPT 표준동향 -SS1/CS2를 중심으로

황진경(Hwang Jinkyung),허성필(Hur Sung-Phil),정만상(Chung Man-Sang),신석현(Shin Suk-Hyun) 한국통신학회 1998 한국통신학회 학술대회 및 강연회 Vol.1998 No.12

추나 치료에 대한 국내 연구 동향 - 임상논문의 종류, 발표 년도, 학회지, 부위에 따른 술기 중심으로

황만석,조현우,이현엽,허광호,황의형,신미숙,신병철,Hwang, Man-Suk,Cho, Hyun-Woo,Lee, Hyeon-Yeop,Heo, Kwang-Ho,Hwang, Eui-Hyoung,Shin, Mi-Suk,Shin, Byung-Cheul 척추신경추나의학회 2013 척추신경추나의학회지 Vol.8 No.1

Objectives: The aim of this study was to analyse the domestic trends of Chuna treatments techniques in Korean literature. Methods: We searched the clinical trials on Chuna treatments through both electronic search(used keyword 'chuna') and hand search in 3 Korean web databases(OASIS, NDSL, RISS) and 4 related journals(The Journal of Korea CHUNA Manual Medicine for Spine & Nerves, Journal of Oriental Rehabilitation Medicine, The Journal of Korean Acupuncture & Moxibustion Society, Journal of Korean Medicine Society). All relevant clinical trials were selected and extracted to be analyzed according to their published year, journals, types of study, used techniques. Results: The number of the clinical studies tends to increase every year. The studies on Chuna treatments were mainly published in The Journal of Korea Chuna Manual Medicine for Spine & Nerves. In case of types of study, case reports and case series were predominant. The most frequently adopted techniques of Chuna in studies were flexion distraction technique for lumbar spine and JS supine position cervical spine distraction. Conclusions: Through the results of this study, we hope that the more qualitative education could be conducted by strengthening the techniques which often used. Also analysis of the reason of rarely used techniques should be conducted and the modification or developing techinques should be followed as a counter measures. As applying more rigorous methodology, more qualitative evidence based Chuna studies should be conducted in future clinical research.

배수혈의 내장기 치료 기전에 관한 연구

황만석 ( Man-suk Hwang ) 대한경락경혈학회 2016 Korean Journal of Acupuncture Vol.33 No.3

Objectives : This study aims to overview the therapeutic mechanism of back-shu points in terms of sympathetic visceral motor nervous system. Methods : Studies about autonomic nervous system, and studies and ancient texts about back-shu points were reviewed. We interpreted possible mechanism of back-shu points considering similarities of anatomical and physiological characteristics of back-shu points and visceral motor nervous system. Results : Afferent signals for organ lesions that can develop the symptoms of autonomic neurological symptoms, pain, hyperalgesia through the skin segment. Through a physical examination of the myotome and dermatome, it is possible to diagnose segmental disorders. Treatment stimulation of the thick fibers of the disorder segment skin can reduce abnormal autonomic influence over the sympathetic reflex mechanism. In addition, if spinal muscles are relaxed, the pressure on the nerve roots could be reduced and consequently the hyperactivity of the sympathetic visceral motor signal would be suppressed. Conclusions : The back-shu points treatments work through the mechanism of the sympathetic nervous reflex. Moreover, segmental acupuncture can reduce tension of the spinal muscles, thereby improving pathological conditions of the sympathetic nervous system.

『黃帝內經ㆍ素問』에 수록된 '東'字, '西'字, '南'字, '北'字의 解釋 및 飜譯

Hwang Man-suk(黃萬錫),Kim Jeong-soo(金楨洙),Kwon Young-kyu(權寧奎),Baek Jin-ung(白晋雄) 대한한의학원전학회 2009 대한한의학원전학회지 Vol.22 No.2

The existing interpretations and translations do not give adequate explanations about hidden meanings of the oriental theory, making it not easy for other researchers not majoring in oriental medicine to understand oriental medical classics. For other researchers who are trying to understand oriental medical classics and perform interdisciplinary co-research, we suggest there should be more detailed explanations about the hidden meaning of oriental theory such as Eumyang(陰陽, Yinyang) theory, Five-phase[五行] theory, Un-gi(運氣) theory. This paper, interpreting and translating the east(東), the west(西), the south(南), the north(北) in 『HwangjenaegyeongㆍSomun(黃帝內經ㆍ素問)』 focusing on the meaning of each character, will be a good example of such detailed explanation.

일차성 불면증의 추나 치료에 대한 문헌 연구 보고

황만석 ( Man-suk Hwang ) 대한한의학회 한방재활의학과학회 2016 한방재활의학과학회지 Vol.26 No.3

Objectives To evaluate the evidence supporting the effectiveness of Chuna manual therapy for primary insomnia. Methods The researcher conducted search across the 3 electronic databases (Pubmed, CAJ and Oasis) to find all of randomized controlled clinical trials(RCTs) that used Chuna manual therapy as a treatment for primary insomnia. Results Four RCTs met inclusion criteria. The meta-analysis showed positive results for the use of Chuna manual therapy in terms of the PSQI when compared to medication treatments alone. Positive results were also obtained, in terms of the PSQI, when comparing Chuna manual therapy combined with acupuncture therapy to acupuncture therapy alone, but was not statistically significant. Conclusions The review found encouraging but limited evidence of Chuna manual therapy for primary insomnia. We recommend clinical trials which compare the effectiveness of Chuna manual therapy with usual care to obtain stronger evidence without the demerits of trial design. (J Korean Med Rehabil 2016;26(3):79-84)