http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
노정우 ( Jung Woo Noh ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.1
Toll-like receptors (TLRs) are pattern-recognition receptors which identify pathogens or microorganisms associated molecular patterns (PAMP or MAMP) at the very early stage of their invasion to the host. So TLRs had been known to play a key role in the innate immune system only at first. However, a growing body of evidence that they participate in the adaptive immune system has accumulated as well. Though the primary role of TLRs is the surveillance of invading pathogens and evocation of the innate immune system against them. TLRs, unfortunately, are also found to be involved in pathogenetic processes of many diseases. So over- or under-activation of TLRs is regarded as being related with the course of many diseases. Many kidney diseases including urinary tract infection, sepsis, ischemiareperfusion injury, acute and chronic renal failure, glomerulonephritides either primary or secondary, and so forth are good examples where TLRs are working seriously. The author summarized the most recent evidences of the relationship between TLRs and the pathogenetic processes of many renal diseases.
만성신부전 환자에서 혈액투석이 혈장 Catecholamine 에 미치는 영향
노정우(Jung Woo Noh),김형건(Hyung Gun Kim),김형규(Hyung Kyu Kim) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A It is well known that the plasma catecholamine level indicates sympatho-adreno-medullary system activity. Using an advanced method of HPLC with ECD, the authars evaluated the syampatho-adrene-medullary system activity and the effect of hemodialysis on the plasma catecholamine level in 39 patients with ehronic renal failure accompanying hypertension, The results were as follows: 1. The base-line plasma concentrations of norepinephrine. epinephrine, dopamine, DOPA and DOPAC were significantly elevated in patients with chronic renal failure regardless of receiving hemodialysis 2. Intradialysis and single pass effects on plasma catecholamine levels showed that all catecholamines and their metabolites are dialyzable. 3. The intradialysis effect on the plasma catecholamine level was less in the group with dialysis induced hypotension than in the group without it, for all catecholamines except norepinephrine. 4. Norepinephrine was the most dialyzable but least responsive to dialysis induced hypotension among all the catecholamines. Epinephrine was the most responsive to dialysis induced hypotension of among all the catcholamines. 5. The difference in the intradialysis effect on the plama catecholamine level according to the type of dialyzer and vascular access was not significant. 6. There was no significant correlation between the intradialysis effect on the plama catecholamine level and blood flow rate or ultrafiltration rate. From the above findings, it is conclude4 that plasma catecholamine is responsible for the pathogenesis of dialysis induced hypotension and of hypertension in chronic renal failure.
급성망막괴사증후군 의심 환자에서 항바이러스제 정맥주사 후 발생한 급성신부전 1 예
조준희,장주현,이동훈,이영기,노정우,배지현,김하경,Joon Hee Cho,Joo Hyun Jang,Dong Hun Lee,Young Ki Lee,Jung Woo Noh,Ji Hyun Bae,Ha Kyoung Kim 대한안과학회 2010 대한안과학회지 Vol.51 No.11
Purpose: To report a case of acyclovir-induced acute renal failure (ARF) suspected as acute retinal necrosis syndrome. Case summary: The authors report a 55-year-old male patient who presented with left eye visual disturbance due to suspected acute retinal necrosis syndrome. Non-oliguric ARF developed after the infusion of intravenous acyclovir (850 mg every 8 hours). The patient did not show any uremic symptoms or signs. The crystal was not discovered in the urine. After stopping the acyclovir infusion and hydration, acyclovir-induced ARF was reversed. Conclusions: Although possessing critical nephrotoxicity, acyclovir is a useful antiviral drug. Therefore, when using acyclovir, the importance of hydration and preventing acyclovir-induced ARF should be considered. J Korean Ophthalmol Soc 2010;51(11):1528-1531
알코올성 간경변에 동반된 반월상을 보이는 IgA 신병증 1예
정다혜 ( Da Hye Jung ),이영기 ( Young Ki Lee ),손승연 ( Seung Yeon Son ),황상익 ( Sang Ik Hwang ),이승민 ( Seung Min Lee ),이동훈 ( Dong Hun Lee ),노정우 ( Jung Woo Noh ),오국환 ( Kook Hwan Oh ),문경철 ( Kyung Chl Moon ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6
It has been reported that IgA nephropathy is associated with alcoholic liver cirrhosis. However, crescentic glomerulonephritis or nephrotic syndrome are relatively rare. We experienced a patient with IgA nephropathy complicated with alcoholic liver cirrhosis who showed favorable clinical outcomes through steroid treatment. A 54-year-old man with alcoholic liver cirrhosis was hospitalized for generalized edema, nephrotic-range proteinuria and azotemia. We performed a renal biopsy and crescentic formations were found in half of the glomeruli. After use of steroid, azotemia and proteinuria improved gradually.
