비후성 반흔 각질세포와 정상 각질세포의 유전자 비교분석

최성원,정호윤,임영국,김훈남,오지원,김문규,전세화,홍용택,Choi, Sung-Won,Chung, Ho-Yun,Lim, Young-Kook,Kim, Hoon-Nam,Oh, Ji-Won,Kim, Moon-Kyu,Jeon, Sae-Hwa,Hong, Yong-Taek 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

효소 , 대사물질 Streptomyces endus YP - 1 이 생산하는 항암활성 물질의 분리 및 정제

최성원,김병찬,최선진,김동섭,여익현,문순옥,오두환 ( Sung Won Choi,Byoung Chan Kim,Sun Jin Choi,Dong Seob Kim,Ick Hyun Yeo,Soon Ok Moon,Doo Hwan Oh ) 한국미생물생명공학회 1997 한국미생물·생명공학회지 Vol.25 No.5

예측알고리즘 적용을 위한 데이터세트 구성이 근적외선 분광광도계를 이용한 옥수수 품질평가에 미치는 영향

최성원,이창석,박창희,김동희,박성권,김법균,문상호,Choi, Sung-Won,Lee, Chang-Sug,Park, Chang-Hee,Kim, Dong-Hee,Park, Sung-Kwon,Kim, Beob-Gyun,Moon, Sang-Ho 한국축산환경학회 2014 한국축산시설환경학회지 Vol.20 No.3

The objectives were to assess the use of near-infrared reflectance spectroscopy (NIRS) as a tool for estimating nutrient compositions of corn kernel, and to apply an NIRS-based indium gallium arsenide array detector to the system for collecting spectra and analyzing calibration equations using equipments designed for field application. Partial Least Squares Regression (PLSR) was employed to develop calibration equations based on representative data sets. The kennard-stone algorithm was applied to induce a calibration set and a validation set. As a result, the method for structuring a calibration set significantly affected prediction accuracy. The prediction of chemical composition of corn kernel resulted in the following (kennard-stone algorithm: relative) moisture ($R^2=0.82$, RMSEP=0.183), crude protein ($R^2=0.80$, RMSEP=0.142), crude fat ($R^2=0.84$, RMSEP=0.098), crude fiber ($R^2=0.74$, RMSEP=0.098), and crude ash ($R^2=0.81$, RMSEP=0.048). Result of this experiment showed the potential of NIRS to predict the chemical composition of corn kernel.

40세 이하에서 발생한 열공망막박리의 고찰

최성원,김광수,김유철,Sung Won Choi,MD,Kwang Soo Kim,MD,Yu Cheol Kim,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.12

Purpose: To investigate the risk factors and the factors affecting surgical and visual outcomes of rhegmatogenous retinal detachment in patients under 40 years of age. Methods: This retrospective study included 88 patients (96 eyes) diagnosed with rhegmatogenous retinal detachment that were followed up for more than 3 months postoperatively. Patients were categorized into 3 groups according to age. The etiologic risk factors and the primary anatomical and functional success rates were analyzed. Preoperative factors that could affect postoperative visual acuity and primary anatomical outcome, such as subretinal strands and proliferative vitreoretinopathy (grade C or worse), were analyzed. Results: Myopia more severe than -4.0 diopters was the most common predisposing factor in all 3 groups. Anatomical success rates and functional success rates were not significantly different among the groups. Prevalence of macular detachment and proliferative vitreoretinopathy were highest in group 1. The presence of subretinal strands was highest in group 2 and proliferative vitreoretinopathy was highest in group 1. Patients with preoperative subretinal strands showed a lower primary anatomical success rate in group 1 and poor postoperative visual acuity in groups 1 and 2. Patients with proliferative vitreoretinopathy had poor postoperative visual acuity however there was no significant difference in primary anatomical success rate among the groups.Conclusions: Proliferative vitreoretinopathy did not affect the anatomical success rate but did affect visual outcome in rhegmatogenous retinal detachment in patients under age 40. Subretinal strands contributed to a lower anatomical success rate and poorer visual outcome in such patients that were under age 18. J Korean Ophthalmol Soc 2014;55(12):1808-1813

당뇨망막병증 환자에서의 망막지혈증

최성원,김유철.Sung Won Choi. MD. Yu Cheol Kim. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To report a case of lipemia retinalis in a patient with diabetes. Case summary: A 27-year-old female with type 2 diabetes visited our clinic with visual disturbance in her left eye while being followed up from a pars plana vitrectomy in her right eye for proliferative diabetic retinopathy. On fundus examination of both eyes, the retinal vessels were creamy white and the retinal veins were undistinguishable from the retinal arteries. The serum triglyceride level was 2,676 mg/dL. The patient was asymptomatic except for visual impairment due to vitreous hemorrhage in her left eye. The patient was diagnosed with lipemia retinalis and chylomicronemia syndrome. After controlling the triglyceride level, funduscopic findings in the both eyes were improved. However, the visual acuity in her right eye remained unchanged. Conclusions: Lipemia retinalis can be a sign of a systemic condition although it may not affect visual acuity. Fundus examination may be a useful tool in the early diagnosis of hyperlipidemia. J Korean Ophthalmol Soc 2014;55(4):623-627

