카바마제핀 장기 투여가 백서(白鼠) 뇌의 Protein Kinase A와 Protein Kinase C 활성도에 미치는 영향

임두원,김인,서광윤,Rheem, Doo-Won,Kim, Leen,Suh, Kwang-Yoon 대한생물정신의학회 1998 생물정신의학 Vol.5 No.2

Objective : Many evidences suggest that patients with bipolar disorder have functional abnormalities in their postreceptor signal transduction pathways, and mood stabilizing effect of lithium is exerted by modulating this dysfunctioning system. Carbamazepine, an antiepileptic agent, is also known to be effective in the treatment and prevention of bipolar disorder. But the precise mechanism of action of the drug is still poorly understood. This study was performed to elucidate the possible therapeutic mechanism of carbamazepine. Method : The effects of chronic carbamazepine administration on protein kinase A and protein kinase C activities in frontal cortex of rat brain after 2 weeks of drug administration were measured and compared with those of control subjects. Results : Mean(${\pm}SE$) value of activity(phosphate transfer ${\mu}mol/mg$ of $protein{\cdot}min$) of protein kinase A in control and test group was $0.249563{\pm}0.036$ and $0.539853{\pm}0.078$, and that of protein kinase C was $0.654817{\pm}0.053$ and $1.146205{\pm}0.052$ respectively, being increased in test group. And differences between the two groups were statistically significant for both enzymes(protein kinase A ; p<0.01, protein kinase C ; p<0.001). Conclusion : These results show that chronic carbamazepine administration increases protein kinase A and C activities, and concerning the possible mode of therapeutic action in bipolar disorder it is suggested that enhanced enzymes phosphorylate receptor-G-protein-effector complexes to dampen hyperfunctioning neuronal activity and thus stabilize the system.

기질성 환각증의 카바마제핀 치료

임두원 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.2

각각 알코올과 해마 경색에 의해 유발된 것으로 추정되며, 항정신병약물 치료에 별 반응이 없었던 기질성 환각증 2예에 대해 카마바제핀 치료를 시도하여 좋은 결과를 얻었기에 문헌 고찰과 함께 보고한다. 이전의 연구에서도 기질성 환각증의 경우 항정신병약물에는 별로 반응이 없으나 카마바제핀에는 잘 반응하는 경우가 있다는 보고가 있었다. 따라서 향우 기질성 환각증의 치료시 이점을 고려해 보는 것도 도움이 될 것이다. Empirical experiences until now reveal that antipsychotics may be preferable drugs in the treatment of organic hallucinosis. However recent trials of carbamazepine on organic hallucinosis sometimes show better response than antipsychotics. The author also experienced good results with carbamazepine in 2 cases of antipsychotic-resistant organic hallucinosis, predominantly with auditory hallucinations. Therefore carbamazepine trial on organic hallucinosis especially in antipsychotic-resistant cases may recommended.

물품음란애(Fetishism)를 동반한 Tourette syndrome 1례 보고

정희연,임두원 순천향대학교 1992 논문집 Vol.15 No.2

We report a rare case of Tourette syndrome associated with fetishism. In our opinion, there is a need for further evaluation about the association between this syndrome and hypersexuality of his father, and there is also another need for evaluation about the pathophysiologic mechanisms involved other than dopamine.

중심성 뇌교 수초 용해증 2例

임두원,권영준,정희연 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.3

Central pontine myelinolysis(CPM) is one of neurologic diseases occuring after rapid correction of hyponatremia. Neurologic symptoms of CPM may mimic psychologic symptoms of psychiatric disorders, warning us to be careful in differential diagnosis, especially when the patient has already has had psychiatric diagnosis. The authors report two cases of CPM, otherwise would have been misdiagnosed as psychiatric disorders. We suggest that when psychiatric evaluation is reguested in patients with sodium supplementation, the diagnosis of CPM should be kept in mind.

정신분열증 환자에서 대뇌 반구간 정보전달

임두원,이대희,이병윤 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.6

The author studied on the callosal function of 20 chronic schizophrenic patients who met DSM-Ⅲ criteria and compared the results with those of age, sex matched 20 controls. In this study Cross Retrieval of Small Test Objects, Cross Replication of Hand Postures and Cross Localization of Fingertips, which are known as test that can evaluate interhemispheric transfer of information, were used. The results were as follows: 1) Correct answers in normal control group were 633 out of 640 total questions with 98.9% of correctness, which approximates almost 100%. 2) Number of mean errors in patient group(2.8000±2.262) was higher than that of control group (0.400±0.503) and the difference between the 2 groups was significant (p<0.001). 3) Number of delayed responses in the patient group(3.100±2.789) was also higher than of control group (0.5500±0.887)and the difference between the 2 groups was significant too (p<0.001). 4)Subtype (paranoid vs undifferentiated), family history of mental and/or neurological disease and sex in the patient group made no difference. With the above results the author suggest that chronic schizophrenics suffer from callosal dysfunction and schizophrenic patients (in the case of paranoid and undifferentiated type)are homogeneous in terms of callosal function as far as family history and sex are concerned.