Paraquat 중독 환자에 대한 hemoperfusion 과 continuous veno-venous hemofiltration 의 치료 효과
노희종(Hee Jong Noh),구자룡(Ja Ryong Koo),이정열(Jeong Yeol Lee),주민하(Min Ha Joo),전만조(Man Jo Jeon),김진철(Jin Cheol Kim),김근호(Gheun Ho Kim),전노원(Rho Won Chun),김형직(Hyung Jik Kim),채동완(Dong Wan Chae),노정우(Jung Woo Noh) 대한내과학회 2000 대한내과학회지 Vol.59 No.6
N/A Background : In Korea, paraquat accounts for most of fatal poisoning with 500 or more deaths per year. It has been known that patients who ingested more than 1/2 mouthful of 20% concentrate paraquat usually die of multiorgan failure and pulmonary fibrosis. But the effect of charcoal hemoperfusion which can enhance elimination of paraquat remains controversial. Because acute paraquat poisoning is also characterized by multiorgan failure including kidney and marked rebound in plasma paraquat level after hemoperfusion, Continuous veon-venous hemofiltration(CVVH) may have theoretical benefits in the treatment of paraquat poisoning. So we evaluated the effect of early charcoal hemoperfusion and prophylactic CVVH after hemoperfusion in patients with paraquat poisoning. Methods : There were 80 patients with paraquat poisoning admitted within 24 hours after ingestion (August 1996 - March 1998). All of them were treated with hemoperfusion (duration of hemoperfusion, 6.4±3.0 hours) within 24 hours of ingestion. The amount of ingestion was 2.1±1.0 mouthful (as 20% concentrate) and 78 (98%) were urine sodium dithionite test positive which is a poor prognosis factor. Forty-four patients received hemoperfusion only and 36 were followed by CVVH (duration, 50.4±20.9 hours; ultrafiltration volume, 33.8±3.9 L/day) after hemoperfusion. Results : There was no difference between the hemoperfusion group and hemoperfusion+CVVH group in age, sex, initial serum creatinine, arterial oxygen saturation, severity of poisoning (as assessed by serum paraquat level determined by HPLC and amount of ingestion), or in the time elapsed from ingestion to the beginning of hemoperfusion. The total mortality was 65% (52/80) with no difference between the hemoperfusion group (64%, 28/44) and hemoperfusion+CVVH group (67%, 24/36). The mortality according to amount of ingestion was as follows: 〈 1 mouthful, 0% (0/5); 1 mouthful, 53% (8/15); 2 mouthful, 65% (11/17); ≥ 3 mouthful, 82% (27/33); unknown, 60% (6/10). Conclusion : Early hemoperfusion can be effective in reducing mortality in patients who ingest less than 2 mouthful. Even though prophylactic CVVH after hemoperfusion has no additional benefit in reducing mortality in paraquat poisoning, it prolonged the time to death after ingestion.(Korean J Med 59:651-656, 2000)
임규성(Kyu Sung Rim),김우중(Woo Joong Kim),노정우(Jung Woo Noh),서정은(Jung Eun suh),박충기(choong Ki Park) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
Benign tumors of esophagus are rare pathologic conditions. Among them, squamous cell papilloma of esophagus is a distinctly rare disorder which is reported with increasing frequency recently. Usually it is found by accident as a small mass without developing symptoms during gastrofibers- copic examination. Squamous cell papillorna of esophagus is small polypoid tumor with benign nature. Pathologically surface epithelium composed of finger like projections is lined by increased numbers of squamous cells and there are fibrovascular cores. Squamus cell papilloma of esophagus is known to be found more in frequency in men than in women and in lower esophagus than in upper esophagus but our cases revealed reversed pattern. More cases should be examined for evaluation in detail. Recently we had the opportunity to observe 3 cases of pathologically demonstrated squamous cell papilloma of esophagus. Our purpose here is to report these cases and to review the literatures.