단안 상사근 마비와 동반된 수평 사시의 특징 및 치료 예후

최성원,정세환,라상훈,Sung Won Choi,Se Hwan Jung,Sang Hoon Rah 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To review the clinical characteristics and treatment outcomes in horizontal strabismus combined with unilateral superior oblique palsy (SOP). Methods: A retrospective review of medical records was conducted in 21 patients with unilateral SOP treated between January 2001 and December 2005. Patients had more than 6 months of follow-up at the Department of Ophthalmology, Wonju College of Medicine. Results: Among 21 patients (11 male, 10 female) with unilateral SOP, 57.1% of patients had horizontal strabismus. The mean vertical deviation was 12.56±3.81 (8~24) PD. All patients with horizontal strabismus had exotropia and the mean deviation was 10.57±4.58 (6~20) PD. A standard 10mm inferior oblique (IO) recession was performed uniformly at the paretic eye in all patients. In 7 of the patients (58.3%, exotropia greater than or equal to 10PD), horizontal rectus muscle recession was performed simultaneously. In these 7 cases, vertical and horizontal deviation less than or equal to 4PD was achieved (one patient with 10PD remaining hypertropia excluded). In 5 cases with exodeviation less than 10PD, isolated IO recession without horizontal rectus recession on the ipsilateral side achieved orthophoria in the primary position. In 9 cases of isolated SOP, all patients showed orthophoria in the primary position. Conclusions: This study demonstrates horizontal strabismus is combined with unilateral SOP in a high percentage of patients. Additionally, in all cases, all the incidents of horizontal deviation was involved exotropia. A standard 10 mm recession of the IO in combination with horizontal rectus recession is an effective surgical technique. It has an especially high success rate in patients with unilateral SOP (≤14PD vertical deviation) with exodeviation greater than 10PD. In patients with exodeviation less than 10PD, an isolated IO recession is sufficiently effective.

한방 닭죽 개발 및 최적 배합비율 확립

김경연 ( Kyung Yeon Kim ),백무열 ( Moo Yeol Baik ),박천석 ( Cheon Seok Park ),최성원 ( Sung Won Choi ),김창남 ( Chang Nam Kim ),김병용 ( Byung Yong Kim ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.1

죽의 기능성 향상을 위하여 2:1:1:1의 배합으로 혼합한 한약재료(가시오가피, 숙지황, 산약, 백복령)와 닭가슴살 등의 재료를 사용해 한방 영양죽을 제조하였다. 한방 닭죽의 DPPH radical 소거능, SOD 유사활성, 맛의 선호도, cost는 수학적인 canonical model과 trace plot을 이용하여 분석한 결과, SOD 유사활성 이외에는 각 성분들이 독립적으로 작용하여 상호작용이 없는 선형 모델을 보여주었다. DPPH radical 소거능, SOD 유사활성, 맛의 선호도를 최대로, cost를 최소로 목적 범위를 설정하고, 각각의 canonical 계수를 이용하여 수적 최적화를 통하여 최적 배합비를 구한 결과, 한약 혼합물 101g, 닭가슴살 38.66g, 찹쌀 비율 41.34g의 최적 배합비를 구하였으며, 이 배합비에 따른 맛의 선호도는 6.39, DPPH radical 소거능은 17.25㎎VCE/ℓ, SOD 유사활성은 2.25%, cost는 1,382.39 won으로 나타났으며, 여러 결과들 사이에 최적화된 한 값에 수렴하는 desirability는 0.714로 나타났다. 이는 한약혼합물이 많을수록 기능성 면에서는 높게 나타나지만 맛의 선호도면에서는 낮게 나타냈고, 닭가슴살의 경우에도 그 함량이 많을수록 맛의 선호도는 올라갔지만 그에 반해 cost가 높게 올라간 것을 반영한 결과로 사료된다. The objectives of this study were to develop porridge with medicinal herbs and chicken breast meat and to find out the optimum mixing ratio. Several herb extracts such as Acanthopanacis senticosus, Rehmannia glutinosa, Disocorea japonica, and Poria cocos Wolf were used in the ratio of 2, 1, 1, and 1, respectively. The optimum processing condition for herbal chicken porridge was determined by a design expert program. Seventeen experimental points were selected, and herb extracts (82∼101g), chicken breast meat (30∼50g), and glutinous rice (40∼60g) were chosen as the independent variables. The measured responses were preference of taste, DPPH radical scavenging, SOD-like activity, and cost. The optimum formulation of herbal chicken porridge using the numerical analysis was set at herbal extracts (101g), chicken breast meat (38.66g), and glutinous rice (41.34g) with a 0.714 desirability value. DPPH radical scavenging effect, preference of taste and the cost showed a linear model, whereas SOD-like activity showed a quadratic model indicating a higher interaction among the mixture. As a result of proximate composition of optimized herbal chicken porridge, the contents of moisture, carbohydrate, crude protein, crude lipid, and ash contents were 76.4, 9.0, 1.4, 0.5, and 1.6%, the calories of the porridge was 46.1kcal/100g.

