감두탕 약침액의 암예방 효과에 관한 연구

한상훈,박인규,문진영,임종국,Han, Sang-Hoon,Park, In-Kyu,Moon, Jin-Young,Lim, Jong-Kook 대한침구의학회 2000 대한침구의학회지 Vol.17 No.1

Gamdutang aqua-acupuncture solution(GAS), Gamdutang water-extracted solution(GWS) and Degamdutang aqua-acupuncture solution(DGAS) were prepared and tested for potential antitumor activities. It was used three biomarkers (quinone reductase, omithine decarboxylase, glutathione) to test chemopreventive potentials of GAS, GWS, DGAS. GAS was potent inducer of quinone reductase activity in Hepalclc7 murine hepatoma cells in culture, whereas GWS is less potent. GAS, GWS and DGAS were significantly induced quinone reductase activity in cultured rat normal liver cell, Ac2F. Glutathione levels were increased about 1.8-fold with GAS, 1.0-1.1 fold with GWS, DGAS in cultured murine hepatoma hepaiclc7 cells. In addition glutathione s-transferase levels were increased with GAS, GWS and DGAS. The effects of GAS, GWS and DGAS were tested on the growth of Acanthamoeba castellanii. Proliferation of Acanthamoeba castellanii was inhibited by GAS, GWS and DGAS at concentradons of $1{\times}$ and $5{\times}$. These results suggest that GAS has chemopreventive potential by inducing quinone reductase and quinone reductase activities, inhibition of ornithine decarboxylase activity, and increasing glutathione levels.

Belite 시멘트를 사용한 고강도 철근콘크리트 보의 휨 거동에 관한 실험연구

한상훈,구봉근,김기수,조홍동,전채만,Han, Sang-Hoon,Koo, Bong-Kuen,Kim, Gee-Soo,Cho, Hong-Dong,Juen, Chea-Man 한국콘크리트학회 1999 콘크리트학회지 Vol.11 No.1

본 연구는 Belite를 사용한 고강도 철근콘크리트 보의 휨 거동에 관한 연구이다. 이를 위하여 Belite 시험체의 (1) 하중-처짐 관계와 시험체 중앙단면의 변형률 분호, (2) 하중-중립축관계와 모멘트-곡률 관계, (3) 연성평가, (4) 기존규준식과 실험값에 의한 휨강도 비교 등을 통하여 1종 보통 포트랜드 시멘트를 사용한 기준시험체(OPC)의 실험결과와 비교분석 하였다. 주요 실험변수는 콘크리트의 강도(350, 600kgf/$cm^2$)와 철근비(2D-13, 2D-16, 2D-19, 2D-22 and 2D-25)로 하였으며, 3점 재하를 실시하였다. 실험결과, 고강도${\cdot}$고유동 Belite 콘크리트를 사용한 본 실험의 경우, 전반적으로 1종 콘크리트의 휨거동 특성과 비슷한 경향을 보였다. A study was conducted to investigate the flexural behavior of reinforced high-strength concrete beams using Belite cement. In this study, fourteen reinforced Belite and control beams were tested. The major experimental variables are compressive strength(350kgf/$cm^2$ and 600kgf/$cm^2$)of concrete and reinforcement ratios(0.0086~0.0345). They were tested by three point loading method. Comparing with flexural behavior of normal reinforced concrete beams, the investigation were to : (1) determine experimentally the load-displacement relationships and the strain distribution on the section of test beams : (2) determine experimentally the moment-curvature and the load-neutral axis relationship of Belite ; (3) investigate the flexural ductility of Belite ; (4) estimate the ratio of the capacities of nominal moment strength as a function of ACI to as a experiment. From the test results, the flexural behavior of reinforced high-strength concrete beams using Belite cement are similar to flexural behavior of normal reinforced concrete beams.

