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Glucose 의 Rodox 반응에 의한 인슐린 방출 Device 의 설계와 합성
정동준,심정섭 ( Dong June Chung,Yoshihiro Ito,Yukio Imanishi,Jyong Sup Shim ) 한국공업화학회 1990 공업화학 Vol.1 No.2
New insulin-releasing system on the basis of the redox reaction of glucose was synthesized by immobilizing insulin through a disulfide bond(5, 5`-dithiobis(2-nitrobenzoic acid) to polymer membrane(poly(methyl methacrylate)) and enzyme(glucose oxidase). The disulfide bonds were cleaved upon oxidation of glucose with glucose dehydrogenase and glucose oxidase, releasing insulin from the membrane and enzyme. Sensitivity to glucose concentration was enhanced by coimmobilization of enzyme cofactors(nicotinamide adenin dinucleotide and flavin adenin dinucleotide) acting as electron mediator(for the membrane device), and further enhanced by direct immobilization of insulin on glucose oxidase(for the protein device). Both systems were specific to glucose, and the released insulin was indistinguishable from native insulin. The biological activity of released insulin was 81% of native insulin.
가평지역 잣나무 풍매차대검정림 (風媒次代儉定林)의 가계별 (家系別) 생장과 생리적 특성에 관한 연구
정동준(Dong Jun Chung),신만용(Man Yong Shin),장용석(Yong Seok Chang),전상근(Sang Keun Chon) 한국산림과학회 2001 한국산림과학회지 Vol.90 No.1
This study was conducted to reveal the relationship between physiological characteristics and growth by family for open-pollinated progeny stand of Korean white pine in Gapyung site. Average growth performance of total 25 families for 18 years old progeny stand in this study site showed 5.9m in mean height, 8.9㎝ in mean DBH, 12.0㎡ in basal area per hectare and 46.5㎥ in volume per hectare, respectively. By the analysis result of growth performance for all 25 families, family No. 20 showed the most excellent growth and middle in family No. 10. On the other hand, family No. 3 represented the worst growth among the 25 families. The change of seasonal photosynthesis rate by increasing luminous intensity was the same tendency as the growth pattern of all 25 families and showed the same results in all four seasons. In the seasonal analysis, the photosynthesis rate was increased as the season has changed from winter to summer. Chlorophyll contents was also increased from winter to summer. Especially, family No. 20 which is the best in growth performance has more chlorophyll contents than the others. In addition, family No. 20 was also better than other families in the weight of assimilation tissue(g), length of needle(㎝), width of needle(㎝), and number of Stoma. However, in water utilization rate, family No. 3 which is the worst in the growth performance showed the best result that is reverse tendency compared with the photosynthesis rate. The changes of water utilization rate represented to be increased as the season has changed from winter to summer.
북한예방의학회지 ($1997{\sim}2006$) 게재논문의 핵심어 네트워크 분석
정민수,정동준,최만규,Jung, Min-Soo,Chung, Dong-Jun,Choi, Man-Kyu 대한예방의학회 2008 예방의학회지 Vol.41 No.6
Objectives : There are very few researches on North Korea's academic activities. Furthermore, it is doubtful that the available data are reliable. This study investigated research activities and knowledge structure in the field of Preventive Medicine in North Korea with a network analysis using co-authors and keywords. Methods : The data was composed of the North Korean Journal of preventive medicine ranged from Vol. 1 of 1997 to Vol. 4 of 2006. It was the matrix of 1,172 articles by 1,567 co-authors. We applied R procedure for keywords abstraction, and then sought for the outcome of network forms by spring-KK and shrinking network. Results : To comprehend the whole networks explicitly demonstrated that the academic activities in North Korea s preventive medicine were predisposed to centralization as similar as South Korea's, but on the other aspect they were prone to one-off intermittent segmentation. The principal co-author networks were formulated around some outstanding medical universities seemingly in addition to possible intervention by major researchers. The knowledge structure of network was based on experimentation judging from keywords such as drug, immunity, virus detection, infection, bacteria, anti-inflammation, etc. Conclusions : Though North Korea is a socialist regime, there were network of academic activities, which were deemed the existence of inducive mechanism affordable for free research. Article keywords has laid greater emphasis on experiment-based bacterial defection, sustainable immune system and prevention of infection. The kind of trend was a consistent characteristic in preventive medicine of North Korea haying close correlation with Koryo medical science.
