산조인이 백서 뇌에 미치는 영향 - 세로토닌, 수면시간, 수면뇌파, 자동운동을 중심으로 -

정희연,권영준,박인준,권준택,한병훈,이성필,Jeong, Hee-Yeon,Kwon, Young-Joon,Park, In-Joon,Kwon, Joon-Taek,Han, Byung-Hoon,Lee, Sung-Pil 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

Objects : Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. Method : Sleeping time, sleep recordings of EEG, EMG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. Results : 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded ${\beta}$-wave in sleep recordings of EEG. In EMG, there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. Conclusion : These results suggest that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.

자살시도 환자의 혈소판내 세로토닌 농도와 심리학적 특성에 관한 연구

정희연,권영준,박인준,홍세용,최의정,진혁희,Jeong, Hee Yeon,Kwon, Young Joon,Park, In Joon,Hong, Se Yong,Choi, Eui Jung,Jin, Hyuk-Hee 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1

자살 시도군 21명, 우울증 환자군 14명, 그리고 정상 대조군 10명을 대상으로 혈소판내 세로토닌의 농도, 반 구조화된 설문조사, 다면적 인성검사, HAM-D, 충동성 검사를 시행하여 비교한 결과는 다음과 같았으며, 자살 시도군의 자살방법은 대부분 농약 중독이었다. 1) 자살 시도자의 남녀 비는 차이가 없었다. 2) 혈소판내의 세로토닌의 농도는 자살 시도군, 우울증 환자군 및 정상 대조군간에 차이가 없었다. 3) 다면적 인성검사 결과는 자살 시도군의 경우 D, Hs, Pt 척도가 높았으며, 우울증 환자군의 경우 D, Pa, Si 척도가 높았다. 4) HAM-D 점수는 우울증 환자군과 자살 시도군 모두에서 높았으며, 특히 우울증 환자군의 경우 더 의미 있게 높았다. 5) 충동성 검사 결과는 자살 시도군이 우울증 환자군에 비하여 무계획 충동성, 운동 충동성이 의미 있게 높았다. Objectives : Significant progress has been made in understanding psychosocial, psychological, and environmental factors associated with suicide. However it is only recently that attention has been paid to the understanding of the neurobiology of suicide. The aim of this study was to examine the relationship between platelet serotonin level and suicidal behavior and psychological features of the suicidal attempters. Methods : After a suicidal attempt platelet serotonin level was measured from 21 patients and compared it with those from depression patients and normal controls. Also MMPI, HAM-D, Barratt impulsiveness scale(BIS) were done to evaluate their psychological features. Results : 1) There was no significant difference in sex ratio of the suicidal attempters. 2) There was no significant difference in platelet serotonin levels among three groups. 3) The analysis of MMPI revealed that the scores of D, Hs, Pt in clinical scales were significantly higher in suicide patients and scores of D, Pa, Si were in depression patients. 4) The HAM-D score was significantly higher in depression and suicide patients, especially in depression patients. 5) The analysis of Barratt impulsiveness scale revealed that the scores of nonplanning, motor and cognitive impulsiveness scale were significantly higher in suicide patients. Conclusions : There was no significant difference in platelet serotonin levels among three groups. However the analysis of psychological features revealed significant differences. Therefore we concluded that psychological examinations are benefit to evaluate the suicidal tendency.

Haloperidol로 치료한 Tourette 장애에서 발생한 항정신병약물-퇴행 증후군 1례

정희연,조현주,권영준,박인준,진혁희,Jeong, Hee-Yeon,Cho, Hyun-Ju,Kwon, Young-Joon,Park, In-Joon,Jin, Hyuk-Hee 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

Authors report a case of separation anxiety disorder, which developed as a side effect during haloperidol treatment of Tourette syndrome(TS). In this case, 14 years old boy developed attention deficit symptoms during his infancy. At 4th grade of primary school, he developed vocal tic, motor tic, and coprolalia. With 5mg/day of haloperidol treatment his symptoms of TS were subsided. During the treatment, he developed features of separation anxiety disorder, including dependence, pleading, clinging, and sadness. Symptoms of attention deficit and separation anxiety disorder were improved by 25mg/day of imipramine treatment. During haloperidol treatment of TS, careful observation may be needed whether separation anxiety disorder-like symptom develops.

