국방 표준화 정책 로드맵에 관한 연구

김진철,최석철,Kim, Jin-Chul,Choi, Seok-Cheol 한국군사과학기술학회 2008 한국군사과학기술학회지 Vol.11 No.1

Many advanced countries including the U.S. consider defense standardization as a critical task for the efficient acquisition and effective operation of weapon systems and have implemented the appropriate standardization policy by synchronizing the defense acquisition strategies and nation standardization policy with defense standardization. It is required to develop the long-term defense standardization policy that can cope with the future domestic and international defense environmental changes. Therefore, it is an inevitable task to investigate the standardization trends and strategy in the domestic and international perspectives. The study aims to provide the vision of defense standardization policy, act/regulation, organization/personnel, education/training and information system.

Factors Affecting the Postoperative Outcome in Adult Cardiac Surgery with Cardiopulmonary Bypass

Sung-Chul Lee(이성철),Yun-Tae Kim(김윤태),Seong-Min Moon(문성민),Kyung-Yae Hyun(현경예),Dae-Sik Kim(김대식),Seok-Cheol Choi(최석철) 한국생명과학회 2008 생명과학회지 Vol.18 No.11

본 연구는 심폐바이패스를 이용한 성인 심장수술 시 수술 후 환자의 회복 결과에 영향을 미치는 인자들을 규명하기 위해 시행하였다. 성인 심장수술 환자 32명을 대상으로 하여 연구하였다. 심장수술 시 밸혈구 수, GOT, troponin-I (cTNI), interleukin-6 (IL-6), endothelin-1 (ET-1), D-dimer, neuron-specific enolase (NSE) 등의 혈장농도는 유의하게 증가한데 비해 혈소판 수는 감소하였다. 수술 직후 GOT 및 D-dimer 농도와 24 시간 및 총출혈량, 기계호흡보조 시간, 중환자실 치료기간, 재원일수와 각각 양의 상관성이 있었다. 혈소판 수와 기계호흡보조 시간, 중환자실 치료기간, 재원일수와 각각 음의 상관관계가 있었다. Creatinine 농도와 기계호흡보조 시간, 중환자실 치료기간 사이에 양의 상관성이 있었다. NSE 농도와 24 시간 출혈량 사이에 양의 상관관계를 보였다. cTNI 농도와 재원일수 간에 양의 상관성이 있었다. 대동맥 교차차단 및 총심폐바이패스 실시 시간과 24 시간 및 총 출혈량, 재원일수 사이에 양의 상관관계를 나타내었다. 결론적으로 본 연구의 결과들은 심폐바이패스를 적용한 성인 심장수술 시 수술 후 환자의 결과와 회복에 영향을 미치는 가장 중요한 변수는 수술 종료 직후(CPB-off)의 GOT, BUN, creatinine, D-dimer 등의 농도와 혈소판 수임을 시사하고 있다. We defined factors affecting the postoperative outcome in adult cardiac surgery with cardiopulmonary bypass (CPB). Thirty-two adult patients scheduled for elective cardiac surgery participated in this study. Levels of leukocyte, glutamic oxaloacetic transaminase (GOT), troponin-I (cTNI), interleukin-6 (IL-6), D-dimer and neuron-specific enolase (NSE) were significantly elevated, whereas platelet count declined in cardiac surgery with CPB. GOT and D-dimer levels at CPB-off each had a positive significant correlation significantly with 24 hrs-bleeding, total bleeding, mechanical ventilatory assist time, ICU stay time and length of hospitalization. BUN levels at CPB-off were directly related to total bleeding, mechanical ventilatory assist time, ICU stay time and length of hospitalization. Platelet count at CPB-off was inversely related to mechanical ventilatory assist time, ICU stay time and length of hospitalization. Creatinine concentration at CPB-off interrelated positively with mechanical ventilatory assist time and ICU stay time. NSE levels at CPB-off had a positive relationship with postoperative 24 hrs-bleeding. The length of hospitalization was prolonged proportionally to the elevation of cTNI levels in cardiac surgery. Aortic cross-clamping and total CPB times also related with increase of 24 hrs and total bleeding volumes and the length of hospitalization. IL-6 and ET-1 had no mutual relation with any postoperative outcome. These data suggest that GOT, BUN, creatinine, D-dimer and platelet levels are the most important factors affecting postoperative outcomes and patient's recovery in adult cardiac surgery with CPB.

