정상 성인에서 총콜레스테롤의 분별치와 관련 요인

홍인선(In-Sun Hong),김지식(Chi-Shik Kim),여영규(Yeong-Gyu Yeo) 대한의생명과학회 1996 Biomedical Science Letters Vol.2 No.2

정상 성인에서 혈청 총 콜레스테롤의 분별치 및 관련된 제요인을 파악하기 위하여 1995년 3월부터 10월까지 8개월 동안 전주 예수병원에서 의료보험 피보험자와 피부양자를 대상으로 한 정기 건강 검진을 받은 대상자 중 성별, 연령별, 혈압, 체중, 기타 생화학적 검사 결과를 분석하였으며, 이들 중 고혈압 등 질병이 없는 건강한 집단으로 1,818명을 분석하였다. 혈청 총 콜레스테롤의 분별치를 산정하기 위한 75th percentile값을 보면, 21~30세군에서 191 ㎎/㎗ 31~40군에서 195 ㎎/㎗, 41~50세군에서 214 ㎎/㎗, 51~60세군에서 227 ㎎/㎗, 그리고 61세 이상 군에서 222 ㎎/㎗ 이었다. 90th percentile값을 보면, 21~30세군에서 214 ㎎/㎗, 31~40군에서 214 ㎎/㎗, 41~50세군에서 239 ㎎/㎗, 51~60세군에서 253 ㎎/㎗, 그리고 61세 이상군에서 248 ㎎/㎗ 이었다. 혈청 총 콜레스테롤과 각 변수간의 상관관계는 연령과는 남ㆍ여 모두 유의한 관계를 보였고(p<0.001), 특히 여자에서 높은 상관성을 보였다. 비만지수인 PIBW, BMI와도 유의한 상관성을 보였고, 수축기혈압과 이완기혈압과도 관련성을 보였다. 대상자들의 흡연 여부와 혈청 총 콜레스테롤과의 관계는 흡연군이 191.6±35.0 ㎎/㎗ 이었고, 비흡연군이 194.9±35.9 ㎎/㎗였으며 두 집단간에는 유의한 차이를 보이지 않았다. 음주에 따른 혈청 총 콜레스테롤의 측정치는 비음주군에서는 196.0±36.0 ㎎/㎗ 이었고, 음주 군에서는 188.9±34.5 ㎎/㎗로 두 군간에는 유의한 차이를 보였다. 운동 습관과 혈청 총 콜레스테롤의 관계는 규칙적으로 운동을 하는 군은 192.1±33.3 ㎎/㎗이었고, 운동을 하지 않는 군은 195.8±37.0 ㎎/㎗였으며 두 군간에는 유의한 차이를 보였다. The cut-off values and related factors for total cholesterol of serum in normal Korean adults were studied from March to October, 1995, based on the data of 1,818 healthy adults of human involved the male and female. The comparisons of the serum total cholesterol levels were analyzed by sex, age, systolic blood pressure, diastolic blood pressure, body weight, height, PIBW, BMI and other biochemical tests. 1. The serum total cholesterol level were 194.4 ㎎/㎗ in total group, 186.9 ㎎/㎗ for male, and 197.6 ㎎/㎗ for female. 2. There was no significant differences by sex among the 21 to 50 ages group, but significantly higher in women than in men over 51 years old. 3. In general, the levels of serum total cholesterol were increased with age, the highest level in men was 192.7 ㎎/㎗ in 51 to 60 years old, and 210.5 ㎎/㎗ in more than 60 years old in women. 4. The cut-off values of serum total cholesterol for moderate risk. were 191 ㎎/㎗ in 21 to 30 years group, 195 ㎎/㎗ in 31 to 40 years, 214 ㎎/㎗ in 41 to 50 years, 227 ㎎/㎗ in 51 to 60 years, and 222 ㎎/㎗ in more than 61 years. The cut-off values of serum total cholesterol for high risk were 214 ㎎/㎗ in 21 to 30 years group, 214 ㎎/㎗ in 31 to 40 years, 239 ㎎/㎗ in 41 to 50 years, 253 ㎎/㎗ in 51 to 60 years, and 248 ㎎/㎗ in more than 61 years. 5. The mean values of serum total cholesterol were showed positive correlation with age, PIBW, BMI, systolic blood pressure and diastolic blood pressure. 6. Serum total cholesterol level of drinking group(188.9±34.5㎎/㎗) was showed lower than those of non-drinking group(196.0±36.0㎎/㎗). 7. Serum total cholesterol levels of regular excercise group(192.1±33.3 ㎎/㎗) was significantly lower than those of non regular excercise group(195.8±37.0 ㎎/㎗).

