비만(肥滿)에 관(關)한 문헌적(文獻的) 고찰(考察)

정지행,정석희,이종수 한방재활의학과학회 1992 한방재활의학과학회지 Vol.2 No.1

트레드밀 지구성 운동과 PDE5 억제제가 알츠하이머질환 동물 모델의 병리학적 특징과 인지기능에 미치는 영향

정지행,조준용 한국체육대학교 체육과학연구소 2022 스포츠사이언스 Vol.40 No.2

The purpose of the study was to evaluate the impact of treadmill endurance exercise(TEE) and/or Sildenafil(SIL) treatment, a PDE5 inhibitor on pathological main hallmarks and cognitive deficits of AlCl3-induced Alzheimer's Disease(AD) mice model. To induce AD in an animal model, all mice except the CON group were administrated AlCl3 (40mg/kg) for 60 days. After last treatment, AlCl3-induced AD mice were conducted TEE(10~20m/min, 50 min, 5 days/week) and/or SIL treatment(7mg/kg/day, 5 days/week) for 4 weeks. Increased the level of amyloid-β and cleaved caspase-3 induced by AlCl3 was decreased following TEE and/or SIL treatment. In addition, low-density lipoprotein receptor-related protein-1(LRP-1) protein was reduced and the receptor for advanced glycation end products (RAGE) was increased induced by AlCl3 treatment. However, only LRP-1 protein was elevated following TEE and/or SIL treatment. Moreover, reduced antioxidant enzymes such as superoxide dismutase-1(SOD-1), superoxide dismutase-2(SOD-2), and catalase were increased by TEE and/or SIL treatment. Finally, cognitive function and Nest formation score were significantly reduced following AlCl3 treatment, but it was improved following TEE and/or SIL treatment. Collectively, our data suggested that TEE and/or SIL treatment may regulate amyloid-β expression, cerebrovascular function, and antioxidant enzymes, thereby ameliorating AlCl3-induced cognitive deficits in AD mice.

비만환자(肥滿患者)에 대(對)한 설문모형(說問模型) 연구(硏究)

정지행,신현대 대한한의학회 한방재활의학과학회 1993 한방재활의학과학회지 Vol.3 No.1

교사의 음성문제 유발 요인 및 주관적 음성평가에 대한 원격수업과 대면수업 간 비교

정지행,김재옥 한국언어청각임상학회 2023 Communication Sciences and Disorders Vol.28 No.2

배경 및 목적: 코로나 바이러스(Corona virus, COVID-19)로 인한 세계적인 펜데믹 이후, 수많은 원격의사소통 방식이 도입되었다. 원격의사소통 방식은 교사의 음성에 영향을 미칠 가능성이 있다. 따라서 본 연구는 원격수업 방식과 전통적인 대면수업 방식이 교사의 음성문제와 주관적 음성평가에 미치는 영향에 차이가 있는지를 비교하였다. 방법: 초·중·고등학교에 재직 중인 교사 79명을 대상으로 수업방식(대면수업, 원격수업)에 따라 음성문제를 유발할 수 있는 위험요인들(환경, 신체, 음성사용, 심리) 및 주관적 음성평가(음성노력, 성도불편감)에 차이가 나타나는지 알아보았다. 결과: 음성문제를 유발할 수 있는 환경 요인과 음성사용 요인은 대면수업이 원격수업에 비해 유의하게 높은 점수를 나타냈다. 심리 요인은 원격수업이 대면수업보다 유의하게 높은 점수를 보였다. 신체 요인은 두 수업방식 간에 유의한 차이가 없었다. 주관적 음성평가에서는 원격수업이 대면수업에 비하여 음성노력도, 성도불편감에서 유의미하게 높게 나타났다. 논의 및 결론: 본 연구를 통해 교사들은 원격수업에 비하여 대면수업에서 더 많은 음성 불편함을 느끼고 음성노력이 더 요구될 뿐만 아니라 성도불편감을 높게 경험한다는 것을 알 수 있다. 따라서 원격수업에서는 교사들이 좀더 편하게 음성을 산출하는 것으로 나타났다.

小柴胡湯이 肥滿誘導白鼠의 肝 및 副睾丸脂肪組織과 血淸脂質의 變化에 미치는 影響

申鉉大,金性洙,鄭智行 慶熙大學校韓醫科大學韓醫學硏究所 1997 慶熙韓醫大論文集 Vol.20 No.2

This experimental study was designed to investigate the effects of Soshihotang on the weight and lipid metabolism in obese rats induced by high fat diet. Total population of sixty male rats(Sprague-Dawley) were utilized for this investigation. All rats selected for this study were six weeks old with weight of 190±5g. The first group of twenty rats(Normal) were fed with normal diet(Samyang Co. Korea), second group of twenty rats(Control) were fed with high fat diet(Harlan. TD94095, USA), and the remaining twenty rats(Sample) fed with high fat diet and the Soshihotang. The measurement has been performed on (1) the weight of epididymal fat pad with electric weight gauge(Librorel-1200H, Shimadzu, Japan) (2) the average size and the number of epididymal fat cells with light microscope(Olympus, Japan) and personal computer(Image Analysis System. LECO 2001, Canada) (3) the area % of fat drops in hepatic lobule with Light microscope and Computer image analysis system (4) the quantity of total cholesterol in serum on enzyme method COD-POD system (5) the quantity of triglyceride in serum on enzyme method LPL-GK-GPO system (6) the quantity of free fatty acid in serum on enzyme method ACS-ACO system (7) the quantity of total lipid in serum on Sulfo-phosphovanillin method (8) the quantity or insulin in serum on Radioimmunoassay method. The results are as follows : 1. It showed significant evidence that high fat diet conjunction with Soshihotang decreased the weight of rats compare to control group. 2. It showed significant evidence that high fat diet conjunction with Soshihotang decreased the epididymal fat pad weight, the average size of epididymal fat cells and the number of epididymal fat cells compare to control group. 3. It showed significant evidence that high fat diet conjunction with Soshihotang decreased the area % of rat drops in hepatic lobule compare to control group. 4. It showed significant evidence that high fat diet conjunction with Soshihotang decreased total cholesterol, triglyceride, free fatty acid and total lipid in serum compare to control group. 5. It showed significant evidence that high fat diet conjunction with Soshihotang decreased insulin level in serum to control group. Based on these results, it is proved that Soshihotang decreased the weight of fat, the size of fat cells and the number of fat cells. So it is concluded that the clinical application of Soshihotang can help the treatment of obesity.

