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유상영(Sang Young Ryu),강순범(Soon Beom Kang),이철민(Chul Min Lee),김재원(Jae Won Kim),박노현(Noh Hyun Park),송용상(Yong Sang Song),이효표(Hyo Pyo Lee) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
N/A From Jan. 1984 to Dec. 1993, 46 patients with malignant germ cell tumor of ovary were identified in tumor registry of Seoul National University Hospital. The clinicopathologic features of these patients were reviewed. The mean age of patient was 21.6 years (range 1-54), and common presenting symptoms were abdominal mass (19/46), abdominal pain (9/46), abdominal distension (7/46), and epigastric discomfort (2/46) in order. Dysgerminoma was the most common histologic type (19/46, 41.3%), followed by endodermal sinus tumor (13/46, 28.2%), mixed germ cell tumor (6/46, 13/0%), embryonal carcinoma(5/46, 10.8%), immature teratoma(2/46, 4.3%), and chorio- carcinoma (1/46, 2.1%). Among 6 mixed germ cell tumors, dysgerminoma mixed with endodermal sinus tumor component was the most frequent combination. Fifty percent of patients were with FIGO stage I, and 26% with stage III. Overall two year disease free survival was 89.1%. Patients with dysgerminoma showed more favorable 2 year disease free survival (100%) than endodermal sinus tumor or mixed germ cell tumor (84.6%, 66.6% respectively). Patients age, disease stage, histologic type and future child-bearings should be considered in the management of malignant ovarian germ cell tumor. Multicenter prospective randomized studies are needed to identify the more rational treatment strateges of these rare malignant tumors.
자궁경부암 환자에서 난소전위술 시행 후 발견된 난소 전이
김상헌 ( Sang Heon Kim ),권도영 ( Do Young Kwon ),유유숙 ( Yu Suk Yu ),김법종 ( Beob Jong Kim ),김문홍 ( Moon Hong Kim ),최석철 ( Seok Chul Choi ),유상영 ( Sang Young Ryu ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9
In case of young women treated with ovarian preservation in cervical cancer surgery, it is regarded pertinent to reduce the risk of early menopause resulting from adjuvant pelvic irradiation through ovarian transposition. On the other hand, lots of authors have raised questions in regard with the ovary being possibly affected by micrometastasis. Studies have reported appropriate indications of ovarian transposition and risk factors of ovarian metastasis to cope with this problem. We conducted ovarian transposition with cervical cancer patient who had no ovarian metastasis risk factors reported in previous literature and experienced such case that metastasis took place only in the ovary without spreading to other organs. This study is to report that case based on brief literature review.
유유숙 ( Yu Suk Yu ),권도영 ( Do Young Kwon ),박지민 ( Ji Min Park ),최석철 ( Seok Cheol Choi ),유상영 ( Sang Young Ryu ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.12
Schwannomas arise from schwann cells in the peripheral nerve sheath, without involving the nerve fibers. Schwannomas are benign, slow-growing tumors that infrequently recur and rarely undergo malignant change. Also schwannomas of the female genitalia are considered extremely rare. We report a case of schwannoma of the clitoris. A 76-year-old woman without neurofibromatosis presented with a 2.0 × 1.7 cm, painless mass of the clitoris. Simple surgical excision of the mass was undertaken, and final pathology revealed schwannoma of the clitoris. No evidence of local recurrence was noted after 1 year of follow-up.
상피성 난소암에서 수술후 일차 항암화학요법으로 시행된 Paclitaxel - Cisplatin 의 효용성에 대한 연구
김상희(Sang Hee Kim),송용중(Yong Jung Song),이향(Hyang Lee),이삼미(Sam Mi Lee),최석철(Suck Chul Choi),유상영(Sang Young Ryu),김병기(Byoung Gie Kim),박상윤(Sang Yoon Park),이경희(Kyung Hee Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A Objective : The purpose of this retrospective study is to assess the efficacy and toxicity of paclitaxel/cisplatin as first-line chemotherapy after cytoreductive surgery in patients with epithelial ovarian cancer. Material & Methods : From November 1999 to April 2001, 31 patients with histologically-proven epithelial ovarian cancer not previously treated with chemotherapy entered the study. FIGO stage IA or IB and grade 1 or 2 tumors were excluded. A comprehensive staging was performed during initial laparotomy. Paclitaxel was administered at a dose of 135 mg/m2, intravenously with cisplatin (75 mg/m2) every 3 weeks for 6 planned cycles, with prophylactic oral dexamethasone regimen (20 mg b.I.d.). The response of patients was evaluated with tumor markers and CT before and after chemotherapy. Responses and toxicities were defined according to the Gynecologic Oncology Group (GOG) criteria. Results : The overall response rates were 73% (16/22) in patients with residual disease after cytoreductive surgery (complete response, 64%; partial response, 9%). The median survival was 18 months. Grade 3/4 neutropenia and neuropathy (grade 2) were observed in 16 (52%), 12 (39%) patients, respectively. Conclusion : The combination of paclitaxel and cisplatin is a well tolerated regimen with significant activity in the treatment of epithelial ovarian carcinoma after surgery.
