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신세포암종에서 Osteopontin 발현의 예후 인자로서 의의
홍희연,이향란,김태숙,윤길숙 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.3
Background : Osteopontin (OPN) is a glycoprotein and it participates in cell-cell and cell-matrix interactions. In vitro studies suggest that the OPN expression is associated with tumor metastasis, and especially with the metastasis of osteotropic tumors originating in breast, prostate and lungs. Since no human tissue study has suggested the means by which OPN participates in the tumorigenesis, angiogenesis, progression and metastasis of renal cell carcinoma (RCC), we evaluated the expression and prognostic significance of OPN in RCC. Methods : Immunohistochemistry was performed with using the primary antibody for OPN on the archival paraffin-embedded tissue microarray specimens from 51 RCC patients who underwent radical or simple nephrectomy. Results : In the normal kidney specimens, OPN was expressed in a few compressed distal tubules adjacent to the RCCs. In RCCs, the OPN expression was elevated in larger tumors (p<0.05) and in the tumor with low microvessel density (p<0.01). In the present study, univariate analysis indicated that stage, tumor size, lymph node and distant organ metastasis are significant prognostic factors for disease free survival (DFS) in RCC patients (p<0.01), but OPN is not (p=0.0661). Multivariate analysis indicated lymph node metastasis is the independent prognostic indicator of DFS (p<0.05). Conclusion : Though this study has statistical limitations, these results suggest OPN plays a role in tumor progression and metastasis and it may act as a potential prognostic indicator to predict the prognosis of RCC patients.
농업경영정보시스템 사용의도에 미치는 사회심리학적 요인 분석: 우수농업경영정보시스템을 중심으로
홍희연 ( Hee Yeon Hong ),문정훈 ( Jung Hoon Moon ),유철우 ( Chul Woo Yoo ),최영찬 ( Yong Chan Choe ) 한국농촌지도학회 2008 농촌지도와 개발 Vol.15 No.4
The purpose of this study is to empirically analyze factors that influence farm managers` intentions to use an agricultural farm management information systems. It focused on LFcenter System, a leading information system operated by the Rural Development Administration for farm management. Participants of this study are classified into two groups: a group of leading farm managers and a group fo regular farm managers. A total of 192 survey samples on users` intentions are collected; 85 samples from leading farm managers and 107 from regular farm managers. The theoretical background of this study is developed based on Theory of Reasoned Action(TRA), Technology Acceptance Model(TAM), Diffusion of Innovation(DOI), Social Cognitive Theory(SCT), and Theory of Planned Behavior(TPB). Partial Least Squares(PLS) method is used to test a proposed Structural Equation Model(SEM), including nine hypotheses. The differences between two groups are investigated using Smith-Satterthwait test. The findings from this study are: First of all, in terms of average comparison of most variables used in this study, a group of leading farm managers shows higher value that the other group in most cases. Second, hypothesis tests how that subjective norms, goal to study, perceived usefulness, perceived enjoyment, and intention to use significantly influence the intention to use an agricultural management information system in the group of leading farm managers. However, subjective norms, goal to study, perceived ease of use, perceived usefulness, perceived enjoyment, and intention to use turned out to significantly influence the intention to use an agricultural management information system in the group of regular farms managers. Based on the results of Smith-Satterthwait test, compared with a group of leading farms managers, the impact of goal to study on intention to use is significantly stronger. On the other hand, in the group of leading farms managers, perceived usefulness and perceived enjoyment turned out to be main drivers of intention to use.
외상후 스트레스장애에 대한 하타 스타일 요가 치료의 해외 임상연구 동향
홍희연 ( Hee-yeon Hong ),홍민호 ( Min-ho Hong ),구병수 ( Byung-su Koo ),김근우 ( Geun-woo Kim ) 대한한방신경정신과학회 2020 동의신경정신과학회지 Vol.31 No.1
Objectives: The purpose of this study was to review the research trends in the treatment of hatha-style yoga on Post Traumatic Stress Disorder (PTSD). Methods: We searched articles in Pubmed and the China National Knowledge Infrastructure (CNKI) January 2010-December 2019, for studies to treat PTSD using hatha-style yoga. Selected studies were evaluated by the CLEAR-NPT (A Checklist to Evaluate a Report of a Non-pharmacological Trial). Results: Seven randomized controlled clinical trials were selected. PSS-I (PTSD Symptom Scale-Interview) was the most frequently used as diagnostic criteria. The PCL (PTSD Checklist) was also the most commonly used outcome measurement. Of the seven articles, most studies reported that hatha-style yoga was effective to reduce symptoms of PTSD. Conclusions: Hatha-style yoga practice intervention can be used to relieve symptoms of PTSD. More studies should be conducted to make hatha-style yoga as protocol (complementary therapy) for PTSD patients.