국내 예방의학 분야의 공저자.핵심어 네트워크와 군집 양상 - 대한예방의학회지($1991{\sim}2006$) 게재논문의 분석 -
정민수,정동준,Jung, Min-Soo,Chung, Dong-Jun 대한예방의학회 2008 예방의학회지 Vol.41 No.1
Objectives : This study evaluated knowledge structure and its effect factor by analysis of co-author and keyword networks in Korea's preventive medicine sector. Methods : The data was extracted from 873 papers listed in the Journal of Preventive Medicine and Public Health, and was transformed into a co-author and keyword matrix where the existence of a 'link' was judged by impact factors calculated by the weight value of the role and rate of author participation. Research achievement was dependent upon the author's status and networking index, as analyzed by neighborhood degree, multidimensional scaling, correspondence analysis, and multiple regression. Results : Co-author networks developed as randomness network in the center of a few high-productivity researchers. In particular, closeness centrality was more developed than degree centrality. Also, power law distribution was discovered in impact factor and research productivity by college affiliation. In multiple regression, the effect of the author's role was significant in both the impact factor calculated by the participatory rate and the number of listed articles. However, the number of listed articles varied by sex. Conclusions : This study shows that the small world phenomenon exists in co-author and keyword networks in a journal, as in citation networks. However, the differentiation of knowledge structure in the field of preventive medicine was relatively restricted by specialization.
의치세정제와 소독제가 의치상 레진의 색조, 표면경도, 표면조도에 미치는 영향에 대한 연구
양희진,장복숙,정동준,허성주,한동후,심준성,장명우,Yang Hee-Jin,Jang Bok-Sook,Chung Dong-June,Heo Seong-Joo,Han Dong-Hoo,Shim June-Sung,Chang Myung-Woo 대한치과보철학회 2001 대한치과보철학회지 Vol.39 No.1
The purpose of this study is to compare effects of denture cleansers and disinfectants on the color. surface hardness, and surface roughness of reinforced acrylic resin using polyhedral oligosilsesquioxane molecules(POSS resin) to those of common resins. According to manufacturer's instructions, 45 specimens were made from three denture resins(Luciton 199, Paladent 20, POSS resin), and polished. Five denture cleansers(distilled water, glutaraldehyde, alkaline hypochlorites, chlorhexidine, alkaline peroxides) in combination with three denture resins were evaluated before and after immersion for 7 days. Color data in $L^*a^*b^*$ system were measured with a colorimeter. Surface hardness data were measured with a microhardness tester. Surface roughness data were measured with a 3-dimensional surface analyzer. Data were analyzed with two-way ANOVA, one-way ANOVA, and t-test. The results were as follows : 1. All resins(Luciton 199, Paladent 20, POSS resin) showed significant differences in color after immersion in hypochlorites(p<0.05). 2. POSS resin showed significant differences in color compared with Paladent 20 in all denture cleansers, but no statistically significant differences with Luciton 199(p<0.05). 3. Luciton 199 showed significant differences of surface hardness in chlorhexidine, Paladent 20 showed significant differences in glutaraldehyde and chlorhexidine. POSS resin showed a little change of surface in all denture cleanser, but no statistically significant differences(p<0.05). 4. Luciton 199 and Paladent 20 showed significant differences of surface roughness in hypochlorites and glutaraldehyde, and POSS resin showed no statistically significant differences in all denture cleansers(p<0.05).