임플란트의 수와 어태치먼트의 종류에 따른 하악 임플란트 지지 오버덴춰의 삼차원 광탄성 응력분석

한상훈,태윤섭,진태호,조혜원,Han, Sang-Hoon,Tae, Yoon-Sup,Jin, Tae-Ho,Cho, Hye-Won 대한치과보철학회 1997 대한치과보철학회지 Vol.35 No.3

The purpose of this study is to evaluate the stress distribution in the bone around dental implants supporting mandibular overdenture according to the number of implant and the type of attachment. Two or four implants were placed in an edentulous mandibular model and three dimensional photoelastic stress analysis was carried out to measure the fringe order around the implant supporting structure and also to calculate principal stress components at cervical area of each implant. The attachments tested were rigid and resilient type of Dolder bar, Round bar, Hader bar and Dal-Ro attchment. The results were as follows ; 1. In 2-implant supported overdenture using Round bar, Hader bar, and Dal-Ro attachment, compressive stress pattern was observed on the supporting structure of implant on loaded side, while tensile stress pattern in unloaded side. 2. In 2-implant supported overdenture using Dolder bar, the rigid Dolder bar shared the occlusal loads between 2 implants in a more favorable manner than was exhibited by the resilient type, while the resilient type placed a more stress on the distocervical area of the implant on the loaded side. But compressive stress pattern was observed in both the loaded and unloaded sides in either case. 3. In 2-implant supported overdenture, rigid and resilient type of Dolder bar exhibited more cross arch involvement than the Round bar, Hader bar, or Dal-Ro attachment. 4. In 4-implant supported overdenture using resilient Dolder bar and Hader bar, stress turned out to be distributed evenly among the implants between loaded and unloaded side, but thor was no reduction in the magnitude of the stress in the surrounding structure of implant contratry to 2-implant supported overdenture. 5. The stress pattern at cervical area of implant was different with the number of implant or the type of attachment but the overload, harmful to surrounding structure of implant, was not observed.

힘 근사화 기법에 의한 3차원 연속체 구조물의 형상최적화

한상훈,이웅종,Han, Sang Hoon,Lee, Woong Jong 대한토목학회 1993 대한토목학회논문집 Vol.13 No.1

양질의 근사화 방법을 이용하여 형상최적설계의 효율성을 증진시킬 수 있는 방법들을 개발하기 위한 필요성이 제기되어 왔다. 본 연구에서는 3차원 구조물의 형상적설계를 수행하기 위해 형상변수에 대한 절점력들의 Taylor급수 전개에 근거를 둔 효율적인 근사화 방법을 제안하였다. 수치예로서 캔틸레버보와 양단고정보를 취하여 제안된 방법에 의해 최적형상을 구하였다. 제안된 방법에 의해 얻어진 결과를 기 발표된 다른 방법들의 결과와 비교하여 효율성 및 수렴성에 관해 비교하였다. 그 결과 최적화를 위한 총 구조해석의 수가 크게 줄어들었고, 단면최적화만의 경우와 거의 같은 정도의 효율성을 갖게 됨을 알 수 있었다. 또한 최적형상을 얻기위해 적용된 다항식에 의한 경계표현기법은 최적형상을 얻기위한 유용한 방법임을 알 수 있었다. The need to develop method which can improve the shape design efficiency using high quality approximation is being brought up. In this study, to perform shape optimal design of three-dimensional continuum structures an efficient approximation method for stress constraints is proposed, based on expanding the nodal forces in Taylor series with respect to shape variables. Numerical examples are performed using the 3-D cantilever beam and fixed-fixed beam and compared with other method to demonstrate the efficiency and convergence rate of the Force Approximation method. It is shown that by taking advantage of this high quality approximation, the total number of finite element analysis required for shape optimization of 3-D continuum structures can be reduced significantly, resulting to the same level of efficiency achieved previously in sizing optimization problems. Also, shape representation by super curve technique applied to obtain optimal shape finds useful method.

체외수정시술 시 획득한 미성숙난자의 환자 연령에 따른 체외성숙률 및 수정률 비교

한상훈,이정렬,김현준,문정희,지병철,구승엽,서창석,김석현,최영민,김정구,문신용,Han, Sang Hoon,Lee, Jung Ryeol,Kim, Hyun Jun,Moon, Jung Hee,Jee, Byung Chul,Ku, Seung-Yup,Suh, Chang Suk,Kim, Seok Hyun,Choi, Young Min,Kim, Jung-Gu,Moon, S 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.4