포르말린 고정 파라핀 포매된 유육종증 환자의 조직을 이용한 안지오텐신 전환 효소 유전자 다형성 검색
김태숙,홍희연,이인철 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.4
Background : Sarcoidosis is a systemic disease characterized by nonnecrotizing granulomas involving the lung and hilar lymph nodes. Serum angiotensin converting enzyme (sACE) levels in patients with sarcoidosis have been implicated as an indicator of granuloma burden. Recently, it has been found that ACE gene insertion/deletion (ID) polymorphism affects sACE levels in healthy individuals. Moreover, reported sACE levels were highest in the deletion/deletion (DD) genotype. Previous studies to investigate the distribution of ACE genotypes according to ethnic groups have revealed various results and have caused controversy. Methods : Polymerase chain reactions were performed to determine the ACE genotypes in fifteen formalinfixed, paraffin-embedded tissues from patients with sarcoidosis. Results : The distribution of ACE gene (I/D) polymorphism in patients with sarcoidosis was significantly different from that in normal controls. The DD genotype was more frequent in patients with sarcoidosis than in the normal controls. The D allele frequency was also higher in patients with sarcoidosis than in the normal controls. The relative risk of sarcoidosis was higher in DD homozygotes. Conclusions : These results suggested the ACE gene I/D polymorphism may play an important role in the pathogenesis and progression of sarcoidosis.
윤길숙,홍희연,김태숙 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.4
Background : CD44 is a transmembranous glycoprotein that participates in cell-cell and cellmatrix interactions, and it also contributes to cell migration. In vitro studies have suggested that the expression of CD44 isoforms is associated with tumor metastasis. Since it is not clear whether the CD44 isoforms play a role in the tumorigenesis, differentiation, progression or metastasis of renal cell carcinomas (RCCs). Methods : We performed immunohistochemistry with primary antibodies for the standard CD44 (CD44s) and the CD44 variant exon 6 (CD44v6) on the archival paraffin-embedded tissue microarray (TMA) specimens from 51 RCC patients. Results : In the normal kidney, the expressions of both CD44s and CD44v6 were negligible. The CD44s expression was increased in accordance with the tumor size (p<0.01), but it was not related to the microvessel density (MVD). No CD44v6 expression was observed in all RCC cases. Univariate analysis indicated that stage, tumor size, lymph node metastasis and distant organ metastasis were the statistically significant prognostic factors for disease free survival (DFS) (p<0.01), and the multivariate analysis proved that stage (p<0.01) and tumor size (p< 0.05) were the independent prognostic factors for DFS. Conclusions : Our results suggest that CD44s, but not CD44v6, plays a role in tumor progression and it could be a potential prognostic factor for patients with RCCs.
한약재의 효소적 갈변방지에 관한 연구 : crude drug materials
강길진,오금순,홍희연,고용석,서일원,김용재,박동희,서진,정의섭 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
식품원료용 한약재의 효소적 갈변방지를 위하여 기존의 방법 (연탈건조, 유황훈증, 아황산염류 처리등의 건조가공법)을 대체하여 한약재의 안전성을 확보할 수 있는 새로운 갈변방지 기술의 개발이 필요하였다. 먼저 유기산 및 그 유도체를 대상 (구연산외 12종)으로 한약재의 갈변방지 효과를 실헙한 결과, 1% 수준에서 구연산, 아스코르빈산, 이소아스코르빈산, 초산 순으로 효과가 있었다. 그 중에서도 구연산과 아왑산염 (Na2s205)에 대하여 독활, 갈근, 작약을 대상으로 비교 실험했을 때, 구연산은 아황산염 (Naasf05)과 유사한 괌변방지 효과를 보였다. 구연산을 이용한 작약의 갈변방지 기술을 개발하였는데, 이 기술은 3% 구연산액 (린t)에 작약 절편을 30분간 침지한 다음 40t 열풍건조하는 기술이다. 건조시간은 약 6-7시간 소요되었으며 약효성분의 변화토 크지 않았다. 이 기술은 갈변방지는 물론이고 건조시간 단축, 비용절감 등의 효과가 커서 앞으로 식품원료용 한약재의 갈변방지 기술로 기대된다. This research are to find an effective antibrowning agents for sulfites substitutes and to deve?op an effective method for inhibition of rnfyrrlatic browning in meacalherbs (crude drug matenals). An effective antibrowning agent for sulfites suhstihites ininhibition of enzYmatic browning of medical herbs was citric acid. And an effecti)7eantibrowning rrlethod cf foeoniore Fodir rusro was developed using 40'E heated air dryingafter immersion for 30 rUn at 25'E with 3% citric acld solution. In this method, the dryingtime of foeoHiore rafi'』 rusro was 6-7 hour and the content of its paeoniflorin was notchanged bareIH. These results )vere the most an effectiye method (or inhibition of enzymatic browning inrriedical heFbs.