류마티스 관절염 병인에서 제2형 콜라겐에 대한 면역반응의 역할

정영옥,홍승재,김호연,Jung, Young Ok,Hong, Seung-Jae,Kim, Ho-Youn 대한면역학회 2003 Immune Network Vol.3 No.1

Type II collagen (CII), major component of hyaline cartilage, has been considered as an auto-antigen in rheumatoid arthritis (RA). However, the clinical and biological significances with regard to the CII autoimmunity need to be clarified in human RA. The presence of antibodies to CII has been identified in sera, synovial fluid, and cartilage of patients with RA. In our study, the increased titer of IgG anti-CII in sera was well correlated with C-reactive protein, suggesting that this antibody may reflect the inflammatory status of RA. The titer of anti-CII antibodies (anti-CII Abs) tended to be higher in early stages of diseases. In our extending study, among 997 patients with RA, 269 (27.0%) were positive for circulatory IgG antibody to CII, those levels were fluctuated over time. It is hard to assess the significant amount of T cell responses to CII and CII (255~274) in RA. By using a sensitive method of antigen specific mixed lymphocyte culture, we can detect the presence of CII-reactive T cells in peripheral blood mononuclear cells of RA patients. Sixty seven (46.9%) of 143 patients showed positive CII reactive T cell responses to CII or CII (255~274). The frequencies of CII reactive T cells were more prominent in inflamed synovial fluid (SF) than in peripheral blood. These T cells could be clonally expanded after consecutive stimulation of CII with feeding of autologous irradiated antigen presenting cells (APC). Moreover, the production of Th1-related cytokine, such as IFN-${\gamma}$, was strongly up-regulated by CII reactive T cells. These data suggest that T cells responding to CII, which are probably presenting the IFN-${\gamma}$ producing cells, may play an important role in the perpetuation of inflammatory process in RA. To evaluate the effector function of CII reactive T cells, we investigated the effect of CII reactive T cells and fibroblasts-like synoviocytes (FLS) interaction on the production of pro-inflammatory cytokines. When the CII reactive T cells were co-cultured with FLS, the production of IL-15 and TNF-${\alpha}$ from FLS were significantly increased (2 to 3 fold increase) and this increase was clearly presented in accord to the expansion of CII reactive T cells. In addition, the production of IFN-${\gamma}$ and IL-17, T cell derived cytokines, were also increased by the co-incubation of CII reactive T cells with FLS. We also examined the impact of CII reactive T cells on chemokines production. When FLS were co-cultured with CII stimulated T cells, the production of IL-8, MCP-1, and MIP-1${\alpha}$ were significantly enhanced. The increased production of these chemokines was strongly correlated with increase the frequency of CII reactive T cells. Conclusively, immune response to CII was frequently found in RA. Activated T cells in response to CII contributed to increase the production of proinflammatory cytokines and chemokines, which were critical for inflammatory responses in RA. The interaction of CII-reactive T cells with FLS further augmented this phenomenon. Taken together, our recent studies have suggested that autoimmunity to CII could play a crucial role not only in the initiation but amplification/perpetuation of inflammatory process in human RA.

무릎 골관절염 환자에서 초음파로 평가된 위중도와 연골 및 활막의 생화학적 지표 간의 상관관계

정영옥 ( Young Ok Jung ),김해림 ( Hae Rim Kim ),강효종 ( Hyo Jong Kang ),유승아 ( Seung Ah Yoo ),나종명 ( Jong Myoung Nah ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ),김완욱 ( Wan Uk Kim ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.1

Objective: Ultrasonography has benefit in detecting soft tissue abnormalities within the joints, which cannot be assessed by conventional X-ray. In this study, we investigated the relationship between soft tissue and/or bony abnormalities on ultrasonography and biochemical markers of synovium and cartilage in knee osteoarthritis (OA) patients Methods: Fifty-one knee OA patients who fulfilled the ACR criteria were enrolled in this study. Knee ultrasonography was performed in affected knee joints with a 12 MHz linear probe to assess the presence of effusion, synovial proliferation, capsular distension, length of osteophytes, and thickness of cartilage. At the same time, the serum levels of hyaluronic acid (HA) and cartilage oligomeric protein (COMP) were measured by ELISA and serum osteocalcin levels were determined by RIA. Results: The patients with longer medial osteophytes showed higher levels of serum HA and COMP than those with shorter ones. Serum HA levels were significantly higher in patients with larger amount of effusion and/or synovial proliferation, suggesting inflammatory changes within the joint, than those without. In addition, the severity of capsular distention was also correlated well with serum HA and COMP levels. However, the length of lateral osteophytes and thickness of femoral cartilage were not correlated with serum HA or COMP levels. Serum osteocalcin levels did not show any association with above ultrasonographic parameters, either. Conclusion: Using knee ultrasonography, we demonstrated that serum HA and COMP levels were elevated in more severe OA patients than less severe patients. This result suggests that detailed pathologic changes in the soft tissue and/or bone of OA joints on ultrasonography are being directly reflected to biochemical markers measured in the peripheral blood.