항암제 유발 말초신경병증 변증평가도구의 신뢰도 및 타당도 평가

박지혜,정인철,이서현,이석훈,최석철,유화승,Park, Ji-hye,Jung, In-chul,Lee, Seo-hyun,Lee, Suk-hoon,Choi, Seok-cheol,Yoo, Hwa-seung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.4

Objectives: The purpose of this study was to evaluate the reliability and validity of an instrument for pattern identification and evaluation in chemotherapy-induced peripheral neuropathy (CIPN).Methods: The study consisted of 66 patients with CIPN (visual analog scale ≥30 mm, Eastern Cooperative Oncology Group ≤2). The test-retest reliability of the instrument for pattern identification and evaluation in CIPN was tested twice with the same patients in one week.Results: Pearson’s coefficient test-retest reliability of the instrument was 0.601-0.777. The internal reliability of each part was 0.619-0.811. To confirm the validity of the instrument for pattern identification and evaluation for CIPN, the correlation between the score for each identification pattern and that of other CIPN instruments was analyzed. The results revealed a positive correlation between the Functional Assessment of Cancer Therapy-General and CIPN-20.Conclusion: The reliability of the instrument for pattern identification and evaluation in CIPN was moderate, and the validity analysis revealed a positive correlation.

자궁경부암 환자에서 난소전위술 시행 후 발견된 난소 전이

김상헌 ( Sang Heon Kim ),권도영 ( Do Young Kwon ),유유숙 ( Yu Suk Yu ),김법종 ( Beob Jong Kim ),김문홍 ( Moon Hong Kim ),최석철 ( Seok Chul Choi ),유상영 ( Sang Young Ryu ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9

In case of young women treated with ovarian preservation in cervical cancer surgery, it is regarded pertinent to reduce the risk of early menopause resulting from adjuvant pelvic irradiation through ovarian transposition. On the other hand, lots of authors have raised questions in regard with the ovary being possibly affected by micrometastasis. Studies have reported appropriate indications of ovarian transposition and risk factors of ovarian metastasis to cope with this problem. We conducted ovarian transposition with cervical cancer patient who had no ovarian metastasis risk factors reported in previous literature and experienced such case that metastasis took place only in the ovary without spreading to other organs. This study is to report that case based on brief literature review.

자궁 경부의 육종양 편평상피세포암

강정진 ( Jeong Jin Kang ),박천숙 ( Cheon Suk Park ),송흥섭 ( Heung Seop Song ),장시내 ( Si Nae Jang ),김법종 ( Beob Jong Kim ),김문홍 ( Moon Hong Kim ),최석철 ( Seok Chul Choi ),이의돈 ( Eui Don Lee ),이경희 ( Kyung Hee Lee ),김 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.11

난소암 환자에서 이차 추시 개복술 전 FDG - PET 의 가능성

정원호(Won Ho Jung),강무삼(Mu Sam Kang),박천숙(Chun Suk Park),김문홍(Mun Hong Kim),김성일(Sung Il Kim),최석철(Seok Chul Choi),유상영(Sang Young Ryu),이경희(Kyung Hee Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10