Objective: To investigate the effects of female age on in vitro maturation and fertilization of immature oocytes from controlled ovarian hyperstimulation (COH) in human IVF-ET program. Method: A total of 96 immature oocytes (GV & metaphase I) obtained from 40 cycles of IVF-ET (29 patients). The mean age of female patients was $31.8{\pm}3.1years$. Ovulation was triggered by urinary or recombinant hCG. Immature oocytes were cultured with YS medium containing 30% of patients' human follicular fluids, LH (1 IU/mL), FSH (1 IU/mL) and EGF (10 ng/mL), and then matured oocytes were fertilized by ICSI. In vitro maturation and fertilization of immature oocytes were analyzed according to age of female (< 34 or ${\geq}34years$). Results: The maturation rate was similar between two groups (68% vs 64%). The fertilization rate of in?vitro-matured oocytes was higher in patients < 34 years old, but there was no statistical significance (64% vs 50%, p=0.347). The fertilization rate of in-vitro-matured oocytes was significantly lower compared with those of in-vivo-matured oocytes in both age groups (64% vs 79%, p=0.035, 50% vs 86%, p=0.007). Conclusion: In older female group, fertilization rate of in-vitro-matured oocytes seems to be decreased. Further investigations should be warranted to increase fertilization potential of in-vitro-matured oocytes.

아치구조의 형상 최적화

한상훈,변근주,Han, Sang Hoon,Byun, Keun Joo 대한토목학회 1984 대한토목학회논문집 Vol.4 No.4

본 연구는 실제 하중을 받는 강재 아치구조의 최적형상을 다루었다. 목적함수로는 아치의 중량을 취했으며, 제약조건으로는 단면력, 체적, 아치리브의 길이, 아치부채 단연적의 조합으로 구성된 웅력제약초건을 고려하였다. 형상최적화문제는 아치부재의 단면척이 설계변수의 항으로 형성되었으며, 첫단계로 구조해석의 정밀도가 최적 설계의 목적함수값에 미치는 영향을 분석하였다. 형상최적화 알고리즘은 Two-space System 으로 형성되었고, Space 1 에서는 Modified Newton-Raphson Method에 의한 단면최적화, Space 2 에서는 Powell Method 에 의한 형상최적화를 시도하여 형상최적화 알고리즘을 도출하였다. 본 연구에서 도출된 최적화 알고리즘을 이용하여 아치의 단면최적화와 최적 아치형상에 관한 연구가 수행되었다. 이 알고리즘에 의해 실제 조건하에서 아치의 최적 Span-Rise 비를 구할 수 있다. This paper considers the problem of optimum shaping of steel arches subjected to general loading. The weight of arches is considered as the objective function and the appropriate combinations of section forces, material volume, arc length, and closed section area of arches are considered as the stress constraints. The shape optimization problems are formulated in terms of the design variables of sectional areas of each element. First the cost sensitivity of the design is investigated. Then the investigation comprises the search for the optimum arch form as well as the optimum area distribution along the arch. Two spaces of shape optimization algorithm will be treated, the first space corresponding to the section optimization by the Modified Newton Raphson Method, and the second space to the coordinate optimization by the Powell Method. The optimization algorithm is evaluated and the optimum span-rise ratios for the given arches are evaluated.

열처리 온도에 따른 8YSZ 후막의 미세구조

한상훈,노효섭,나동명,김광호,이운영,박진성,Han, Sang-Hoon,Noh, Hyo-Seop,Na, Dong-Myung,Jin, Guang-Hu,Lee, Woon-Young,Park, Jin-Seong 한국세라믹학회 2011 한국세라믹학회지 Vol.48 No.1

In order to fabricate 8YSZ thick film by silk screen printing, YSZ(yttria-stabilized zirconia) commercial powder was used as starting materials. Paste for screen printing was made by mixing 8YSZ powder and organic vehicles. 8YSZ thick film was formed on $Al_2O_3$ substrate. The crystal structure, and microstructure were investigated. Grain size of 8YSZ was increased with increasing calcination temperature and rapid grain growth was shown after calcination at $1300^{\circ}C$. Microstructure showed the mixture of large and small grain size after $1400^{\circ}C$ sintering. Shrinkage rate of 8YSZ thick film sintered at $1400^{\circ}C$ was more than 40%.

커피에 의한 의치상 레진의 색 변화에 관한 연구

한상훈,동진근,진태호,Han Sang-Hoon,Dong Jin-Keun,Jin Tai-Ho 대한치과보철학회 1993 대한치과보철학회지 Vol.31 No.4