랫드와 비글에서 GC-100X 세정제의 독성에 대한 연구

강경선,조성대,안남식,정지원,양세란,박준석,박기수,홍인선,서민수,조은혜,이영순,Kang, Kyung-Sun,Cho, Sung-Dae,Ahn, Nam-Shik,Jung, Ji-Won,Yang, Se-Ran,Park, Joon-Suk,Park, Ki-Soo,Hong, In-Sun,Seo, Min-Soo,Jo, Eun-Hye,Nguyen, Ba Tiep,Lee, 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.1

Because cleaning products are part of our everyday lives, it is essential that they should not present significant risks to health. However, many petrochemicals in most soaps and detergents can be absorbed through the scalp and skin and, over time, accumulate in the organs and tissues. This accumulation may result in brain, nerve, and liver damage. Therefore, it is interested in developing non-harmful detergent. According to Korea Research Institute of Chemical Technology, GC-100X may be non-harmful and non-corrosive alkaline ionic water (pH 12). It is composed of hydroxyl radicals and supplemented with xylitol. To evaluate influence of GC-100X on rats and beagles, GC-100X was diluted with distilled water (25%, 50%, and 100% solution respectively). Each of diluted GC-100X was daily treated per oral. In body weight analysis, urinary analysis, ophthalmological test and autopsy, we did not find any significance, but in serum biochemical analysis and hematological analysis, we found some significances in middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by GC-100X, because it was not found to be significant from control group in histopathological examination. Thus, it is concluded that NOEL(No Observed Effect Level) of GC-100X may be higher than all treatment doses used in this study, and GC-100X may be a non-toxic detergent.

자폐증 환아의 두침(頭鍼)치료 치험 1례

홍상준,최가혜,송인선,Hong, Sang-June,Choi, Ka-Hye,Song, In-Sun 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.3

Objectives The study was designed to report the clinical effects of scalp acupuncture on autistic children. Methods These patients were treated by scalp acupuncture. We observed the improvement of his disease through K-CARS and E-CLAC tests. Results By using scalp acupuncture, we could make a considerable improvement of autistic score(K-CARS). Conclusions The above results suggest that scalp acupuncture can be an effective treatment for autistic children.

Endometrial Cell Culture: Isolation, Characterization, and Immortalization

홍인선,김석현,궁미경,전진현,이영순,강경선,Hong, In-Sun,Kim, Seok-Hyun,Koong, Mi-Kyoung,Jun, Jin-Hyun,Lee, Yong-Soon,Kang, Kyung-Sun The Korean Society for Reproductive Medicine 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.4

목 적: 본 실험의 목적은 자궁내막세포를 분리 및 배양법 확립과 함께 불멸화 시키는 것이다. 방 법: 자궁내막에서 상피세포(epithelial cells)와 기질세포(stromal cells)의 분리는 Satyawaroop 등(1979)의 방법에 기초를 두었다. 자궁내막에서 상피세포와 기질세포의 순수 분리도를 확인하고, 불멸화된 기질세포에서 SV40 large T antigen을 확인하기 위하여 면역형광 염색(immunocytochemistry)과 Western blot 기법을 이용하였다. 정상 기질세포의 경우 subconfluence (60%) 상태에서 transfection을 진행하였다. 순수 분리된 plasmid DNA와 Qiagen 사의 superfect를 이용하여 transfection을 실시하였다. 결 과: 본 연구에서 우리는 두 가지 형태의 자궁내막 세포의 분리 및 배양에 성공하였다. 상피세포는 다면체의 형태를 띠며, 선(grandular)조직의 조각으로부터 나선형으로 자란다.기질 세포는 길쭉한 형태를 띠며, 상피세포에 비해 오래 살고, 빠르게 증식하여 나란한 형태로 배열된 세포 다발(cell bundle)을 형성한다. 이렇게 분리된 세포들은 95%의 균질성을 보였으며, 면역형광염색과 western blot을 통해 확인 하였다. 한편 SV40(Simian Virus 40) large T 항원을 암호화 하고 있는 염기 서열을 포함한 플라스미드 벡터로 안정적인 트랜스펙션을 시킴으로써 불멸화 된 자궁내막의 기질 세포주를 확립하였다. 불멸화 된 세포는 그 세포가 유래한 정상의 세포와 동일한 표현형을 가지고 있었다. 결 론: 본 연구에서, 우리는 자궁내막에서 상피세포(epithelial cells)과 기질세포(stromal cells)를 분리하여 배양법을 확립하였다. 동시에 SV40 large T antigen을 이용하여 불멸화된 세포주를 확립하였다. 이렇게 확립된 세포주는 자궁의 생리작용 연구 및 자궁내막증(Endometriosis)과 자궁암(Endometrial cancer) 등과 같은 여러 자궁관련 질병 연구에 많은 도움이 될 것으로 사료된다.

청소년기의 구조적 척추 측만증 치험 2례

홍상준,최가혜,송인선,이철휘,Hong, Sang-Joon,Choi, Ka-Hye,Song, In-Sun,Lee, Chul-Hwi 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.3

Objectives: The purpose of this study is to report two cases of adolescent patient with structural spinal scoliosis treated by Chuna therapy. Methods: We examined two adolescent patients with an X-ray examination. These patients were diagnosed with structural scoliosis, and we used acupuncture and Chuna method at these patients. Cobb's angle and VAS(Visual Analogue Scale) were used to evaluate effects of the treatment. Results and Conclusions: After the treatment, we got these improvement results : In one case, the Cobb's angle was improved by $8.4^{\circ}$ ($19^{\circ}$ to $10.6^{\circ}$) at thoracic level (44.2% correctability) and VAS has been changed from 5 to 1-2. In another case, the Cobb's angle was improved by $4.3^{\circ}$($11.3^{\circ}$ to $7^{\circ}$) at lumbar level(38.0% correctability) and VAS has been changed from 7 to 1-2.