양익,정수영,박해정,이열,전노원,노정우,Yang, Ik,Chung, Soo-Young,Park, Hai-Jung,Lee, Yul,Chun, Rho-Won,Noh, Jung-Woo 대한영상의학회 1995 대한영상의학회지 Vol.33 No.5
발작성 야간혈색소뇨증은 매우 드문 용혈성 빈혈로 MR 소견이 보고되기전까지는 특징적인 방사선학적 소견에 대하여 별로 알려져 있지 않았다. 그러나 최근 MR과 CT의 특 징적 소견이 외국 문헌에는 보고된 바 있으나 국내 보고는 없어 MR 및 CT 소견을 보고한 다. 암적색 혈뇨와 만성 빈혈증상으로 반복 수혈후 발작성 야간혈색소뇨증으로 진단된 61세 여자 환자로 복부 MR의 T1, T2 강조영상에서 신피질은 신수질과 비교해 특징적인 저신호 강도를 보였으며 이러한 저신호강도 부위는 조영제를 사용치 않은 CT에서 신피질의 증가된 음영과 일치하였다. 다량 수혈에 의한 혈철증으로 간은 MR에서 저신호강도를 보였고 비장 은 정상이었으며 또한 조영전 CT 상 비장과 비교해 증가된 간 음영을 볼 수 있었다. Paroxysmal nocturnal hemoglobinuria(PNH) is a rare, acquired disease involving multiple hematopoietic celllines. Characteristics of PNH are intrinsic hemolytic anemia, iron deficiency anemia and venous thrombosis. Wereport a case of PNH with characterostoc MR and CT findings. The signal intensity of renal cortex was lower thanthat of medulla on both T1- and T2- weighted MR imaging. On T2 weighted MR images, the liver showed very lowsignal intensity but the signal intensity of the spleen was normal. On precontrast CT the attenuation of renalcortex was higher than that of renal medulla and the attenuation of liver was higher than that of the spleen.These findings of MR imaging and CT were the result from the deposition of hemosiderin in the cells of proximalconvoluted tubules and transfusional hemosiderosis of liver.
가토에서 실험적으로 유발된 겸상 사구체 신염에 관한 Gd-DTPA 조영 증강 후의 역동적 신 자기공명영상
양익,정수영,이열,이경원,원미숙,이일성,이관섭,노정우,전노원,김현태,박문향,Yang, Ik,Chung, Soo-Young,Lee, Yul,Lee, Kyung-Won,Won, Mi-Sook,Lee, Eil-Seoung,Lee, Kwan-Sup,Noh, Jung-Woo,Chun, Roh-Won,Kim, Hyun-Tae,Park, Moon-Hyang 대한영상의학회 1998 대한영상의학회지 Vol.38 No.2
Purpose: The purpose of this study was to evaluate the utility of Gd-DTPA-enhanced dynamic MRI (DMRI) in earlydiagnosis and the assessment of disease processing in experimentally-induced crescentic glomerulonephritis (CGN)in rabbits. Materials and Methods: In six rabbits, CGN was induced by an injection of anti-glomerular basementmembrane Ab. A time-signal intensity curve (TSC) was obtained from DMRI on the day before, and at 1, 4, 7, 15, 45and 113 days after the induction of CGN. Sequential renal biopsies and blood sampling (serum creatinine) wereperformed on the same days, and the results of DMRI and TSC, were compared. Results: In normal kidneys, sequentialDMRI demonstrated the intratubular passage of Gd-DTPA as an inwardly migrating, thin, dark, band pattern. On days1 and 4, the thin dark band appeared but was poorly defined and TSC revealed a delay in peak time. On days 7 and15, movement of the band was seen to be weak and slow, and there was no centripetal migration. The maximal signalintensity of TSC was delayed, and the curves declined very slowly. On days 45 and 113, the dark band pattern wasvery weak and slow, and again there was no centripetal migration. Conclusion: GD-DTPA-enhanced DMRI may be ofvalue in the evaluation of disease processing and the severity of CGN.