당뇨망막병증 환자에서의 망막지혈증

최성원,김유철.Sung Won Choi. MD. Yu Cheol Kim. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To report a case of lipemia retinalis in a patient with diabetes. Case summary: A 27-year-old female with type 2 diabetes visited our clinic with visual disturbance in her left eye while being followed up from a pars plana vitrectomy in her right eye for proliferative diabetic retinopathy. On fundus examination of both eyes, the retinal vessels were creamy white and the retinal veins were undistinguishable from the retinal arteries. The serum triglyceride level was 2,676 mg/dL. The patient was asymptomatic except for visual impairment due to vitreous hemorrhage in her left eye. The patient was diagnosed with lipemia retinalis and chylomicronemia syndrome. After controlling the triglyceride level, funduscopic findings in the both eyes were improved. However, the visual acuity in her right eye remained unchanged. Conclusions: Lipemia retinalis can be a sign of a systemic condition although it may not affect visual acuity. Fundus examination may be a useful tool in the early diagnosis of hyperlipidemia. J Korean Ophthalmol Soc 2014;55(4):623-627

40세 이하에서 발생한 열공망막박리의 고찰

최성원,김광수,김유철,Sung Won Choi,MD,Kwang Soo Kim,MD,Yu Cheol Kim,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.12

Purpose: To investigate the risk factors and the factors affecting surgical and visual outcomes of rhegmatogenous retinal detachment in patients under 40 years of age. Methods: This retrospective study included 88 patients (96 eyes) diagnosed with rhegmatogenous retinal detachment that were followed up for more than 3 months postoperatively. Patients were categorized into 3 groups according to age. The etiologic risk factors and the primary anatomical and functional success rates were analyzed. Preoperative factors that could affect postoperative visual acuity and primary anatomical outcome, such as subretinal strands and proliferative vitreoretinopathy (grade C or worse), were analyzed. Results: Myopia more severe than -4.0 diopters was the most common predisposing factor in all 3 groups. Anatomical success rates and functional success rates were not significantly different among the groups. Prevalence of macular detachment and proliferative vitreoretinopathy were highest in group 1. The presence of subretinal strands was highest in group 2 and proliferative vitreoretinopathy was highest in group 1. Patients with preoperative subretinal strands showed a lower primary anatomical success rate in group 1 and poor postoperative visual acuity in groups 1 and 2. Patients with proliferative vitreoretinopathy had poor postoperative visual acuity however there was no significant difference in primary anatomical success rate among the groups.Conclusions: Proliferative vitreoretinopathy did not affect the anatomical success rate but did affect visual outcome in rhegmatogenous retinal detachment in patients under age 40. Subretinal strands contributed to a lower anatomical success rate and poorer visual outcome in such patients that were under age 18. J Korean Ophthalmol Soc 2014;55(12):1808-1813

효소 , 대사물질 Streptomyces endus YP - 1 이 생산하는 항암활성 물질의 분리 및 정제

최성원,김병찬,최선진,김동섭,여익현,문순옥,오두환 ( Sung Won Choi,Byoung Chan Kim,Sun Jin Choi,Dong Seob Kim,Ick Hyun Yeo,Soon Ok Moon,Doo Hwan Oh ) 한국미생물생명공학회 1997 한국미생물·생명공학회지 Vol.25 No.5