The purpose of this study was to investigate the color change of denture base resins by coffee. Denture base resins for this study were Triad VLG Denture Base (Dentsply, York Div. U.S.A.), Premium Super-20 (Lang Dental Mfg. Co., Inc., U.S.A.) for denture base, Toughron Rebase (Miki Chemical Prod., Kyoto, Japan), Jet Repair Acrylic (Lang Dental Mfg. Co., Inc., U.S.A.), Triad Reline (Dentsply, fork Div. U.S.A.) and Tokuso Rebase (Tokuyama Soda Co., Ltd., Japan) for denture rebase. Twenty specimens of each denture base resin were made and polished. The color of specimens was measured by colorimeter (Model Tc-6FX, Tokyo Denshoku Co. Japan), and they were stored in coffee for three weeks and then color changes were measured. The obtained results were as follows : 1. The L*, a*, b* and the E*ab values of all denture base resins were changed after three weeks. 2. The amount of color change on L*, a*, b* and the E*ab value of each specimens showed different patterns. 3. The b* values of Triad Reline materials were changed more than the other materials. 4. The E*ab values of Triad Denture Base materials were changed more than the other materials.

전방의 차량포착을 위한 연속영상의 대상영역을 제한한 효율적인 차선 검출

한상훈,조형제,Han, Sang-Hoon,Cho, Hyung-Je 한국정보처리학회 2001 정보처리학회논문지B Vol.8 No.6

이 논문에서는 카메라로 연속으로 촬영한 일련의 그레이레벨 영상으로부터 전방의 차량을 포착하기 위한 빠른 차선검출방법을 제안한다. 개별 영상에서 가려지지 않는 제한된 영역을 대상으로 차선의 위치를 검출하고, 에지 영상을 이용하여 차선의 기울기를 구한다. 이를 근거로 차량이 존재할 가능성이 있는 관심영역을 구하고 그 영역 내에서 에지 성분을 이용하여 구조적 방법으로 전방 차량의 위치를 포착한다. 제안된 방식의 효과를 검증하기 위해 노트북 PC와 PC용 CCD 카메라로 도로에서의 영상을 촬영하고 차선검출알고리즘을 적용한 처리 시간, 정확도, 차량검지 등의 결과를 보인다. In this paper, we propose a rapid lane detection method to extract a preceding vehicle from sequential images captured by a single monocular CCD camera. We detect positions of lanes for an individual image within the limited area that would not be hidden and thereby compute the slopes of the detected lanes. Then we find a search area where vehicles would exist and extract the position of the preceding vehicle within the area with edge component by applying a structured method. To verify the effects of the proposed method, we capture the road images with a notebook PC and a CCD camera for PC and present the results such as processing time for lane detection, accuracy and vehicles detection against the images.

공학용 가상 실험실을 위한 Web용 기반 시스템의 구축

한상훈,유성현,조형제,Han Sang-Hoon,You Sung-Hyun,Cho Hyung-Je 한국공학교육학회 2000 공학교육연구 Vol.3 No.1

최근 인터넷을 기반으로 일반 사용자들에게 멀티미디어 정보를 이용하여 효과적인 교육수단을 제공하려는 연구가 활발히 진행되고 있다. 그 대표적인 예가 원격교육, 가상대학 등으로 이른 위주의 일반 교과 과목에 대한 교육은 많이 시도되고 있으나 공학 분야의 실험실습 교육을 위한 경우는 비교적 적은 편이다. 본 논문에서는 인터넷을 바탕으로 한 실험실습 교육의 일환으로 기계, 전자, 화학 등 공학분야의 가상 실험실습실을 지원하기 위해 구축한 기반시스템에 대해 소개한다. 여기에 도입된 가상 실험실의 모델로 클라이언트/서버 방식을 기초로 하여 서버에서 시뮬레이터가 수행되고 클라이언트를 통해 결과를 볼 수 있는 시뮬레이티브 방식이 먼저 논의되고, 이와는 달리 사용자가 초기에 한번 관리 서버를 경유한 이후로는 별도의 실습서버와 직접 통신하며 실험실습의 결과뿐 아니라 진행 상태도 영상으로 볼 수 있는 인터랙티브 방식이 소개된다. Recently there have been many Internet-based studies to provide personal users an efficient educational tool making use of multimedia data. The typical examples are remote education and virtual university where many educational trials on theory-based contents have been performed more frequently than those on experiment-based contents for engineering area. This paper describes about a base system implemented as an example of Internet-based experiment-oriented educations to establish cyber engineering laboratories for mechanics, electronics and chemistry. For the first time as a model of cyber engineering laboratories we herein Introduce in detail a server-and-client-based simulative method in which the result may be displayed on computer monitor of client PC while a simulator program is executed on the server. Secondly we introduce an interactive method in which the user of client PC may not only communicate directly with experiment server after initial connection with management server but also he can confirm the status of experiment being performed by way of video as well as experimental result.