종양이식 생쥐모델에서 도두(刀豆), 우방근(牛蒡根) 추출물의 대장암 억제 효과

장지혜,지건영,최형석,양원경,김한영,김근회,강형식,이영철,김승형,Jang, Ji-Hye,Ji, Kon-Young,Choi, Hyung-Seok,Yang, Won-Kyung,Kim, Han-Young,Kim, Kun-hoae,Kang, Hyung-Sik,Lee, Young-Cheol,Kim, Seung-Hyung 대한본초학회 2017 大韓本草學會誌 Vol.32 No.5

Objective : In the present study, we examined whether Canavalia gladiata D.C. (CG) and Arctium lappa L., Redix (AL) mixture (CGAL), their components, lupeol and chicoric acid, regulate immune system and suppress the tumor in vitro and in vivo. Methods : LPS-induced reactive oxygen species (ROS) and nitric oxide (NO) were measured after treatment with CG extract (CGE), CGAL, lupeol, chicoric acid and lupeol and chicoric acid mixture (lupeol+CA) in Raw264.7 cell. To determine the effect of CGE on immune responses, immune cell population and IgG production were assessed in mice. To investigate the effect of CGAL and their component on anti-tumor activity, tumor volume and weight were measured, cell cycles and immune cell population were analyzed in MC38 injected tumor bearing mice. Also, NK cell activity was determined in splenocyte isolated from tumor bearing mice. Results : CGE, CGAL, lupeol, chicoric acid and lupeol+CA decreased the LPS-induced ROS and NO production without cell toxicity in RAW264.7 cells. CGE increased the immune cell populations of $CD4^+T$, $CD8^+T$ and macrophages in various immune organ of mice. In tumor bearing mice, CGAL, lupeol, chicoric acid and lupeol+CA suppressed tumor volume and weight. In cell cycle analysis, they decreased the percentages of S phase. In addition, CGAL, lupeol, chicoric acid and lupeol+CA immune cell populations of $CD4^+T$, $CD8^+Tcell$, NK cell and macrophage in tumor as well as NK cell activity. Conclusion : CGAL and its compounds may enhance immune responses and suppress tumor growth, and may be capable of developing health functional foods.

소아 아토피 피부염에 관한 임상적 고찰

장지혜,이준문,이승연,Jang, Ji-Hye,Lee, Jun-Moon,Lee, Seung-Yeon 대한한방소아과학회 2005 대한한방소아과학회지 Vol.19 No.2

Objective : The objective of this study is to investigate treatment results and reasons of difference of treatment result. Method : 22 patients with atopic dermatitis were evaluated for the symptoms and signs according to SCORAD index before and after Oriental medical treatment. And they were divided into two groups(G1: the lower group, G2: the higher group) with 30 scores in standard and analyzed for differences of treatment result. Reasult : 22 patients's Change of total SCORAD index before and after treatment were $35.79{\pm}10.86$ and period were $4.55{\pm}2.94$ months. There were no significant differences between two groups in sex, age, congenital fever, onset and hospital treatment. There were many differences between two groups in the weakness of Digestive system. There were more familial histories in G2 than G1. Past years were $3.20{\pm}3.72$ years in G1 and $1.75{\pm}1.68$ years in G2. There were more deterioration fetors in G1 than G2. Sleep conditions before treatment were worse in G2 than G1 but all children except one were good after treatment. SCORAD index before treatment were worse in G2 than G1. The used herbal medicines were Bangpungtongsungsan gagambang, Yukmijihawangtang gagambang, Saenghyeolyunbuum gagambang. The most frequently used herbal medicine was Bangpungtongsungsan gagambang in G1, Yukmijihawangtang gagambang in G2. Conclusion : On the basis of this study, we thought factors which affected treatment result were the weakness of Digestive system, past years, deterioration factors and SCORAD index before treatment. But this study's cases are small in number so more study is need.

비전형자폐 소아 환자 치험 2례 보고

장지혜,임영우,이승연,Jang, Ji-Hye,Lim, Young-Woo,Lee, Seung-Yeon 대한한방소아과학회 2005 대한한방소아과학회지 Vol.19 No.2

Objective : The purpose of this study is to assess the clinical effect of Yukmijihawangtang gamibang on autism. Methods : This clinical study was carried out with two atypical autistic children. We treated them with the herb medicine(Yukmijihawangtang gamibang) for several months and observed them once a month. And we checked the dregrees of autism with Korean-Autism Diagnostic Scale at June 29 and October 13. Results : Two cases's dregrees of autism were improved significantly. Autistic probability of case 1 was below the average at first test and very low at second test And case 2 was above the average at first test and very low at second test. And language was improved at last. Conclusion : Yukmijihawangtang gamibang was effective in the treatment of autism and more study about this disease is needed.