식품기업의 마케팅 커뮤니케이션 전략에서 광고와 퍼블리시티의 효과 차이 분석

정영옥(Young-Ok Jung),정재엽(Jae-Yeob Jeong),김현철(Hyeon-Cheol Kim) 한국산업경제학회 2016 산업경제연구 Vol.29 No.2

근래 식품기업들은 기업에 대한 소비자의 신뢰를 회복하고 자사 제품에 대한 안전한 정보를 제공하기 위해 다양한 커뮤니케이션 수단을 이용하고 있다. 이에 본 연구는 주부를 대상으로 식품 기업의 커뮤니케이션 유형과 소비자의 안전추구행동 수준, 식품의 유형이 메시지신뢰도, 제품사용태도, 제품구매의도에 미치는 영향을 살펴보았다. 실험설계는 2(커뮤니케이션유형: 광고 vs. 퍼블리시티) × 2(식품유형: 쾌락적 제품 vs. 실용적 제품) × 2(안전추구행동의 수준: 높은 집단 vs. 낮은 집단)으로 하였다. 실험결과 소비자들은 식품의 광고보다 퍼블리시티로 제품에 대한 메시지를 전달할 때 메시지 신뢰도가 높았으며, 제품사용태도와 구매의도도 호의적이었다. 또한 식품의 광고에서는 쾌락적 식품을, 퍼블리시티에서는 실용적 식품을 노출하는 것이 메시지 신뢰도와 제품 사용태도 및 구매의도에 긍정적인 영향을 미치는 것으로 나타났다. 마지막으로 커뮤니케이션 유형과 소비자의 안전추구행동의 수준에 따른 상호작용효과를 알아본 연구에서는 안전추구행동이 낮은 집단에게는 광고를, 안전추구행동이 높은 집단에게는 퍼블리시티 형태의 메시지를 제시하는 것이 제품 정보에 대한 메시지 신뢰에 긍정적인 영향을 미치는 것으로 나타났다. The research was structured as a 2 (communication type : advertisement vs. publicity) x 2 (product type : hedonic product vs. utilitarian products) x 2 (safety pursuit behavior : high vs. low). Results show that consumers have more trust for messages that are delivered through publicity (rather than advertisements), and had more positive purchase intentions and product usage behavior. Also, message credibility and purchase intentions were higher for hedonic products when they were exposed through advertisements, while in utilitarian products, publicity increased message credibility, product usage behavior, and purchase intentions. Lastly, in terms of communication types and safety pursuit behaviors, advertisements were more effective on consumers with low safety pursuit behaviors, while publicity was more effective on consumers with high safety pursuit behaviors.

종설 : 통풍의 최신지견

정영옥 ( Young Ok Jung ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5

Gout is a common chronic inflammatory arthritis that can lead to significant disability. Gout is one of the few rheumatologic diseases that can be diagnosed with certainty and can be cured with appropriate therapy. Alcohol and dietary consumption are related to hyperuricemia and gout attacks. A moderate intake of purine-rich vegetables or protein is not related to an increased risk of gout. A weight-reducing, calorie-restricted diet with moderate carbohydrate restriction was beneficial for gout patients and reduced the serum uric acid and frequency of gout attacks, although these findings need to be confirmed. Clinicians should consider therapeutic options that do not increase the serum uric acid when treating associated conditions in gout patients. The acute gout attack can be treated appropriately with non-steroidal anti-inflammatory drugs, colchicine, or glucocorticoids. Hypouricemic treatment reduces the uric acid concentration by inhibiting its production (allopurinol) or enhancing its excretion (benzbromarone). Allopurinol is the agent used most commonly, but the recommended dose often fails to control the serum uric acid. Benzbromarone effectively reduces the serum uric acid, but possible hepatotoxicity should be monitored. Febuxostat, a new xanthine oxidase inhibitor, was recently approved by the Federal Drug Administration (FDA). PEGylated uricase, a potent parenteral hypouricemic agent, is under investigation for the treatment of gout. (Korean J Med 76:538-543, 2009)