정신분열병 환자에 있어서 가족력과 임상유형(Type I, Type II)에 따른 안구추적운동의 차이

정희연,임두원,권영준,주경수,서미경,김동수,Jeong, Hee Yeon,Rheem, Doo Won,Kwon, Young Joon,Joo, Gyung Soo,Seo, Mi Kyoung,Kim, Dong Soo 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

Smooth pursuit eye movement, one of the reliable biological markers of schizophrenia, is not always abnormal in schizophrenic patients. Therefore the authors studied it in schizophrenic patients and normal controls and compared the results according to the presence or abscence of family history of psychosis and types (type I and type II). The results are as follows: 1) In the 18 normal control group (8 mole, 10 female), there was no sex difference in the responses of smooth pursuit eye movement. 2) In th 44 schizophrenic group (28 male, 16 female), there also was no sex difference in the responses of smooth pursuit eye movement. 3) In comparison of 44 schizophrenic group to 18 normal control group, there was significantly increased abnormal response in smooth pursuit eye movement in schizophrenic group (P < 0.005). 4) In schizophrenic group, there was no difference in the responses of smooth pursuit eye movement between type I and type II schizophrenia. 5) The presence or abscence of family history of psychosis made no difference in the responses of smooth pursuit eye movement in schizophrenic group. 6) Subdivision of type I or type II in each case of presence or abscence of family history made no difference in the responses of smooth pursuit eye movement in schizophrenic group.

Tardive Dyskinesia를 Calcium Blocker로 치료한 1례 보고

최원,임두원,정희연,권영준 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.1

Short duration(5 days) of antipsychotic medication induced tardive dyskinesia(TD) in a mood disorder patient with hyperthyroidism, giving us an experience that TD is more liable in a sensitive patient and is not always induced by high potency drugs. TD in a patient with mood disorder who also had hyperthyroidism improved within 14 days when treated with calcium blocker, diltiazem.

병적도벽 4례

정희연,임두원,서미경 순천향대학교 1993 논문집 Vol.16 No.2

The authors present 4 cases of kleptomania, and conclude some characteristics. Those are : 1) they feel tension, anxiety and guilt, self-accusation before and after kleptomanic activity. 2) most frequently associated psychiatric diagnosis is mood disorder. 3)more frequent in female, and age at onset is between their teens and twenties. 4) there was no precipitating factor. 5) we found no relation with temporal lobe epilepsy or antisocial personality. 6) family members' psychiatric problems are mood disorder, drug abuse, and kleptomaina. 7) kleptomanic symptom improved in accordance with amelioration of psychiatric symptoms.

국내 중소 과학관 현황 분석: 과학관의 조직, 운영, 교육을 중심으로

신영준 ( Young Joon Shin ),신명경 ( Myeong Kyeong Shin ),전영석 ( Young Seok Jhun ),정광훈 ( Kwnag Hoon Chung ),임두원 ( Doo Won Lim ),문만용 ( Man Young Moon ),임지은 ( Ji Eun Lim ),이봉우 ( Bong Woo Lee ) 한국과학교육학회 2013 한국과학교육학회지 Vol.33 No.2

이 연구의 목적은 지방 과학관의 조직, 운영, 교육 등의 실태를 분석하는 것이다. 이를 위하여 과학관 분석을 위한 평가틀을 개발하고, 28개의 과학관을 선정하여 관계자와의 심층면담을 실시하였다. 주요 연구 결과는 다음과 같다. 첫째, 과학관의 전문 인력이 부족하여 원활한 과학관 운영이 어려웠다. 둘째, 과학관의 재정상태가 매우 좋지 않았다. 셋째, 과학관의 시설이나 전시물 관리에서 부족한 측면이 다수 발견되었다. 넷째, 과학관의 관람객을 이끌 수 있는 다양한 홍보나 마케팅이 소극적으로 이루어지고 있었다. 다섯째, 과학관의 연구 및 교육프로그램에 미흡한 부분이 많이 발견되었다. 실태조사 결과를 바탕으로 지방 과학관의 발전 방안을 위한 방안을 논의하였다. This study aims to investigate the current status of science museum in terms of evaluating its organization, management, and education program. The analytical framework developed for examination are as follows: First, the lack of professional staff in most target museums is the biggest impediment for domestic science museums to function properly. Second, funding has been very poor. Third, most museums failed to properly sustain exhibits, equipment, and facilities. Fourth, various advertising and marketing efforts for attracting more visitors are hardly done. And lastly, the domestic museums made little effort in pursuing research focusing on improving exhibitions and education program. Based on these findings, the future directions for domestic science museums to step-up opportunities have been discussed in this study.