건강한 여아에서 발생한 황반부를 침범한 급성 망막분지동맥폐쇄 1예

장지혜,문종원,조영욱,Ji Hye Jang,MD,Jong Won Moon,MD,Young Wook Cho,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.2

Purpose: We report a case of branch retinal artery occlusion (BRAO) interconnected with the perifoveal capillaries in a healthy young female. Case summary: A 16- year- old female presented with sudden loss of vision in her left eye. Upon initial examination, her left visual acuity was 0.02 and intraocular pressure was 31 mm Hg. Fundus examination revealed pallid retinal edema of the inferior posterior pole and retinal hemorrhage below optic disc. Ocular massage followed by anterior chamber paracentesis was performed for 30 minutes within 4 hours after the onset of vision loss. Fluorescein angiography (FAG) showed a very slow blood flow in the superotemporal and inferotemporal retinal arteries and a delay in retinal arteriovenous transit time. We performed hemodynamic tests such as blood pressure, echocardiography, and the hematologic test for thrombogenicity and all tests were normal. At three weeks after treatment, vision in the left eye was 0.7 and FAG revealed normal retinal arterial circulation and venous drainage time. Conclusions: This is the first report regarding acute BRAO in a healthy Korean child without any detectable systemic disorder. Prompt treatment can prevent permanent visual loss in BRAO involving the macular area. J Korean Ophthalmol Soc 2014;55(2):304-308

소아의 한약 복용과 비만에 대한 후향적 연구

장지혜,강현경,이승연,Jang, Ji-Hye,Kang, Hyun-Kyoung,Lee, Seung-Yeon 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.2

Objective : As today obese children have increased rapidly in Korea, the interest has been much increased. And parents concern about the effect of Herbal Medication(HM) on gaining weight. Therefore we had a retrospective study HM and obesity for children. Method : We examined medical record of 38 patients who visited to Department of Pediatrics in 00 medical center from 2002 to 2006 and took HM. Their Hight, Weight, Obesity Index(OI) were estimated at two points: before and after HM treatment. And they were divided into two groups according to the HM type and analyzed for differences of OI. Result : There were no significant changes in 38 patients's OI before and after treatment. But only one case gained over weight(OI: 21.31). OI increased slightly after treatment but there were not statistically significance. OI according to the HM type had slightly difference but there were not statistically significance. There were no connections between HM type, the number of days taking HM and changes of OI. Conclusion : On the basis of this study, we thought there were no connections between HM and obesity for children. But this study's cases are small in number so more study is need.

중등도 이상의 소아 비만 치험 3례 보고

장지혜,이승연,Jang, Ji-Hye,Lee, Seung-Yeon 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.2

Objective : As today obese children have increased rapidly in Korea, the interest has been much increased. The childhood obesity causes not only physical problems but also psychosocial problems and it is more difficult than that of adult to treat. That's why we started to intervene actively. Methods : In the Oriental Medical Center, several children were treated for obesity with aroma massage, low frequency wave acupuncture therapy. auricular acupuncture therapy and behavior modification and 3 children over the middle level are mentioned in this study with good results. Results : 1) After treatments, they became taller$(1.1667{\pm}0.8505cm)$. 2) After treatments, they lost their weights$(1.6333{\pm}0.7768kg)$. 3) After treatments, their BMI and OI were reduced$(1.4667{\pm}0.5774kg/m^2,\;9.8{\pm}1.7776%)$. Conclusion : We report the good results of oriental medicine on three cases of obese children over the middle level. And the further study is needed with more cases, longer duration and other tools.

하악 대구치에서 치근단 병소가 치근 이개부 감염에 미치는 영향

장지혜,서성찬,이은숙,김형섭,Jang, Ji-Hye,Seo, Sung-Chan,Lee, Eun-Suk,Kim, Hyung-Seop 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.1

The purpose of the study was to investigate the influence of an endodontic infection on presence of furcation involvement in periodontally-involved mandibular molars. All first and second mandibualr molars in 45 patients were selected if at least one was root-filled or had a possible periapical radiolucency. The sample consisted of patients from a referral population at a periodotnal clinic which represented an adult population with a mean age of 47.5 years (range 31 to 63) For mandibular molars with periapical destruction at both roots, frequency of horizontal furcation depth ${\geqq}$ 3 mm was significantly more compared to teeth without periapical destruction. Mean periodontal probing depth was significantly greater at mandibular molars with periapical destruction. It is suggested that a root canal infection in periodontitis-involved molars may potentiate periodontitis progression by spreading of endodontic pathgens through patent accessory canals and dentinal tubules. In conclusion, an endodontic infection in mandibular molars was found to be associated with additional attachment loss in the furcation area, and may thus be considered to be one of several risk factors influencing the prognosis of molars in periodontitis-prone patients.