중년여성의 사회적지지, 자기효능감, 지각된 건강상태가 노화불안에 미치는 영향

정영옥(Jung, Young-Ok),오효숙(Oh, Hyo-Sook) 한국보건간호학회 2016 韓國保健看護學會誌 Vol.30 No.1

Purpose: This study was conducted to determine the effects of middle-aged women’s social support, self-efficacy, and perceived health status on aging anxiety. Methods: Research subjects were 210 middle-aged women between 40 - 60 years living in G-city. Data were collected from July 21<SUP>st</SUP> 2014 to August 8th using a structured questionnaire and analyzed using t-test, One way ANOVA, and multiple regression analysis using the SPSS/WIN 21.0 program. Results: Aging anxiety showed statistically significant differences in religion (t=2.44, p=.015), satisfaction with married life (F=4.39, p=.014), type of leisure activity (F=8.09, p<.001), and number of friends (F=3.23, p=.024). Aging anxiety showed correlation with social support (r=-.21, p=.003), self-efficacy (r=-.46, p<.001), and perceived health status (r=-.33, p<.001). Factors affecting aging anxiety were self-efficacy (β=-.33, p<.001), perceived health status (β=-.23, p<.001), leisure activity type (β=-.16, p=.010), and religious affiliation (β=-.17, p=.038). The predictive power of these variables was 25% (F=18.63, p<.001). Conclusion: Nursing intervention strategies for improving self-efficacy, perceived health status, and leisure activity are required to relieve aging anxiety of middle-aged women.

동풍 ; 통풍의 합병증 치료

정영옥 ( Young Ok Jung ) 대한내과학회 2011 대한내과학회지 Vol.80 No.3

Chronic tophaceous gout results from long-term uncontrolled hyperuricemia with accumulation of urate crystals in joints, soft tissues, tendon sheaths and bony prominence. Urate-lowering agents should be administered to reduce serum uric acid level to less than 5 mg/dL for tophi reabsorption. Surgical indications include restoration of joint and tendon dysfunction, nerve decompression, debridement of septic joints, pain relief and cosmesis. Gout patients are at greater risk of forming uric acid stones. The renal tubular abnormality related to gout and metabolic syndrome leads to excretion of acidic urine, which favors formation of the relatively insoluble uric acid than more soluble urate. The corner stone of treatment of uric acid stone is urine alkalinization. Lowering serum uric acid with allopurinol and increasing urine volume are also important. Allopurinol is poorly tolerated and ineffective or contraindicated in some patients. Benzbromarone, a uricosuric agent is a useful alternative but possible hepatotoxicity should be monitored. Desensitization of allopurinol can be attempted to patients with mild cutaneous hypersensitivity. For gout patients with chronic renal failure, allopurinol dose need to be adjusted and nonsteroidal anti-inflammatory drugs and colchicine may be contraindicated. (Korean J Med 2011;80:269-272)

일부 농촌주민의 건강증진 생활양식 수행정도

정영옥(Young Ok Jung),김상순(Sang Soon Kim) 한국농촌의학 지역보건학회 1995 농촌의학·지역보건 Vol.20 No.2

고추에서 分離한 微生物의 發育과 Capsaicin의 分解에 關한 硏究

鄭榮玉(Young-Ok Jung),劉太鍾(Tai-Jong Yu) 韓國營養學會 1976 Journal of Nutrition and Health Vol.9 No.3

증례 : 신장 ; 복막투석 환자에서 allopurinol 복용 후 발생한 무과립구증 1예

김진경 ( Jin Kyung Kim ),이영기 ( Young Ki Lee ),노정우 ( Jung Woo Noh ),안병무 ( Byung Moo Ahn ),김정한 ( Jung Han Kim ),정영옥 ( Young Ok Jung ),박민정 ( Min Jeong Park ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3

Agranulocytosis is a rare, but sometimes dangerous, adverse reaction to allopurinol. We report the unusual case of a 43-year-old man with agranulocytosis, who received allopurinol while undergoing peritoneal dialysis. The bone marrow biopsy indicated that the agranulocytosis was drug-induced. After ceasing all drugs, isolating the patient, and administering granulocyte colony-stimulating factor (G-CSF), the leukocyte count returned to normal. A relationship between allopurinol therapy and agranulocytosis was presumed. (Korean J Med 76:365-369, 2009)

복막투석 환자에서 allopurinol 복용 후 발생한 무과립구증 1예

김진경 ( Jin Kyung Kim ),이영기 ( Young Ki Lee ),노정우 ( Jung Woo Noh ),안병무 ( Byung Moo Ahn ),김정한 ( Jung Han Kim ),정영옥 ( Young Ok Jung ),박민정 ( Min Jeong Park ) 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1