주정의존 환자에서 가족력 유무에 따른 ${\beta}$-endorphine의 반응

정희연,박인준,권영준,Jeong, Hee-Yeon,Park, In-Joon,Kwon, Young-Joon 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

주정의존에 기여하는 여러 원인 중의 하나로 알려진 ${\beta}$-endorphin의 작용에 대해 알아보기 위해서 가족력 유무에 따라 남자 주정의존 환자 48명의 기본 혈중 alcohol 농도, ${\beta}$-endorphin 농도, cortisol 농도 및 혈당과 알코올 투여 후 각각의 농도를 측정하여 다음의 결과를 얻었다. 1) 가족력이 있는 주정의존 환자군과 가족력이 없는 환자군과의 비율은 약 2 : 1이었다. 2) 입원 당시의 나이는 가족력이 있는 주정의존 환자군이 가족력이 없는 환자군의 나이보다 적었다. 3) 가족력이 있는 환자군과 없는 환자군, 그리고 정상대조군에서 알코올 투여 후 혈중 알코올의 농도변화는 세 군간에 차이가 없었다. 4) 가족력이 있는 환자군과 없는 환자군, 그리고 정상대조군에서 알코올 투여 후 혈중 ${\beta}$-endorphin의 농도변화는 세 군간에 차이가 없었다. 5) 가족력이 있는 환자군과 없는 환자군, 그리고 정상대조군에서 알코올 투여 후 혈중 cortisol의 농도변화는 세 군간에 차이가 없었다. 6) 가족력이 있는 환자군과 없는 환자군에서 알코올 투여 후 혈당변화는 양 군간에 차이가 없었다. Objectives : To evaluate the relation of familial history of alcoholism and plasma level of ${\beta}$-endorphin, ethanol, ${\beta}$-endorphin, cortisol and blood glucose were compared in 48 male alcoholics and 29 normal controls. Methods : Subjects are divided into two groups by family history of alcoholism. Blood samples were obtained before and after 0.75mg/kg of ethanol consumption at 7th admission day. Results : 1) The ratio of family history positive to negative of the patient group was 2 to 1. 2) The age at admission of positive family history group was younger than negative group. 3) There was no significant difference in change of plasma ethanol level among three groups. 4) There was no significant difference in change of plasma ${\beta}$-endorphin level among three groups. 5) There was no significant difference in change of plasma cortisol level among three groups. 6) There was no significant difference in change of fasting blood sugar level between two patient groups.

정신분열병 환자에 있어서 가족력과 임상유형(Type I, Type II)에 따른 안구추적운동의 차이

정희연,임두원,권영준,주경수,서미경,김동수,Jeong, Hee Yeon,Rheem, Doo Won,Kwon, Young Joon,Joo, Gyung Soo,Seo, Mi Kyoung,Kim, Dong Soo 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

Smooth pursuit eye movement, one of the reliable biological markers of schizophrenia, is not always abnormal in schizophrenic patients. Therefore the authors studied it in schizophrenic patients and normal controls and compared the results according to the presence or abscence of family history of psychosis and types (type I and type II). The results are as follows: 1) In the 18 normal control group (8 mole, 10 female), there was no sex difference in the responses of smooth pursuit eye movement. 2) In th 44 schizophrenic group (28 male, 16 female), there also was no sex difference in the responses of smooth pursuit eye movement. 3) In comparison of 44 schizophrenic group to 18 normal control group, there was significantly increased abnormal response in smooth pursuit eye movement in schizophrenic group (P < 0.005). 4) In schizophrenic group, there was no difference in the responses of smooth pursuit eye movement between type I and type II schizophrenia. 5) The presence or abscence of family history of psychosis made no difference in the responses of smooth pursuit eye movement in schizophrenic group. 6) Subdivision of type I or type II in each case of presence or abscence of family history made no difference in the responses of smooth pursuit eye movement in schizophrenic group.

주정의존 환자에서 초발연령에 따른 ${\beta}$-Endorphin의 반응

정희연,박인준,김진만,진혁희,Jeong, Hee-Yeon,Park, In-Joon,Kim, In-Man,Jin, Hyuk-Hee 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

정상대조군 29명 및 남자 주정의존 환자 48명을 발병연령에 따라 분류하여 입원 7일 후 오전 9시에 알코올 0.75gm/kg을 투여하기 전후의 혈중 ${\beta}$-endorphin농도, alcohol농도, cortisol농도, 그리고 혈당을 측정하여 비교한 결과는 다음과 같다. 1) 25세 이전과 25세 이후에 발병한 환자군의 비율은 약 2 : 3이었다. 2) 25세 이전과 25세 이후에 발병한 두 환자군간에 입원 당시의 연령은 차이가 없었다. 3) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 알코올의 농도변화는 세 군간에 차이가 없었다. 4) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 ${\beta}$-endorphin의 농도변화는 세 군간에 차이가 없었다. 5) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 cortisol의 농도변화는 세 군간에 차이가 없었다. 6) 25세 이전과 25세 이후에 발병한 두 환자군에서 알코올 투여 후 혈당변화는 양군간에 차이가 없었다. Objectives : To evaluate the relation of onset-age and plasma level of ${\beta}$-endorphin, Ethanol, ${\beta}$-endorphin, cortisol and blood glucose were compared in 48 male alcoholics and 29 normal controls Methods : Alcoholics are divided into two groups by onset-age of alcoholism. Blood samples were obtained before and after 0.75gm/kg of ethanol consumption at the 7th admission day. Results : 1) The ratio of onset-age before 25 years to after 25 years of the patient group was 2 to 3. 2) There was no significant difference in age at admission between two patient groups. 3) There was no significant difference in change of plasma ethanol levels among three groups. 4) There was no significant difference in change of plasma ${\beta}$-endorphin levels among three groups. 5) There was no significant difference in change of plasma cortisol level among three groups. 6) There was no significant difference in change of fasting blood sugar level among two patient groups.