Intra Oral CMOS X-ray Image Sensor용 DC-DC 변환기 설계

장지혜,김려연,허성근,김태우,하판봉,김영희,Jang, Ji-Hye,Jin, Li-Yan,Heo, Subg-Kyn,Josonen, Jari Pekka,Kim, Tae-Woo,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.10

본 논문에서는 구강센서를 소형화하고 제조 원가를 낮추기 위해 구강센서에서 필요로 하는 바이어스 회로를 구강센서 칩 내부에서 만들어주었다. 제안된 DC-DC 변환기 회로는 기준전류 발생기(reference current generator) 회로의 IREF를 이용하여 전압 레귤레이터(voltage regulator)에 필요한 기준전류와 바이어스 전류를 각각 공급해준다. 이들 전류가 각각의 전압 레귤레이 회로에서 해당되는 기준전압을 생성하여 부궤환(negative feedback)에 의해 목표전압을 regulation하게 된다. 그리고 기준전류가 전류 복사비(current mirror ratio)에 의해 mirroring되어 정전류인 IB0/IB1을 공급해주고, VREF 전압을 공급해주도록 설계하였다. $0.18{\mu}m$ X-ray CMOS 이미지 센서 공정을 이용하여 설계된 구강센서의 DC-DC 변환기의 출력 전압의 평균 전압, ${\sigma}$와 $4{\sigma}$는 양호한 측정 결과를 얻었다. 그리고 line-pair pattern 영상은 blurring 없이 높은 해상도 특성을 보였으며, 좋은 구강 영상을 획득하였다. A bias circuit required for an oral sensor is manufactured inside the oral sensor chip to reduce its size and cost. The proposed DC-DC converter supplies the required reference and bias currents for their corresponding regulators by using IREF of the reference current generator. Their target voltages of the voltage regulators are regulated by the negative mechanism by generating their reference voltages required for their corresponding regulators. In addition, a constant current IB0/IB1 is supplied by being mirrored by a current mirror ratio and then VREF is generated. It is confirmed by measurements that the average volatge, ${\sigma}$, and $4{\sigma}$ of the designed DC-DC converter for intra oral sensors with a $0.18{\mu}m$ X-ray CMOS process are within their required ranges. And the line-pair pattern image shows a high-resolution characteristic without blurring. Also, a good oral image can be obtained.

