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임플란트 식립후 발생한 동통성 지각이상의 미세외과적 처치와 경과
김명래(Myung Rae Kim),이원호(Won Ho Lee),최장우(Chang Woo Choi),정현주(/Hyun Ju Chung) 대한구강악안면외과학회 1998 대한구강악안면외과학회지 Vol.24 No.4
Purpose : This study is to examine the painful dysesthesia of lip & gingiva followed after implant surgeries and to evaluate the prognosis of microsurgical epineurotomy & tubulization with e-PTFE tubes. Method : Three patients who had been suffered from painful anesthesia and dysesthesia following dental implant surgeries were examined periodically and followed for over 1 year after epineurotomy and e-PTFE tubulization. Neurosensory dysfunctions were examined by Static Light Touch Threshold, Moving Direction Discrimination, Two Point Discrimination, Pin-Prick Nociception Visual Analog Scales and Tinel sign. The subjective symptoms were confirmed by SSEP and DITI prior to surgical exploration. Result : Two patients complained of continuous tearing and lancinating pain disclosed complete avulsion of IAN and degenerative changes with neuroma. One patient complained of mild painful dysesthesia revealed partial adhesion & fibrous epineural changes. Two patients whose IAN were explored after over 1 year resulted in only mild improvement in sensory recovery and moderate reduction of pain score. While the patient to whom decompression & epineural repair were given in 3 months after nerve injuries resulted in satisfactory improvement in sensory function and pain reduction. Conclusion : Painful dysesthesias occurred after implant placement were resulted from neurotmesis and disclosed degenerative neuropathy. Therefore, the micro-surgical explorations and repairs (epineurotomy, decompression neurolysis, and neurorrhaphy) can be recommended for known injuries as early as possible. For the delayed painful dysesthesia lasted over one year, however, epineurotomy & tubulization could be an option to improve the painful discomfort but not satisfactory.
Park, Jae-Woo,Kim, Nam-Kug,Kim, Myung-Jin,Chang, Young-Il The Korean Association Of Orthodontists 2005 대한치과교정학회지 Vol.35 No.4
하악 수술로 치료한 골격성 3급 부정교합 환자의 연조직 변화를 3차원적으로 분석하였다. 수술전과 수술후에 CT를 촬영하고, 연조직과 경조직을 각각의 임계값에 따라 segmentation였다. FH.평면, 정중시상면, PNS를 포함하는 전두면을 기준으로 공통 좌표계를 구성하고, 이 좌표계를 기준으로 술전, 술후 영상을 위치시켰다. 술후의 변화를 측정하기 위해 각각의 모형에 대해 전두면에 평행한 grid를 형성하였다. Grid내의 교점에서 골조직과 연조직 모형에 투사하여 만나는 점의 좌표값을 구하고, 이를 바탕으로 술후의 변화를 측정하였다. 하악골 후퇴술시 안모의 변화는 하악골 부분에서만 발생한 것이 아니라, 구각부에서도 관찰되었다. 하악골 부위의 연조직 변화는 대응되는 골조직 이동량에 따른 상대적인 값으로 계산하였다. 정중시상면에서의 변화율은 $77\~102\%$로 나타났다. (p<0.05). 정중시상면 이외의 부분의 변화양상도 이와 유사하였다. 구각부에서의 변화는 하악골의 이동을 대표할 수 있는 점의 이동량에 대한 상대적인 값으로 계산하였다. 정중시상면에서의 변화는 B점을 기준으로 $14\~29\%$이고, Pog점을 기준으로 $17\~37\%$, grid상 83번째 점을 기준으로 $11\~22\%$로 관찰되었다.(p<0.05) The three-dimensional (3D) changes of bone, soft tissue and the ratio of soft tissue to bony movement was investigated in 8 skeletal Class III patients treated by mandibular setback surgery. CT scans of each patient at pre- and post-operative states were taken. Each scan was segmented by a threshold value and registered to a universal three-dimensional coordinate system, consisting of an FH plane, a mid-sagittal plane, and a coronal plane defined by PNS. In the study, the grid parallel to the coronal plane was proposed for the comparison of the changes. The bone or soft tissue was intersected by the projected line from each point on the gird. The coordinate values of intersected point were measured and compared between the pre- and post-operative models. The facial surface changes after setback surgery occurred not only in the mandible, but also in the mouth corner region. The soft tissue changes of the mandibular area were measured relatively by the proportional ratios to the bone changes. The ratios at the mid-sagittal plane were $77\~102\%(p<0.05)$. The ratios at all other sagittal planes had similar patterns to the mid-sagittal plane, but with decreased values. And, the changes in the maxillary region were calculated as a ratio, relative to the movement of a point representing a mandibular movement. When B point was used as a representative point, the ratios were $14\~29\%$, and when Pog was used, the ratios were $17\~37\%(9<0.05)$. In case of the 83rd point of the grid, the ratios were $11\~22\%(p<0.05)$.