다채널 보청기의 해제시간에 따른 무의미음절인지도와 선호도의 변화

정지행(Ji haeng Jeong),이경원(Kyoung won Lee) 한국청각언어재활학회 2018 Audiology and Speech Research Vol.14 No.4

Purpose: To determine the effective release time (RT) for listening to Korean sounds when wearing hearing aids, we evaluated Korean non-sense syllabic word recognition scores (NSRS) and the clarity of conversation sounds, the size of noise, and the overall preferences as a function of RT. Methods: Twenty adults and elderly people with mild to severe sensorineural hearing loss were participated as subjects. In the quiet and noise environment, NSRS and preferences were evaluated after setting the RT of the multi-channel hearing aids to 70, 200, and 600 ms. Presentation level of non-sense syllabic word was 45 dB HL and signal-to-noise ratio was 6 dB in noise environment. Results: NSRS was not different as a function of RT in quiet, but NSRS of 200 ms was higher than 70 ms and 600 ms in noise environment. However, clarity, loudness of noise, and overall preference did not show a difference in RT in a quiet and noisy environment. Conclusion: Through this study, it was confirmed that Korean NSRS can be affected by RT. Therefore, in order to develop a hearing aid fitting formula that is effective in recognition of Korean speech sound, it is necessary to consider the RT

대식세포에서 산화질소 생성에 대한 當歸 에탄올 추출물의 억제효과

정미영,박히준,정지행,김진용,강전모,이나경,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objective : The Angelica gigas Nakai ethanol extract (AGE) was investigated to compare nitric oxide (NO) production and NF-kB activity from RAW 264.7 cells, since NO and nuclear factor-kB(NF-kB) have been shown to be factors implicated In inflammatory disease. Method : AGE was prepared by extracting medicinal herb with 70% (v/v) ethanol solution. We investigated production nitric oxide (NO) and inducible nitric oxide synthase (iNOS) gene expression by ARE in LPS-stimulated RAW 264.7 macrophage cells. We also investigated inhibition of LPS-induced activation of NF-kB on western blot. Result : LPS-induced RAW 264.7 cells increascd NO production and ,iNOS expression. Upon treatment with AGE, nitrite production was significantly inhibited in a concentration-dependent manner compared to the untreated control. AGE inhibited this LPS-induced ,iNOS mRNA and protein in a dose-dependent manner. AGE markedly inhibited the expression of iNOS mRNA and protein at a concentration of 100 μg/ml. LPS-induced RAW 264.7 cells with AGE blocked inhibitory factor-kBα degradation. Conclusion : This study shows that AGE seems to attenuate inflammation through inhibition of NO production and iNOS expression by blockade of NF-kB activation in LPS-stimulated RAW 264.7 cells.

탈모증 환자의 한의학적 임상 유형에 대한 연구

이태후,문정배,정지행,임강현,김희택,Lee, Tae-Hoo,Moon, Jung-Bae,Jeong, Jee- Haeng,Leem, Kang-Hyun,Kim, Hee-Taek 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.3

Objectives : This study was planed to evaluate clinical status of the alopecia patients who had visited Korean medicine clinic. And the result from this study would provide a standard in Korean medical diagnostic and classification method of alopecia. Methods : Clinical records of 183 patients with alopecia seen from January 2004 to April 2005 at Korean medical clinic was examined. They were classified into 4 different types according to chief complains besides alopecia by 2 Korean medical doctors. Results and conclusions : We made clinical analysis of patients of alopecia from January 2004 to April 2005. Among the alopecia patients who visit Korean medical clinic, people age between 20 and 30 had high ratio. The duration from the recognition of initial hair loss to the time of the first visit to the Korean medical clinic was less than 12 months in 20.8%(38/138), and less than 60 months in 72.2% (132/183). The condition of alopecia was more worse than other alopecia patients who visit the west medical clinic. Also the ratio with increased temperature of face or scalp is chief complaint except alopecia in alopecia patients was high in men and the ratio with dysfunction of digestive system or chronic weakness was high in women. Among the incidence of alopecia, the androgenic alopecia was most in number; 43.7%(80/183) and the sex distribution showed 83 men and 100 women.

대식세포에서 산화질소 생성에 대한 當歸 에탄올 추출물의 억제효과

정미영(Mi-young Jeong),박히준(Hi-joon Park),정지행(Jee-haeng Jeong),김진용(Jin-young Kim),강전모(Jun-mo Kang),이나경(Na-kyeong Lee),임사비나(Sabina Lim) 대한한의학회 2007 대한한의학회지 Vol.28 No.2