단안 상사근 마비와 동반된 수평 사시의 특징 및 치료 예후

최성원,정세환,라상훈,Sung Won Choi,Se Hwan Jung,Sang Hoon Rah 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To review the clinical characteristics and treatment outcomes in horizontal strabismus combined with unilateral superior oblique palsy (SOP). Methods: A retrospective review of medical records was conducted in 21 patients with unilateral SOP treated between January 2001 and December 2005. Patients had more than 6 months of follow-up at the Department of Ophthalmology, Wonju College of Medicine. Results: Among 21 patients (11 male, 10 female) with unilateral SOP, 57.1% of patients had horizontal strabismus. The mean vertical deviation was 12.56±3.81 (8~24) PD. All patients with horizontal strabismus had exotropia and the mean deviation was 10.57±4.58 (6~20) PD. A standard 10mm inferior oblique (IO) recession was performed uniformly at the paretic eye in all patients. In 7 of the patients (58.3%, exotropia greater than or equal to 10PD), horizontal rectus muscle recession was performed simultaneously. In these 7 cases, vertical and horizontal deviation less than or equal to 4PD was achieved (one patient with 10PD remaining hypertropia excluded). In 5 cases with exodeviation less than 10PD, isolated IO recession without horizontal rectus recession on the ipsilateral side achieved orthophoria in the primary position. In 9 cases of isolated SOP, all patients showed orthophoria in the primary position. Conclusions: This study demonstrates horizontal strabismus is combined with unilateral SOP in a high percentage of patients. Additionally, in all cases, all the incidents of horizontal deviation was involved exotropia. A standard 10 mm recession of the IO in combination with horizontal rectus recession is an effective surgical technique. It has an especially high success rate in patients with unilateral SOP (≤14PD vertical deviation) with exodeviation greater than 10PD. In patients with exodeviation less than 10PD, an isolated IO recession is sufficiently effective.

예측알고리즘 적용을 위한 데이터세트 구성이 근적외선 분광광도계를 이용한 옥수수 품질평가에 미치는 영향

최성원,이창석,박창희,김동희,박성권,김법균,문상호,Choi, Sung-Won,Lee, Chang-Sug,Park, Chang-Hee,Kim, Dong-Hee,Park, Sung-Kwon,Kim, Beob-Gyun,Moon, Sang-Ho 한국축산환경학회 2014 한국축산시설환경학회지 Vol.20 No.3

The objectives were to assess the use of near-infrared reflectance spectroscopy (NIRS) as a tool for estimating nutrient compositions of corn kernel, and to apply an NIRS-based indium gallium arsenide array detector to the system for collecting spectra and analyzing calibration equations using equipments designed for field application. Partial Least Squares Regression (PLSR) was employed to develop calibration equations based on representative data sets. The kennard-stone algorithm was applied to induce a calibration set and a validation set. As a result, the method for structuring a calibration set significantly affected prediction accuracy. The prediction of chemical composition of corn kernel resulted in the following (kennard-stone algorithm: relative) moisture ($R^2=0.82$, RMSEP=0.183), crude protein ($R^2=0.80$, RMSEP=0.142), crude fat ($R^2=0.84$, RMSEP=0.098), crude fiber ($R^2=0.74$, RMSEP=0.098), and crude ash ($R^2=0.81$, RMSEP=0.048). Result of this experiment showed the potential of NIRS to predict the chemical composition of corn kernel.

비후성 반흔 각질세포와 정상 각질세포의 유전자 비교분석

최성원,정호윤,임영국,김훈남,오지원,김문규,전세화,홍용택,Choi, Sung-Won,Chung, Ho-Yun,Lim, Young-Kook,Kim, Hoon-Nam,Oh, Ji-Won,Kim, Moon-Kyu,Jeon, Sae-Hwa,Hong, Yong-Taek 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

수정 Forman 모델을 이용한 고성능 강재의 피로균열전파와 피로수명평가

최성원(Sung-Won Choi),강동환(Dong-Hwan Kang),이종관(Jong-Kwan Lee),김태원(Tae-Won Kim) 대한기계학회 2011 大韓機械學會論文集A Vol.35 No.11