후드캡을 이용한 대장내시경 검사의 유용성 일반 대장내시경 검사와의 비교 연구

최성원 ( Sung Won Choi ),박희승 ( Hee Seung Park ),이재승 ( Jae Seung Lee ),황상연 ( Sang Yon Hwang ),곽성동 ( Sung Dong Kwak ),최성호 ( Seong Ho Choi ) 대한장연구학회 2012 Intestinal Research Vol.10 No.3

Background/Aims: A few studies showed that hood-cap assisted colonoscopy (CAC) had improved cecal intubation rate and cecal intubation time but did not help in finding colon polyps in comparison with conventional colonoscopy (CC). However, other studies have shown different results. Therefore, we investigated the efficacy of CAC for the cecal intubation time and polyp detection rate. Methods: Patients for colonoscopy in Busan St. Mary`s Medical Center were enrolled to this randomized controlled trial between July 2010 and September 2010. The evaluated outcomes were polyp detection rate, adenoma detection rate, and cecal intubation time in all patients, in difficult cases (history of previous abdominal or pelvic surgery, obesity, old age), and in the expert and non-expert groups. Results: A total of 260 patients enrolled in this study were randomly allocated to the CAC group (n=130), or CC group (n=130). The overall cecal intubation time was shorter in the CAC group (5.7±3.4 min vs. 7.8±5.7 min, P<0.001). The polyp detection rate was higher in the CAC group (58.4% vs. 43%, P=0.008). The cecal intubation time in the expert and non-expert groups were shorter in the CAC group (expert: 4.1±2.2 min vs. 5.5±2.0 min, P=0.001; non-expert: 6.7±3.7 min vs. 9.4±5.9 min, P=0.001). Conclusions: The use of CAC improved the detection rate of colon polyps and shortened the cecal intubation time for both the expert and non-expert groups. (Intest Res 2012;10:280-288)

이미지 분류 학습을 위한 새로운 데이터 증강 기법 : Random Scaling

최성원(Seong-Won Choi),조인천(In-Cheon Cho),배성호(Sung-Ho Bae) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.6

논문 : 가상현실을 통한 모바일 쇼핑몰 감성 인터페이스에 관한 연구 -남성 저장을 중심으로-

최성원 ( Sung Won Choi ) 디자인융복합학회 2013 디자인융복합연구 Vol.12 No.4

스마트폰이나 태블릿을 이용한 모바일 시장이 빠르게 성장하고 있다. 이 같은 인기는 장소에 제약이 없어 쇼핑시간이 부족한 소비자들과 젊은 세대를 중심으로 모바일 쇼핑 사용자가 꾸준히 증가하고 있기 때문이다. 그러나 모바일 의류 쇼핑몰이 지금과 같은 성장세를 계속 유지하기 위해서는 해결해야 할 여러 가지 과제들이 있지만 그 중 가장 큰 문제점은 다른 분야에 비해서 상대적으로 높은 구매 후 반품률이다. 이를 위해서 본 연구는 오프라인 상에서 구매자의 감성적 욕구를 대체 하는 수단으로 가상현실을 통해 소비자의 감성적 욕구 - 의복의 착용성·물성 등 - 를 최대한 시각화함과 동시에 인터페이스 정형을 개발하여 소비자의 모바일 쇼핑 구매의 위험성을 줄이고 구매의 편의성을 제공하고자 한다. 그렇게 함으로서 가상현실을 통한 남성정장 모바일 쇼핑몰 감성 인터페이스에 관한 연구는 일반적인 모바일 쇼핑의 단점을 보완하게 될 것이고 그 결과 모바일 쇼핑몰 업체는 성공적인 판매로 이루질 것이며 결과적으로 반품률이 줄어드는 시너지 효과를 창출할 수 있는 것이다. Mobile market that relied upon smart phone and/or tablet grew up quickly. This was because mobile shopping consumers of not only consumers being short of shopping time but also young generation steadily increased to do shopping regardless of time and place. But, mobile garment shopping malls needed to solve some of problems in order to keep growth continuously and the greatest problem was rather high return rate after buying than other areas had. This study produced avatar by using 3D software at 3D virtual reality, and developed emotional interface shaping such as wearing of the garment and physical properties to lessen risks of mobile shopping purchase and to give convenience of the purchase. The study on emotional interface of mobile shopping mall of men`s suits through virtual reality could supplement disadvantages of common mobile shopping to help mobile shopping mall business sell successfully and to lessen return rate and create synergy effects.