미국인의 목가는 없었다: 필립 로스의 『미국의 목가』 읽기

정희연 ( Jeong Heeyeon ) 대한영어영문학회 2016 영어영문학연구 Vol.42 No.3

This paper examines that the protagonist’s dream to be an American in Philip Roth’s American Pastoral is just an endless frustration and tragedy in the end. Starting from the 1940s, Roth asks a question about the definition of “being an American.” Being an American which has a connotation of including the “American dream,” is a fantasy itself. Swede, the main character, has lived as a hero for a Jewish community since his childhood. His dream is to become a WASP beyond his race, being a Jew. The falls of Swede, Newark, and America, however, are juxtaposed. Swede seems like he is attacked by Mary, his daughter as well as a bomb thrower, and a fatal series of American historical events such as the anti-Vietnam War movement and the civil rights movement. His family business failure and a national crisis exist side by side in American Pastoral. Roth reveals that there is no American dream or ideal pastoral. (Pusan National University)

예측 FP-tree를 이용한 어종별 어장 기법

정희연(Jeong, Hui-Yen),조경수(Cho, Kyeong-Soo),김응모(Kim, Ung-Mo) 한국산학기술학회 2010 한국산학기술학회 학술대회 Vol.- No.-

정보화 사회로의 진입이 본격화 되면서 사회의 전반적인 분야에 걸쳐 다양한 용도로 컴퓨터 시스템이 사용되고 있다. 그에 따라 데이터의 방대한 양적 팽창이 이루어졌고, 이러한 데이터를 유용한 정보와 지식으로 바꿔야 하는 필요성들이 생겨났다. 이에 데이터 마이닝이라는 개념이 등장했고 현재 점점 더 많은 분야에서 사용되고 있고 다양한 각도에서 활발한 연구가 진행되고 있다. 현재 어장의 예측 방법은 주관적인 경험에 대부분 의존하고 객관적인 신뢰성이 떨어진다. 이에 본 논문은 데이터 마이닝 기법을 적용하여 데이터베이스의 정보를 이용해 어종별로 가장 빈번하게 이용되어지는 어장을 선별해주는 기법을 제안한다.

바우만의 시각으로 『화이트 노이즈』에 나타난 죽음과 소비주의 읽기

정희연(Jeong, Heeyeon) 미래영어영문학회 2017 영어영문학 Vol.22 No.1

This thesis analyzes Don DeLillo’s White Noise through Zygmunt Bauman’s perspective of the post-modern society. With the backdrop of middle-class American family in the 1980s, Jack Gladney, protagonist of the novel, is terrified with death even though he has a stable life. By shopping, he doesn’t only try to escape the fear of death but also receives stability, satisfaction, and family bond. In White Noise, the fear of death threaten his existence and the shopping center serve as a refuge for him from the threat. Also both of them are closely related to his identity. Gladney is a kind of the individual ‘afloat’ in the post-modernity, which Bauman named ‘Liquid Modern.’ It is by shopping that he temporarily forgets about various anxiety and fear of the unpredictable future and death, and furthermore is deluded to fulfill himself. He is a typical example of ‘consumer"s fantasy.’ Individuals in the Liquid Modern can not live without the lifestyle of a consumer. People shop from start to finish both at the beginning and the end of White Noise. Gladney’s view on death, however, has been changed. He acknowledges that to go shopping is no longer the ultimate way to get rid of the fear on death. After suffering from The Airborne Toxic Event and witnessing son"s bike ride, he learns how to live with death which doesn"t only exist in the shopping center but also is in our daily lives as in ‘white noise.’

눈깜박임을 주소로 내원한 아동에서의 틱 장애

정희연 ( Hee Yeon Jung ),정선주 ( Sun Ju Chung ),황정민 ( Jeong Min Hwang ) 대한안과학회 2002 대한안과학회지 Vol.43 No.2