커버스토리 : 제주특별자치도 완성을 위한 지능기반 발전사회 구현 -제주특별자치도 정보정책과

현경화 한국지역정보개발원 (구 자치정보화조합) 2007 지역정보화 Vol.46 No.-

여성의 피부 건강 관리에 관한 지식 및 태도의 인식 분석

현경화(Hyun Kyunghwa),윤천성(ChunSung Youn) 한국뷰티산업학회 2006 뷰티산업연구 Vol.1 No.1

변화는 사회 환경 속에서 여성들의 피부건강에 관한 관심과 관심에 따른 지식 태도, 그에 따른 인식을 분석함으로서 여성들의 현제 피부건강관리에 대한 방안들을 연 구하고자 하는 목적이 이었다. 사회 속에서 여성들의 위치와 일 상속 에서 여성들의 자아실현의 중요한 몫을 행하는 자신은 가꾸는 일은 고대에서부터 시작되어 왔으며, 오늘날 산업의 발달로 인한 건강에 관여된 모든 제품들이 출시가 되는 와중에 피부건 강에 관한 제품들이 많이 쏟아져 나오고 있으며 제품의 기능 에 따른 사용 방법 과 관리방법이 체계화 되어야 하며, 이에 따른 교육과 홍보가 절실히 필요한 시대라고 할 수가 있다. 피부는 인체를 보호하는 중요한 기관으로 보호를 받아야 하며, 그 보호 속에서 피부건강은 외적으로 유지가 되는 것이다. 무분별한 제품의 오용과 남용, 그릇된 관리 방안에서 이제는 벗어나야 하며, 과학적이고 체계적인 관리방안 과 정확한 정보와 지식, 피부형태 분석, 그에 따른 태도가 필요한 때이다. 본 연구는 자료 분석을 토대로 하여 미비하거나, 개선 되여야 할 피부 건강관리 에서 많은 부분들을 보안하고 피부 건강관리의 중요성을 알리는데 목적이 있는 것 이다. This study investigated an analytic recognition of knowledge and attitude of the skin care management with the woman who lived in Seoul. And we are going to be utilized as a basic data to be helpful to women s skin care management. Of those questioned, over 53.1% said ‘usual’, and the people quizzed said ‘healthy’ (33.1%), ‘bad state of health’ (9.8%), ‘good health’ (3.3%) and ‘very bad state of health’ (0.8%) from responses in the health state questionnaire. They said ‘usual’ (52.2%), ‘ill’ (24.5%), ‘well’ (20.4%), ‘very well’ (1.6%) and ‘very bad’ (1.2%) from responses in facial skin care state questionnaire. On the other hand, they indicated a very high interest in the skin care management. They said ‘concern’ (52.7%), ‘deep concern’ (29.4%), and ‘usual’ (18.0%) from responses in self skin care management questionnaire. They most said ‘mixed skin’ (40.0%), and said ‘dry skin’ (17.6%), ‘neutral skin’ (17.1%), ‘oily skin’ (13.1%) and ‘sensitive skin’ (12.2%) from responses in own skin type questionnaire. They shown ‘My skin doesn t have an elasticity’ (36.3%), ‘My skin is very dry’ (26.9%), ‘A pimple is harsh’ (26.1%) and ‘a capillary vessel appear’ (10.6%) in a questionnaire of skin state. The worry about skin was ‘pimple’ (35.9%), ‘fine wrinkles’ (24.1%), ‘freckles’ (18.4%), ‘other’ (17.6%) and ‘absent’ (4.1%). They said public media like as Tv and newspaper (45.3%), clinic of skin care management (27.3%), the other (11.4%), family and friend colleague(10.2%) office of anddermatology (5.7%) from the questionnaire of How is acquired an information of skin care. They shown ‘often to do’ (48.6%), ‘nothing to do (46.1%), and ‘a lot to do (5.3%) from the questionnaire of ‘Did you test a skin state regularly? . They shown ‘There isn t (52.2%), and ‘There is (47.8%) from the questionnaire of ‘Did you experience a side effects of cosmetics? Those questioned shown ‘yes (92.7%), ‘ignore (5.7%) and ‘no (1.6%) and realized keenly a ncessity of skin management from the questionnaire of ‘Did you think that skin management is necessary? We tested 15 inquiries about knowledge of skin care management. The highest correct answer(98.8%) was shown form questionnaire of ‘Early aging of skin can be prevented through the skin management and ‘If a stress is got, a skin becomes rough . While the lowest correct answer was shown form questionnaire of ‘Hot, or sweet food increases a skin secretion(16.7%), the deep cleaning removes accumulating sebaceous matter(18.8%) and If a skin pulls after eyewashing, it is a dry skin(31.8%) . The knowledge of skin management of those questioned was an average of 11.54 points. The average difference(T-test, ANOVA) by the age, a general characteristic, was verified significantly in the statistics(p<.01). According to Scheffe test, the difference appear the group of under 30 years(M=11.59) and 30~39 years(M=11.60) between the group over 40 years(M=10.71). This result indicate that the group 30~39 years have a most profound knowledge of skin care management. The average difference by married or unmarried was verified significantly in the statistics(p<.05) between unmarried group(M=11.63) and married group(M=11.29). The unmarried group have a more profound than the married group in knowledge of skin care management. But The average difference by ‘education and ‘standard of living was verified unsignificantly in the statistics. We asked 15 inquiries about the attitude of skin care management and that they fill out questionnaire according to the five-grade system from ‘very so to ‘not so at all . The attitude of skin management of those questioned was an average of 56.58points. The average difference(T-test, ANOVA) by the age, a general characteristic, was verified significantly in the statistics(p<.001). According to Scheffe test, the difference appear the group of 30~39 years(M=11.60) between the group over 40 years(M=10.71).