( Jung Hyun Kwon ),( Sang Woo Kim ),( In Sik Chung ),( Myung Gyu Choi ),( Kwan Woo Nam ),( Jung Pil Suh ),( Jae Hyuck Chang ),( Won Haing Hur ),( Yu Kyung Cho ),( Jae Myung Park ),( In Seok Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Westernization in many Asian countries have changed lifestyles and diets, so once rare diseases have now become prevalent. The aim of this study is to investigate the changing pattern of digestive and liver disease in Korea, from 1990 to 2006. Methods: We extracted data specific gastrointestina (GI) disease based on the International Classification of Diseases code from the in-patients records at the Kangnam St. Mary`s Hospital in 1990, 1996 and 2006. This hospital is a tertiary-care hospital in Seoul, Korea, which has a capacity of 800 beds. Results: The admission rate for GI disease increased between 1990 and 2006. Overall in-patients were 1,623 persons in 1990, 2,368 persons in 1996 and 4,166 persons in 2006. The mean age of in-patients increased as time went by. A stomach cancer was the most common diagnosis during all periods, but its prevalence has decreased. Colon cancer ranked the 7th in 1990, but markedly increased and now ranks the second. The third was a hepatocellular carcinoma. The bile duct and gallbladder cancer, pancreas and esophageal cancer ranking followed with little interval change. In cases of cancer patients, a regular admission dramatically increased for chemotherapy. The number of patients admitted with pre-malignant neoplasm of stomach and colon increased remarkably with the development of endoscopy. The liver transplant, inflammatory bowel discase, and reflux esophagitis emerged form mid-1990s with greater frequencies, yet much below the levels found in the West. The admission rate for peptic ulcer, especially ulcer bleeding remained relatively stable, despite a decreased rate for ulcer perforation. Liver cirrhosis, hepatitis, cholelithiasis with cholecystitis-cholangitis, appendicitis, hemorrhoid and gastritis all decreased. Conclusions: The stomach cancer is the leading cause of admission, despite a recent decline. Colon cancer showed a marked rise. The liver transplant, inflammatory bowel disease and reflux esophagitis were new diagnosis with an increased tendency.
측두하악관절 골관절염 환자의 진단에서 Cone Beam 전산화 단층촬영의 유용성
노창세,정연화,태일호,고명연,안용우,Roh, Chang-Se,Jung, Yun-Hoa,Tae, Il-Ho,Ko, Myung-Yun,Ahn, Yong-Woo 대한안면통증구강내과학회 2009 Journal of Oral Medicine and Pain Vol.34 No.1
This study is designed to assess Relationship between clinical diagnosis of Temporomandibular Joint Disorder and diagnostic finding of Cone Beam Computed Tomography(CBCT) The author performed clinical examination for TMD Patients who visited Orofacial pain clinic, Jin-ju ooo Dental office. CBCT(Cone beam computed tomography) was taken for 190 joints in 95 subjects. A Oral medicine and Oral radiologist evaluated CBCT each other. then we compared with that result, Condyle bony changes were classified by no bone change, flattening, erosion and osteophyte. The obtained results were as follow: 1. The Kappa index of the diagnosis between oral medicine and oral radiogist were high, the index of diagnosis by degenerative joint disease were more higher. 2. The Kappa index of panoramic view and CBCT was low, more condylar bone chages were observed by CBCT diagnosis 3. Condylar bone changes of the 54.2% of non-DJD group clinicaly was observed by CBCT diagnosis and no bone changes of the 15.3% of DJD group.was observed by CBCT 4. TMJ pain was associated with erosion of condyle bone change of TMJ. Crepitation and longest duration of TMD were associated with osteophytic bone change.
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
TPD Chromatogram의 해석에 관한 연구 - Ⅰ
우명우,정창남 순천대학교 공업기술연구소 1988 工業技術硏究所論文集 Vol.2 No.-
A theoretical study of TPD chromatogram was carried out theoretically. From this result we concluded that TPD chromatogrom is influenced by desorption kinetics, desorption activation energy and whether readsorption exists or not. Also variations of desorption activation energy with coverage influences the TPD chromatogram. Linear of hyperbolic heating schedule of the experiment is little influencing to the TPD chromatogram.