응력확대계수비와 하중 주파수가 각각 ‘R=0.1, f=0.1 Hz’, ‘R=0.3, f=0.3 Hz’ 및 ‘R=0.5, f=0.5 Hz’인 세가지 하중 조건에서 피로균열전파 실험을 하였으며 이를 바탕으로 고성능 강재의 피로균열전파거동 분석과 피로수명평가를 수행하였다. 하중 조건에 따른 피로균열전파거동을 모사하기 위해 수정된 Forman 모델을 제안하였으며 제안된 모델은 하한 응력확대계수폭과 균열 닫힘 현상에 의한 유효 응력확대계수폭을 고려함으로써 거동의 전 영역을 모사할 수 있었다. 응력확대계수비와 하중 주파수가 0.1 인 경우, 균열이 약 5.0 mm 전파될 때 피로수명을 평가한 결과, Forman 모델은 8,814 cycles, 수정된 모델은 12,292 cycles 의 계산결과를 얻었으며, 이를 12,774 cycles 의 실제 실험결과와 비교할 때 수정된 Forman 모델이 실제 피로균열전파거동을 보다 효과적으로 모사하고 있음을 확인할 수 있었다. Fatigue crack propagation behavior and the fatigue life in-high performance steel were investigated by means of fatigue crack propagation tests under constant loading conditions of ‘R=0.1 and f=0.1 Hz’, ‘R=0.3 and f=0.3 Hz’, and ‘R=0.5 and f=0.5 Hz’ for the load ratio and frequency, respectively. A modified Forman model was developed to describe the fatigue crack propagation behavior for the conditions. The modified Forman model is applicable to all fatigue crack propagation regions I, II, and III by implementing the threshold stress intensity factor range and the effective stress intensity factor range caused by crack closure. The results show that predicted fatigue lives of Forman and modified Forman models were 8,814 and 12,292 cycles, respectively when the crack propagated approximately 5.0 mm and the load ratio and frequency were both 0.1. Comparison of the test results indicates that the modified Forman model showed much more effective fatigue crack propagation behavior in high-performance steel.

정부 ICT R&D 재난안전 과제 동향에 관한 연구

최성원(Sung-Won Choi),안병천(Byung-Chun Ahn),강희조(Heau-Jo Kang) 한국정보기술학회 2019 Proceedings of KIIT Conference Vol.2019 No.6

해체,제거 작업 시 석면함유 건축자재에서 발생되는 섬유 및 입자상 물질의 특성

최성원 ( Sung Won Choi ),장광명 ( Kwang Myoung Jang ),박경훈 ( Kyung Hoon Park ),김대종 ( Dae Jong Kim ),김현욱 ( Hyun Wook Kim ) 한국산업보건학회 2015 한국산업보건학회지 Vol.25 No.2

Objectives: This study focused on three aspects: characterizing concentrations of airborne particles by size distributions and asbestos fibers generated by various building materials; analyzing the characteristics of fibers produced by each simulation and asbestos fibers released from ACBMs; and investigating correlations of airborne asbestos fibers and particles generated and association of particle and asbestos concentrations. Methods: We selected three ACBMs including an insulation board, cement asbestos slate and wallboard. We constructed 4 scenarios; a) crushing with a hammer; b) cutting with a industrial knife; c) brushing with a metal brush; and d) tightening & loosening with a hand drill. We implemented one simulation for 30 seconds followed by 30 seconds resting period. We repeated a total of 5 cycles for 5 minutes. Results: The highest concentration of particulate & fibrous matters was from crushing with a hammer in each scenario followed by brushing with a metal brush, cutting with a industrial knife, and tightening & loosening with a hand drill. For ACBMs studied, asbestos concentrations were highest from an insulation board followed by cement asbestos slate, and wallboard. No difference in terms of concentration was found between an insulation board and asbestos slate. Fibers with 5~20 μm in length were included in 76~90% of total fibrous matters. The distribution of the straight form fibers was greater than that of the curl form. About 90% of PMTotal released from ACBMs was consisted of PM10 while only 10% of PMTotal was PM2.5. Particulate matters like PM2.5 was significantly correlated with fibrous matters(R2=0.81). Conclusions: We found ACBMs can significantly release asbestos fibers as well as PM2.5. Concentrations of asbestos generated by ACBMs were well correlated with PM2.5.

3D 소프트웨어 교육방법에 대한 연구

최성원(CHOI Sung-Won) 한국디자인학회 1999 디자인학연구 Vol.- No.29