한국에서 발생한 신종 인플루엔자(H1N1) 연관 폐렴의 고해상전산화단층촬영의 특징

이병찬,선현주,최송,김진웅,임효순,신상수,김윤현,박경화 대한영상의학회 2011 대한영상의학회지 Vol.64 No.4

Purpose: To evaluate and compare the high-resolution computed tomography (HRCT) findings of patients with H1N1 influenza-associated pneumonia compared usual community acquired pneumonia (CAP), to determine whether there were any useful common HRCT findings predicting their prognosis. Materials and Methods: HRCT findings of 31 patients (M:F = 16:15, mean age 42 yrs) with Influenza A (H1N1) infection were retrospectively reviewed for abnormal HRCT findings and compared to HRCT findings of CAP in matched patients. Patients were matched according to age and sex, from 2009 to January 2010. Results: The predominant HRCT findings of pneumonia consisted of areas of consolidation and/or groundglass opacity (GGO) which showed no statistically significant differences when comparing the two groups. However, the abnormalities of H1N1-related pneumonia showed higher bilaterality and multilobar or multisegmental involvement compared with CAP (p < 0.05). Internal low attenuation or air-densities in pulmonary infiltration /or lymphadenopathy was observed only in patients with CAP (p < 0.05). HRCT findings in 8 patients with poor clinical outcome had bilaterality (p=0.015), multilobar, and multisegmental involvement. Conclusion: The predominant HRCT findings of H1N1-related pneumonia were areas of consolidation and/or GGO. In addition, H1N1-related pneumonia showed higher bilaterality or multilobar/multisegmental involvement compared with CAP. The patients who presented bilaterality had a worse clinical outcome. 목적: H1N1 인플루엔자 바이러스와 연관된 폐렴의 흉부 고해상전산화단층촬영(HRCT) 소견을 보통의 지역사회 획득 폐렴(community acquired pneumonia, 이하 CAP)과 비교해 감별진단에 도움이 되는 영상소견이 있는지를 알아보고 영상소견에서 예후 예측인자가 있는지를 알아보았다. 대상과 방법: 2009년 9월부터 2010년 1월까지 H1N1 감염으로 진단받고 흉부 HRCT에서 이상소견을 보였던 31명(남:여 = 16:15, 평균 연령 42세)과 연령대와 성별을 적합시킨 CAP 환자 31명의 영상소견을 비교 분석했다. 결과: H1N1 연관 폐렴과 CAP의 흉부 HRCT소견은 주로 폐경화, 젖빛 유리음영과 경화의 혼재, 또는 젖빛 유리음영 순이었으며, 두 군 간에 의미 있는 차이는 없었다. 그러나 H1N1 감염 환자는 CAP 환자와 비교해 주로 양측성, 다엽성, 다분절성 폐 침윤을 보였다(p < 0.05). 폐침윤 내에 저음영 또는 공기음영이나 림프절 종대는 CAP환자에서만 보였다(p < 0.05). H1N1 감염 환자 중 8명은 기계적 호흡이 필요했던 중증도 폐렴이었고, 이들 모두에서 병변은 양측성(p=0.015), 다엽성, 다분절성 침범을 보였다. 결론: H1N1 인플루엔자 연관 폐렴의 HRCT 소견은 폐경화, 젖빛 유리음영과 경화의 혼재, 또는 젖빛 유리음영 등으로 나타나며, CAP와 비교했을 때 양측성, 다엽성 또는 다분절성의 침윤을 보이는 경향이 있다. 양측성 폐 병변은 질환의 중증도를 시사했다.