우리나라에서 분리되는 Haemophilus influenzae의 9종 항균제에 대한 시험관내 감수성
장우현,최명식,석종성,정윤섭,서진태 대한화학요법학회 1989 대한화학요법학회지 Vol.7 No.2
To assess the occurrence of antimicrobial resistance among clinical isolates of H. influenzae in Korea, a total of 238 isolates were tested for their in vitro susceptibitlity to ampicillin and cefaclor by disc diffusion and 105 isolates were tested against nine antimicrobial agents-by the agar dilution method recommended by NCCLS. The antimicrobial agents sued for testing were ampicillin (Sigma A-9518, U.S.S.), cefaclor (Daewoong Lilly, Korea), cephalexin (Sigma C-4895, U.S.A.), cephradine (Sigma C-8395, U.S.A.), cephalothin (Sigma C-4520, U.S.A.), cefadroxil (Sigma C-7020, U.S.A.), erythromycin (Sigma E-6376, U.S.A.), teracycline (Sigma T-3383, U.S.A.) and cefatrizine (Dong-A Pharmaceutical Co., Korea). The isolation rate of H. influenzae from various clinical samples was 18.9%. Using the disc diffusion test, the resisant rates to ampicillin and cefaclor were shown to be 21.9% and 3.4%, respectively. Among the 52 ampicillin-resistant strains, 42 were susceptible to cefaclor (80.8%), and only two strains wre resistant. The MIS_(s) of ampicillin ranged from <0.125 ㎍/㎖ to >128 ㎍/㎖, and its MIC_(90) was 1 ㎍/㎖. Ampicillin showed the lowst MIC_(90) among the tested antivicrobial agents. The MIC_(90) of the tested cephalosporins ranged from 9.2㎍/㎖ to > 128. Among them, cefaclor showed the lowest MIC_(90) and its MIC_(90) was 9.2 ㎍/㎖. The MIC_(90) of tetracycline and erythromycin were 2.5 ㎍/㎖ and 14.4 ㎍/㎖, respectively. By the MIC, the resistant for ampicillin, cefalor, cephalexin, cephracine, cephalothin, cefadroxil, erythromycin, tetracycline and cefatrizine were 9.5%, 1.9%, 61.9%, 76.2%, 3.8%, 68.6%, 65.7%, 13.3% and 5.7%, respectively. There was no evidence that the MIC_(s) of cefaclor for the ampicillin-resistant strains differed significantly from those of cefaclor obtained with the ampicillin-susceptible strains. Except two islates, all of the multiple-esistant strains of H. influenzae were suceptible to cefaclor.
고분자 물질의 사슬 절단반응에 의한 분자량 분포 변화에 관한 연구
우명우,정창남 순천대학교 공업기술연구소 1991 工業技術硏究所論文集 Vol.5 No.-
Free-radical reactions, which are related on the chemical modification of polymeric materials, are discussed in relationship to their influence on the chain scission. A mathematical model having the degree of chain scission was studied. Special emphasis is placed on the prediction of random chain scission. Prediction of the variation of molecular weight averages and polydispersity with scission is also made.
장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4
Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.
조명진,장대우,조성호 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.1
파의 부정확한 도달시점에 의해 전단파의 속도가 결정된다면, 동적 탄성계수 또한 부정확하게 된다. 반면, 전단파의 도달시점을 정확히 결정하여 전단파 속도 측정의 정확성을 향상할 수 있다면, 상대적으로 신뢰성이 작지만, 경제적이고 효율적인 다운홀 실험의 적용성을 극대화시킬 수 있다. 따라서, 본 연구에서는 다운홀 시험에서 전단파 속도를 가장 정확하게 결정하는 방법을 결정하기 위해서 현재 적용가능한 도해법, 최대곡률법, 상호교차법, 상호상관법, 위상속도법 등을 비교검토하였다. 또한, 각 깊이에서의 전단파 전파시간으로부터 전단파 속도 주상도를 결정하기 위한 다운홀 해석법인 직접법, 수정 간접법, 역산 해석법 등과 신뢰도가 높은 SASW실험결과를 비교하였다. 그 결과 전달파 전파시간의 결정은 최대곡률법과 교차상관법이 적합한 것으로 판단되었고, 다운홀 해석 법으로는 Snell 법칙을 이용하는 역산해석 법이 신뢰도가 높은 것으로 판단되었다. In case of visual measurement of velocity, there is a potential error for the arrival point of shear wave. Consequently, the error causes incorrect results in the evaluation of dynamic modulus. The disadvantage of downhole test can be improved, if the velocity of shear wave is exactly chosen by arrival point of the wave. Thus, in this study, visual method, cross-over method, cross-correlation method and phase of cross spectrum method were used to find the most reliable procedure for the determination of the S-wave velocity Also, to provide the reliable interpretation procedure to evaluate the S-wave velocity profile from travel times at depths, the results of the direct method, the modified interval method, arid the inversion method were compared with the results of SASW measurments. As a result, the modified interval method and the inversion method based on Snell's method turned out to be the reliable procedures to determine the S-wave velocity profile from the travel times of the S-wave at depths.