쓰기를 통한 에토스 구축의 가능성 모색 -정체성과의 연관을 중심으로-

장지혜 ( Ji Hye Jang ) 한국작문학회 2016 작문연구 Vol.0 No.29

이 연구는 ‘좋은 글’과 ‘덕이 있는 사람’ 사이에서, 그 둘을 매개하기 위한작문 교육의 역할이 무엇인가에 대한 의문에서 시작되었다. 현재의 작문 교육은 장르에 따라 그 초점이 필자 자신의 내부로만 향하거나, 혹은 독자에게로만 향하는 식의 양 극단에서 진동해 왔다. 그러나 글쓰기는 어떤 장르라 하더라도 필자 자신의 정체성과 무관할 수 없으며, 본고는 쓰기를 통한 에토스의 구축이 학습자 스스로의 정체성을 구성하는 데까지 이어질 수 있는 가능성을 탐색하고자 하였다. 아리스토텔레스에 따르면 에토스란 화자에 대한 청자의 신뢰감과 관련된것으로 ‘담론의 결과일 뿐, 웅변가의 성격에 대한 선입견의 결과가 아니’다. 이는 필자의 성격 그 자체, 혹은 필자가 자신에 대한 성찰을 통해 인식하게된 자아가 아니라, 독자와 만나는 지점에서 실제적으로 구축된 자아상에 주목한 것이라는 점에서 에토스의 구축이 담화 속에서 적절하게 필자를 드러내는 방식을 익힘으로써 가능해질 수 있는 작문 교육의 영역임을 함의한다. 이러한 관점에서 에토스는 ‘나 자신’의 이미지가 ‘사회의 윤리·도덕적 가치’에 기반해 조화롭게 결합되어 ‘독자에게 수용’됨으로써 구축될 수 있다. 한편, 쓰기와 관련된 정체성은 자전적 자아, 담화적 자아, 필자로서의 자아, 사회문화·제도적 맥락에서의 자아의 가능성으로 나뉜다. 이중 담화적 자아는 글로 표현된 특정 텍스트 안에서 사회적 맥락에서의 가치, 믿음, 힘에 기반해 독자에게 주는 인상과 관련된다는 점에서 에토스와 유사한 개념이다. 에토스가 ‘자신의 것’으로 기능하기 위해서는 자전적 자아와의 접점 안에서 구축되어야 하며, 사회문화·제도적 자아의 가능성은 언제든 필자로서의 자아가 넘어서서 새롭게 만들어갈 수 있는 것이어야 하고, 필자로서의 자아가 쓰기 과정에서 활발하게 작용할 수 있도록 해야 한다. 내용적으로는 자전적 자아의 경험을 숙고를 거쳐 최대한으로 제시하고, 윤리적인 측면을 고려하여 독자와의 약속의 차원에서 글을 씀으로써, 표현적으로는 상위담화에 대한 이해를 통해 의도적이고 적극적으로 자아의 언표화를 시도함으로써 에토스의 구축이 가능해지며, 이것은 필연적으로 필자자신의 정체성의 구성으로 이어질 수 있다. The study began in the question of what is the role of writing education for mediating between ‘good writing’ and ‘man of virtue’. In the current writing education, instructor focus on only writer’s inward or only reader with the writing genre. Given the close connection between the writer’s identity and writing regardless of genre of it, this study explore the possibility of building ethos through writing leads to identity construction . According to Aristotle, ethos is connected with audience’s trust in the speaker, as a result of discourse, not preconceptions about speaker’s character. From this point of view, ethos is neither writer’s own character or self awareness through introspection. Building ethos will be possible learning express the writer in suitable language, so bulding ethos belongs properly to the domain of writing education. In this respect, ethos is built by ‘gaining acceptance in reader’ writer’s ‘own image’ based on ‘moral values in society’ harmoniously. Otherwise, the identity of writer is sorted out a discoursal self, autobiographical self, self as author, possibilities for self-hood in the socio-cultural and institutional context. discourse self is very similar concept to ethos: relates to impression it makes on the reader based on value, belief, power of social contexts in particular text. For ethos be able to function of ‘writer’s own’, ethos shoud be build in the boundaries of autobiographical self, not only beyond possibilities for self-hood in the socio-cultural and institutional context, but also self as author reconstruct possibilities for self-hood, and self as author work actively in the writing process. This study proposed the next contents as educational contents. It is as follows ; make the best use of personal experience of autobiographical self deliberatively, writing as perspective of promise with reader in the light of ethical aspects, and intentional presentation of the Self through understanding of the metadiscourse.

계룡산 국립공원 산림생태계의 탄소축적량 산정에 관한 연구

장지혜 ( Ji Hye Jang ),이준석 ( Joon Seok Yi ),정지선 ( Ji Sun Jeong ),송태영 ( Tae Young Song ),이경재 ( Kyeng Jae Lee ),서상욱 ( Sang Uk Suh ),이재석 ( Jae Seok Lee ) 한국하천호수학회 2014 생태와 환경 Vol.47 No.4

Understanding and quantifying of carbon storage in ecosystem is very important factor for predicting change of global carbon cycle under the global climate change. We estimated total ecosystem carbon in Gyeryongsan National Park with naturally well preserved ecosystem in Korea. Vegetation of Gyeryongsan National Park was classified with mainly four communities with Quercus mongolica (1,743.5 ha, 38.0%), Quercus variabilis (1,174.0 ha, 25.6%), Quercus serrata (971.9 ha, 21.2%), Pinus densiflora (695.2 ha, 15.2%). Biomass and soil carbons were calculated from biomass allometric equations based on the DBH and carbon contents of soil and litter collected in quadrat in each community. The tree biomass carbon was in Quercus variabilis (130.1 tCha-1), Pinus densiflora (111.1 tCha-1), Quercus mongolica (76.2 tCha-1), Quercus serrata (39.0 tCha-1). Soil carbon storage was in Quercus mongolica (159.7 tCha-1), Quercus serrata (121.0 tCha-1), Pinus densiflora (110.5 tCha-1), Quercus variabilis (90.8 tCha-1). Ecosystem carbon storage was Pinus densiflora (239.9 tCha-1), Quercus mongolica (235.9 tCha-1), Quercus variabilis (226.0 tCha-1), Quercus serrata (165.9 tCha-1), total amount was 867.7 tCha-1. The area of each vegetation carbon storage was Quercus mongolica (411,200 tCha-1), Quercus variabilis (265,300 tCha-1), Pinus densiflora (166,800 tCha-1), Quercus serrata (161,200 tCha-1) and the total ecosystem carbon amount estimated 1,045,400 tCha-1 at Gyeryongsan National Park. Theses results indicate that different in naturally well preserved ecosystem.