옥외광고로 활용된 증강현실의 유형 분석 연구

유다미(주저자) ( Da Mi Yu ),하효정(공동저자) ( Hyo Jung Ha ),현경화(공동저자) ( Gyeong Hwa Hyeon ),함태완(공동저자) ( Tae Wan Ham ),윤재영(교신저자) ( Jae Young Yun ) 커뮤니케이션디자인학회 2016 커뮤니케이션 디자인학연구 Vol.55 No.-

2000년대만 하더라도 증강현실(AugmentedReality)은 시험단계 이었으나 최근에는 그 이용분야가 다양해지고, 특히 광고에서의 성장세가 가파르다. 광고는 더 이상 일방적으로 메시지를 전달하지 않고 AR과 같은 기술을 통한 인터랙션이 일어나는 방향으로 진화하고 있다. 본 연구에서는 증강현실이 적용된 옥외광고의 구현기술을 알아보고 상호작용성의 정도와 기술에 따라 네 가지 유형으로 분류하였다. 연구결과, 일방적 전달유형, 소극적 상호작용유형, 간접적 상호작용유형, 직접적 상호작용 유형으로 분류되었다. 4가지 유형으로 분류되어지나 반드시 특정 유형이 우수하고 유의미하다는 것이 아니라 활용목적에 따라 활용 되어져야 할 것이다. 본 연구가 미래의 기업 광고 분야발전에 기여 할 수 있을 것이라 기대한다. Even in the 2000s, the augmented reality was tentatively applied. However, it is now used in many different areas, and especially, it is rapidly growing in the advertisement which is evolving into interactions based on the use of technologies like AR, instead of simply delivering messages any more. This study examines technologies to realize outdoor advertising using the augmented reality, and then analyzes it in each type to see the characteristics in each. According to the study results, it is classifed into four types - unilateral communication type, negative interaction type, indirect interaction type and direct interaction type- ,however, it does not mean that certain type is superior or meaningful, but it means AR should be used for its purposes. Thus, this study could be expected to contribute to growth of future corporate advertising fields.

전도성 실리콘 및 탄소 소재를 이용한 웨어러블 전극

황도현(Do Hyun HWANG),박현목(Hyun Mok PARK),장경화(Kyung Hwa CHANG),홍순우(Sun Woo HONG),한지훈(Ji Hun HAN),조나연(Na Yun CHO),이상철(Sang Chul LEE),정종필(Jong Pil JEONG),남기창(Ki Chang NAM) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10