목적 : 일차 치료 후 임상적 완전 관해를 보인 진행성 난소암 환자에서 조직 병리학적 완전 관해를 평가 하는데 있어 FDG-PET 촬영의 임상적 효용성을 알아보고자 하였다. 연구 방법 : 일차 종양 감축술을 시행한 다음 Cisplatin을 기반으로 하는 보조 화학요법 후 완전 관해를 보인 진행성 난소암 환자 10명 (ⅡC 4명, ⅢC 6명)을 대상으로 하여 FDG-PET 촬영을 시행하였다. 전신 FDGPET의 촬영은 GE advance scanner를 이용하였고, 370-555MBq (10-15 mCi)의 FDG를 주사한 후 50분 후부터 촬영을 시작하여 전신 영상을 얻었다. 국소 관심 영역의 표준 섭취 계수를 구하여 값이 3.5 SUV 이상이거나 주변 조직에 비해 높은 섭취율을 보인 경우에 양성으로 판정하였다. 이차 추시 개복술은 PET scan 후 평균 4일 이내에 시행되었다. 결과 : 환자의 평균 연령은 45세 였으며 조직학적으로 대부분이 장액성 낭선암 이었다. 골반 및 복강 내에서 PET scan에 양성 (SUV>3.5 kg/ml)을 보인 환자는 없었으나, 이차 추시 개복술을 시행하여 5예 (50%)에서 잔류 종양 양성 소견을 보였다. FDG-PET 촬영에서 폐에서 양성소견을 보인 환자 1예가 있었으며 이는 전이로 확인되었다. 결론 : FEG-PET 촬영은 골반 및 복강내의 작은 난소암 잔류 종양을 확인하는데 효과적이지 못하며, 병리 조직학적 완전 관해를 평가하기 위한 이차 추시 개복술을 대체할 수 없었다. Objective : This study is to investigate whether Positron Emission Tomography (PET) is useful for determining pathologic complete response in patients with ovarian carcinoma who had a clinical complete response after primary treatment. Methods : FDG-PET scans were performed in 10 patients with advanced ovarian cancer (4 patients with stage Ⅱ, 6 patients with ⅢC), who showed complete response with cytoreductive surgery and 6 cycles of post-operative adjuvant Cisplatin-based combination chemotherapy. FDG-PET scan was obtained with GE Advance Scanner, beginning at 50 minutes after injection of 370-555 MBq (10-15 mCi) of ^18F FDG. Uptakes exceeding 3.5 SUV (Standardized Uptake Value) or larger than surrounding tissue were determined as a positive findings. Second-look laparotomy was undertaken within median 4 days after FDG-PET scanning. Results : The mean age of the patients was 45 years and serous cystadenocarcinoma was most common histologic type. None showed active lesion in pelvis or abdomen with FDG-PET scan (SUV: >3.5 ㎏/ml), however, 5 patients (50%) showed residual tumors on multiple biopsy during second look operation. One patient showed positive lesion in lung on FDG-PET scan, which was confirmed to have metastatic lesion. Conclusion : FDG-PET scan is not useful for detection of small ovarian cancer lesions in pelvis and abdomen and cannot substitute for second-look operation to determine pathologic complete response.

자궁경부암 치료 후 FDG-PET로 무병상태 판정을 받은 환자의 무병기간 및 FDG-PET의 추적검사로서의 효용성에 대한 연구

박천숙 ( Chun Sook Park ),강정진 ( Jeong Jin Kang ),신혜림 ( Hae Rim Shin ),김명인 ( Myung In Kim ),김문홍 ( Moon Hong Kim ),천기정 ( Ki Jeong Chun ),김성은 ( Sung Eun Kim ),김법종 ( Beob Jong Kim ),최석철 ( Seok Chul Choi ),유상 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12

목적 : 자궁경부암 치료 후 FDG-PET에서 무병상태 판정을 받은 환자에서의 평균 무병기간 및 자궁경부암 환자의 추적검사로서 FDG-PET의 효용성에 대해 알아보고자 하였다. 연구 방법 : 1998년 5월부터 2003년 2월까지 원자력병원 산부인과에서 치료받은 자궁경부암 환자중 치료 후 3개월에서 16개월 사이에 시행한 FDG-PET에서 무병상태로 판정 받은 환자 443명을 일차적으로 추출하였다. 이 중 추적이 되지 않는 환자, 두 가지 이상의 원발성 Objective : This study was aimed to investigate the disease free interval and feasibility of FDG-PET for following up the patients with no evidence of cervical cancer after primary treatment. Methods : From May, 1998 to February, 2003, 406 patients with n

자궁경부의 선양기저암 1예

윤혜원,김도균,김정란,김승만,양회생,심재철,배철성,최석철,황진석,도은형 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.2

Adenoid basal carcinoma of the cervix is very rare tumor. It is slow-growing and locally invasive tumor amenable to simply hystrectomy. It is common to be associated with severe dysplasia and carcinoma in situ(CIS) of cervix Occasionally, concommitant microinvasive squamous cell carcinoma or adenocarcinoma may also be seen. Differential diagnosis includes adenoid cystic carcinoma, which is more aggressive tumor associated with regional lymph node involvement and late pulmonary metastasis. We have recently experienced a case of adenoid basal carcinoma of the cervix in 61 years-old woman, which is presented with a brief review of the literature.