소아 알레르기 비염에 대한 비내침 치료의 임상적 연구

홍상준,최가혜,송인선,Hong, Sang-Joon,Choi, Ga-Hye,Song, In-Sun 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.2

Objectives: The purpose of this study is to investigate the effect of Intranasal acupuncture treatment in allergic rhinitis patients. Methods: This study was carried with the 42 pediatric allergic rhinitis who had been treated in our hospital. Inner young-hyang was used for the intranasal acupuncture points. Their nasal cavity was observed via anterior rhinoscopy. We induced patient's inferior turbiante bleeding by acupuncture. Patients nasal symtoms and QOL(quality of life) were assessed by the Total Nasal Symptom Score(TNSS) and Quality of Life Questionnaire for Korean Rhinitisian(QLQKR). Results: Total Nasal Symptom Score(TNSS) and Quality of Life Questionnaire for Korean Rhinitisian(QLQKR) were significantly improved. Conclusions: Intranasal acupuncture treatment is relatively effective in treating pediatric allergic rhinitis.

음식섭취와 체중조절에 대한 미용적 메카니즘 고찰

홍인선(In-Sun Hong),김선희(Seon-Hee Kim) 한국화장품미용학회 2013 한국화장품미용학회지 Vol.3 No.1

Body weight and body fat content are well regulated. In humans, body weight tends to remain within a relatively narrow range, despite large day-to-day fluctuations in the amount of food consumed. Although major changes of body adiposity can be induced in humans by restricting energy intake or by overfeeding, body weight and adiposity return very close to baseline levels when ad libitum feeding is resumed. Although there are many peripheral signals that can contribute to feeding behavior and body weight regulation, it is important to recognize that short-term and long-term food intake and energy balance are regulated through distinct, but interacting, mechanisms.This review discusses hormonal and related Sateity signals generated as food is being consumed and upon adiposity signals related to the amount of fat stored in the body that influence food intake and body weight.

점ㆍ선ㆍ면을 활용한 아트메이크업 디자인 연구

박소연(So-Yeon Park),김혜옥(Hye-Ok Kim),장혜정(Hye-Jeong Chang),허선영(Seon-Yeong Huh),홍인선(In-Sun Hong),한가영(Ga-Young Han),하문선(Moon-Sun Ha),김선희(Seon-Hee Kim) 한국화장품미용학회 2014 한국화장품미용학회지 Vol.4 No.2

In modern times, Art make-up can be said experimental genre of formative arts. And the Art Make-up works aren’t taken any constraint in the method of expression. Therefore, the experimental attempt has been tried actively. So the purpose of this study is to propose a more creative expression and artistic values through the Art Make-up work. For that, considered advance researches and books about design elements then created 5 Art Make-up works using Point, Line and Plane. As a result of this study, the scalability of expression was sought by Point, Line and Plane among design elements. This study is expected to suggest some of creative ideas for Art Make-up field. And more in-depth and sustained studies effort should be directed into this field.

한방적 치료 접근을 통한 Evans 증후군 치험 1례

박상은,최인선,장자원,홍상훈,서상호,Park, Sang-Eun,Choi, In-Sun,Jang, Ja-Won,Hong, Sang-Hoon,Seo, Sang-Ho 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Evans syndrome, as originally described, refers to autoimmune hemolytic anemia accompanied by thrombocytopenia. The autoantibodies in Evans syndrome are directed specifically against red cells, platelets, or neutrophils and are not crossreacting. The incidence of autoimmune hemolytic anemia is estimated to be approximately 10 cases per million people. Many patients have associated disorders, such as lupus erythematosus and other autoimmune disease, chronic lymphadenopathy, or hypogammaglobulinemia. In Oriental Medicine, the approach to Evans syndrome is made in view of deficiency of blood. The ailment was treated through methods of Oriental Medicine. Acupucture and herbal medicine were administered to patients diagnosed with Evans Syndrome by ecchymosis at the lower limb after continued gingival bleeding. As a result significant improvement in RBC, Hb, Hct, and PLT were observed and complaints abated.

한방치료(韓方治療)로 호전된 소아(小兒) 뇌출혈(腦出血) 후유증(後遺症) 치험(治驗) 1례(1例)

최가혜,홍상준,송인선,Choi, Ka-Hye,Hong, Sang-June,Song, In-Sun 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.3

Objectives The purpose of the case study is to report the effects of stroke in childhood especially for Intracranial Hemorrhage sequela treated by oriental medical treatment. Methods The patient was treated by herbal medicine, acupuncture, moxa, and physical treatments. Results By using of oriental medical treatment, we could see significant improvement for Stroke symptoms. Conclusions This case study shows that oriental medical treatment can be an effective treatment for Stroke in Childhood. However, the further study with longer, and large clinical trials are needed for accuracy.