건강정보 모니터링을 위한 웨어러블 스마트 디바이스 기술이 발전함에 따라 기기에 적용될 수 있는 전극에 대한 연구가 활발히 진행되고 있다. 생체신호 측정 시 쓰이는 Ag-AgCl 전극의 경우 일회용으로 재사용이 불가능하며 피부 발진 등의 단점으로 인해 장시간 및 연속사용 전극으로는 적합하지 않다. 본 연구에서는 전도성 실리콘과 탄소 소재 코팅을 이용한 2중 구조 및 전도성 실리콘 단일층 구조의 전극 2종을 신체 접촉이 용이하게 의복형으로 개발하고 의료용 전극 규격 시험 및 심전도 측정을 하여 상용 전극과의 성능을 비교하였다. 측정 결과 전도성 실리콘 및 탄소 소재를 이용한 전극 모두 의료용 전극 시험규격을 만족하였다. 개발된 전극 모두 심박수 측정이 가능한 심전도가 측정되었지만 측정 심전도 분석결과 단일층 구조의 전극의 신호대 잡음비가 더욱 높았다.

전도성 실리콘 및 탄소 소재를 이용한 웨어러블 전극

황도현(Do Hyun HWANG),박현목(Hyun Mok PARK),장경화(Kyung Hwa CHANG),홍순우(Sun Woo HONG),한지훈(Ji Hun HAN),조나연(Na Yun CHO),이상철(Sang Chul LEE),정종필(Jong Pil JEONG),남기창(Ki Chang NAM) 대한전기학회 2021 정보 및 제어 심포지엄 논문집 Vol.2021 No.10

경요도 전립선절제술에서 척추마취 시 소용량 Bupivacaine-Fentanyl의 병용투여와 상용용량 Bupivacaine의 임상 효과 비교

곽경화,이수현,전영훈,문철원,백운이 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: The combination of local anesthetics and opioids in the spinal anesthesia has a synergic analgesic effect, Therefore, we compated intraoperative conditions and clinical effects of low dose (5 mg) bupivacaine added with fentanyl versus a conventional dose(10 mg) of bupivacaine in spinal anesthesia for a transurethral resection of the prostate (TURP). Methods: Forty five ASA class 1 and 2 patients scheduled for a TURP were randomly divided into three groups. Group B (n = 15) received bupivacaine 10 mg, group BF (n = 15) received bupivacaine 5 mg added with fentanyl 20 ㎍, and group BFE received bupivacaine 5 mg added with fentanyl 20 ㎍ and 0.2 mg epinephrine. Blood pressure and heart rate were recorded every 5 minutes before and after spinal anesthesia. Sensory blockade was measured by a pin-prick test and motor blockade was evaluated by the Bromage motor scale. Side effects including pruritus, nausea, vomiting, respiratory depression, and intraoperative pain were observed. Results: The duration of sensory and motor blockade in group BF was significantly shorter than in group B and group BFE (P < 0.05). Without statistical significance, hypotension (6.7%) and bradycardia (13.3%) were observed in group B and pruritus (26.7%) and nausea (13.3%) occurred in all patients who received fentanyl. Conclusions: The addition of fentanyl 20 ㎍ to low dose bupivacaine 5 mg resulted in short lasting motor and sensory block, compared with conventional dose bupivacaine 10 mg. Therefore, we concluded that the clinical application of this method could provide adequate analgesia with early discharge and no serious side effects for TURP patients. (Korean J Anesthesiol 2002; 43: 418~423)

Thymopentin 으로 치료한 Job 증후군 1 례

손명현(Myung Hyun Sohn),박경화(Kyung Hwa Park),정병주(Byung Ju Jeong),이현희(Hyun Hee Lee),김규언(Kyu Earn Kim),이기영(Ki Young Lee) 대한소아알레르기호흡기학회 1997 소아알레르기 및 호흡기학회지 Vol.7 No.1

The Job syndrome is a primary immunodeficiency disorder characterized by markedly elevated serum IgE levels, recurrent severe infections of the skin and sinopulmonary tract, including staphylococcal pneumonias, chronic eczematoid dermatitis, coarse facial features, and mild eosinophilia. In 1966, Davis two patients with severe eczema, chroic sinopulmonary infections, et al discribed and recurrent staphylococcal abscesses originally. The reason for immunocompromise in the Job syndrome remains unclear, but a chemotactic defect in neutrophils has been described, We have experienced a case of Job syndrome in a 9-year-old suffered from severe recurrent multiple infections since 2 month treatment with thymopentin, she was improved clinically, A brief review of related literature is presented.

Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER project

이영우,이수현,성재숙,정희준,임아름,김주원,최윤지,박경화,김열홍 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1

Purpose Next-generation sequencing (NGS) can facilitate precision medicine approaches in metastatic colorectal cancer (mCRC) patients. We investigated the molecular profiling of Korean mCRC patients under the K-MASTER project which was initiated in June 2017 as a nationwide precision medicine oncology clinical trial platform which used NGS assay to screen actionable mutations. Materials and Methods As of 22 January 2020, total of 994 mCRC patients were registered in K-MASTER project. Targeted sequencing was performed using three platforms which were composed of the K-MASTER cancer panel v1.1 and the SNUH FIRST Cancer Panel v3.01. If tumor tissue was not available, cell-free DNA was extracted and the targeted sequencing was performed by Axen Cancer Panel as a liquid biopsy. Results In 994 mCRC patients, we found 1,564 clinically meaningful pathogenic variants which mutated in 71 genes. Anti-EGFR therapy candidates were 467 patients (47.0%) and BRAF V600E mutation (n=47, 4.7%), deficient mismatch repair/microsatellite instability–high (n=15, 1.5%), HER2 amplifications (n=10, 1.0%) could be incorporated with recently approved drugs. The patients with high tumor mutation burden (n=101, 12.7%) and DNA damaging response and repair defect pathway alteration (n=42, 4.2%) could be enrolled clinical trials with immune checkpoint inhibitors. There were more colorectal cancer molecular alterations such as PIK3CA, KRAS G12C, atypical BRAF, and HER2 mutations and even rarer but actionable genes that approved or ongoing clinical trials in other solid tumors. Conclusion K-MASTER project provides an intriguing background to investigate new clinical trials with biomarkers and give therapeutic opportunity for mCRC patients.

Subacute Oral Toxicity and Bacterial Mutagenicity Study of a Mixture of Korean Red Ginseng (Panax ginseng C.A. Meyer) and Salvia plebeia R. Br. Extracts

서휘원,서재현,경종수,장경화,소승호 한국독성학회 2019 Toxicological Research Vol.35 No.3

As various populations are rapidly becoming an aging society worldwide and interest in health issues has increased, demand for functional foods including herbal products has increased markedly to maintain a healthy state which has led to safety issues about their intake as an inevitable result. The objective of this study was to identify the safety profile of a Korean red ginseng and Salvia plebeia R. Br. extract mixture (KGC-03-PS) which is a valuable ingredient that can be used as a functional food. In the present study, the subacute oral toxicity and bacterial reverse mutagenicity of KGC-03-PS were evaluated. Sprague Dawley rats were administered KGC-03- PS orally for 28 days by gavage. Daily KGC-03-PS dose concentrations were 0, 500, 1,000, or 2,000 mg/kg body weight (bw) per day. Bacterial reverse mutation test with KGC-03-PS dose levels ranging from 312.5 to 5,000 μg/ plate was carried out by OECD test guideline No. 471. Five bacterial strains (Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2) were tested in the presence or absence of metabolic activation by plate incorporation method. There were no toxicological effects related with test substance in the clinical evaluation of subacute oral toxicity test including clinical signs, body weight, and food consumption. Moreover, no toxicological changes related to KGC-03-PS were observed in the hematological and serum biochemical characteristics as well as in the pathological examinations, which included organ weight measurements and in the gross- or histopathological findings. KGC-03-PS did not induce an increase in the number of revertant colonies in all bacterial strains of the bacterial reverse mutation test. The no-observed-adverse-effect level of KGC-03-PS is greater than 2,000 mg/kg bw/day, and KGC-03-PS did not induce genotoxicity related to bacterial reverse mutations under the conditions used in this study.