김상희(Sang Hee Kim),김현희(Hyun Hee Kim),송용중(Yong Jung Song),윤병선(Byung Sun Yoon),최석철(Suck Chul Choi),유상영(Sang Young Ryu),이경희(Kyung Hee Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1
It is estimated that approximately 35% of patients with invasive cervical cancer will have recurrent or persistent disease following therapy. The common metastatic sites of recurrent cervical cancer included the lung, liver and vertebra, however, colon metastases from cervical cancer were extremely rare. Recently we experienced a case of colonic metastasis in a patient with cervical cancer who had been treated with radiation and chemotherapy. We present this case with a brief review of literature.
권도영 ( Do Young Kwon ),유유숙 ( Yu Suk Yu ),백수현 ( Su Hyun Baek ),최석철 ( Seok Cheol Choi ),유상영 ( Sang Young Ryu ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.1
Yolk sac tumor (YST) is one of the rare malignant germ cell tumor and usually occurs in gonad. Extragondal sites of YSTs are reported in mediastinum, vagina, brain, and retroperitoneum but are extremely rarely in omentum. The clinicopathologic feature of primary omental YST is not well known and there are only 5 cases reported currently. Recently we experienced a primary YST of omentum in 27-year-old woman who was performed exploratory laparotomy due to abdominal distension and pain. She has remained free of diseases for 2 years with normal menstruation after the fertility-saving surgery and postoperative adjuvant chemotherapy with bleomycin, etoposide, cisplatin regimen. The subject of primary YST of omentum is reviewed, and the possible histogenesis of the tumor is discussed.
박서영 ( Seo Yeong Park ),유상영 ( Sang Young Ryu ),박노현 ( Noh Hyun Park ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo Pyo Lee ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
The use of pelviscopy for management of adnexal mass has increased dramatically in the last few years. Pelviscopy is safe and effective diagnostic and therapeutic tool for adnexal mass. But, detection of unpredicted ovarian malignancy is troublesome for proper management. To prevent this hazard, application of strict criteria for preoperative patient selection and careful intraoperative assessment are critical. Recently we experienced a case of dysgerminoma incidentally found after pelviscopic surgery in a 28 year old woman with bilateral adnexal masses. Preoperative evaluation and even intraoperative frozen biopsy showed no evidence of malignancy, but the final pathologic report was dysgerminoma combined with endometriosis. Six cycles of postoperative BEP(B1eomycin, Etoposide, Cisplatin) combination chemotherapy was done, and the patient has shown no evidence of disease for 12-month follow up period. We present this case of dysgerminoma incidentally found after pelviscopic ovarian surgery with a brief review of the literatures.
자궁경부암 환자에서 수술 후 림프절 전이가 확인된 경우 생존율에 영향을 미치는 예휴인자에 관한 연구
성정희(Jeong Hee Sung),김병섭(Byoung Sub Kim),이은희(Eun Hee Lee),윤창범(Chang Beom Yun),유상영(Sang Young Ryu),김종훈(Jong Hoon Kim),김병기(Byoung Gie Kim),박상윤(Sang Yoon Park),이의돈(Eui Don Lee),이경희(Kyung Hee Lee) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
N/A The presence of metastatic lymph nodes in cervical carcinoma is one of the most important prognostic factors to survival. In general, the characteristics of metastatic lymph nodes such as number, site, and bilaterality etc. can modify the survival of patients with lymph node metastasis. This nonrandomized retrospective study was performed to identify prognostic factors for survival in patients with FIGO stage IA2, I B and IIA, IIB carcinoma of the cervix with nodal metastases. From January 1, 1993, to December 31, 1995, 86 patients with FIGO stage I A, I B and IIA, IIB carcinoma of the cervix were found to have nodal metastasis at the time of radical hysterectomy and pelvic lymphadenectomy at the Department of Obstetrics and Gynecology, Korea Cancer Center Hospital. The prognostic significance of number of metastatic lymph nodes, site(s) of lymph node metastases, cervical lesion size, age, FIGO stage have been evaluated. In this study, the 3-year disease free survival rate (DFSR) and clinical characteristics were compared with the prognostic factors. Univariate analysis revealed significant that number of metastatic lymph nodes (p=0.0008) and tumor size (p=0.0490) were significant prognostic factor, but there were no significant differences in 3-year DFSR according to age (p=0.1257), FIGO stage (0.4687), site(s) of lymph node metastases (p=0.5552). However, by multivariate analysis only number of metastatic lymph nodes (p=0.0248) was noted to be a significant prognostic factor determining survival of the patient. A risk of recurrence increased continuously in accordance with increased of the number of metastatic lymph nodes. In particular the 3-year DFSR fell markedly from 85.3% in patient with less than four metastatic lymph node to 25.9% in those with five or more metastatic lymph node (p=0.0008). These results demonstrated that the number of metastatic lymph nodes was the most important and independent prognostic factor in patients with cervical cancer showing lymph node metastasis.